Abstract：
:The human Pegivirus (HPgV, also known as GBV-C virus or hepatitis G virus) is a lymphotropic RNA-virus phylogenetically related to the Hepatitis C virus, which infects approximately 5% of the world's human population. Recently, two novel, presumably hepatotropic, pegiviruses, designated as equine Pegivirus (EPgV) and Theiler's Disease Associated Virus (TDAV), were discovered in horses with clinical and laboratory evidence of hepatic disease. To verify the occurrence of pegiviruses infection in horses from Pará State, northern Brazil, serum samples from 114 horses located in four cities (Acará, Belém, Dom Eliseu and Ananindeua) were submitted for the molecular analysis of EPgV by nested RT-PCR. The results of nucleotide sequencing and phylogenetic analysis of EPgV NS3 and NS5B genomic regions confirmed one positive sample among 114 tested samples (1/114; 0.8%). No evidence of TDAV infection was found, but despite the low prevalence and unknown clinical significance among the studied population, these results represent the first molecular detection of EPgV in horses in South America.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
de Souza AJS,Malheiros AP,de Sousa ERP,Moreira ACN,Silva AL,das Chagas AAC,Freitas PEB,Gemaque BS,de Figueiredo HF,de Sá LRM,Dos Santos PDE,Soares MDCPdoi
10.1016/j.actatropica.2015.08.014subject
Has Abstractpub_date
2015-12-01 00:00:00pages
56-59eissn
0001-706Xissn
1873-6254pii
S0001-706X(15)30091-7journal_volume
152pub_type
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