Immunological alterations in uncomplicated Plasmodium falciparum malaria. Relationship between parasitaemia and indicators of macrophage activation.


:Numerical alterations of circulating lymphocytes were investigated in 37 Brazilian patients with uncomplicated Plasmodium falciparum malaria and in a group of 15 healthy controls. The number of CD4+ T helper/inducer cells was significantly lower in patients than controls, whereas absolute numbers of CD8+ suppressor/cytotoxic T cells did not differ between the groups. TNF and neopterin levels were markedly increased in the plasma of patients and remained slightly elevated after chemotherapy with clindamycin. Neopterin, but not TNF levels, were significantly correlated with parasitaemia. TNF was inversely related to monocyte counts. Interferon gamma could not be detected in the plasma of control subjects and was observed in only one patient. We conclude that in uncomplicated falciparum malaria the distribution of phenotypes of circulating lymphocytes are altered slightly and that the high plasma levels of TNF and neopterin indicate excessive release of these molecules by activated macrophages and the activation of cellular immune mechanisms during the infection.


Acta Trop


Acta tropica


Kremsner PG,Feldmeier H,Zotter GM,Jansen-Rosseck R,Graninger W,Rocha RM,Bienzle U




Has Abstract


1989-10-01 00:00:00














  • Identification of four members of the Anopheles funestus (Diptera: Culicidae) group and their role in Plasmodium falciparum transmission in Bagamoyo coastal Tanzania.

    abstract::The role of Anopheles funestus group in malaria transmission was investigated in Bagamoyo coastal Tanzania, in the process of characterizing the area as a malaria vaccine testing site. Mosquitoes were sampled inside houses and multiplex PCR was used to identify 649 specimens. The following species were found: A. funes...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Temu EA,Minjas JN,Tuno N,Kawada H,Takagi M

    更新日期:2007-05-01 00:00:00

  • Severe malaria in Cameroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-alpha.

    abstract::Plasma levels of three soluble inducible adhesion molecules, namely: intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and endothelial leucocyte adhesion molecule-1 (sELAM-1) or sE-selectin and the pro-inflammatory cytokine, tumour necrosis factor-alpha (TNF-alpha) were measured ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Tchinda VH,Tadem AD,Tako EA,Tene G,Fogako J,Nyonglema P,Sama G,Zhou A,Leke RG

    更新日期:2007-04-01 00:00:00

  • Seroprevalence of dengue in Trinidad using rapid test kits: a cord blood survey.

    abstract::A cross-sectional sero-epidemiological study was conducted to determine the prevalence of dengue in Trinidad. Two commercial rapid test kits, PanBio Dengue Duo IgM and IgG Rapid Strip Test and the Bio-Check Plus Dengue G/M Cassette Test (Brittney) were used. The immunosorbent assay (ELISA) (FOCUS Technologies, Califor...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Campbell CA,George A,Salas RA,Williams SA,Doon R,Chadee DD

    更新日期:2007-02-01 00:00:00

  • A benzimidazole derivative (RCB15) in vitro induces the alternative energetic metabolism and glycolysis in Taenia crassiceps cysticerci.

    abstract::The emergence of resistance to albendazole has encouraged the search for effective alternatives for cysticercosis and other parasitosis treatment. RCB15 is a benzimidazole derivative that may be used against such diseases. The aim of this study was to determine the in vitro effect of RCB15 on the alternative energetic...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: de Andrade Picanço G,de Lima NF,Fraga CM,da Costa TL,Isac E,Ambrosio J,Castillo R,Vinaud MC

    更新日期:2017-12-01 00:00:00

  • Leptospira borgpetersenii from free-living white-eared opossum (Didelphis albiventris): first isolation in Brazil.

    abstract::Leptospirosis is a zoonotic disease that occurs all over the world, caused by bacteria of the genus Leptospira. Marsupial and didelphidae families are considered susceptible to infection caused by a wide range of Leptospira serovars for which they serve as reservoirs. Thirty-three free-living white-eared opossums (Did...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Jorge S,Hartleben CP,Seixas FK,Coimbra MA,Stark CB,Larrondo AG,Amaral MG,Albano AP,Minello LF,Dellagostin OA,Brod CS

    更新日期:2012-11-01 00:00:00

  • Stormwater drains and catch basins as sources for production of Aedes aegypti and Culex quinquefasciatus.

