Abstract:
:The promise of new interventions against malaria and other infectious diseases of global health importance derived from pathogen genomic sequence data may only be realized through the coordinated effort of genomic and post-genomics scientists, vaccine and drug developers along with lab- and field-based investigators. With the availability of the Plasmodium falciparum genome and the genomes of related species, post-genomics research can now be applied to the development of new interventions against malaria and may provide a more complete understanding of complex parasite biology. The vast amount of data that are generated through these new approaches must be organized, assembled and made accessible in a useful manner. By establishing a set of "credentials" for each gene in the genome, which captures information about gene expression, diversity, function and other information, the time and resources needed to test and evaluate candidate drugs and vaccines can be substantially reduced and a more complete picture of parasite biology can be created.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Carucci DJdoi
10.1016/j.actatropica.2005.06.010subject
Has Abstractpub_date
2005-09-01 00:00:00pages
260-4issue
3eissn
0001-706Xissn
1873-6254pii
S0001-706X(05)00160-9journal_volume
95pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract::A key tool for the control, elimination, and eradication of Plasmodium vivax is the development of an effective vaccine. The thrombospondin-related adhesion protein (TRAP) is one of the major sporozoite antigens that plays an important role in the invasion of mosquito salivary glands and hepatocytes by sporozoites. Th...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2017.05.026
更新日期:2017-09-01 00:00:00
abstract::Alpha-amylase and alpha-glucosidase activities were found in homogenates of young, unfed male and female Phlebotomus papatasi and in gut and salivary gland preparations. A significant increase in both enzyme activities in females and of alpha-amylase in males was recorded for flies that had fed overnight on a plant (C...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(00)00164-9
更新日期:2001-01-15 00:00:00
abstract::Bartonella elizabethae has been known to cause endocarditis and neuroretinitis in humans. The genomic features and virulence profiles of a B. elizabethae strain (designated as BeUM) isolated from the spleen of a wild rat in Kuala Lumpur, Malaysia are described in this study. The BeUM strain has a genome size of 1,932,...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2015.11.019
更新日期:2016-03-01 00:00:00
abstract::There is considerable evidence that trypanosomatid species vary in their metabolic characteristics, that they vary in the mechanisms by which they control these characteristics, and that a single species may vary metabolically without varying structurally. Studies to date from a number of laboratories also indicate th...
journal_title:Acta tropica
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::The Clean India Mission is a national campaign that aims for complete elimination of open defecation from the country. In India, 564 million people do not have access to toilets and defecate in the open environment. The 'Millennium development goals' have given increased weightage to elimination of open defecation for...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2018.06.024
更新日期:2018-10-01 00:00:00
abstract::The effect of vaccines against the pre-erythrocytic, the erythrocytic and the sexual stages of malaria on the transmission of malaria was examined using a simulation model of seasonal or epidemic transmission. The primary outcome of the model was the number of cases of malaria present at the end of the transmission se...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/0001-706x(93)90013-2
更新日期:1993-01-01 00:00:00
abstract::Lyophilized cells (sealed and unsealed) and water dispersible powders (WDPs) of two indigenous isolates of Bacillus thuringiensis var.israelensis were stored at -10, 4, 30 and 40 degrees C for up to 4 years and checked for activity. Lyophilized cells stored in sealed condition at -10, 4 and 30 degrees C and WDPs store...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2007.11.002
更新日期:2008-02-01 00:00:00
abstract::The structure of the Phlebotomine sand fly community from the Venezuelan Andes was studied using null-model tests. The analyses, at the living zones and altitudes scales, revealed C-scores larger than those expected by random, independently of the collection technique (P < 0.05). These results imply that sand fly spec...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2004.08.001
