Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy.

Abstract:

:We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2-4-fold significant increase (p<0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.

authors

Malik AN,Shahni R,Iqbal MM

doi

10.1016/j.diabres.2009.07.002

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

e22-4

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(09)00301-5

journal_volume

86

pub_type

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