Abstract：
:Malaria is second only to tuberculosis as the leading cause of morbidity and mortality as a consequence of a single infectious agent. Much of the pathology of malaria arises from the inappropriate or excessive immune response mounted by the host in an attempt to eliminate the parasite. We here report the inflammatory changes observed in the cerebral microvasculature of C57BL/6 and BALB/c mice that had been inoculated with Plasmodium berghei NK65, a lethal strain of rodent malaria. Although no neurological signs were observed in experimentally infected mice, inflammation of the cerebral microvasculature was clearly evident. Histopathological analysis demonstrated that alterations in cerebral tissue were more intense in infected C57Bl/6 mice than in infected BALB/c animals. Intravital microscopic examination of the cerebral microvasculature revealed increased leukocyte rolling and adhesion in pial venules of infected mice compared with non-infected animals. The extravasation of Evans blue dye into the cerebral parenchyma was also elevated in infected mice in comparison with their non-infected counterparts. Additionally, protein levels of TNF-α, MIG/CXCL9, MCP-1/CCL2, MIP-1α/CCL3 and RANTES/CCL5 were up-regulated in brain samples derived from infected C57Bl/6 mice. Taken together, the data reported here illustrate the complex strain-dependent relationships between leukocyte recruitment, blood brain barrier permeability and chemokine production.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Lacerda-Queiroz N,Lima OC,Carneiro CM,Vilela MC,Teixeira AL,Teixeira-Carvalho A,Araújo MS,Martins-Filho OA,Braga EM,Carvalho-Tavares Jdoi
10.1016/j.actatropica.2011.04.020subject
Has Abstractpub_date
2011-10-01 00:00:00pages
31-9issue
1-2eissn
0001-706Xissn
1873-6254pii
S0001-706X(11)00183-5journal_volume
120pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract：:Arboviruses have become a major public health concern in Brazil, especially after Zika virus (ZIKV) and Chikungunya virus (CHIKV) introduction, leading to massive epidemics. We conducted an investigation of arboviruses in patients with acute febrile illness for less than five days in Mato Grosso state (MT) during the ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.12.019
更新日期：2019-02-01 00:00:00
abstract：:During a period of 2 years, the ecology of Bulinus globosus was studied in 8 habitats in two streams near Ifakara, SE-Tanzania. The relative Bulinus densities were followed monthly. Two different methods for estimating snail densities (man/time vs. palmleaf traps) gave comparable results. Bulinus densities were consta...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:Leptospirosis is a zoonotic disease that occurs all over the world, caused by bacteria of the genus Leptospira. Marsupial and didelphidae families are considered susceptible to infection caused by a wide range of Leptospira serovars for which they serve as reservoirs. Thirty-three free-living white-eared opossums (Did...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2012.07.009
更新日期：2012-11-01 00:00:00
abstract：:We have developed a molecular method using PCR-direct sequencing to identify the infective 3rd juvenile stage of Angiostrongylus cantonensis, a nematode parasite of rodents that can accidentally infect humans and cause eosinophilic meningitis. We demonstrate that the 5' end of the small subunit (SSU) ribosomal (r) RNA...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2007.10.007
更新日期：2008-02-01 00:00:00
abstract：:A survey involving 77 individuals living in two savannah villages near Bobo Dioulasso (Burkina Faso, West Africa), was performed in June 1987 (before), August-September (during) and January 1988 after the seasonal transmission. The clinical longitudinal study during the seasonal period permitted us to define three dif...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(92)90064-5
更新日期：1992-04-01 00:00:00
abstract：:The London School of Tropical Medicine, and indeed the 'new' discipline of tropical medicine, originated in 1899 at the Albert Dock Hospital - situated in London's east-end. The founder of the discipline was Patrick Manson - with a great deal of political assistance from the British Secretary of State for the Colonies...
