Immunological alterations in uncomplicated Plasmodium falciparum malaria. Relationship between parasitaemia and indicators of macrophage activation.


:Numerical alterations of circulating lymphocytes were investigated in 37 Brazilian patients with uncomplicated Plasmodium falciparum malaria and in a group of 15 healthy controls. The number of CD4+ T helper/inducer cells was significantly lower in patients than controls, whereas absolute numbers of CD8+ suppressor/cytotoxic T cells did not differ between the groups. TNF and neopterin levels were markedly increased in the plasma of patients and remained slightly elevated after chemotherapy with clindamycin. Neopterin, but not TNF levels, were significantly correlated with parasitaemia. TNF was inversely related to monocyte counts. Interferon gamma could not be detected in the plasma of control subjects and was observed in only one patient. We conclude that in uncomplicated falciparum malaria the distribution of phenotypes of circulating lymphocytes are altered slightly and that the high plasma levels of TNF and neopterin indicate excessive release of these molecules by activated macrophages and the activation of cellular immune mechanisms during the infection.


Acta Trop


Acta tropica


Kremsner PG,Feldmeier H,Zotter GM,Jansen-Rosseck R,Graninger W,Rocha RM,Bienzle U




Has Abstract


1989-10-01 00:00:00














  • Evaluation of nitazoxanide as a novel drug for the treatment of acute and chronic toxoplasmosis.

    abstract::Toxoplasmosis is a widespread, neglected disease with significant morbidity and mortality. In search of an effective treatment, nitazoxanide (NTZ) was evaluated in the treatment of acute and chronic toxoplasmosis in experimental mice. For this purpose, mice were infected with 20 cysts (acute infection model) or 10 cys...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: El-Kowrany SI,El Ghaffar AEA,Shoheib ZS,Mady RF,Gamea GAM

    更新日期:2019-07-01 00:00:00

  • Development of Trypanosoma cruzi in the vector in the absence of blood.

    abstract::First stage nymphs of Triatoma infestans and Dipetalogaster maximus which had never fed after egg hatching, were allowed to ingest by artificial feeding a blood-free suspension of Trypanosoma cruzi trypomastigotes collected from experimentally infected mice. A high percentage of the vectors acquired a normal infection...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Alvarenga NJ,Brener Z

    更新日期:1978-12-01 00:00:00

  • Factors associated with dog rabies immunisation status in Bamako, Mali.

    abstract::We conducted a cross-sectional survey in Bamako, Mali, to determine for the first time the seroprevalence of rabies virus antibodies in the dog population and people's knowledge, attitudes and practices (KAP) towards the disease and its control. Antibody detection was done with the fluorescent antibody virus neutralis...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Mauti S,Traoré A,Hattendorf J,Schelling E,Wasniewski M,Schereffer JL,Zinsstag J,Cliquet F

    更新日期:2017-01-01 00:00:00

  • Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro.

    abstract::Azithromycin, an azalide analog of erythromycin was assayed for its in vitro activity against multidrug-resistant Plasmodium falciparum K1 strain by measuring the 3H-hypoxanthine incorporation. Azithromycin caused inhibitory effects on the parasite growth with IC50 and IC90 values of 8.4+/-1.2 microM and 26.0+/-0.9 mi...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Nakornchai S,Konthiang P

    更新日期:2006-12-01 00:00:00

  • Risk of infection with Brucella abortus and Escherichia coli O157:H7 associated with marketing of unpasteurized milk in Kenya.

    abstract::As part of a study to assess zoonotic milk-borne health risks, seasonal survey data and unpasteurized milk samples were collected between January 1999 and February 2000 from randomly selected informal milk market agents (220 and 236 samples in the dry and wet seasons, respectively) and from households purchasing raw m...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Arimi SM,Koroti E,Kang'ethe EK,Omore AO,McDermott JJ

    更新日期:2005-10-01 00:00:00

  • Occurrence and prevalence of fish-borne Anisakis larvae in the spotted mackerel Scomber australasicus from Taiwanese waters.

    abstract::Anisakid nematodes have been found in a variety of marine fishes throughout the world and they are known to cause anisakiasis in human hosts. The present study investigated the prevalence of potentially zoonotic anisakid larvae in spotted mackerel caught from Taiwanese waters where fish represents an important food so...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Chen HY,Shih HH

