Abstract:
BACKGROUND:The receptor activator for nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) are the key factors controlling the osteoclast and osteoblast action in the bone. PURPOSE:The study objective was to investigate the expression level of RANKL and OPG in cholesteatoma and granulation tissue, and to assess the relationship between their expression levels and osteolysis. MATERIAL AND METHODS:Patients with chronic otitis media with cholesteatoma (n = 28) and without cholesteatoma (n = 24) treated surgically at the Department of Otolaryngology of the Medical University of Gdańsk were included in the study. RANKL and OPG expressions were analyzed by immunohistochemistry and Western blot. RESULTS:RANKL and OPG were expressed in all cholesteatoma and granulation tissues. RANKL expression was mainly observed in cholesteatoma subepithelial stroma, whereas OPG-positive cells originated from the epithelium. The number of OPG-positive cells in the normal skin was significantly higher than in cholesteatoma tissues. The RANKL protein level in cholesteatoma tissues was 1.8- and 1.5-fold higher than in the auditory canal skin and granulation tissues, respectively. The number of RANKL-positive cells in cholesteatoma tissues was significantly higher than in the normal skin. No substantial differences were found in average OPG protein levels between cholesteatoma tissues and the normal auditory canal skin. The ratio of RANKL/OPG was significantly higher in cholesteatoma tissues (2.93 ± 0.79) than in the skin samples (1.36 ± 0.34). CONCLUSIONS:Altered ratio of RANKL/OPG protein level in cholesteatoma tissues suggests that these proteins might be somehow involved in the pathogenesis of cholesteatoma. However, to resolve this issue a study on a larger group of patients should be conducted.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Kuczkowski J,Sakowicz-Burkiewicz M,Iżycka-Świeszewska Edoi
10.1016/j.amjoto.2009.06.004subject
Has Abstractpub_date
2010-11-01 00:00:00pages
404-9issue
6eissn
0196-0709issn
1532-818Xpii
S0196-0709(09)00126-4journal_volume
31pub_type
杂志文章abstract::Branhamella catarrhalis has gained increasing recognition as a pathogen in the respiratory tract. During the past 18 years, since its transfer from the genus Neisseria, it has been associated with infection in cavities of the respiratory tract (sinuses and middle ear). It has been recognized as playing a role in laryn...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/0196-0709(91)90046-i
更新日期:1991-03-01 00:00:00
abstract:PURPOSE:To present a prospective temporal bone fracture database, and study facial and cochleovestibular sequelae and their impact on quality of life. MATERIALS AND METHODS:Prospective study of consecutive cases of 39 patients with 45 temporal bone fractures over 11-month period in a university tertiary referral cente...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2014.12.011
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:This study aims to report the postoperative complications and management of cochlear implantation in pediatric patients at our institution. All procedures were carried out by a single surgeon utilizing minimally invasive techniques. The impact of past surgical history of tympanostomy tubes was also reviewed to ...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2015.09.002
更新日期:2016-01-01 00:00:00
abstract::Synchronous appearance of 2 different malignancies in one patient is a rare phenomenon. We describe our experience of 2 patients with synchronous malignancies of the testis and thyroid gland, and of a third patient who developed a thyroid neoplasm unrelated to recent treatment for a germ cell tumor. The medical record...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1053/ajot.2000.18887
更新日期:2000-11-01 00:00:00
abstract::This clinical review presents a survey of the different types of epithelial neoplasms in the parotid gland. The incidence, histopathological classification, grade of malignancy, and staging system are discussed. Diagnostic procedures are reviewed and a scheme for treatment is proposed for the different types of epithe...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
doi:10.1016/s0196-0709(80)80011-1
更新日期:1980-02-01 00:00:00
abstract:PURPOSE:The purpose of the study was to determine the prognostic significance of the ratio between metastatic and examined lymph nodes to the survival rate of patients with squamous cell carcinoma of the head and neck. MATERIALS AND METHODS:The study included 142 patients in whom metastatic lymph nodes were observed i...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2009.03.004
更新日期:2010-09-01 00:00:00
abstract::This case report describes a patient who was found to have a cerebrospinal fluid (CSF) leak originating from the petrous apex. The patient initially presented with multiple bouts of meningitis. The patient was treated surgically via a middle cranial fossa approach but presented five years later with recurrent meningit...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2014.02.013
更新日期:2014-05-01 00:00:00
abstract::Two cases of inner ear injury caused by suppressed sneezing are described. One patient experienced vestibular symptoms in the form of reflexogenic vertigo that was relieved by surgical section of the tensor tympani tendon. The other patient had a sudden severe permanent sensorineural hearing loss. It is proposed that ...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(85)80027-2