journal_title：Acta tropica
pub_type： 历史文章,杂志文章
doi：10.1016/s0001-706x(01)00127-9
更新日期：2001-06-22 00:00:00
abstract：:The incidence of Echis carinatus (saw-scaled or carpet viper) bite and its mortality have been investigated in the Nigerian savanna region. A geographical area was defined in which the snake was particularly abundant and bites were frequent. Perennial and seasonal fluctuations in incidence and mortality, the circumsta...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:In an endemic area for Wuchereria bancrofti filariasis in the Nile Delta, survival of adult female Culex pipiens was estimated by parity rate, mosquito infection and infectivity rates. Infection rates and 4th instar larval populations, as well as infection and parity rates, were linearly correlated. Infectivity correl...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(89)90034-x
更新日期：1989-05-01 00:00:00
abstract：:This paper reviews various imaging techniques in different organs. Ultrasound is the most popular and readily available technique. Special emphasis is given to computerized tomography (CT) and magnetic resonance imaging (MRI) findings and their advantages for a confident diagnosis and treatment. ...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/s0001-706x(97)00052-1
更新日期：1997-09-15 00:00:00
abstract：:Cutaneous leishmaniasis (CL) is an important public health problem with around 2.000 autochthonous reported cases each year in Turkey. Due to the civil war in Syria, Turkey received around three million refugees and they are mainly located at either camps or homes in south/southeastern part of Turkey. In the present s...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.10.019
更新日期：2017-02-01 00:00:00
abstract：:Along with the determination of malaria infection rate among suspected patients attending hospitals in Hodeidah governorate, the present study evaluated the accuracy of Plasmodium falciparum histidine-rich protein-2 (PfHRP-2)/parasite-specific lactate dehydrogenase (pLDH)-based rapid diagnostic test (RDT) for the diag...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.12.006
更新日期：2018-02-01 00:00:00
abstract：:We conducted a cross-sectional survey in Bamako, Mali, to determine for the first time the seroprevalence of rabies virus antibodies in the dog population and people's knowledge, attitudes and practices (KAP) towards the disease and its control. Antibody detection was done with the fluorescent antibody virus neutralis...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.10.016
更新日期：2017-01-01 00:00:00
abstract：:Live bird market (LBM) is integral component in the perpetuation of HPAI H5N1, while biosecurity is crucial and key to the prevention and control of infectious diseases. Biosecurity compliance level and risk factor assessments in 155LBMs was evaluated in Nigeria and Egypt through the administration of a 68-item biosec...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.08.030
更新日期：2016-12-01 00:00:00
abstract：:Primaquine has been the drug of choice for the prevention of Plasmodium vivax relapse for more than 60 years. Primaquine tolerant strain of P. vivax was identified in 1944. Significant mortality and disease burden of P. vivax calls for the need of new drugs. Primaquine resistance is a complex issue, as the mechanism o...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2016.04.009
更新日期：2016-08-01 00:00:00
abstract：:Worldwide, Bartonella species are known to infect a wide range of mammalian and arthropod hosts, including humans. The current study aimed to investigate the prevalence of Bartonella spp. in synanthropic mammals captured in peri-urban areas from Central-Western and Southern Brazil and their ectoparasites. For this aim...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105513
更新日期：2020-07-01 00:00:00
abstract：:Three Entamoeba spp. including E. suis, zoonotic E. polecki, and E. histolytica, have been described in pigs to date. However, little is known about the molecular epidemiology of these neglected parasites in pigs globally. In this study we surveyed the occurrence and molecular epidemiology of porcine Entamoeba spp. in...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.06.020
更新日期：2018-09-01 00:00:00
abstract：:Leishmaniasis is a protozoan infectious disease widely distributed all around the world. First line drugs including antimoniales are insufficient due to resistance in endemic areas and high toxicity. Azole antifungals like ketoconazole (KCZ) are also used as antileishmanial agents for several decades. In the present s...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.12.027
更新日期：2017-03-01 00:00:00
abstract：:Manipulating the endogenous immune responses of the mosquito such as temporal and spatial expression of antimicrobial peptides may help in the development of a refractory mosquito, unable to transmit malaria. In mosquito several small antimicrobial peptides are activated locally in the midgut and salivary glands upon ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.01.001
