Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.


:We used previously immunized (partially resistant) and naive (highly susceptible) BALB/c mice infected with Leishmania amazonensis for evaluating the role of granulocytes in the course of murine leishmaniasis. The animals were examined at different times post-infection and granulocytes counted in lesion tissues examined ultra-structurally. Polymorphonuclear granulocytes predominated during the early phase of infection and their number decreased with progression of infection; their number was similar in both groups during the early and intermediate phases of infection, though slightly higher in immunized animals during the late phase. Eosinophils represented approximately 10% of cells in the inflammatory infiltrate, being higher during the intermediate phase, and not differing between the groups. Another approach was the evaluation of granulocyte migration to the peritoneal cavity of susceptible BALB/c mice or resistant C57BL/6 mice under several stimuli. There was no statistically significant difference between resistant and susceptible animals in any of the treatments. Despite the influx of granulocytes to the lesion and its possible role in the initial destruction of injected Leishmania, this aspect does not seem to have an important effect on the outcome of the leishmanial infection.


Acta Trop


Acta tropica


Pompeu ML,Freitas LA,Santos ML,Khouri M,Barral-Netto M




Has Abstract


1991-01-01 00:00:00














  • Analysis of population structure and insecticide resistance in mosquitoes of the genus Culex, Anopheles and Aedes from different environments of Greece with a history of mosquito borne disease transmission.

    abstract::Greece has been recently affected by several mosquito borne diseases with the West Nile Virus (WNV) outbreak in 2010 being one of the largest reported in Europe. Currently at the epicenter of an economic and refugee crisis and visited by over 16 million tourists a year the integrated management of diseases transmitted...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Fotakis EA,Chaskopoulou A,Grigoraki L,Tsiamantas A,Kounadi S,Georgiou L,Vontas J

    更新日期:2017-10-01 00:00:00

  • Analysis of the genetic structure of allopatric populations of Lutzomyia umbratilis using the period clock gene.

    abstract::In South America, Lutzomyia umbratilis is the main vector of Leishmania guyanensis, one of the species involved in the transmission of American tegumentary leishmaniasis. In Brazil, L. umbratilis has been recorded in the Amazon region, and an isolated population has been identified in the state of Pernambuco, Northeas...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: de Souza Freitas MT,Ríos-Velasquez CM,da Silva LG,Costa CR Jr,Marcelino A,Leal-Balbino TC,Balbino Vde Q,Pessoa FA

    更新日期:2016-02-01 00:00:00

  • A benzimidazole derivative (RCB15) in vitro induces the alternative energetic metabolism and glycolysis in Taenia crassiceps cysticerci.

    abstract::The emergence of resistance to albendazole has encouraged the search for effective alternatives for cysticercosis and other parasitosis treatment. RCB15 is a benzimidazole derivative that may be used against such diseases. The aim of this study was to determine the in vitro effect of RCB15 on the alternative energetic...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: de Andrade Picanço G,de Lima NF,Fraga CM,da Costa TL,Isac E,Ambrosio J,Castillo R,Vinaud MC

    更新日期:2017-12-01 00:00:00

  • TLRs innate immunereceptors and Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) CIDR1α-driven human polyclonal B-cell activation.

    abstract::Chronic malaria severely affects the immune system and causes polyclonal B-cell activation, as evidenced by the presence of hypergammaglobulinemia, elevated levels of autoantibodies, loss of B-cell memory and the frequent occurrence of Burkitt's lymphomas (BL) in children living in malaria endemic areas. Previous stud...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Simone O,Bejarano MT,Pierce SK,Antonaci S,Wahlgren M,Troye-Blomberg M,Donati D

    更新日期:2011-08-01 00:00:00

  • Study of antimicrobial resistance and physiological biomarkers with special reference to Salmonellosis in diarrheic foals in Punjab, Pakistan.

    abstract::Antimicrobial resistance results in selective colonization in animals. In the present study, 447 diarrheic foals (235 horse foals, 165 donkey foals and 47 mule foal) were selected from Lahore and Sahiwal districts of Punjab, Pakistan. Fresh fecal and blood samples from diarrheic foals were collected for isolation and ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Haq I,Durrani AZ,Khan MS,Mushtaq MH,Ahmad I

    更新日期:2017-12-01 00:00:00

  • Time series analysis of dengue surveillance data in two Brazilian cities.

