Abstract:
BACKGROUND:Laryngeal squamous cell carcinoma (LSCC) is strongly associated with tobacco use, but recent reports suggest an increasing incidence of LSCC in patients without traditional risk factors, suggesting an alternative etiology of tumorigenesis. The purpose of this study is to characterize this non-smoking population and to compare immunohistochemical markers in tumor specimens from non-smokers and smokers with LSCC. METHODS:A retrospective chart review of patients with LSCC at Johns Hopkins Hospital (JHH) was performed. A tissue microarray (TMA) was constructed with tumor specimen from non-smokers with stage and age-matched smokers and stained for a variety of immunologic and molecular targets. RESULTS:In the JHH cohort of 521 patients, 12% (n = 63) were non-smokers. Non-smokers were more likely to be <45 years old at time of diagnosis (OR 4.13, p = 0.001) and to have glottic tumors (OR 2.46, p = 0.003). The TMA was comprised of tumors from 34 patients (14 non-smokers, 20 smokers). Only 2 patients (6%) were human-papillomavirus (HPV) positive by high-risk RNA in situ hybridization (ISH). There was no correlation between smoking status and p16 (p = 0.36), HPV-ISH positivity (p = 0.79), phosphatase and tensin homolog (PTEN, p = 0.91), p53 (p = 0.14), or programmed death-ligand 1 (PD-L1, p = 0.27) expression. CONCLUSIONS:Non-smokers with LSCC are more likely to be younger at the time of diagnosis and have glottic tumors than smokers with LSCC. In TMA analysis of stage and age-matched specimens from smoker and non-smokers with LSCC, the pattern of expression for common molecular and immunologic markers is similar. Further, HPV does not appear to be a major causative etiology of LSCC in either smokers or non-smokers in our cohort of patients.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Malm IJ,Rooper LM,Bishop JA,Ozgursoy SK,Hillel AT,Akst LM,Best SRdoi
10.1016/j.amjoto.2018.11.009subject
Has Abstractpub_date
2019-01-01 00:00:00pages
213-217issue
2eissn
0196-0709issn
1532-818Xpii
S0196-0709(18)30882-2journal_volume
40pub_type
杂志文章abstract::Bilateral congenital cholesteatomas are rare entities. Nine cases have been previously described in the literature. Many different etiologies for the development of congenital cholesteatoma have been proposed. The case of a five-year-old boy with bilateral congenital cholesteatoma is discussed. A lesion of the left ea...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2004.02.004
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:Describe current practices and challenges in personal protective equipment (PPE) use among US otolaryngologists during the COVID-19 pandemic. STUDY DESIGN:Online survey. SETTING:Academic and non-academic healthcare institutions. SUBJECTS AND METHODS:Subjects included US otolaryngology physicians. Emails we...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2020.102735
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Edema of the arytenoid and wound hematoma are principal causes of inspiratory distress after arytenoid adduction and type I thyroplasty. The purpose of the present study was demonstrate esophageal regurgitation one of the causes of inspiratory distress after thyroplastic surgeries. STUDY DESIGN:Two case rep...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2006.01.017
更新日期:2006-11-01 00:00:00
abstract::Experiments performed within the last 15 years on cochleas of live animals indicate that the cochlear sound analysis is much sharper than was expected from Békésy's experiments on postmortem preparations. The mechanism underlying the sharp analysis has not yet been ascertained experimentally. However, details of mecha...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(82)80032-x
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:To investigate the combined use of a nanocarbon (NC) suspension and low-dose 99mTc-MIBI for parathyroid localization during surgery in patients with secondary hyperparathyroidism (sHPT). METHODS:Between March 2010 and September 2015, 40 patients with sHPT were enrolled in this study and were randomized to re...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.amjoto.2017.12.008
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:We treated allergic rhinitis with trichloroacetic acid (TCA) applied to the inferior turbinates. Further clinical evaluations were made to determine the effect of TCA application on symptoms of allergic rhinitis. We also report the results of measurement of the mucociliary transit time (saccharin time) and nasa...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2006.12.006