    abstract::We present data showing that structures serving as drains and catch basins for stormwater are important sources for production of the mosquito arbovirus vectors Aedes aegypti and Culex quinquefasciatus in Mérida City, México. We examined 1761 stormwater drains - located in 45 different neighborhoods spread across the ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Arana-Guardia R,Baak-Baak CM,Loroño-Pino MA,Machain-Williams C,Beaty BJ,Eisen L,García-Rejón JE

    更新日期:2014-06-01 00:00:00

  • The natural history of cystic echinococcosis in untreated and albendazole-treated patients.

    abstract::The World Health Organization (WHO) treatment protocols for cystic echinococcosis (CE) are based on the standardized ultrasound (US) classification. This study examined whether the classification reflected the natural history of CE in untreated and albendazole-treated patients. Data were collected during mass US scree...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Solomon N,Kachani M,Zeyhle E,Macpherson CNL

    更新日期:2017-07-01 00:00:00

  • Anaplasmataceae, Borrelia and Hepatozoon agents in ticks (Acari: Argasidae, Ixodidae) from Chile.

    abstract::Microorganisms harbored by Chilean autochthonous ticks have been scarcely studied and current knowledge is restricted to three species of hard ticks only. The current study aimed to assess the presence of Anaplasmataceae, Borrelia and Hepatozoon agents in ticks collected directly from the environment, on reptiles, bir...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Muñoz-Leal S,Lopes MG,Marcili A,Martins TF,González-Acuña D,Labruna MB

    更新日期:2019-04-01 00:00:00

  • Natural host odours as possible attractants for Glossina tachinoides and G. longipalpis (Diptera: Glossinidae).

    abstract::As strictly haematophagous insects, tsetse flies feed on a wide variety of wild and domestic animals. Although these are mainly mammals, some tsetse species also feed on reptiles. The present study investigated whether the odours of several potential natural tsetse hosts may be used as novel attractants to improve the...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Späth J

    更新日期:1997-11-01 00:00:00

  • Molecular epidemiological survey of cutaneous leishmaniasis from Azad Jammu and Kashmir, Pakistan.

    abstract::Cutaneous leishmaniasis (CL) is an emerging neglected tropical disease in Azad Jammu and Kashmir which is an underdeveloped area. Prevalence and parasite species identification are the key factors to control disease in a particular population, which were the objectives of the present study. Due to a lack of previous d...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Shaheen N,Qureshi NA,Qureshi MZ,Fatima H,Afzal M,Alhewairini SS

    更新日期:2020-06-01 00:00:00

  • An outbreak of peste des petits ruminants (PPR) in camels in the Sudan.

    abstract::In mid-August 2004, an outbreak of a previously unknown fatal disease of camels was reported to Kassala State veterinary authorities. Several areas in the state were visited during August-October 2004 to collect epidemiological data and specimens for diagnosis. Clinically the disease was characterized by sudden death ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Khalafalla AI,Saeed IK,Ali YH,Abdurrahman MB,Kwiatek O,Libeau G,Obeida AA,Abbas Z

    更新日期:2010-11-01 00:00:00

  • Transmission of Leishmania infantum MON-98 to hamsters by the bite of Phlebotomus langeroni Nitzulescu (Diptera: Psychodidae).

    abstract::The ability of Phlebotomus langeroni to successfully acquire and transmit Leishmania infantum MON-98 to hamsters was demonstrated. Sand flies and Leishmania both originated from an infantile visceral leishmaniasis focus in El Agamy Egypt. P. langeroni females were infected by feeding on lesions of needle-inoculated ha...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: El Sawaf BM,Doha SA,Imam MI

    更新日期:2012-01-01 00:00:00

  • The small subunit (SSU) ribosomal (r) RNA gene as a genetic marker for identifying infective 3rd juvenile stage Angiostrongylus cantonensis.

    abstract::We have developed a molecular method using PCR-direct sequencing to identify the infective 3rd juvenile stage of Angiostrongylus cantonensis, a nematode parasite of rodents that can accidentally infect humans and cause eosinophilic meningitis. We demonstrate that the 5' end of the small subunit (SSU) ribosomal (r) RNA...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Fontanilla IK,Wade CM

    更新日期:2008-02-01 00:00:00

  • Responses of Anopheles minimus to DDT residual spraying in a cleared forested foothill area in central Thailand.

    abstract::Anopheles balabacensis balabacensis and Anopheles minimus are the main malaria vectors in Thailand. In a cleared forested foothill area in the central part of the country A. minimus was the most prevalent anopheline species found, only 6 specimens of A. b. balabacensis being collected over a 3-year period. Cattle were...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Ismail IA,Phinichpongse S,Boonrasri P