    更新日期:2015-05-01 00:00:00

  • Molecular detection of reptile-associated Borrelia in Boa constrictor (Squamata: Boidae) from Veracruz, Mexico.

    abstract::The reptile-associated Borrelia represent a monophyletic group of bacteria transmitted by several species of hard ticks, which has been reported to only infect amphibians and reptiles in Eurasia and Middle East, however, this bacterial group has not been studied in North America. The aim of this study was to assess th...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Morales-Diaz J,Colunga-Salas P,Romero-Salas D,Sánchez-Montes S,Estrada-Souza IM,Ochoa-Ochoa LM,Becker I,Flores-Primo A,Cruz-Romero A

    更新日期:2020-05-01 00:00:00

  • Culicidae (Diptera) community structure, spatial and temporal distribution in three environments of the province of Chaco, Argentina.

    abstract::The aim of this work was to study the composition of the Culicidae community in three environments with different degrees of anthropic disturbance in the province of Chaco. The nonparametric richness estimator ACE was calculated to measure the completeness of the sampling in each environment, and the diversity of each...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Stein M,Santana M,Galindo LM,Etchepare E,Willener JA,Almirón WR

    更新日期:2016-04-01 00:00:00

  • The public health laboratory service (PHLS) and its role in the control of zoonotic disease.

    abstract::The aetiology of zoonotic infections embraces organisms from every branch of the microbial world. In addition, zoonoses must be considered as a truly global problem, both in terms of their distribution and the measures required for their control. Within the UK, zoonotic disease is considered to be less frequent than i...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Coleman TJ

    更新日期:2000-07-21 00:00:00

  • Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern Côte d'Ivoire.

    abstract::Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cro...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kanouté YB,Gragnon BG,Schindler C,Bonfoh B,Schelling E

    更新日期:2017-01-01 00:00:00

  • Multiple drug resistance in the pathogenic protozoa.

    abstract::Evidence for the phenomenon of multiple drug resistance (MDR) in the well studied pathogenic protozoa has been examined. This has been placed in the more familiar context of the MDR efflux transporters and the cloned mdr genes of mammalian cells. Homologues of the mdr gene family in protozoa and their possible role in...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Upcroft P

    更新日期:1994-03-01 00:00:00

  • Japanese encephalitis in Indonesia: An update on epidemiology and transmission ecology.

    abstract::The Japanese Encephalitis (JE) virus circulation in Indonesia was first documented in Lombok in 1960, and the virus was first isolated in 1972 from Culex tritaeniorhynchus in Bekasi, West Java and Kapuk, West Jakarta. Since then, Indonesia has been recognized as an endemic country for JE transmission. Up to now, JE ca...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Garjito TA,Widiarti,Anggraeni YM,Alfiah S,Tunggul Satoto TB,Farchanny A,Samaan G,Afelt A,Manguin S,Frutos R,Aditama TY

    更新日期:2018-11-01 00:00:00

  • COVID-19 in China: Risk Factors and R0 Revisited.

    abstract::The COVID-19 epidemic spread rapidly through China and subsequently proliferated globally leading to a pandemic situation around the globe. Human-to-human transmission, as well as asymptomatic transmission of the infection, have been confirmed. As of April 03, 2020, public health crisis in China due to COVID-19 was po...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Khan IM,Haque U,Zhang W,Zafar S,Wang Y,He J,Sun H,Lubinda J,Rahman MS

    更新日期:2021-01-01 00:00:00

  • Chagas cardiomyopathy: The potential effect of benznidazole treatment on diastolic dysfunction and cardiac damage in dogs chronically infected with Trypanosoma cruzi.

    abstract::Cardiac involvement represents the main cause of mortality among patients with Chagas disease, and the relevance of trypanocidal treatment to improving diastolic dysfunction is still doubtful. In the present study, we used a canine model infected with the benznidazole-sensitive Berenice-78 Trypanosoma cruzi strain to ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Santos FM,Mazzeti AL,Caldas S,Gonçalves KR,Lima WG,Torres RM,Bahia MT

    更新日期:2016-09-01 00:00:00

  • Assessment of the relationship between entomologic indicators of Aedes aegypti and the epidemic occurrence of dengue virus 3 in a susceptible population, São José do Rio Preto, São Paulo, Brazil.