更新日期:2008-01-01 00:00:00
abstract:IMPORTANCE:Sympathetic ophthalmia (SO), a rare bilateral panuveitis following penetrating ocular trauma or ocular surgery to one eye, shares a strikingly similar ocular pathology to that of Vogt-Koyanagi-Harada disease (VKH). Audiovestibular dysfunction is a major extraocular manifestation of VKH; however, to date, onl...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2015.02.007
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:Eustachian tube balloon dilation (ETBD) has been recently described as feasible treatment for patients with refractory Eustachian tube dysfunction (ETD). The aim of this study was to evaluate the efficacy of ETBD in the treatment of symptomatic Eustachian tube dysfunction (SETD) by subjective and objective anal...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2015.10.010
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:The purpose of the study was to systematically explore the fire and burn risk associated with fiberoptic cables and electrosurgical devices. MATERIALS AND METHODS:A 300-W light source was connected to a standard gray fiberoptic light cable. The end of the cable was either rested atop or buried within a cotton ...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2007.05.006
更新日期:2008-05-01 00:00:00
abstract::Sinus nitric oxide (NO) measurements present a novel and promising approach to help overcome difficulties and confounding variables associated with nasal NO measurements such as the nasal cycle, ostial patency, and individual contribution to total NO production of each sinus. Conflicting results reported on nasal NO m...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2013.01.007
更新日期:2013-07-01 00:00:00
abstract::Tracheoesophageal puncture and insertion of a prosthetic voice device is currently the most widely surgical procedure for vocal rehabilitation after total laryngectomy. The disadvantages of voice prostheses are high initial phonation pressure, formation of granulation tissue around the voice shunt, blockage, displacem...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/0196-0709(90)90004-f
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the added value of diffusion weighted magnetic resonance imaging (DW-MRI) in characterization of salivary gland lesions. STUDY DESIGN:A prospective study was carried out between January 2013, and March 2015. METHODS:The study included 46 patients. The consultant radiologist, who reviewed the sca...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2016.09.002
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Studies suggest that hypercholesterolemia promotes the development of inner ear disorders such as tinnitus. However, the underlying pathomechanisms are still not clearly defined. METHODS:A retrospective study was performed to assess whether a reduction of serum cholesterol by 3-hydroxy-3-methylglutaryl coen...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2009.09.004
更新日期:2011-01-01 00:00:00
abstract::Carotid body tumors constitute the third commonest group of parapharyngeal tumors. Newer diagnostic modalities such as computed tomography scan, magnetic resonance imaging, and Doppler ultrasound are commonly used for diagnosing lesions at this site. However, simple technique of fine-needle aspiration (FNA) cytology i...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2005.02.012
更新日期:2005-09-01 00:00:00
abstract::The effectiveness of the auditory brainstem evoked response (ABR) test as a screening test for permanent hearing loss in neonates is examined in 32 published studies including 4,945 infants. Follow-up studies validating initial test failure were available for only 658 infants. Significant differences in methodology ex...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
doi:10.1016/s0196-0709(85)80050-8
更新日期:1985-03-01 00:00:00
abstract:PURPOSE:Little is known about prognostic factors and treatment outcomes in young patients with anaplastic thyroid cancer (ATC). The goal of this study is to define the clinical features of this subgroup. MATERIAL AND METHODS:Patients age 55 or younger with either ATC or well-differentiated thyroid cancer (WDTC) with a...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2013.07.008
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:The objective of this study is to determine the results of functional endoscopic sinus surgeries (FESS) for chronic rhinosinusitis with polyps and assess the association between surgery and specific quality of life outcomes. MATERIALS AND METHODS:A prospective study was performed in a tertiary referral center....