更新日期：2008-04-01 00:00:00
abstract：:Immune sera obtained from either BALB/c mice (susceptible) at 7 weeks, or C57BL/6 mice (resistant), at 7 weeks after infection with L. m. amazonensis, were effective in increasing internalization of homologous promastigotes into starch-induced peritoneal macrophages (from both mouse strains). Both the internalization ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:We assessed the diversity and distribution of Trypanosoma cruzi discrete typing units (DTU) in Triatoma infestans populations and its association with local vector-borne transmission levels at various geographic scales. At a local scale, we found high predominance (92.4%) of TcVI over TcV in 68 microscope-positive T. ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.07.014
更新日期：2014-12-01 00:00:00
abstract：:Treatment failure of chloroquine for Plasmodium vivax infection has increased in endemic countries. However, the molecular mechanisms for resistance and in vitro susceptibility of P. vivax to chloroquine remain elusive. We investigated the prevalence of mutations in the pvmdr1 and pvcrt-o genes, and the copy number of...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2010.08.011
更新日期：2011-02-01 00:00:00
abstract：:Although, pleural (PT) and disseminated tuberculosis (DT) have been considered as extreme endpoints of the Th1-Th2 immunological spectrum of the Mycobacterium tuberculosis infection, these conditions can occur together. The presence of PT and DT could be explained by (1) PT as primary condition, with progression of HI...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2007.07.009
更新日期：2007-11-01 00:00:00
abstract：:Anti-T. dionisii and anti-T. vespertilionis monoclonal antibodies secreted by 17 hybridoma clones were tested against various strains of T. dionisii, T. vespertilionis, T. cruzi and T. cruzi marinkellei. Strain and species specific antigens were detected for the homologous immunizing strains. The common antigenic dete...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:Global health has substantially improved over the past 20 years. In low- and middle-income countries, in particular, great strives have been made in the control of communicable diseases, including helminth infections. Nevertheless, the most marginalised communities still suffer from infectious diseases that are intima...
journal_title：Acta tropica
pub_type： 社论
doi：10.1016/j.actatropica.2014.10.010
更新日期：2015-01-01 00:00:00
abstract：:Thymidylate kinase (TMK) is a potential chemotherapeutic target because it is directly involved in the synthesis of deoxythymidine triphosphate, which is an essential component for DNA synthesis. The gene encoding thymidylate kinase of Brugia malayi was amplified by PCR and expressed in Escherichia coli. The native mo...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.02.003
更新日期：2014-05-01 00:00:00
abstract：:The information in this protocol covers from the basic steps and material necessary to start a sand fly colony up to the specific details which are important to the success of a Nyssomyia neivai colony. The greatest problems in our colony of Ny. neivai were solved with specific care, for instance, using vermiculite an...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.07.010
更新日期：2017-10-01 00:00:00
abstract：:The role of toxic component of leaf litter in mediating the outcome of mosquito species interactions is not well documented. To examine the effect of leaf litter toxins on mosquito performance and interspecific interactions, we reared monospecific and heterospecific cultures of Aedes aegypti L. and Aedes albopictus Sk...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2011.12.006
更新日期：2012-04-01 00:00:00
abstract：:Rapid urbanization in resource poor countries often results in expansion of unplanned settlements with overcrowding and inadequate sanitation. These conditions potentially support transmission of schistosomiasis and soil transmitted helminths (STH), but knowledge on the occurrence, transmission and control of these in...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.01.012
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:To better understand the epidemiology of tick-borne disease in Mongolia, a comprehensive seroprevalence study was conducted investigating exposure to Anaplasma spp. and spotted fever group (SFG) Rickettsia spp. in nomadic herders and their livestock across three provinces from 2014 to 2015. METHODS:Blood wa...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.10.015
更新日期：2018-01-01 00:00:00
abstract：:Crimean-Congo hemorrhagic fever (CCHF) is one of the most important public health threats in many regions across Africa, Europe, and Asia. This study used ecological niche modeling analyses to map the environmental suitability of both CCHF virus (CCHFV), and its tick vectors (Amblyomma variegatum, Dermacentor marginat...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.105319
更新日期：2020-03-01 00:00:00
