Abstract：
PURPOSE:The study objective is to evaluate the clinical features and outcomes of patients treated for head and neck malignant fibrous histiocytoma at a tertiary care medical facility. MATERIALS AND METHODS:This is a retrospective case series of 17 adult subjects with malignant fibrous histiocytoma of the head and neck who were treated between January 1, 1965, and December 31, 2010. This study was conducted using patient charts at a tertiary medical center. Subject selection was conducted using Current Procedural Terminology numbers; International Classification of Diseases, Ninth Revision, codes; and a search of the tumor registry. RESULTS:Chart review of the 17 identified subjects revealed an overwhelming male predominance (88%) with an overall mean age of 69 years(52-87 years). Thirteen patients (78%) underwent some form of surgical resection, 6 patients (35%) received radiation therapy, and 6 (35%) were given chemotherapy over the course of treatment. Nine tumors (53%) had a cutaneous origin, whereas 8 lesions (47.1%) were found in the soft tissue of the head and neck region. The local recurrence rate following a single resection was 46%. Overall median survival following diagnosis was found to be 65 months, with a 5-year survival rate of 52%. Median disease-free survival was 20 months, with a 5-year disease-free survival rate of 37%. Overall median and 5-year survival rates were found to increase with clear surgical margins, as was 5-year survival. CONCLUSIONS:Aggressive surgical management to achieve clear margins is central to the effective treatment of malignant fibrous histiocytoma of the head and neck. Metastatic disease portends a dismal prognosis.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Hardison SA,Davis PL 3rd,Browne JDdoi
10.1016/j.amjoto.2012.06.010subject
Has Abstractpub_date
2013-01-01 00:00:00pages
10-5issue
1eissn
0196-0709issn
1532-818Xpii
S0196-0709(12)00135-4journal_volume
34pub_type
杂志文章abstract：OBJECTIVE:Microvascular anastomosis is generally performed by attending surgeons or fellows, with published success rates >95%. Since otolaryngology residents do not typically perform microvascular anastomosis, it is unknown if they achieve similar results. The objective of this study is to determine the success rate a...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.amjoto.2013.02.005
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:Blindly administered bilateral (B/L) superior laryngeal nerve (SLN) blocks, have been used to decrease the perioperative stress response of endoscopic laryngosurgeries. Use of ultrasound (USG) for giving these blocks is more likely to be successful, with fewer complications. We evaluated the efficacy of US...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.amjoto.2018.09.004
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:To review surgical outcomes of stapes surgery for otosclerosis with persistence of the stapedial artery. MATERIALS AND METHODS:A retrospective case review of a tertiary neurotology referral center of patient with otosclerosis undergoing primary stapes surgery between 2010 and 2017 found to have a persistent st...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102684
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare the quality of life (QoL) of adult CI users with the QoL of adults in the healthy and normal-hearing population. MATERIALS AND METHODS:31 patients with CIs were included in the CI group, and 31 normal-hearing subjects were included in the control group. The QoL was evaluate...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2019.06.010
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:US Food and Drug Administration (USFDA) has licensed four Haemophilus influenzae type B (Hib) vaccines for use in children. Haemophilus influenzae type B is by far the most common pathogen in childhood epiglottitis and it is hoped that with the introduction of the Hib vaccine that a corresponding decrease ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(94)90085-x
更新日期：1994-11-01 00:00:00
abstract：:Bilateral congenital cholesteatomas are rare entities. Nine cases have been previously described in the literature. Many different etiologies for the development of congenital cholesteatoma have been proposed. The case of a five-year-old boy with bilateral congenital cholesteatoma is discussed. A lesion of the left ea...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2004.02.004
更新日期：2004-07-01 00:00:00
abstract：:Olfactory neuroblastoma is a rare malignant tumor of the nasal cavity arising from the olfactory neuroepithelium. It usually presents as a polypoid mass high in the nasal vault including the cribriform plate, superior turbinate, and superior portion of nasal septum. An 89-year-old man visited our office with symptoms ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2006.07.013