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2014.09.003
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The type of allergy and other diagnostic procedures were analyzed in a group of elderly seasonal allergic rhinitis (SAR) patients and were compared with young SAR people and a control group. MATERIALS AND METHODS:Study group consisted of 248 patients with mean age 64.1 ± 4.2 years. They were compared with 289 ...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2009.11.002
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To describe systematic methods developed over 40 years among over 5000 patients at The Taste and Smell Clinic in Washington, DC to evaluate taste and smell dysfunction. MATERIALS AND METHODS:A tripartite methodology was developed. First, methods to determine clinical pathology underlying the multiple disease p...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2013.04.006
更新日期:2013-09-01 00:00:00
abstract::Four patients had Eikenella corrodens infections involving the head and neck in different ways. The organism is discussed as a pathogen in mixed infections and as the predominant organism in other processes. As part of the resident microflora of mucous membrane surfaces, it is an important potential pathogen in a numb...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(86)80018-7
更新日期:1986-11-01 00:00:00
abstract::In a group of patients with unilateral labyrinthine dysfunction, the maximal velocity of the slow component response to caloric stimulation was compared with that to horizontal vestibular rotatory stimulation by a low-frequency stimulus. It was found that the larger the magnitude of the caloric response, the larger we...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(84)80027-7
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVE:Microvascular anastomosis is generally performed by attending surgeons or fellows, with published success rates >95%. Since otolaryngology residents do not typically perform microvascular anastomosis, it is unknown if they achieve similar results. The objective of this study is to determine the success rate a...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.amjoto.2013.02.005
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:CT temporal bone scans are often performed to aid in surgical planning and management of cholesteatomas. With improvements in the resolution of CT scans today, it is now possible to obtain more information from these scans than before. The aim of this study is to compare findings on high resolution CT (HRCT) ...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.amjoto.2014.02.015
更新日期:2014-07-01 00:00:00
abstract::We report the case of a man affected by a unilateral Ménière's disease who, after being free from vertigo spells and tinnitus for more than ten years, manifested an exacerbation of symptoms just before the diagnosis of a choroidal melanoma. Melanoma is an aggressive form of cancer derived from neuroectodermal melanocy...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2014.04.007
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:Most cases of endoscopic sinus surgery are amenable to techniques using local anesthesia with monitored sedation. However, it is frequently the preference of the patient to have surgery under general anesthesia. One major drawback of general anesthesia is the increased bleeding encountered which can interfere w...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/0196-0709(93)90072-f
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:Langerhans cell histiocytosis (LCH) is a rare clinical disorder. We retrospectively analysed the clinical manifestations, treatments and prognoses of LCH cases involving the ear, nose, and neck. MATERIALS AND METHODS:28 cases with confirmed LCH in ear, nose or neck were reviewed. We recorded patient age, sex...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2019.102369
更新日期:2020-01-01 00:00:00
abstract::Tuberculosis is a systemic disease and its occurrence in the larynx and in the oral cavity is well-documented in the literature. Tuberculosis of the larynx involves mainly the vocal folds and the ventricular band and is associated with pulmonary tuberculosis in 80% of cases. Isolated epiglottic tuberculosis has rarely...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
doi:10.1053/ajot.2002.123441
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:The aim of the study was to investigate the feasibility and effectiveness of botulinum toxin therapy in salivary secretory disorders. MATERIALS AND METHODS:We treated 24 patients with botulinum neurotoxin type A for drooling, salivary fistulas, sialoceles, recurrent parotitis, and Frey's syndrome; each parotid...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2007.10.003
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:Tracheostomy is commonly used to provide control of the upper airway in pediatric patients. The traditional approach, which uses a midline vertical incision in the anterior tracheal wall, is associated with relatively high rates of complications when it is used on a long-term basis. Alternative approaches, such...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/s0196-0709(96)90090-3
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVES:Malignant cutaneous adnexal tumors (MCAT) are rare and comprise a heterogeneous group of cancers. There have been several studies reviewing prognostic factors of these tumors, but no studies focusing on the head and neck. This study aimed to review a large population based database to evaluate prognostic fac...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2018.09.011
更新日期:2019-01-01 00:00:00