Therapeutic effect of lipoprostaglandin E1 on sudden hearing loss.

Abstract:

PURPOSE:The authors conducted a prospective, comparative clinical trial for the purpose of additional effect of lipoprostaglandin E 1 (lipo-PGE 1 ) on sudden hearing loss. MATERIALS AND METHODS:With the approval of the institute ethics committee, a total of 128 consecutive patients with diagnoses of sudden hearing loss were included in the study. The patients in the lipo-PGE 1 group received continuous infusion of 10 microL lipo-PGE 1 and 48 mg methylprednisolone for 5 days, and the patient in the control group were treated with only 48 mg methylprednisolone. RESULTS:The total recovery rate after the treatment was 67.2%. There were 70.5% recovery rate in lipo-PGE 1 group and 60.5% recovery rate in control group. However, no significant differences were observed in the improvements of pure tone average and subjective symptoms between the lipo-PGE 1 and control groups. CONCLUSION:The results failed to prove a beneficial effect of lipo-PGE 1 in the treatment of sudden hearing loss in spite of its higher cure rate.

journal_name

Am J Otolaryngol

authors

Ahn JH,Kim MR,Kim HC

doi

10.1016/j.amjoto.2005.01.009

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

245-8

issue

4

eissn

0196-0709

issn

1532-818X

pii

S0196070905000128

journal_volume

26

pub_type

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