Menière's disease as a manifestation of vestibular ganglionitis.

Abstract:

OBJECTIVE:To present morphologic evidence of viral-induced vestibular nerve pathology in Menière's Disease (MD). MATERIAL STUDIED: Twelve temporal bones (TB) from 8 patients with the clinical symptoms of MD. RESULTS:There was endolymphatic hydrops (EH) and perilymphatic fibrosis in 10 of the 12 TB from MD patients. Of the 10 TB with EH of the pars inferior, 3 also contained outpouchings in the pars superior (utricle and canals), and 3 showed apical spiral ganglion cell loss. Focal vestibular nerve axonal degeneration was observed in all but one TB. CONCLUSION:Morphologic changes in TB of patients with MD, and clinical observations in patients with recurrent vestibulopathy, support the concept that the pathologic mechanism responsible for auditory and vestibular symptoms in MD may be reactivation of a latent viral vestibular ganglionitis.

journal_name

Am J Otolaryngol

authors

Gacek RR,Gacek MR

doi

10.1053/ajot.2001.24822

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

241-50

issue

4

eissn

0196-0709

issn

1532-818X

pii

S0196-0709(01)87529-3

journal_volume

22

pub_type

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