Abstract：
:Schistosoma mansoni, being transmitted by some freshwater Biomphalaria snails, is a major causative agent of human schistosomiasis. In the absence of effective vaccine and alternative drug designs to fight against the disease, and with the limitations of molluscicide application, developing more efficient strategies to interrupt the snail-mediated parasite transmission is being emphasized as potentially instrumental in the efforts toward schistosomiasis elimination, hence, necessitating thorough and comprehensive understanding of the fundamental mechanisms involved in the transmission process. Based on the current advances, this paper presents a concise exposition of the cellular, biochemical, genetic and immunological dynamics of the complex and statge-by-stage interactions between the parasite and its vector in their aquatic environment. It also highlights the possible crosstalk between the parasite's intracellular cyclic adenosine monophosphate (cAMP) and p38 mitogen-activated protein kinase (p38 MAPK) during the intramolluscan stage. Undoubtedly, decades of intensive investigation have untangled many S. mansoni-B. glabrata complexities, yet many aspects of the parasite-vector cycle which can help define potential control clues await further elucidation.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Famakinde DOdoi
10.1016/j.actatropica.2017.07.021subject
Has Abstractpub_date
2017-12-01 00:00:00pages
98-104eissn
0001-706Xissn
1873-6254pii
S0001-706X(17)30748-9journal_volume
176pub_type
杂志文章,评审相关文献
ACTA TROPICA文献大全abstract：:An adaptation of a modified procedure using anion-exchange centrifugation was evaluated to isolate and freeze in field conditions a high number of bloodstream forms of Trypanosoma brucei gambiense for direct in vitro culture. Pellets of trypanosomes were obtained from 62 patients in Central Africa. The presence of try...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2003.10.017
更新日期：2004-04-01 00:00:00
abstract：:Rapid urbanization in resource poor countries often results in expansion of unplanned settlements with overcrowding and inadequate sanitation. These conditions potentially support transmission of schistosomiasis and soil transmitted helminths (STH), but knowledge on the occurrence, transmission and control of these in...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.01.012
更新日期：2014-05-01 00:00:00
abstract：:Neurocysticercosis (NC) is a serious public health problem mainly in developing countries. NC caused by the cysticercus stage from cestode Taenia solium is considered by the WHO and ITFDE as a potentially eradicable disease. Definitive diagnosis of NC is challenging because of the unspecific clinical manifestations su...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.11.001
更新日期：2016-02-01 00:00:00
abstract：:Vector-borne diseases (VBDs) infect over one billion people and are responsible for over one million deaths each year, globally. Chikungunya (CHIK) and Dengue Fever (DENF) are emerging VBDs due to overpopulation, increases in urbanization, climate change, and other factors. Colombia has recently experienced severe out...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.04.023
更新日期：2018-09-01 00:00:00
abstract：:The clinicoepidemiologic profile of 143 cases (93 males and 50 females) with cutaneous leishmaniasis from 18 villages of Hajjah governorate, Yemen was studied. Dry-type lesions were seen in 98.6% and wet-type lesions in 1.4% of patients. Lesions were localized in all cases with different morphological patterns. Micros...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.08.012
更新日期：2016-11-01 00:00:00
abstract：:Loop-mediated isothermal amplification (LAMP) is a novel molecular method that accelerates and facilitates DNA amplification and detection under isothermal conditions. It represents a revolution in molecular biology by reducing the high cost, turnaround time and technicality of polymerase chain reaction and other ampl...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2012.02.004
更新日期：2012-06-01 00:00:00
abstract：:The prevalence and associated risk factors for Giardia duodenalis in canine and human populations in Temple communities of Bangkok, Thailand were determined by evaluating three common diagnostic methods utilised to detect Giardia, namely zinc sulphate flotation and microscopy, an immunofluoresence antibody test and ne...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.03.006
更新日期：2009-08-01 00:00:00
abstract：:In Triatominae, female fecundity and fertility may be affected by age, adult nutritional status (i.e., blood meal source and amount of blood ingested) and number of matings. Triatoma infestans (Klug) is the main vector of Chagas disease in southern South America and considering that reproductive success is intimately ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2011.05.015
