Prognostic value of metastatic lymph node ratio in node-positive head and neck carcinomas.

Abstract:

PURPOSE:The purpose of the study was to determine the prognostic significance of the ratio between metastatic and examined lymph nodes to the survival rate of patients with squamous cell carcinoma of the head and neck. MATERIALS AND METHODS:The study included 142 patients in whom metastatic lymph nodes were observed in neck dissection specimens. The number of metastatic lymph nodes and the ratio of metastatic lymph nodes (RMLN) were compared as prognostic factors affecting overall survival (OS) and disease-free survival (DFS) rates. Survival curves were made using Kaplan-Meier analysis and were assessed by the log-rank test and Cox regression method. RESULTS:The median number of metastatic lymph nodes and RMLN for the entire study population were 2 and 4%, respectively. The OS and DFS rates were analyzed in the groups according to such stratification. The result of analysis of OS and DFS showed a statistically significant difference between patients with RMLN of at least 4% and those with RMLN less than 4% (hazard ratio, 3.4 and 2.7; P = .015 and P = .001, respectively). CONCLUSIONS:The ratio of metastatic lymph nodes has a significant impact on the survival period.

journal_name

Am J Otolaryngol

authors

Süslü N,Hoşal AS,Sözeri B

doi

10.1016/j.amjoto.2009.03.004

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

315-9

issue

5

eissn

0196-0709

issn

1532-818X

pii

S0196-0709(09)00055-6

journal_volume

31

pub_type

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