更新日期:2004-11-01 00:00:00
abstract::Evidence for the phenomenon of multiple drug resistance (MDR) in the well studied pathogenic protozoa has been examined. This has been placed in the more familiar context of the MDR efflux transporters and the cloned mdr genes of mammalian cells. Homologues of the mdr gene family in protozoa and their possible role in...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/0001-706x(94)90063-9
更新日期:1994-03-01 00:00:00
abstract::Monitoring and evaluation of programme to eliminate lymphatic filariasis (LF) depends on epidemiological assessment using appropriate indicators. Minimum efforts using reliable tests are necessary to guide the programme managers in decision-making. Impact of Mass Drug Administration (MDA) towards filariasis eliminatio...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2008.07.011
更新日期:2008-09-01 00:00:00
abstract::Homidium bromide was used in a strategic chemoprophylactic regime to control trypanosomiasis in Boran cattle in Kenya. Trypanosome infection rates in cattle receiving homidium bromide prophylaxis were compared with those in control cattle which received no prophylaxis but were treated with diminazene aceturate when in...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/0001-706x(90)90019-v
更新日期:1990-03-01 00:00:00
abstract::Five years after a single dose treatment, prevalence, intensity and morbidity of schistosomiasis mansoni were evaluated in Agua Branca, a low endemic community in the South East Brazil (cure rate 94%). At community level, prevalence showed a decrease from 38.9 to 24.5% and the intensity of infection dropped from 119.5...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(01)00190-5
更新日期:2002-02-01 00:00:00
abstract::The aim of this study is to investigate the feasibility and outcomes of using Gravid Oviposition Sticky (GOS) trap and dengue NS1 antigen tests for indoor and outdoor dengue/Aedes surveillance in the field. A one-year community-based study was carried out at Sungai Buloh Hospital Quarters, Selangor, Malaysia. GOS trap...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2021.105829
更新日期:2021-01-16 00:00:00
abstract::Chagas disease is a tropical parasitic disease endemic to Latin America which affects more than 10 million people, and kills more than 15,000 people each year. This condition, caused by the protozoan parasite Trypanosoma cruzi, is principally transmitted by kissing bugs (Triatominae). In Bolivia, recent reports by the...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2010.10.005
更新日期:2011-02-01 00:00:00
abstract::Northeast India with its rich and diverse avifauna acts as a hotbed for emerging virulent Newcastle disease virus (NDV) strains. The present work describes the molecular and pathogenic characterization of NDV strain isolated from Pandu, Assam, India. Clinicopathological and genetic analysis showed the virulent nature ...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2017.04.018
更新日期:2017-08-01 00:00:00
abstract::Assessing the biting behaviour of malaria vectors plays an integral role in understanding the dynamics of malaria transmission in a region. Biting times and preference for biting indoors or outdoors varies among mosquito species and across regions. These behaviours may also change over time in response to vector contr...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2019.105059
更新日期:2019-09-01 00:00:00
abstract::The London School of Tropical Medicine, and indeed the 'new' discipline of tropical medicine, originated in 1899 at the Albert Dock Hospital - situated in London's east-end. The founder of the discipline was Patrick Manson - with a great deal of political assistance from the British Secretary of State for the Colonies...
journal_title:Acta tropica
pub_type: 历史文章,杂志文章
doi:10.1016/s0001-706x(01)00127-9
更新日期:2001-06-22 00:00:00
abstract::Plasmodium vivax merozoite surface protein 1 (PvMSP-1) is a leading malaria vaccine candidate. This protein is processed to give rise to various sized fragments during merozoite maturation. Here, we describe the analysis of genetic diversity in the 42 kDa C-terminal part of this protein among 33 Indian P. vivax isolat...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2008.08.011
更新日期:2008-10-01 00:00:00
abstract::Immune sera obtained from either BALB/c mice (susceptible) at 7 weeks, or C57BL/6 mice (resistant), at 7 weeks after infection with L. m. amazonensis, were effective in increasing internalization of homologous promastigotes into starch-induced peritoneal macrophages (from both mouse strains). Both the internalization ...
