Abstract：
PURPOSE:To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits. MATERIALS AND METHODS:Medical records of 62 patients with squamous cell carcinoma of the hypopharynx, Stage III or IV (AJCC, 1992), were retrospectively reviewed. RESULTS:Neoadjuvant chemotherapy showed an overall response rate of 87% and a complete remission (CR) rate was 67% following chemotherapy and radiation therapy. The patients who did not show CR after chemotherapy had a high likelihood of treatment failure, even though they achieved CR following subsequent radiotherapy. Thirteen of 30 patients were able to preserve their larynges for more than 3 years by chemotherapy and radiation. CONCLUSION:This approach appeared to be as effective as radical surgery with postoperative radiation therapy without comprising survival. To improve the cure rates, we need to develop better strategies to increase CR rates with chemotherapy and determine the best treatment option for patients who are partially or nonresponsive to chemotherapy.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Kim KH,Sung MW,Rhee CS,Koo JW,Koh TY,Lee DW,Heo DS,Park CIdoi
10.1016/s0196-0709(98)90064-3subject
Has Abstractpub_date
1998-01-01 00:00:00pages
40-4issue
1eissn
0196-0709issn
1532-818Xpii
S0196-0709(98)90064-3journal_volume
19pub_type
杂志文章abstract：:The characteristics of response of 98 vestibular nuclei neurons were investigated in the barbiturate anesthetized cat. All type I and type II neurons (tonic and kinetic) responded to stimulation of the horizontal canals with step and impulse accelerations. Seventy-seven (79 per cent) neurons of all types demonstrated ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(80)80019-6
更新日期：1980-11-01 00:00:00
abstract：:In vitro studies of B-cells immortalized by Epstein-Barr Virus (EBV) have shown that B-cell leukemia/lymphoma-2 (bcl-2) protein expression is upregulated by the EBV-latency-associated antigen, latent membrane protein 1 (LMP1). The same phenomenon has also been observed in epithelial cells in vitro. However, such corre...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1053/ajot.2001.28071
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study is to determine the immediate effects of intraperitoneal doses of gentamicin (GM) which would result in variable degrees of destruction of crista ampullary hair cells of frogs. This information will serve as a baseline guide to cell regeneration experiments on the damaged vestibular sens...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2004.08.007
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:Adenoid cystic carcinoma (ACC) is a uncommon salivary malignant tumor. Our aim was to review our experience with parotid ACC, to identify clinical-pathological parameters predictive for outcome. MATERIALS AND METHODS:We retrospectively reviewed 228 patients affected by parotid gland carcinomas surgically treat...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2017.03.008
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:We aimed to evaluate the possible changes in the middle ears of patients with rheumatoid arthritis (RA) and to measure their hearing functions by eleven different test frequencies including standard and high frequencies. MATERIALS AND METHODS:The study group was comprised of 74 patients with RA. The control gr...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2004.06.001
更新日期：2004-11-01 00:00:00
abstract：PURPOSE:The purpose to this study is to identify correlations between pathology and dynamic contrast-enhanced magnetic resonance imaging (MRI) and to assess the utility of this technique in the evaluation of radiation response for head and neck cancer. MATERIALS AND METHODS:MRI was prospectively performed after radiot...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2004.11.011
更新日期：2005-05-01 00:00:00
abstract：PURPOSE:The purpose of the study was to systematically explore the fire and burn risk associated with fiberoptic cables and electrosurgical devices. MATERIALS AND METHODS:A 300-W light source was connected to a standard gray fiberoptic light cable. The end of the cable was either rested atop or buried within a cotton ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2007.05.006
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To present morphologic evidence of viral-induced vestibular nerve pathology in Menière's Disease (MD). MATERIAL STUDIED: Twelve temporal bones (TB) from 8 patients with the clinical symptoms of MD. RESULTS:There was endolymphatic hydrops (EH) and perilymphatic fibrosis in 10 of the 12 TB from MD patients. Of...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1053/ajot.2001.24822
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:The risk-benefit ratio of central neck dissection (CND) in patients affected by papillary thyroid carcinoma (PTC) without clinical or ultrasonographic (US) evidence of neck lymph node metastasis (cN0) is currently debated. The aim of this study was to evaluate long-term outcome of CND on locoregional recurren...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2017.06.004
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:The non-invasive diagnosis of acute rhinosinusitis (ARS) remains an unresolved problem of modern otolaryngology. Analog diaphanoscopy of reduced transillumination (shading) could be enhanced by a digital image processing of the maxillary sinuses. By this means, the limited ergonomics of this safe and low-cost m...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102444
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:This study was performed to evaluate the usefulness of Hounsfield unit (HU) to better distinguish cholesteatoma from other inflammatory conditions in the mastoid ad antrum before primary mastoid surgery. MATERIALS AND METHODS:We enrolled 82 patients who underwent tympanomastoidectomy for treatment of chronic o...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2010.01.008
更新日期：2011-05-01 00:00:00
abstract：:Experiments performed within the last 15 years on cochleas of live animals indicate that the cochlear sound analysis is much sharper than was expected from Békésy's experiments on postmortem preparations. The mechanism underlying the sharp analysis has not yet been ascertained experimentally. However, details of mecha...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(82)80032-x
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVES:To review our results with elective superior mediastinal dissections for thyroid carcinomas. STUDY DESIGN:Retrospective review. METHODS:We searched operative case logs for all patients with thyroid carcinoma treated with an elective superior mediastinal dissection by the senior author (Y.D.) during a 6-yea...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2008.05.003