更新日期:1985-11-01 00:00:00
abstract:PURPOSE:Cystic masses of the supraclavicular fossa (SCF) are uncommon. The diverse anatomical structures within the SCF create an extended differential diagnosis for any mass arising in the SCF. This study describes the presenting symptoms, radiologic findings, medical and surgical management, and posttreatment outcome...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
doi:10.1016/j.amjoto.2009.08.008
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:In pituitary macroadenomas with extensive suprasellar extension (SSE), suprasellar region can be approached by extending exposure either anteriorly by adding bone removal of the tuberculum sellae and planum sphenoidal or posteriorly from inside the sellar cavity through diaphragma sella. The later approach ha...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2020.102808
更新日期:2021-01-01 00:00:00
abstract::Aminoglycoside antibiotics are frequently employed in the treatment of serious infections caused by aerobic gram negative bacilli. The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted by glomerular filtration at a rate proportional to the ...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(80)80012-3
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:The surgical management of benign parotid tumors is aimed at complete extirpation of the mass with preservation of facial nerve function. There is a relative paucity of literature pertaining to complications after benign parotid surgery and related risk factors. We aim to critically review the outcomes follo...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2017.11.015
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Deep neck infections may be lethal if life-threatening complications occur, especially in immunocompromised hosts such as diabetic patients. This study was undertaken to better define the clinical features and prognosis of deep neck infections in the diabetic patients with special emphasis on the use of empiric...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(00)85019-x
更新日期:2000-05-01 00:00:00
abstract:PURPOSE:The objective of this study is to determine the results of functional endoscopic sinus surgeries (FESS) for chronic rhinosinusitis with polyps and assess the association between surgery and specific quality of life outcomes. MATERIALS AND METHODS:A prospective study was performed in a tertiary referral center....
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2014.09.003
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to review the diagnosis and treatment of primary immunodeficiency disease (PID) and the role of otolaryngologists in the management of PID. METHODS:A search was conducted of PubMed and the Web sites of organizations for PID patients for literature pertaining to the diagnosis an...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
doi:10.1016/j.amjoto.2010.05.001
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To present morphologic evidence of viral-induced vestibular nerve pathology in Menière's Disease (MD). MATERIAL STUDIED: Twelve temporal bones (TB) from 8 patients with the clinical symptoms of MD. RESULTS:There was endolymphatic hydrops (EH) and perilymphatic fibrosis in 10 of the 12 TB from MD patients. Of...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1053/ajot.2001.24822
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to report 2 cases of extramedullary plasmacytoma (EP) with localization to middle ear that were diagnosed and managed in our department. METHODS:The first patient was a 60-year-old man with progressive hearing loss, tinnitus, recurrent episodes of otalgia, and otorrhea in his right e...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
doi:10.1016/j.amjoto.2008.07.004
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:To explore surgical timing of facial paralysis after temporal bone trauma. METHODS:The clinical data of the patients with facial paralysis after temporal bone trauma who underwent subtotal facial nerve decompression were retrospectively collected, and 80 cases followed-up for one year were enrolled in the s...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2017.01.002
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:COVID-19 is a pandemic disease known with one of the symptoms is sudden onset anosmia. This symptom sometimes may be the only sign of the disease, therefore it must be research widely. OBJECTIVE:We aim to evaluate odor dysfunction in COVID-19 patients objectively and safely without any risk of transmittin...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2020.102761
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The goal of this study is to describe a unique finding of ulcerative lesions of the larynx in two pediatric patients presenting with prolonged acute laryngotracheitis and compare to previously described reports to determine the typical clinical picture, need for intervention, and management model. METHODS:We...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2013.02.007
更新日期:2013-09-01 00:00:00
abstract::The history of stapedectomy dates back to the late 19th century. Although otologists in both the United States and Europe were performing stapedectomy operations at the turn of the century, stapes surgery ceased in the early 1900s. This paper examines the early and recent history of stapes surgery. An analysis of the ...
