Abstract：
:Tropomyosins of invertebrates are pan-allergens responsible for wide spread allergic reactions against seafood and arthropods. As invertebrate tropomyosins are highly conserved, helminth tropomyosins are likely to show properties similar to these medically important allergens. Studies with a monoclonal antibody, NR1, raised against tropomyosin of the rodent filarial nematode Acanthocheilonema viteae revealed a B cell epitope common to helminths and marine mollusks, which does not occur in vertebrate tropomyosin. This antibody detected tropomyosin of A. viteae, other filariids, nematodes, trematodes and a cestode, and recognized as well tropomyosin of oyster, squid and octopus, but not of arthropods and vertebrates. Immunohistological analyses of A. viteae, Onchocerca volvulus and other nematodes using NR1 showed that tropomyosin is located in the fibrillar part of the body wall muscles and the uterus, and is also conspicuous in muscles of the pharynx, the vagina and other organs of the nematodes. The abundance of a pan-allergen like tropomyosin in parasitic worms and the counterintuitive, but well documented protection against allergic reactivity by some chronic helminth infections is discussed.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Sereda MJ,Hartmann S,Büttner DW,Volkmer R,Hovestädt M,Brattig N,Lucius Rdoi
10.1016/j.actatropica.2010.05.010subject
Has Abstractpub_date
2010-10-01 00:00:00pages
61-7issue
1eissn
0001-706Xissn
1873-6254pii
S0001-706X(10)00171-3journal_volume
116pub_type
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