Abstract：
:Currently, benzimidazoles are used as chemotherapeutic agents and as a complement to surgery and PAIR in the treatment of cystic echinococcosis (CE). They are generally applied at high doses causing side effects and, 50% of cases do not respond favorably to such chemotherapy. The use of essential oils obtained by distillation from aromatic plants would be an effective alternative or complementary to the synthetic compounds, because would not bring the appearance of side effects. Carvacrol and his isomer thymol are the main phenolic components from essential oils of Origanum vulgare (oregano) and Thymus vulgaris (thyme). The aim of the present work was to evaluate the in vitro and in vivo efficacy of carvacrol against Echinococcus granulosus metacestodes. For the in vitro assay, protoscoleces and cysts of E. granulosus were incubated with carvacrol at the following final concentrations: 10, 5 and 1μg/ml of carvacrol. The maximum protoscolicidal effect was found with 10μg/ml of carvacrol. Results of viability tests were consistent with the structural and ultrastructural damage observed in protoscoleces. Ultrastructural studies revealed that the germinal layer of cysts treated with carvacrol lost the multicellular structure feature. In the clinical efficacy study, a reduction in cyst weight was observed after the administration of 40mg/kg of carvacrol during 20days in mice with cysts developed during 4 months, compared to that of those collected from control mice. Given that the in vivo effect of carvacrol was comparable with the treatment of reference with ABZ and the fact that is a safe compound, we postulated that carvacrol may be an alternative option for treatment of human CE.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Fabbri J,Maggiore MA,Pensel PE,Denegri GM,Gende LB,Elissondo MCdoi
10.1016/j.actatropica.2016.09.001subject
Has Abstractpub_date
2016-12-01 00:00:00pages
272-279eissn
0001-706Xissn
1873-6254pii
S0001-706X(16)30345-Xjournal_volume
164pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract：:Cameroon lacks the capacity for routine Pneumocystis pneumonia (PcP) diagnosis, thus, the prevalence of Cameroonian exposure to this microbe is unknown. It is known that Pneumocystis infecting different mammalian host species represent diverse phylogenetic backgrounds and are now designated as separate species. The hi...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.07.030
更新日期：2009-11-01 00:00:00
abstract：:On the ecological scale of an organism, a homogeneous geographical landscape can represent a mosaic of heterogeneous landscapes. The bionomy of Kerteszia mosquitoes can contribute to foundation landscape ecology by virtue of in the role of the configuration and composition of the habitat played in the distribution of ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.09.023
更新日期：2016-12-01 00:00:00
abstract：INTRODUCTION:In areas of low-to-moderate risk of malaria transmission, the World Health Organization recommends parasitic confirmation before treatment. Such areas have usually low budget for health care and malaria diagnosis is mostly based on clinical assumption. Algorithms have been developed to improve health care ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.05.011
更新日期：2008-09-01 00:00:00
abstract：:The human Pegivirus (HPgV, also known as GBV-C virus or hepatitis G virus) is a lymphotropic RNA-virus phylogenetically related to the Hepatitis C virus, which infects approximately 5% of the world's human population. Recently, two novel, presumably hepatotropic, pegiviruses, designated as equine Pegivirus (EPgV) and ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.08.014
更新日期：2015-12-01 00:00:00
abstract：:Chagas disease is a zoonosis caused by the protozoan parasite Trypanosoma cruzi and transmitted by triatomine insects to several mammalian species acting as reservoir hosts. In the present study, we assess T. cruzi-prevalence and DTU composition of the endemic rodent Octodon degus from a hyper-endemic area of Chagas d...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.06.008
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Foodborne Neglected Zoonotic Helminths (FNZH) are parasites of both economic and public health importance. They include Taenia solium, Echinococcus granulosus sensu lato, Echinococcus multilocularis and Foodborne trematodes (FBT). FNZH are earmarked for major interventions for control, elimination and eradic...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.03.030
更新日期：2019-06-01 00:00:00
abstract：:In this study, 27 CDC traps were modified with various attractive features and compared with a CDC trap with no light source or baits to evaluate the effects on attraction to Phlebotomus papatasi (Scopoli) north of the Dead Sea near Jericho. Attractive features included CO2, lights, colored trap bodies, heat, moisture...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.06.007