journal_title:American journal of otolaryngology
pub_type: 历史文章,杂志文章
doi:10.1016/s0196-0709(83)80015-5
更新日期:1983-03-01 00:00:00
abstract::In a group of patients with unilateral labyrinthine dysfunction, the maximal velocity of the slow component response to caloric stimulation was compared with that to horizontal vestibular rotatory stimulation by a low-frequency stimulus. It was found that the larger the magnitude of the caloric response, the larger we...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(84)80027-7
更新日期:1984-03-01 00:00:00
abstract:PURPOSE:The non-invasive diagnosis of acute rhinosinusitis (ARS) remains an unresolved problem of modern otolaryngology. Analog diaphanoscopy of reduced transillumination (shading) could be enhanced by a digital image processing of the maxillary sinuses. By this means, the limited ergonomics of this safe and low-cost m...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2020.102444
更新日期:2020-01-01 00:00:00
abstract::Ectopic thyroid is a rare developmental anomaly. It can be found anywhere between the foramen cecum and the normal position of the thyroid gland. Massive bleeding from an ectopic lingual thyroid is unusual and occasionally fatal. We present a case of a 22-year-old woman who had a large mass at the base of the tongue f...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1053/ajot.2002.123432
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:This study was designed for better understanding of the role of different methods of nasal endoscopy in the assessment of adenoid hypertrophy and comparing them with lateral neck radiography and patients' symptoms. SUBJECTS AND METHOD:From August 2007 until January 2009, in the otolaryngology ward of a terti...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2009.11.003
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Due to the COVID-19 pandemic, aerosol-generating procedures (AGPs) such as flexible endoscopic evaluation of swallowing (FEES) have been deemed high-risk and in some cases restricted, indicating the need for additional personal protective equipment. The aim of this study was to erect and study a protective barr...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2020.102888
更新日期:2021-01-04 00:00:00
abstract::Current indications for TT placement are (1) persistent SOM that has not responded to a 6 to 12-week course of medical treatment. This includes full and prophylactic doses of antimicrobials (and corticosteroids, as indicated); (2) recurrent AOM (at least three episodes in 6 months or four episodes in 12 months) that d...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
doi:10.1016/0196-0709(94)90058-2
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:The purpose to this study is to identify correlations between pathology and dynamic contrast-enhanced magnetic resonance imaging (MRI) and to assess the utility of this technique in the evaluation of radiation response for head and neck cancer. MATERIALS AND METHODS:MRI was prospectively performed after radiot...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2004.11.011
更新日期:2005-05-01 00:00:00
abstract::Observations from clinical and research applications of brain stem evoked response audiometry and electrocochleography have suggested that tone bursts of only a few milliseconds' duration can elicit frequency specific responses. Because such brief stimuli are not perceived as being total, the extent to which the audit...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(81)80027-0
更新日期:1981-05-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to determine the association of the bedside test of head-shaking nystagmus (HSN) with patients' self-perceived dizziness handicap as well as this test's sensitivity and specificity in unilateral peripheral vestibular hypofunction. STUDY DESIGN:A retrospective case-control stu...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2010.11.004
更新日期:2011-11-01 00:00:00