Abstract:
PURPOSE:The purpose to this study is to identify correlations between pathology and dynamic contrast-enhanced magnetic resonance imaging (MRI) and to assess the utility of this technique in the evaluation of radiation response for head and neck cancer. MATERIALS AND METHODS:MRI was prospectively performed after radiotherapy in 27 patients with various head and neck tumors. After bolus injection of contrast material, a dynamic study was performed using a spoiled gradient-recalled imaging sequence. The maximum slope of increase (MSI) on the time-intensity curve was displayed as a color-coded image. The ratio of MSI (MSIR) was obtained for tumor and normal muscles. Pathological specimens were obtained after MRI in all cases. Histological grading of irradiation changes was classified into 5 grades (0-4). Correlations between MSIR and histological grade were examined. RESULTS:Histologically, 18 tumors were classified as grade 2 (presence of viable tumor cells), 4 were grade 3 (nonviable tumor cells), and 5 were grade 4 (no tumor cells). Although the mean +/- SD of MSIR in patients with histological grade 2 or 3 was 7.4 +/- 7.9, MSIR in patients with grade 4 was 1.8 +/- 0.73, representing a significant difference ( P < .05). Every patient with grade 4 displayed an MSIR of 2.5 or less, although 5 of 22 patients with grade 2 or 3 had an MSIR of 2.5 or less. CONCLUSIONS:MSI quantitatively reflects response to radiotherapy for head and neck cancer. Color-coded MSI display is feasible for depicting permeability changes after radiotherapy.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Tomura N,Omachi K,Sakuma I,Takahashi S,Izumi J,Watanabe O,Watarai J,Sageshima Mdoi
10.1016/j.amjoto.2004.11.011subject
Has Abstractpub_date
2005-05-01 00:00:00pages
163-7issue
3eissn
0196-0709issn
1532-818Xpii
S0196070904001851journal_volume
26pub_type
杂志文章abstract:PURPOSE:Our study goal was to identify clinical factors associated with, and that might predict, treatment outcome for patients with an isolated cervical recurrence of squamous cell carcinoma in the previously treated neck (ICR-PTN). MATERIALS AND METHODS:We reviewed all patients with noncutaneous head and neck squamo...
journal_title:American journal of otolaryngology
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journal_title:American journal of otolaryngology
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abstract::Current indications for TT placement are (1) persistent SOM that has not responded to a 6 to 12-week course of medical treatment. This includes full and prophylactic doses of antimicrobials (and corticosteroids, as indicated); (2) recurrent AOM (at least three episodes in 6 months or four episodes in 12 months) that d...
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pub_type: 杂志文章,多中心研究
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更新日期:2011-01-01 00:00:00
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journal_title:American journal of otolaryngology
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journal_title:American journal of otolaryngology
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更新日期:2017-01-01 00:00:00
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更新日期:2002-05-01 00:00:00
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更新日期:2020-01-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2011-03-01 00:00:00
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journal_title:American journal of otolaryngology
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journal_title:American journal of otolaryngology
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doi:10.1016/j.amjoto.2006.01.010
更新日期:2006-11-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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更新日期:2020-01-01 00:00:00