    更新日期:1978-03-01 00:00:00

  • Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats.

    abstract::The antidiarrhoeal effects of the methanol extract of Zizyphus spina-christi stem bark were evaluated in laboratory rodents. Studies on castor oil induced diarrhoea, intraluminal fluid accumulation, and gastrointestinal transit time were carried out. Results obtained revealed that the extract caused a dose dependent p...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Adzu B,Amos S,Amizan MB,Gamaniel K

    更新日期:2003-07-01 00:00:00

  • Ecdysteroids in urine of African patients infected with helminths.

    abstract::The insect molting hormone and related compounds (ecdysteroids) have been found in patients infected with helminths. To investigate this phenomenon, we quantified and analyzed the urinary ecdysteroids in Malian subjects suffering from various helminthiases, as well as in Europeans. Very high titers (up to 100 nM) were...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Baswaïd S,Gharib B,Doumbo O,Quilici M,de Reggi M

    更新日期:1990-05-01 00:00:00

  • Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones.

    abstract::Resistance to chloroquine (CQ) in Plasmodium falciparum has a major impact on malaria control worldwide. To gain insight into early parasite stress response, mRNA expression profiles were determined for a set of 10 antioxidant defence genes in synchronized CQ-sensitive (3D7) and CQ-resistant (Dd2) clones under transie...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Nogueira F,Diez A,Radfar A,Pérez-Benavente S,do Rosario VE,Puyet A,Bautista JM

    更新日期:2010-05-01 00:00:00

  • Establishment of a satellite rearing facility to support the release of sterile Aedes albopictus males. I. Optimization of mass rearing parameters.

    abstract::The vector species Aedes albopictus (Skuse, 1894) was recorded in Turkey for the first time, near the Greek border, in 2011 and a high risk of expansion towards Aegean and Mediterranean coasts of Turkey was estimated. A preliminary study was planned to evaluate the possibility of creating a satellite mass rearing faci...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Dogan M,Gunay F,Puggioli A,Balestrino F,Oncu C,Alten B,Bellini R

    更新日期:2016-07-01 00:00:00

  • Ultrastructural description and phylogeny of a novel microsporidian, Glugea eda n. sp. from the striated fusilier, Caesio striata, in the Red Sea off Saudi Arabia.

    abstract::Glugea eda n. sp. is described from the mesenteries of the striated fusilier, Caesio striata, collected from the Red Sea coast off Yanbu' al Bahr, Saudi Arabia. Numerous blackish xenomas, ranged from 3 to 5 mm, were found in the body cavity associated with the mesenteries. Mature spores are monomorphic, ellipsoidal wi...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Mansour L,Zhang JY,Abdel-Haleem HM,Darwish AB,Al-Quraishy S,Abdel-Baki AS

    更新日期:2020-04-01 00:00:00

  • Molecular detection of Trypanosoma cruzi in acai pulp and sugarcane juice.

    abstract::Chagas disease, caused by Trypanosoma cruzi affects about 6-8 million people worldwide. Although transmission by triatomine insects has been controlled, other means of transmission maintain the infection. These forms of transmission are responsible for introducing Chagas disease in other non-endemic countries of the w...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Mattos EC,Meira-Strejevitch CDS,Marciano MAM,Faccini CC,Lourenço AM,Pereira-Chioccola VL

    更新日期:2017-12-01 00:00:00

  • Spatial analysis of scrub typhus infection and its association with environmental and socioeconomic factors in Taiwan.

    abstract::We analyzed the spatial distribution of human cases of scrub typhus on the main island of Taiwan from 2003 to 2008 and implemented an island-wide survey of scrub typhus vectors (trombiculid chiggers) in 2007 and 2008. The standardized incidence rate 'SIR' incorporating inter-district variations in population, gender a...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kuo CC,Huang JL,Ko CY,Lee PF,Wang HC

    更新日期:2011-10-01 00:00:00

  • Parvaquone and buparvaquone: HPLC analysis and comparative pharmacokinetics in cattle.

    abstract::A high performance liquid chromatographic (HPLC) method for the determination of the antitheilerial drugs parvaquone and buparvaquone in plasma was developed. Both compounds were extracted from plasma with ether. After evaporating the extracts to dryness the residue was dissolved in methanol and an aliquot was injecte...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kinabo LD,Bogan JA

