Abstract：
INTRODUCTION:Cell adhesion molecules are cell surface proteins that allow specific cell-cell interactions among leukocytes, as well as between leukocytes and other cells. Because middle ear cholesteatoma is characterized by the presence of leukocyte infiltrates, the presence of the two molecule types of intercellular adhesion molecules (ICAM-1 and ICAM-2) was investigated on cholesteatoma using monoclonal antibodies. METHODS:Tissue sections from 10 patients with cholesteatoma, and normal skin from 5 patients were prepared for alkaline-phosphatase--anti-alkaline-phosphatase (APAAP) staining. RESULTS:ICAM-1 and ICAM-2 were present in normal skin in microvascular endothelial cells and in intersticial cells of the dermis. Cholesteatoma showed a very important increase of the ICAM-1 expression with comparison to human skin. All infiltrating immune cells showed positive reactions for the antibody. Furthermore, the intensity of the staining of vessels cells was higher than in normal skin. Keratinocytes were only positive if a very heavy infiltrate was present subepidermally. ICAM-2 was present in endothelial and intersticial cells in normal skin and in cholesteatoma. Most of the infiltrating cells in the cholesteatoma stroma showed positive reactions for the anti-ICAM-2 antibody. CONCLUSION:Our results suggest that both ICAM-1 and ICAM-2 play a central role in the regulation of the inflammatory disorders observed in cholesteatoma.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Bujía J,Holly A,Kim C,Scanady N,Kastenbauer Edoi
10.1016/0196-0709(94)90094-9subject
Has Abstractpub_date
1994-07-01 00:00:00pages
271-5issue
4eissn
0196-0709issn
1532-818Xpii
0196-0709(94)90094-9journal_volume
15pub_type
杂志文章abstract：PURPOSE:A case-control study was done to confirm the higher prevalence of sensorineural hearing loss (SNHL) among sickle cell patients (HbSS) from southern Brazil. PATIENTS AND METHODS:Twenty-eight patients and 28 matched normal controls were studied. Besides complete anamneses and physical otolaryngological examinati...
journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
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更新日期：2012-11-01 00:00:00
abstract：PURPOSE:Obstructive sleep apnea is characterized by repetitive cessation of breathing during sleep. It affects different aspects of sexuality. We aimed to assess male sexual function & risk factors in obstructive sleep apnea patients. METHODS:This case control study included 2 groups, 45 healthy volunteers as control ...
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2012.11.006
更新日期：2013-05-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2005.01.013
更新日期：2005-09-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
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journal_title：American journal of otolaryngology
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更新日期：2017-01-01 00:00:00
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journal_title：American journal of otolaryngology
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更新日期：2020-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102858
更新日期：2021-01-04 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(86)80027-8
更新日期：1986-09-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2008.08.009
更新日期：2010-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1053/ajot.2002.123453
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：1993-07-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1053/ajot.2002.30628
更新日期：2002-03-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(98)90123-5
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
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更新日期：1981-11-01 00:00:00
abstract：:Semicircular canal dehiscence (SCD) is a condition of the inner ear wherein the temporal bone adjacent to the vestibular apparatus thins or erodes completely. It has no clear epidemiological predisposing factors that have been identified to date. Its diagnosis is made difficult by a clinical presentation that often ov...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
