Abstract：
:We aimed to assess the effect of exogenous Interleukin (IL)-17A in experimental model of echinococcosis. Swiss mice were inoculated intra-peritoneally with viable protoscoleces (PSCs). Then, IL-17A was administered at 100, 125 or 150 pg/mL two weeks after cystic echinococcosis (CE) induction. Cyst development and hepatic damage were macroscopically and histologically analyzed. We observed that in vivo IL-17A treatment at 100, 125, and 150 pg/mL, reduced metacestode growth by 72.3%, 93.8%, and 96.9%, respectively. Interestingly an amelioration of liver architecture was noted at 125 pg/mL without toxic effect. In this context, we showed less fibrosis reaction and reduced expression of iNOS, TNF-α, NF-κb and CD68 in hepatic parenchyma of treated mice by 125 pg/mL of IL-17A. Collectively, our results indicate an antihydatic effect and immunoprotective properties of IL-17A and suggest its potential therapeutic value against Echinococcus granulosus infection.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Labsi M,Soufli I,Khelifi L,Amir ZC,Touil-Boukoffa Cdoi
10.1016/j.actatropica.2018.01.014subject
Has Abstractpub_date
2018-05-01 00:00:00pages
6-10eissn
0001-706Xissn
1873-6254pii
S0001-706X(17)30752-0journal_volume
181pub_type
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