    abstract::The aims of this study were to describe the occurrence of dengue in space and time and to assess the relationships between dengue incidence and entomologic indicators. We selected the dengue autochthonous cases that occurred between September 2005 and August 2007 in São José do Rio Preto to calculate incidence rates b...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Chiaravalloti-Neto F,Pereira M,Fávaro EA,Dibo MR,Mondini A,Rodrigues-Junior AL,Chierotti AP,Nogueira ML

    更新日期:2015-02-01 00:00:00

  • Biochemical analysis of a recombinant glutathione transferase from the cestode Echinococcus granulosus.

    abstract::Glutathione transferases (GSTs) are believed to be a major detoxification system in helminths. We describe the expression and functional analysis of EgGST, a cytosolic GST from Echinococcus granulosus, related to the Mu-class of mammalian enzymes. EgGST was produced as an enzymatically active dimeric protein (rEgGST),...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Harispe L,García G,Arbildi P,Pascovich L,Chalar C,Zaha A,Fernandez C,Fernandez V

    更新日期:2010-04-01 00:00:00

  • Is K-O Tab 1-2-3((R)) long lasting on non-polyester mosquito nets?

    abstract::Many societies use locally sourced mosquito nets made from a variety of materials. For protecting against malaria these require regular re-treatment with insecticide. K-O Tab 1-2-3 is a 'dip-it-yourself' long-lasting formulation with time-limited interim recommendation from WHO for treatment of washed white and colour...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Oxborough RM,Weir V,Irish S,Kaur H,N'Guessan R,Boko P,Odjo A,Metonnou C,Yates A,Akogbeto M,Rowland MW

    更新日期:2009-10-01 00:00:00

  • Exploring the impact of house screening intervention on entomological indices and incidence of malaria in Arba Minch town, southwest Ethiopia: A randomized control trial.

    abstract::House is the major site for malaria infection where most human-vector contact takes place. Hence, improving housing might reduce the risk of malaria infection by limiting house entry of vectors. This study aimed to explore the impact of screening doors and windows with wire meshes on density and entomological inoculat...

    journal_title:Acta tropica

    pub_type: 杂志文章,随机对照试验


    authors: Getawen SK,Ashine T,Massebo F,Woldeyes D,Lindtjørn B

    更新日期:2018-05-01 00:00:00

  • Advantages of bioconjugated silica-coated nanoparticles as an innovative diagnosis for human toxoplasmosis.

    abstract::Nanotechnology is a promising arena for generating new applications in Medicine. To successfully functionalised nanoparticles for a given biomedical application, a wide range of chemical, physical and biological factors have to be taken into account. Silica-coated nanoparticles, (SiO2NP) exhibit substantial diagnostic...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Aly I,Taher EE,El Nain G,El Sayed H,Mohammed FA,Hamad RS,Bayoumy EM

    更新日期:2018-01-01 00:00:00

  • Predicted altitudinal shifts and reduced spatial distribution of Leishmania infantum vector species under climate change scenarios in Colombia.

    abstract::Visceral leishmaniasis (VL) is caused by the trypanosomatid parasite Leishmania infantum (=Leishmania chagasi), and is epidemiologically relevant due to its wide geographic distribution, the number of annual cases reported and the increase in its co-infection with HIV. Two vector species have been incriminated in the ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: González C,Paz A,Ferro C

    更新日期:2014-01-01 00:00:00

  • Schistosomiasis in Egypt: A never-ending story?

    abstract::Schistosomiasis has plagued the Egyptian population since the antiquity. The disease is still a public health problem in Egypt, despite the tendency of being overlooked. In the first part of this review, the past and current trends of schistosomiasis in Egypt are reviewed, including history, epidemiology, morbidity, t...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Othman AA,Soliman RH

    更新日期:2015-08-01 00:00:00

  • Breeding protocol for the sand fly Nyssomyia neivai (Diptera: Psychodidae) in laboratory conditions.

    abstract::The information in this protocol covers from the basic steps and material necessary to start a sand fly colony up to the specific details which are important to the success of a Nyssomyia neivai colony. The greatest problems in our colony of Ny. neivai were solved with specific care, for instance, using vermiculite an...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Goulart TM,da Rocha Silva FB,Machado VE,Oliveira WHC,de Castro CF,Rodrigues MVN,Pinto MC