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:Cell adhesion molecules are cell surface proteins that allow specific cell-cell interactions among leukocytes, as well as between leukocytes and other cells. Because middle ear cholesteatoma is characterized by the presence of leukocyte infiltrates, the presence of the two molecule types of intercellular a...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(94)90094-9
更新日期：1994-07-01 00:00:00
abstract：:This article describes a woman with hemorrhagic telangiectasia, or Osler-Weber-Rendu disease, with recurrent nosebleeds despite prior septal dermoplasty and laser treatments. Telangiectasias were clearly shown at the time of angiography. Embolization of abnormal vessels on both sides resulted in cessation of epistaxis...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(95)90047-0
更新日期：1995-03-01 00:00:00
abstract：:We report a case of chondrosarcoma of the larynx, diagnosed by a percutaneous core-needle biopsy (CNB). Cartilaginous tumors of the larynx are usually diagnosed by biopsy with direct laryngomicroscopy under general anesthesia. However, patients find it difficult to undergo a biopsy under general anesthesia, for physic...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2014.03.013
更新日期：2014-07-01 00:00:00
abstract：:Rupture of the carotid artery has been one of the most feared postoperative complications in head and neck cancer patients. Traditional management of carotid artery rupture has been disappointing, and morbidity and mortality have been high. Experience with carotid artery rupture at the authors' institution over the pa...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(86)80009-6
更新日期：1986-05-01 00:00:00
abstract：PURPOSE:To determine differences in size of cochlear nerves among subjects with deafness due to connexin 26 (Cx26) mutations, subjects with deafness of unknown origin, and normal hearing subjects by sagittal high-resolution magnetic resonance (HRMR) imaging of the temporal bone. MATERIALS AND METHODS:Cross-sectional a...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2005.09.007
更新日期：2006-05-01 00:00:00
abstract：:Acquired tracheal pouch known also as tracheocele is a rare air-filled diverticulum of tracheal pars membranacea. This disease may be due to esophageal or tracheal surgery, orotracheal intubation, or increased intralunimal pressure through a weak area of tracheal wall. When symptomatic and medical therapy is insuffici...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2009.02.011
更新日期：2010-07-01 00:00:00
abstract：PURPOSE:Determine the clinical efficacy of comprehensive neurotologic testing in patients presenting with complaints of hearing loss, tinnitus and/or dizziness. METHODS:This is a retrospective analysis of 1170 consecutive charts of patients who presented between 1980 and 2013 with neurotologic complaints. Demographic ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2018.09.009
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:The objective of our randomized, double-blind study was to compare the effectiveness of intratympanic (IT) dexamethasone versus high-dosage of betahistine in the treatment of patients with intractable unilateral Meniere disease (MD). MATERIALS AND METHODS:Sixty six patients with definite unilateral MD were ran...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.amjoto.2014.10.032
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:Patients with chronic otitis media with/without cholesteatoma present a significant challenge to safe cochlear implantation (CI). The aim of our study is to describe our experience and propose management options for CI in patients with chronic otitis media. STUDY DESIGN:Retrospective case study. SETTING:Ter...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2014.08.001
更新日期：2014-11-01 00:00:00
abstract：:Type III frontal recess air cell as a cause of frontal sinus pneumocele has not been previously reported in literature. A 31-year-old woman with chronic history of sinusitis presented with pressure in the left eye on blowing the nose. Computed tomography examination of the orbits and paranasal sinuses with coronal and...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.amjoto.2009.01.001
更新日期：2010-05-01 00:00:00
abstract：:Observations from clinical and research applications of brain stem evoked response audiometry and electrocochleography have suggested that tone bursts of only a few milliseconds' duration can elicit frequency specific responses. Because such brief stimuli are not perceived as being total, the extent to which the audit...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(81)80027-0
更新日期：1981-05-01 00:00:00