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:A collapsible upper airway is a common cause of obstructive sleep apnea. The exact pathophysiology leading to a more collapsible airway is not well understood. A progressive neuropathy of the soft palate and pharyngeal dilators may be associated with the progression of snoring to OSA. The purpose of this stud...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.amjoto.2018.03.006
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:PFAPA syndrome is derived from the initials of the English words of the findings that make up the syndrome ("Periodic Fever", "Aphthous Stomatitis", "Pharyngitis", "Adenitis"). This study aims to evaluate the vestibular system in patients with PFAPA syndrome by the cVEMP test and to give a general review of P...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2021.102903
更新日期：2021-01-08 00:00:00
abstract：:This clinical review presents a survey of the different types of epithelial neoplasms in the parotid gland. The incidence, histopathological classification, grade of malignancy, and staging system are discussed. Diagnostic procedures are reviewed and a scheme for treatment is proposed for the different types of epithe...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/s0196-0709(80)80011-1
更新日期：1980-02-01 00:00:00
abstract：PURPOSE:To determine differences in size of cochlear nerves among subjects with deafness due to connexin 26 (Cx26) mutations, subjects with deafness of unknown origin, and normal hearing subjects by sagittal high-resolution magnetic resonance (HRMR) imaging of the temporal bone. MATERIALS AND METHODS:Cross-sectional a...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2005.09.007
更新日期：2006-05-01 00:00:00
abstract：:Semicircular canal dehiscence (SCD) is a condition of the inner ear wherein the temporal bone adjacent to the vestibular apparatus thins or erodes completely. It has no clear epidemiological predisposing factors that have been identified to date. Its diagnosis is made difficult by a clinical presentation that often ov...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2014.08.012
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:Most cases of endoscopic sinus surgery are amenable to techniques using local anesthesia with monitored sedation. However, it is frequently the preference of the patient to have surgery under general anesthesia. One major drawback of general anesthesia is the increased bleeding encountered which can interfere w...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(93)90072-f
更新日期：1993-07-01 00:00:00
abstract：OBJECTIVE:To evaluate foot and ankle function in a series of patients undergoing fibula microvascular free tissue transfer. STUDY DESIGN:A nonrandomized, nonblinded analysis was performed using the ankle-hindfoot scale as well as radiographic analysis to determine donor site morbidity. RESULTS:Overall, foot ankle fun...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2005.07.003
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To determine the neurologic morbidity and oncologic effectiveness of carotid resection in patients with advanced squamous cell carcinoma of the head and neck. METHODS:A retrospective review of all published cases of squamous cell carcinoma of the head and neck treated by carotid resection was performed. RESUL...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,meta分析
doi：10.1016/0196-0709(92)90079-9
更新日期：1992-11-01 00:00:00
abstract：PURPOSE:The aim of this article is to present the development of brown tumors in the jaws as a definite feature of hyperparathyroidism (HPT), whether primary or secondary. PATIENTS AND METHODS:The study included 2 cases of primary HPT and 3 cases of secondary HPT associated with brown tumors in the jaws. The patients ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.amjoto.2005.11.004
更新日期：2006-07-01 00:00:00
abstract：PURPOSE:In this study, we aimed to determine the function of the cochlea and peripheral and central auditory pathways with migraine. MATERIALS AND METHODS:Fifty-eight patients with migraine and 40 healthy subjects were assessed using routine diagnostic audiometry along with transient evoked otoacoustic emissions (TOAE...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2011.10.008
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:In pituitary macroadenomas with extensive suprasellar extension (SSE), suprasellar region can be approached by extending exposure either anteriorly by adding bone removal of the tuberculum sellae and planum sphenoidal or posteriorly from inside the sellar cavity through diaphragma sella. The later approach ha...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102808
更新日期：2021-01-01 00:00:00
abstract：PURPOSE:Facial nerve monitoring is often used to predict postoperative facial function after acoustic neuroma tumor removal. In this study, three methods of predicting facial nerve function were compared. These methods used various parameters of the evoked electromyographic monitoring. MATERIALS AND METHODS:Thirty-fou...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(98)90103-x
更新日期：1998-03-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between facial cephalometric measures and response to uvulopalatopharyngoplasty (UPPP). PATIENTS AND METHODS:Retrospective analysis of skeletal cephalometric measures obtained from a consecutive sample of 43 patients with obstructive sleep apnea syndrome (OSAS) who underwent body m...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(97)90079-x
更新日期：1997-05-01 00:00:00
abstract：OBJECTIVE:Cochlear nerve preserving translabyrinthine vestibular schwannoma (VS) resection enables concurrent cochlear implantation. Implantation in patients with VS raises important concerns including the ability to undergo postoperative magnetic resonance imaging (MRI) monitoring of residual tumor growth or tumor rec...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102518
更新日期：2020-01-01 00:00:00
abstract：:Lightning induced damage to the ear is multifaceted. The seventh and eighth cranial nerves, the labyrinthine system, and the tympanic membrane are most commonly injured. A case report demonstrating all these injuries is presented. ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(80)80036-6
更新日期：1980-08-01 00:00:00
abstract：INTRODUCTION:Sir Charles Bell is renowned and revered as an outstanding surgeon, anatomist, clinician and teacher and his many contributions to various medical fields have been amply described. What are less well-known are his contributions to the field of laryngology. METHODS:Selected clinical and physiological publi...
journal_title：American journal of otolaryngology
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.amjoto.2017.04.011
更新日期：2017-01-01 00:00:00
abstract：:Exercise after vestibular injury is potentially an important modality in the recovery process. In this study, the effects of injury on the vestibular system were examined experimentally in cats. Data from healthy normal cats, labyrinthectomized cats, and labyrinthectomized cats treated with exercise were examined. Eva...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(82)80017-3
更新日期：1982-11-01 00:00:00
