Abstract：
:Numerical alterations of circulating lymphocytes were investigated in 37 Brazilian patients with uncomplicated Plasmodium falciparum malaria and in a group of 15 healthy controls. The number of CD4+ T helper/inducer cells was significantly lower in patients than controls, whereas absolute numbers of CD8+ suppressor/cytotoxic T cells did not differ between the groups. TNF and neopterin levels were markedly increased in the plasma of patients and remained slightly elevated after chemotherapy with clindamycin. Neopterin, but not TNF levels, were significantly correlated with parasitaemia. TNF was inversely related to monocyte counts. Interferon gamma could not be detected in the plasma of control subjects and was observed in only one patient. We conclude that in uncomplicated falciparum malaria the distribution of phenotypes of circulating lymphocytes are altered slightly and that the high plasma levels of TNF and neopterin indicate excessive release of these molecules by activated macrophages and the activation of cellular immune mechanisms during the infection.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Kremsner PG,Feldmeier H,Zotter GM,Jansen-Rosseck R,Graninger W,Rocha RM,Bienzle Udoi
10.1016/0001-706x(89)90047-8subject
Has Abstractpub_date
1989-10-01 00:00:00pages
351-9issue
5-6eissn
0001-706Xissn
1873-6254pii
0001-706X(89)90047-8journal_volume
46pub_type
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