    更新日期:2017-10-01 00:00:00

  • Maintenance of Glossina morsitans morsitans on antiserum to procyclic trypanosomes reduces infection rates with homologous and heterologous Trypanosoma congolense stocks.

    abstract::Three experimental groups of male Glossina morsitans morsitans were infected at their first feed with procyclic forms of different stocks of Trypanosoma congolense and subsequently maintained on a diet containing rabbit antiserum to one of these stocks. Control flies were similarly infected but were then maintained on...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Maudlin I,Turner MJ,Dukes P,Miller N

    更新日期:1984-09-01 00:00:00

  • Molecular cloning and characterization of Brugia malayi thymidylate kinase.

    abstract::Thymidylate kinase (TMK) is a potential chemotherapeutic target because it is directly involved in the synthesis of deoxythymidine triphosphate, which is an essential component for DNA synthesis. The gene encoding thymidylate kinase of Brugia malayi was amplified by PCR and expressed in Escherichia coli. The native mo...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Doharey PK,Suthar MK,Verma A,Kumar V,Yadav S,Balaramnavar VM,Rathaur S,Saxena AK,Siddiqi MI,Saxena JK

    更新日期:2014-05-01 00:00:00

  • Imaging findings in neurocysticercosis.

    abstract::The diagnosis of neurocysticercosis was greatly improved by the introduction of computed tomography (CT) and magnetic resonance imaging (MRI). These techniques demonstrate the number and topography of lesions, their stage of involution, and the degree of inflammatory reaction of the host against the parasites and have...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: García HH,Del Brutto OH

    更新日期:2003-06-01 00:00:00

  • Water and health: From environmental pressures to integrated responses.

    abstract::The water-related exposome is a significant determinant of human health. The disease burden through water results from water-associated communicable and non-communicable diseases and is influenced by water pollution with chemicals, solid waste (mainly plastics), pathogens, insects and other disease vectors. This paper...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Boelee E,Geerling G,van der Zaan B,Blauw A,Vethaak AD

    更新日期:2019-05-01 00:00:00

  • The electronic song "Scary Monsters and Nice Sprites" reduces host attack and mating success in the dengue vector Aedes aegypti.

    abstract::Sound and its reception are crucial for reproduction, survival, and population maintenance of many animals. In insects, low-frequency vibrations facilitate sexual interactions, whereas noise disrupts the perception of signals from conspecifics and hosts. Despite evidence that mosquitoes respond to sound frequencies be...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Dieng H,The CC,Satho T,Miake F,Wydiamala E,Kassim NFA,Hashim NA,Morales Vargas RE,Morales NP

    更新日期:2019-06-01 00:00:00

  • Comparison of the isometamidium-based trypanocidal drugs Samorin and Veridium in cattle under field conditions at Nguruman, Kenya.

    abstract::The trypanocidal activity of two commercially available isometamidium-based products, Samorin (Merial, USA) and Veridium (Sanofi Santé Nutrition Animale, France), used at a dose rate of 0.5 mg kg(-1) bodyweight, was compared in a field trial involving groups of approximately 30 zebu cattle in a trypanosomosis endemic ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Stevenson P,Okech G,Mwendia C,Sones KR

    更新日期:2000-11-02 00:00:00

  • An annotated checklist of the horse flies (Diptera: Tabanidae) of the Sinai Peninsula Egypt with remarks on ecology and zoogeography.

    abstract::During a 20-year survey we routinely collected Tabanidae in the Sinai resulting in a checklist of 22 species. We recorded 2 species for the Levant (Tabanus mordax Austen, 1911 and Tabanus gratus Loew, 1858), 4 species for Egypt (Nemorius irritans (Ricardo, 1901), Chrysops flavipes Meigen, 1804, Haematopota coronata Au...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Müller GC,Revay EE,Hogsette JA,Zeegers T,Kline D,Kravchenko VD,Schlein Y

    更新日期:2012-05-01 00:00:00

  • Viruses of parasites as actors in the parasite-host relationship: A "ménage à trois".

    abstract::The complex parasite-host relationship involves multiple mechanisms. Moreover, parasites infected by viruses modify this relationship adding more complexity to the system that now comprises three partners. Viruses infecting parasites were described several decades ago. However, until recently little was known about th...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Gómez-Arreaza A,Haenni AL,Dunia I,Avilán L

    更新日期:2017-02-01 00:00:00