Genetic correlation in otosclerosis.

Abstract:

PURPOSE:The aim of this study was to determine the relationship of HLA typing in patients with otosclerosis. MATERIALS AND METHODS:We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosis patients were compared with age and sex matched normal individuals. RESULTS:HLA-A3, HLA-A9, HLA-A11, and HLA-B13 were found to be significantly higher (P < .05, .01, and .01, respectively). HLA-A9 and HLA-A11 were found to be higher (P < .01) in patients with a positive family history, indicating genetic heterogenicity. CONCLUSIONS:Higher values of HLA-A9, HLA-11, and HLA-B13 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component.

journal_name

Am J Otolaryngol

authors

Singhal SK,Mann SB,Datta U,Panda NK,Gupta AK

doi

10.1016/s0196-0709(99)90019-4

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

102-5

issue

2

eissn

0196-0709

issn

1532-818X

pii

S0196-0709(99)90019-4

journal_volume

20

pub_type

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