更新日期：2011-08-01 00:00:00
abstract：:Bovine cryptosporidiosis is mainly caused by four distinct species: Cryptosporidium parvum, C. bovis, C. ryanae and C. andersoni. The first, C. parvum, is a major concern in livestock causing economic losses, in addition to public health impact because of its zoonotic characteristics. The present study aimed to determ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2013.11.002
更新日期：2014-02-01 00:00:00
abstract：:Wuchereria bancrofti, a nematode parasite causing human lymphatic filariasis is widely distributed in India. The phylogeography of this parasite was studied by constructing RAPD profiles of parasite populations collected from 71 microfilaria carriers residing in different geoclimatic regions of India. The analysis sho...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2006.06.004
更新日期：2006-07-01 00:00:00
abstract：:The Japanese Encephalitis (JE) virus circulation in Indonesia was first documented in Lombok in 1960, and the virus was first isolated in 1972 from Culex tritaeniorhynchus in Bekasi, West Java and Kapuk, West Jakarta. Since then, Indonesia has been recognized as an endemic country for JE transmission. Up to now, JE ca...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2018.08.017
更新日期：2018-11-01 00:00:00
abstract：:Glutathione transferases (GSTs) perform several catalytic and non-catalytic roles in the defense against toxicities of electrophile compounds and oxidative stress, and therefore are involved in stress-response and cell detoxification. Previously, we have provided evidence indicating that EgGST2 and EgGST3, two phyloge...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.01.007
更新日期：2018-04-01 00:00:00
abstract：:The drugs currently available for Chagas'disease treatment are unsatisfactory due to limited efficacy and toxic side effects, making the search for more specific pharmacological agents a priority. The components of the Trypanosoma cruzi trypanothione-dependent antioxidant system have been pointed out as potential chem...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2006.12.001
更新日期：2007-01-01 00:00:00
abstract：:The polyamines, spermine and spermidine--organic polycations that are absolutely required for eukaryotic cell growth--are shown here to function in Trypanosoma cruzi epimastigotes, as protectors of membrane lipoperoxidation by reactive oxygen species generated either by H2O2/Fe2+ or nifurtimox. In vitro, spermine and ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2006.02.005
更新日期：2006-04-01 00:00:00
abstract：:Malaria in pregnancy is associated with increased risks of maternal anemia, spontaneous abortion, low birth weight, premature delivery and other adverse effects on health. In Brazil, disease transmission is highly concentrated in the multi-state region that constitutes the Brazilian Amazon (more than 99% of all cases)...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2012.11.004
更新日期：2013-02-01 00:00:00
abstract：:17-N-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) is an inhibitor of heat shock protein 90 (Hsp90), which has been studied in the treatment of cancer such as leukemia or solid tumors. Alternatively, 17-AAG may represent a promising therapeutic agent against leishmaniasis. However, the delivery of 17-AAG ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105595
更新日期：2020-11-01 00:00:00
abstract：:The formation of metacyclic trypomastigotes of Trypanosoma cruzi in cultures initiated by freshly isolated bloodstream trypomastigotes was studied using three strains of parasites (Peru, CL, and Y) and two different media (L-15 and Grace's medium). Serum (10% newborn calf serum) and various sugars were required for in...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
abstract：:Tropomyosins of invertebrates are pan-allergens responsible for wide spread allergic reactions against seafood and arthropods. As invertebrate tropomyosins are highly conserved, helminth tropomyosins are likely to show properties similar to these medically important allergens. Studies with a monoclonal antibody, NR1, ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2010.05.010
更新日期：2010-10-01 00:00:00
abstract：:The persistence of Trypanosoma cruzi in seropositive individuals, previously diagnosed as chronic chagasic patients (CCP), was detected for the first time in biopsies taken from gingival inflammatory foci processed by polymerase chain reaction (PCR). Seven out of 31 (22.5%) gum samples from selected unquestionably CCP...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2010.12.010