更新日期：2015-01-01 00:00:00
abstract：:In all, 40 native triatomine species and subspecies occur in NA, belonging to six genera from the Triatomini (Triatoma, Paratriatoma, Panstrongylus, Dipetalogaster, Belminus, Eratyrus), and one genus from the Rhodniini (represented by one non-native species Rhodnius prolixus, formerly occurring exclusively in domestic...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.11.012
更新日期：2009-05-01 00:00:00
abstract：:Gut lectins of the insect vectors play important roles in the transmission of pathogens. Galactosamine, a sandfly midgut lectin inhibitor, was previously demonstrated to increase the intensity of Leishmania infection in sandflies; it was suggested that this was due to the inhibition of sandfly midgut lectin. However, ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(00)00105-4
更新日期：2000-10-02 00:00:00
abstract：:The chewing lice (Mallophaga) are common parasites of different animals. Most of them infest terrestrial and marine birds, including pigeons, doves, swans, cormorants and penguins. Mallophaga have not been found on marine mammals but only on terrestrial ones, including livestock and pets. Their bites damage cattle, sh...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2017.05.031
更新日期：2018-01-01 00:00:00
abstract：:Four hundred and forty-eight samples of total blood from wild monkeys living in areas where human autochthonous malaria cases have been reported were screened for the presence of Plasmodium using microscopy and PCR analysis. Samples came from the following distinct ecological areas of Brazil: Atlantic forest (N=140), ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.05.020
更新日期：2008-08-01 00:00:00
abstract：:The fluid mechanics of the flow of blood through the labrum of Glossina is described in uninfected and trypanosome infected flies. The flow is characterised by the Reynolds number, and a frequency parameter for the pulsating flow and non-newtonian viscosity effects are considered. The effects of colonies of trypanosom...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：:The persistence of Trypanosoma cruzi in seropositive individuals, previously diagnosed as chronic chagasic patients (CCP), was detected for the first time in biopsies taken from gingival inflammatory foci processed by polymerase chain reaction (PCR). Seven out of 31 (22.5%) gum samples from selected unquestionably CCP...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2010.12.010
更新日期：2011-03-01 00:00:00
abstract：:The pathological events in human cerebral malaria are mimicked in the experimental cerebral malaria (ECM) in Plasmodium berghei ANKA (PBA)-infected C57BL/6 mice. Although previously implied in ECM, the kinetics of cytokines and chemokines expression-an essential functional feature for defining causality in ECM develop...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.04.025
更新日期：2017-08-01 00:00:00
abstract：:In Burkina Faso, where malaria is hyper-endemic and transmission intensity is very high, the majority of malaria-related morbidity and mortality occurs in children less than 5 years of age. A control measure such as the use of insecticide-treated curtains (ITC) significantly reduces transmission of malaria infection. ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2003.12.004
更新日期：2004-05-01 00:00:00
abstract：:The Fast Agglutination Screening Test (FAST) was employed on sera obtained from an endemic area of visceral leishmaniasis in southwestern Ethiopia, in February 2000. The study involved (i) active case detection among 1575 residents of two villages; and (ii) passive case detection in an outpatient clinic. Sera of 1587 ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(02)00063-3
更新日期：2002-08-01 00:00:00
abstract：:Although, pleural (PT) and disseminated tuberculosis (DT) have been considered as extreme endpoints of the Th1-Th2 immunological spectrum of the Mycobacterium tuberculosis infection, these conditions can occur together. The presence of PT and DT could be explained by (1) PT as primary condition, with progression of HI...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2007.07.009
更新日期：2007-11-01 00:00:00
abstract：:The aim of this work was to study the composition of the Culicidae community in three environments with different degrees of anthropic disturbance in the province of Chaco. The nonparametric richness estimator ACE was calculated to measure the completeness of the sampling in each environment, and the diversity of each...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.12.002
更新日期：2016-04-01 00:00:00
