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Chronic allograft nephropathy--a clinical syndrome: early detection and the potential role of proliferation signal inhibitors.

Abstract：

:Chronic allograft nephropathy (CAN) leads to the majority of late graft loss following renal transplantation. Detection of CAN is often too late to permit early intervention and successful management. Most current strategies for managing CAN rely on minimizing or eliminating calcineurin inhibitors (CNIs) once CAN has become established. The proliferation signal inhibitors everolimus and sirolimus have potent immunosuppressive and antiproliferative actions, with the potential to alter the natural history of CAN by reducing CNI exposure whilst avoiding acute rejection. Whilst data will be forthcoming from a number of clinical trials investigating this potential, we discuss early detection of CAN and the rationale for a role for this class of agent.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Campistol JM,Boletis IN,Dantal J,de Fijter JW,Hertig A,Neumayer HH,Oyen O,Pascual J,Pohanka E,Ruiz JC,Scolari MP,Stefoni S,Serón D,Sparacino V,Arns W,Chapman JR

doi

10.1111/j.1399-0012.2009.01057.x

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

769-77

issue

6

eissn

0902-0063

issn

1399-0012

pii

CTR1057

journal_volume

23

pub_type

杂志文章,评审

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