更新日期：2011-03-01 00:00:00
abstract：:Assessing the biting behaviour of malaria vectors plays an integral role in understanding the dynamics of malaria transmission in a region. Biting times and preference for biting indoors or outdoors varies among mosquito species and across regions. These behaviours may also change over time in response to vector contr...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.105059
更新日期：2019-09-01 00:00:00
abstract：:Greece has been recently affected by several mosquito borne diseases with the West Nile Virus (WNV) outbreak in 2010 being one of the largest reported in Europe. Currently at the epicenter of an economic and refugee crisis and visited by over 16 million tourists a year the integrated management of diseases transmitted...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.06.005
更新日期：2017-10-01 00:00:00
abstract：:Culex mosquitoes can act as vectors of several important diseases, including Japanese encephalitis, West Nile virus, St. Louis encephalitis and equine encephalitis. Besides the neurological sequelae caused in humans, Japanese encephalitis can lead to abortion in sows and encephalitis in horses. Effective vector contro...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.04.006
更新日期：2018-07-01 00:00:00
abstract：:"Anomalous", as yet unreported forms of brood capsules (BC) in cystic echinococcosis larvae from humans and sheep are described, thought to be the likely effect of degenerative involution of the parasite. Morphological examination showed an inner laminated layer (LL) in the brood capsules in intimate contact with the ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2007.12.006
更新日期：2008-03-01 00:00:00
abstract：:Benflumetol, a novel antimalarial compound belonging to the fluorenes (2,3-benzindenes), has high blood schizontocidal activity, in vitro and in vivo, against mammalian plasmodia, including chloroquine-resistant Plasmodium falciparum. Due to its molecular structure benflumetol occurs in the dextrorotatory and the laev...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00141-1
更新日期：1998-06-15 00:00:00
abstract：:Mosquito-borne diseases affect millions of individuals worldwide; the area of endemic transmission has been increasing due to several factors linked to globalization, urban sprawl, and climate change. The Aedes aegypti mosquito plays a central role in the dissemination of dengue, Zika, chikungunya, and urban yellow fe...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105398
更新日期：2020-05-01 00:00:00
abstract：:Since humans rarely play the role as Echinococcus oligarthrus host, there is lack of knowledge about the complex infectious process. Only three cases have been reported to occur in humans in the neotropics until now. We present the anatomo-clinical and molecular findings describing a new case of infection by E. oligar...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2012.09.004
更新日期：2013-01-01 00:00:00
abstract：:Giardiasis is an intestinal parasitosis that affects millions of people worldwide and is considered a zoonotic disease. Frequently in contact with humans, dogs are the main host involved in this zoonotic transmission. Here, we compared some aspects of Giardia duodenalis biology between two strains: a recently isolated...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.07.002
更新日期：2017-10-01 00:00:00
abstract：:In South America, Lutzomyia umbratilis is the main vector of Leishmania guyanensis, one of the species involved in the transmission of American tegumentary leishmaniasis. In Brazil, L. umbratilis has been recorded in the Amazon region, and an isolated population has been identified in the state of Pernambuco, Northeas...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.11.014
更新日期：2016-02-01 00:00:00
abstract：:Although, pleural (PT) and disseminated tuberculosis (DT) have been considered as extreme endpoints of the Th1-Th2 immunological spectrum of the Mycobacterium tuberculosis infection, these conditions can occur together. The presence of PT and DT could be explained by (1) PT as primary condition, with progression of HI...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2007.07.009
更新日期：2007-11-01 00:00:00
abstract：:The Kato-Katz, conventional ethyl-acetate sedimentation, and Midi Parasep(®) methods for diagnosing infection with soil-transmitted helminths were compared. The Kato-Katz technique gave the best overall diagnostic performance with the highest results in all measures (prevalence, faecal egg count, sensitivity) followed...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2013.02.018
更新日期：2013-06-01 00:00:00
