Abstract：
:The expression of variable antigen types (VATs) was determined among dividing populations of T. congolense growing in vivo in rabbit chancres and in vitro on bovine aorta endothelial cell monolayers. Experiments were performed in which a single metacyclic VAT (M-VAT) was deleted from a cultured metacyclic population by neutralisation with a monoclonal antibody and complement. Subsequent expression of the deleted M-VAT and two unrelated M-VATs was determined by an indirect immunofluorescent antibody test. The deleted M-VAT was re-expressed both in vivo and in vitro and the proportions of unrelated M-VATs were not markedly affected by the neutralisation of this single M-VAT. In addition, an overall similarity was observed between M-VAT expression and re-expression in vivo and in vitro.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Sutherland DV,Ross CA,Luckins AGdoi
10.1016/0001-706x(91)90038-lsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
193-9issue
3eissn
0001-706Xissn
1873-6254pii
0001-706X(91)90038-Ljournal_volume
49pub_type
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