    更新日期:1988-03-01 00:00:00

  • Pangonius theodori a new horse fly species for science from Israel and Lebanon (Diptera: Tabanidae: Pangoniinae).

    abstract::Pangonius theodori a new horse fly species (Diptera: Tabanidae: Pangoniinae) from northern Israel and southern Lebanon is described. The zoogeography, habitat preference and taxonomic position within the genus of the new species is discussed in detail. ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Zeegers T,Kravchenko VD,Müller GC

    更新日期:2013-03-01 00:00:00

  • Field evaluation of a semi-automatic funnel trap targeted the medically important non-biting flies.

    abstract::Bait-trapping is a useful approach for monitoring fly population dynamics, and it is an effective tool for physical control of pest species. The aim of this study was to test a newly developed semi-automatic funnel fly trap with some modifications of the former prototype fly trap to study medically important fly popul...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Klong-Klaew T,Sontigun N,Sanit S,Samerjai C,Sukontason K,Kurahashi H,Koehler PG,Pereira RM,Limsopatham K,Suwannayod S,Thanapornpoonpong SN,Chareonviriyaphap T,Sukontason KL

    更新日期:2017-12-01 00:00:00

  • Interspecific differentiation of Trypanosoma cruzi, Trypanosoma conorhini and Trypanosoma rangeli by lectins in combination with complement lysis.

    abstract::Four-day-old epimastigote culture forms of Trypanosoma cruzi, Trypanosoma rangeli and Trypanosoma conorhini were tested with 21 lectins. Furthermore T. conorhini was incubated with the following sera: rat, Wistar HAN, germ free; normal fresh hen, rat and human serum. T. rangeli was agglutinated only by the D-mannose s...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Schottelius J,Müller V

    更新日期:1984-03-01 00:00:00

  • The use of impregnated curtains does not affect antibody responses against Plasmodium falciparum and complexity of infecting parasite populations in children from Burkina Faso.

    abstract::In Burkina Faso, where malaria is hyper-endemic and transmission intensity is very high, the majority of malaria-related morbidity and mortality occurs in children less than 5 years of age. A control measure such as the use of insecticide-treated curtains (ITC) significantly reduces transmission of malaria infection. ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Bolad A,Nebié I,Esposito F,Berzins K

    更新日期:2004-05-01 00:00:00

  • Application of environmental DNA analysis for the detection of Opisthorchis viverrini DNA in water samples.

    abstract::Opisthorchiasis, which can lead to cholangiocarcinoma in cases of chronic infection, is a major public health problem in Southeast Asian countries. The trematode, Opisthorchis viverrini, is the causative agent of the disease. Accurate and rapid monitoring of O. viverrini is crucial for disease prevention and containme...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Hashizume H,Sato M,Sato MO,Ikeda S,Yoonuan T,Sanguankiat S,Pongvongsa T,Moji K,Minamoto T

    更新日期:2017-05-01 00:00:00

  • Heterogeneous distribution of Culex pipiens, Culex quinquefasciatus and their hybrids along the urbanisation gradient.

    abstract::The mosquitoes of the Culex pipiens complex, hereafter referred to as the Pipiens Assemblage, are vectors of arbovirus of worldwide concern including West Nile and St. Louis encephalitis. Given their distinct eco-physiology and vectorial capacity, accurate specimen identification and insight in the environmental drive...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Cardo MV,Rubio A,Junges MT,Vezzani D,Carbajo AE

    更新日期:2018-02-01 00:00:00

  • Morphological and physiological characteristics of a virulent and zoonotic assemblage A Giardia duodenalis canine strain.

    abstract::Giardiasis is an intestinal parasitosis that affects millions of people worldwide and is considered a zoonotic disease. Frequently in contact with humans, dogs are the main host involved in this zoonotic transmission. Here, we compared some aspects of Giardia duodenalis biology between two strains: a recently isolated...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Coelho CH,Silva ACC,Costa AO,Fernandes AP

    更新日期:2017-10-01 00:00:00

  • Japanese Encephalitis and Associated Environmental Risk Factors in Eastern Uttar Pradesh: A time series analysis from 2001 to 2016.

    abstract::India and other Southeast Asian countries are severely affected by Japanese encephalitis (JE), one of the deadliest vector-borne disease threat to human health. Several epidemiological observations suggest climate variables play a role in providing a favorable environment for mosquito development and virus transmissio...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Singh H,Singh N,Mall RK

    更新日期:2020-12-01 00:00:00