abstract：:Bashagard is an important malaria endemic area in south of Iran. An epidemiological and entomological survey was performed during 2002-2010. The aim of study was to determine malaria situation, species composition of anopheline mosquitoes and susceptibility status of main vectors to insecticides/larvicides. A total of...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2011.04.017
更新日期：2012-02-01 00:00:00
abstract：:30 Trypanosoma cruzi strains isolated from chronic chagasic patients were studied at the genotype level by RAPD with arbitrary primers and SSR-PCR analysis. The genetic distance of strains was measured by the percentage of unshared bands. The results showed that the strains isolated from chronic patients from differen...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00122-8
更新日期：1998-05-01 00:00:00
abstract：:Theileria annulata schizont transformed bovine lymphocytes show the feature of permanent proliferation in vitro culture. In this study, we optimized a suitable culture medium for transformed cells to ensure a high yield of quality cells in suspension culture. As the basis for the optimized medium, we combined 75% Gibc...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.105237
更新日期：2020-02-01 00:00:00
abstract：:The phlebotomine sand fly Lutzomyia longipalpis takes blood from a variety of wild and domestic animals and transmits Leishmania (Leishmania) infantum chagasi, etiological agent of American visceral leishmaniasis. Blood meal identification in sand flies has depended largely on serological methods but a new protocol de...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.06.003
更新日期：2008-09-01 00:00:00
abstract：:In an endemic area for Wuchereria bancrofti filariasis in the Nile Delta, survival of adult female Culex pipiens was estimated by parity rate, mosquito infection and infectivity rates. Infection rates and 4th instar larval populations, as well as infection and parity rates, were linearly correlated. Infectivity correl...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(89)90034-x
更新日期：1989-05-01 00:00:00
abstract：:The effect of vaccines against the pre-erythrocytic, the erythrocytic and the sexual stages of malaria on the transmission of malaria was examined using a simulation model of seasonal or epidemic transmission. The primary outcome of the model was the number of cases of malaria present at the end of the transmission se...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/0001-706x(93)90013-2
更新日期：1993-01-01 00:00:00
abstract：:A monomorphic strain of Trypanosoma brucei brucei (EATRO 110) was cultured as long slender bloodstream forms in vitro for 24 h with 100 microM Eflornithine HCl. This resulted in depletion of intracellular putrescine, a greater than 50% decrease in spermidine, and a cessation of cell division. These Eflornithine treate...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(93)90076-n
更新日期：1993-11-01 00:00:00
abstract：:As Guinea worm eradication programmes have got under way in endemic countries over the last decade, there has been a shift towards more participatory methods. The approach to surveillance has changed from periodic cross-sectional surveys to monthly village-based reporting of cases by a volunteer village health worker....
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(95)00106-o
更新日期：1996-04-01 00:00:00
abstract：:Using degenerate oligonucleotide primers based on conserved active site residues, we have isolated a cDNA encoding an aspartic protease from the nematode parasite Strongyloides stercoralis, an important, enteric pathogen of humans. cDNAs encoding the aspartic protease were isolated from the infective, third stage larv...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(98)00050-3
更新日期：1998-08-15 00:00:00
abstract：:Preliminary data from an ongoing epidemiological survey in the pastoral zone of Samorogouan (Kénédougou) indicate the occurrence of multiple-drug-resistant Trypanosoma congolense. Despite frequent trypanocidal drug treatments with diminazene aceturate (Berenil, Hoechst) at 7 mg/kg body weight (bw) at intervals of 2 to...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(92)90041-u
更新日期：1992-08-01 00:00:00
abstract：:A survey was undertaken between November 1994 and January 1995 to assess the knowledge and practice with respect to malaria of 1946 randomly selected households in endemic urban and rural areas of Hormozgan, Kerman and Sistan and Baluchistan Provinces, southeast Iran. Knowledge of inhabitants was relatively poor in th...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(96)00609-2
更新日期：1997-04-15 00:00:00
abstract：:African animal trypanosomosis, transmitted cyclically by tsetse flies or mechanically by other biting flies, causes serious health problems in livestock. Although tsetse infestations have been observed in Blue Nile State in Sudan, tsetse was eradicated in West Kordofan in 1962, and no further studies have been carried...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.105302
更新日期：2020-03-01 00:00:00