journal_title:Acta tropica
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
abstract::Mosquito-borne diseases affect millions of individuals worldwide; the area of endemic transmission has been increasing due to several factors linked to globalization, urban sprawl, and climate change. The Aedes aegypti mosquito plays a central role in the dissemination of dengue, Zika, chikungunya, and urban yellow fe...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2020.105398
更新日期:2020-05-01 00:00:00
abstract::Accumulation, degradation and excretion by the host of helminth metabolic end products, such as branched-chain volatile fatty acids are poorly studied although they play an appreciable role in host-parasite interactions and, being detectable in excreta, provide a reliable diagnostic test for at least some helminthiase...
journal_title:Acta tropica
pub_type: 杂志文章
doi:
更新日期:1981-12-01 00:00:00
abstract::The conventional method of estimating parasite densities employ an assumption of 8000 white blood cells (WBCs)/μl. However, due to leucopenia in malaria patients, this number appears to overestimate parasite densities. In this study, we assessed the accuracy of parasite density estimated using this assumed WBC count i...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2016.01.018
更新日期:2016-04-01 00:00:00
abstract::Chagas disease is a zoonosis caused by the protozoan parasite Trypanosoma cruzi and transmitted by triatomine insects to several mammalian species acting as reservoir hosts. In the present study, we assess T. cruzi-prevalence and DTU composition of the endemic rodent Octodon degus from a hyper-endemic area of Chagas d...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2015.06.008
更新日期:2015-11-01 00:00:00
abstract::This study aimed to investigate the prevalence of cercarial infections in freshwater snails collected from the Chai Nat province of Central Thailand. Moreover, we aimed to develop a duplex PCR technique, using the ITS2 and candidate MT-ND1 gene, to determine the dissemination of H. taichui and H. pumilio, respectively...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2020.105795
更新日期:2020-12-10 00:00:00
abstract::Phenanthridine trypanocides (isometamidium chloride hydrochloride, ISM, and Ethidium bromide, EBr) have been widely used to treat African trypanosomiasis in livestock for more than 40 years. Their main action is to inhibit nucleic acid synthesis in trypanosome parasites, by intercalation between the DNA base pairs. Th...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(02)00188-2
更新日期:2002-12-01 00:00:00
abstract::Five hundred and sixty teneral male Glossina morsitans centralis were fed, at the height of parasitaemia, on a goat infected with Trypanosoma brucei brucei. Thereafter, the tsetse were divided into 4 equal groups. Group I was fed in vitro once weekly for 4 weeks and Group II twice weekly for 4 weeks on fresh defibrina...
journal_title:Acta tropica
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::The benzimidazole derivative, 6-chloro-5-(2,3-dichlorophenoxy)-2-(trifluoromethyl)-1H-benzimidazole (RCB15), has a similar mode of action and efficacy as albendazole, a commonly used anthelminthic drugs. The aim of this study was to evaluate its influence on the tricarboxylic acid cycle in Taenia crassiceps cysticerci...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2019.105254
更新日期:2020-02-01 00:00:00
abstract::Rabies is a public health problem in the world especially in Côte d'Ivoire. The epidemiological surveillance of rabies revealed 10,197 exposures with 17 deaths in 2015 and 11,481 exposures with 18 deaths in 2016. The management of exposed people was based on WHO's intramuscular (IM) protocols (Essen and Zagreb). The u...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2020.105710
更新日期:2020-12-01 00:00:00
abstract::Schistosomiasis has plagued the Egyptian population since the antiquity. The disease is still a public health problem in Egypt, despite the tendency of being overlooked. In the first part of this review, the past and current trends of schistosomiasis in Egypt are reviewed, including history, epidemiology, morbidity, t...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2015.04.016
更新日期:2015-08-01 00:00:00
abstract::Glutathione transferases (GSTs) perform several catalytic and non-catalytic roles in the defense against toxicities of electrophile compounds and oxidative stress, and therefore are involved in stress-response and cell detoxification. Previously, we have provided evidence indicating that EgGST2 and EgGST3, two phyloge...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2018.01.007
更新日期:2018-04-01 00:00:00