    abstract::The aim of the study was to evaluate the temporal patterns of dengue incidence from 2001 to 2014 and forecast for 2015 in two Brazilian cities. We analysed dengue surveillance data (SINAN) from Recife, 1.6 million population, and Goiania, 1.4 million population. We used Auto-Regressive Integrated Moving Average (ARIMA...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Cortes F,Turchi Martelli CM,Arraes de Alencar Ximenes R,Montarroyos UR,Siqueira Junior JB,Gonçalves Cruz O,Alexander N,Vieira de Souza W

    更新日期:2018-06-01 00:00:00

  • Control of soil-transmitted helminths in sub-Saharan Africa: diagnosis, drug efficacy concerns and challenges.

    abstract::Soil-transmitted helminthiasis (STH) occur throughout the developing world and remain a major public health problem in the poorest communities with enormous consequences on health and development of school-aged and preschool children. The extent of the problem has long been neglected because these diseases rarely kill...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Tchuem Tchuenté LA

    更新日期:2011-09-01 00:00:00

  • Effect of nitazoxanide on diarrhea: A systematic review and network meta-analysis of randomized controlled trials.

    abstract::We aimed to systematically review evidence pertaining to the safety and efficacy of nitazoxanide in treating infectious diarrhea. On September 21, 2017, we identified relevant studies using 12 databases. The estimates of the included studies were pooled as a risk ratio (RR). We conducted a network and pairwise random-...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Hashan MR,Elhusseiny KM,Huu-Hoai L,Tieu TM,Low SK,Minh LHN,Nghia TLB,Loc LQ,Y MN,Eid PS,Abed M,Elkolaly SS,Tawfik GM,Huy NT

    更新日期:2020-10-01 00:00:00

  • Molecular cloning and characterization of Brugia malayi thymidylate kinase.

    abstract::Thymidylate kinase (TMK) is a potential chemotherapeutic target because it is directly involved in the synthesis of deoxythymidine triphosphate, which is an essential component for DNA synthesis. The gene encoding thymidylate kinase of Brugia malayi was amplified by PCR and expressed in Escherichia coli. The native mo...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Doharey PK,Suthar MK,Verma A,Kumar V,Yadav S,Balaramnavar VM,Rathaur S,Saxena AK,Siddiqi MI,Saxena JK

    更新日期:2014-05-01 00:00:00

  • Presence of hemagglutination inhibition and neutralization antibodies to Japanese encephalitis virus in wild pigs on an offshore island in Singapore.

    abstract::A study was conducted to determine the presence of hemagglutination inhibition (HI) and neutralization antibodies against Japanese encephalitis virus (JEV) in wild pigs on an offshore island in Singapore. Blood samples were collected from 28 wild pigs on the island. All the sera tested with HI assay and plaque reducti...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: See E,Tan HC,Wang D,Ooi EE,Lee MA

    更新日期:2002-03-01 00:00:00

  • Protection against mosquito vectors Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus using a novel insect repellent, ethyl anthranilate.

    abstract::Growing concern on the application of synthetic mosquito repellents in the recent years has instigated the identification and development of better alternatives to control different mosquito-borne diseases. In view of above, present investigation evaluates the repellent activity of ethyl anthranilate (EA), a non-toxic...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Islam J,Zaman K,Tyagi V,Duarah S,Dhiman S,Chattopadhyay P

    更新日期:2017-10-01 00:00:00

  • Neuroinvasion by Chandipura virus.

    abstract::Chandipura virus (CHPV) is an arthropod borne rhabdovirus associated with acute encephalitis in children below the age of 15 years in the tropical states of India. Although the entry of the virus into the nervous system is among the crucial events in the pathogenesis of CHPV, the exact mechanism allowing CHPV to invad...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Rajasekharan S,Rana J,Gulati S,Gupta V,Gupta S

    更新日期:2014-07-01 00:00:00

  • Plant products used as mosquito repellents in Guinea Bissau, West Africa.

    abstract::By standardized interviews of people in 23 rural villages, in the Oio region of Guinea Bissau, we collected data on which plant species and plant derived products or methods people use to reduce mosquito biting activity. The following plants were used to reduce numbers of mosquitoes indoors at night: fresh or smoulder...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Pålsson K,Jaenson TG

    更新日期:1999-01-15 00:00:00

  • Functional analysis of the 5' untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum.