abstract：PURPOSE:Most cases of endoscopic sinus surgery are amenable to techniques using local anesthesia with monitored sedation. However, it is frequently the preference of the patient to have surgery under general anesthesia. One major drawback of general anesthesia is the increased bleeding encountered which can interfere w...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(93)90072-f
更新日期：1993-07-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare the efficacy and safety of moxifloxacin with that of amoxicillin/clavulanate for the treatment of acute bacterial sinusitis in adults. MATERIALS AND METHODS:Five hundred seventy-five patients from Latin American countries were randomized to receive oral moxifloxacin 400 mg ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.amjoto.2006.06.016
更新日期：2007-03-01 00:00:00
abstract：PURPOSE:The authors conducted a prospective, comparative clinical trial for the purpose of additional effect of lipoprostaglandin E 1 (lipo-PGE 1 ) on sudden hearing loss. MATERIALS AND METHODS:With the approval of the institute ethics committee, a total of 128 consecutive patients with diagnoses of sudden hearing los...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.amjoto.2005.01.009
更新日期：2005-07-01 00:00:00
abstract：INTRODUCTION:Sir Charles Bell is renowned and revered as an outstanding surgeon, anatomist, clinician and teacher and his many contributions to various medical fields have been amply described. What are less well-known are his contributions to the field of laryngology. METHODS:Selected clinical and physiological publi...
journal_title：American journal of otolaryngology
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.amjoto.2017.04.011
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits. MATERIALS AND METHODS:Medical records of 62 patients with squamous cell ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(98)90064-3
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To find a correlation between increasing levels of serum bilirubin and auditory brainstem responses (ABR) and to find the use of ABR as a bilirubin neurotoxicity marker. MATERIAL AND METHODS:A prospective study of 60 neonates in which ABR of hyperbilirubinemic neonates was compared with the normal neonates. Al...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(98)90123-5
更新日期：1998-07-01 00:00:00
abstract：:Tinnitus is one of the most represented otological symptom, affecting 15% of adults, worldwide. Literature describes subjective tinnitus when it's perceived by the patient only, and objective tinnitus when it's heard both, by patient and examiner. An objective tinnitus can be caused by a large variety of anomalies and...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102739
更新日期：2020-01-01 00:00:00
abstract：:Lateralization of bilaterally applied bone-conducted signals could be accomplished by variation of time (delta t) or intensity (delta I) differences between signals. The task was relatively easy with clicks and with tone pips with short rise times. When rise times were made longer than 1 msec the ability to localize d...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(82)80044-6
更新日期：1982-03-01 00:00:00
abstract：PURPOSE:To further enhance and assess the ability to characterize middle ear effusion (MEE) using non-invasive ultrasound technology. MATERIALS AND METHODS:This is a prospective unblinded comparison study. Fifty-six children between the ages of 6 months and 17 years scheduled to undergo bilateral myringotomy with pres...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2012.08.005
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:The goal of this study is to describe a unique finding of ulcerative lesions of the larynx in two pediatric patients presenting with prolonged acute laryngotracheitis and compare to previously described reports to determine the typical clinical picture, need for intervention, and management model. METHODS:We...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2013.02.007
更新日期：2013-09-01 00:00:00
abstract：OUTCOME OBJECTIVES:METHODS: Case Report, April 2016. RESULTS:A 27-year-old female presented with a three-week history of flu-like symptoms including sore throat, myalgia and insidious nasal congestion. Her hospital course was complicated by pancytopenia, extensive GI bleed of unknown origin and fever. Radiographic stu...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2018.07.017
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:To demonstrate non-inferiority of eberconazole 1% otic solution to clotrimazole 1% solution, and to compare their safety profiles in the treatment of otomycosis. MATERIALS AND METHODS:Multicenter, randomized, double-blind, active treatment-controlled phase 3 clinical trial. One hundred and ninety patients with...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.amjoto.2018.03.017
更新日期：2018-01-01 00:00:00