    abstract::Plasmodium falciparum transcripts contain long untranslated regions (UTR), with some of the longest in any eukaryote that uses monocistronic transcription. Owing to the extreme AT nucleotide bias within the intergenic regions that encode these UTR, attempts to characterise how they are apportioned over genes and to de...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Hasenkamp S,Russell K,Ullah I,Horrocks P

    更新日期:2013-07-01 00:00:00

  • Screening and identification of a human domain antibody against Brucella abortus VirB5.

    abstract::Brucellosis is caused by the genus Brucella. Brucella is widely distributed in cattle, swine, sheep, goat and other mammals including human. Animal brucellosis causes severe economic losses and affects related international transportation and trade. Human brucellosis causes both acute and chronic symptoms of multi-org...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Deng H,Zhou J,Gong B,Xiao M,Zhang M,Pang Q,Zhang X,Zhao B,Zhou X

    更新日期:2019-09-01 00:00:00

  • Environmental factors underlying spatial patterns of sand flies (Diptera: Psychodidae) associated with leishmaniasis in southern Sinai, Egypt.

    abstract::Although Leishmania major is endemic in parts of the Sinai of Egypt, the ecology and distribution of Leishmania sand fly vectors in southern Sinai has not been well characterized. Accordingly, additional sand fly samples were obtained at 41 sites in the southern Sinai region during 1996-1997, and analyzed to improve t...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kassem HA,Siri J,Kamal HA,Wilson ML

    更新日期:2012-07-01 00:00:00

  • Comparative efficacy of two rounds of indoor residual spraying of DDT 75% @ 1g/m2 with that of DDT 50% @ 1g/m2 against the malaria vectors in India.

    abstract::While, dichlorodiphenyl-trichloroethane (DDT) water dispersible powder (WDP) 75% is considered as the high performance long lasting formulation for indoor residual spraying (IRS), no information is available regarding the comparative epidemiological effectiveness of the two DDT formulations when used for IRS in Indian...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kasinathan G,Sahu SS,Nallan K,Tharmalingam V,Swaminathan S,Behera KP,Pradhan MM,Purusothaman J

    更新日期:2019-06-01 00:00:00

  • High infection frequency, low diversity of Leishmania major and first detection of Leishmania turanica in human in northern Iran.

    abstract::Smears of suspected patients infected with zoonotic cutaneous leishmaniasis (ZCL) were stained and examined under a light microscopic observation. DNA of parasites within human ulcers was extracted directly from their smears. Nested PCR was used to amplify a fragment containing the internal transcribed spacers of the ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Bordbar A,Parvizi P

    更新日期:2014-05-01 00:00:00

  • Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern Côte d'Ivoire.

    abstract::Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cro...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kanouté YB,Gragnon BG,Schindler C,Bonfoh B,Schelling E

    更新日期:2017-01-01 00:00:00

  • Morphological and physiological characteristics of a virulent and zoonotic assemblage A Giardia duodenalis canine strain.

    abstract::Giardiasis is an intestinal parasitosis that affects millions of people worldwide and is considered a zoonotic disease. Frequently in contact with humans, dogs are the main host involved in this zoonotic transmission. Here, we compared some aspects of Giardia duodenalis biology between two strains: a recently isolated...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Coelho CH,Silva ACC,Costa AO,Fernandes AP

    更新日期:2017-10-01 00:00:00

  • Epidemic outbreak of anthroponotic cutaneous leishmaniasis in Kohat District, Khyber Pakhtunkhwa, Pakistan.

    abstract::An epidemiological and molecular study was carried out for the first time in Kohat District of Khyber Pakhtunkhwa (KP) province, Pakistan from April 2015 to May 2016 to determine the prevalence of Cutaneous Leishmaniasis (CL) in local population and Internally Displaced People (IDPs). In 13 different villages, a total...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Hussain M,Munir S,Jamal MA,Ayaz S,Akhoundi M,Mohamed K

    更新日期:2017-08-01 00:00:00

  • A novel real-time PCR assay for the detection of Plasmodium falciparum and Plasmodium vivax malaria in low parasitized individuals.

    abstract::The rapid, accurate diagnosis of Plasmodium spp. is essential for the effective control of malaria, especially in asymptomatic infections. In this study, we developed a sensitive, genus-specific, real-time quantitative PCR assay. It was compared with the microscopic examination of Giemsa-stained blood smears and two d...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Hwang SY,Kim SH,Lee GY,Hang VT,Moon CS,Shin JH,Koo WL,Kim SY,Park HJ,Park HO,Kho WG

    更新日期:2011-10-01 00:00:00

  • First record of Leishmania braziliensis presence detected in bats, Mato Grosso do Sul, southwest Brazil.

    abstract::Leishmaniasis, a zoonotic disease caused by parasites of the genus Leishmania, has expanded beyond its natural range and is becoming increasingly urban. Using PCR and PCR-RFLP, we detected Leishmania (Viannia) braziliensis in two bats (Chiroptera) in Mato Grosso do Sul, Brazil, an endemic area. This is the first recor...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Shapiro JT,da Costa Lima Junior MS,Dorval ME,de Oliveira França A,Cepa Matos Mde F,Bordignon MO

    更新日期:2013-10-01 00:00:00

  • Evidence for high prevalence of Pneumocystis jirovecii exposure among Cameroonians.

    abstract::Cameroon lacks the capacity for routine Pneumocystis pneumonia (PcP) diagnosis, thus, the prevalence of Cameroonian exposure to this microbe is unknown. It is known that Pneumocystis infecting different mammalian host species represent diverse phylogenetic backgrounds and are now designated as separate species. The hi...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Nkinin SW,Daly KR,Walzer PD,Ndzi ES,Asonganyi T,Respaldiza N,Medrano FJ,Kaneshiro ES

    更新日期:2009-11-01 00:00:00

  • Seroprevalence and risk factors of Toxoplasma gondii infection in horses in Jilin Province and Inner Mongolia Autonomous Region, northern China.

    abstract::Toxoplasmosis is caused by the protozoon Toxoplasma gondii that can infect almost all warm-blooded hosts including horses and humans. Horse meat is one of the most important meat products for human consumption. However, data on seroprevalence of T. gondii in horses intended for human consumption in Northern China is s...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Zhang XX,Ren WX,Hou G,Liu Q,Yu TQ,Zhao Q,Ni HB

    更新日期:2018-11-01 00:00:00

  • Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats.

    abstract::The antidiarrhoeal effects of the methanol extract of Zizyphus spina-christi stem bark were evaluated in laboratory rodents. Studies on castor oil induced diarrhoea, intraluminal fluid accumulation, and gastrointestinal transit time were carried out. Results obtained revealed that the extract caused a dose dependent p...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Adzu B,Amos S,Amizan MB,Gamaniel K

    更新日期:2003-07-01 00:00:00

  • Time to death from starvation and compulsive killing by the larvae of Toxorhynchites splendens (Diptera: Culicidae).

    abstract::Time to death from starvation and compulsive killing without eating of the prey by larvae of Toxorhynchites splendens were studied in the laboratory. The first and second instars survived without food for 3 days while third and fourth instars survived for 7.8 and 14 days, respectively. When the corresponding instars o...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Amalraj DD,Das PK

    更新日期:1994-11-01 00:00:00

  • Imaging of cystic echinococcosis.

    abstract::This paper reviews various imaging techniques in different organs. Ultrasound is the most popular and readily available technique. Special emphasis is given to computerized tomography (CT) and magnetic resonance imaging (MRI) findings and their advantages for a confident diagnosis and treatment. ...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: von Sinner WN

    更新日期:1997-09-15 00:00:00

  • Omega polyunsaturated fatty acids and parasitic infections: An overview.

    abstract::Omega-3 and omega-6 polyunsaturated fatty acids are synthesized from the essential fatty acids alpha-linolenic acid and linoleic acid, respectively. They are pivotal components of all mammalian cells and were found to be useful in prevention and treatment of a variety of health problems owing to their anti-inflammator...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Alhusseiny SM,El-Beshbishi SN

    更新日期:2020-07-01 00:00:00

  • Importance of worldwide asymptomatic carriers of Leishmania infantum (L. chagasi) in human.

    abstract::Leishmaniasis due to Leishmania infantum (syn. L. chagasi) infection is a zoonotic disease present mainly in Mediterranean basin, central Asia and Brazil. Besides a limited number of human cases of clinical visceral leishmaniasis, a great number of infections remains asymptomatic. In this review, the prevalence of asy...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Michel G,Pomares C,Ferrua B,Marty P

    更新日期:2011-08-01 00:00:00