A once-daily dasatinib dosing strategy for chronic myeloid leukemia.

Abstract:

:The BCR-ABL inhibitor imatinib is standard first-line therapy for patients with chronic myeloid leukemia (CML) and has revolutionized treatment of the disease. However, resistance and intolerance to the agent have emerged as major clinical complications. Dasatinib is the first and only dual BCR-ABL/SRC family kinase inhibitor approved by the U.S. Food and Drug Administration for the treatment of patients with CML in any phase or Philadelphia chromosome-positive acute lymphoblastic leukemia who are resistant to or intolerant of imatinib. The agent is well tolerated and has shown clinical activity in such patients. As with other oral tyrosine kinase inhibitors, nonadherence to the prescribed dasatinib treatment regimen could obstruct a successful outcome. A new recommended dose of 100 mg once daily has been approved for patients with chronic phase CML. That dosing regimen, combined with appropriate management of dasatinib-related adverse events, may help patients adhere to their prescribed treatment and achieve maximum therapeutic benefit. This article highlights recent changes to the dasatinib label, including results with the 100 mg once-daily starting dose for patients with chronic phase CML, and discusses nursing strategies for the successful management of adverse events in patients receiving dasatinib.

journal_name

Clin J Oncol Nurs

authors

Bryant G

doi

10.1188/09.CJON.316-323

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

316-23

issue

3

eissn

1092-1095

issn

1538-067X

pii

42671L192003J580

journal_volume

13

pub_type

杂志文章
  • Managing neutropenia in older patients with cancer receiving chemotherapy in a community setting.

    abstract::Older patients with cancer who may be more susceptible than younger patients to the myelosuppressive effects of chemotherapy undergo dose delays and reductions that can compromise treatment outcomes. Incidence of neutropenic complications and suboptimal chemotherapy delivery can be reduced with prophylactic colony-sti...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1188/10.CJON.81-86

    authors: Flores IQ,Ershler W

    更新日期:2010-02-01 00:00:00

  • Sexual Health: Exploring Patient Needs and Healthcare Provider Comfort and Knowledge.

    abstract:BACKGROUND:Sexual health is an important quality-of-life issue for many cancer survivors; however, this issue remains inadequately discussed by healthcare providers (HCPs) and patients. OBJECTIVES:The purpose of this study is to explore whether clinical oncology HCPs have adequate knowledge and are comfortable address...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/16.CJON.E162-E167

    authors: Leonardi-Warren K,Neff I,Mancuso M,Wenger B,Galbraith M,Fink R

    更新日期:2016-12-01 00:00:00

  • Patient Dignity: Exploring Oncology Nurses' Perceptions During End-of-Life Care.

    abstract:BACKGROUND:Research on nurses' perceptions of dignity is limited, with much work instead focusing on patients' experiences. Maintaining the dignity of patients is considered to be an important element of nursing care; however, it is often diminished by the acts and omissions of healthcare providers. OBJECTIVES:The pur...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.E46-E51

    authors: Crump B

    更新日期:2019-06-01 00:00:00

  • Computer-Based Cognitive Training for Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors.

    abstract:BACKGROUND:Advancements in chemotherapy have greatly increased breast cancer survival, leading to an increased focus on the management of long-term effects of treatment. Chemotherapy-related cognitive impairment, one such long-term effect, is experienced by as many as 90% of breast cancer survivors (BCS) and negatively...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/16.CJON.504-509

    authors: Bail J,Meneses K

    更新日期:2016-10-01 00:00:00

  • Caregiver Burden in End-Stage Ovarian Cancer.

    abstract:BACKGROUND:Caregiver burden associated with caring for women with ovarian cancer has received limited focus. However, these patients often have complex needs, requiring a high level of care at home and imposing substantial burdens on caregivers. OBJECTIVES:This pilot study assessed the level of caregiver burden experi...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/16.CJON.169-173

    authors: Hartnett J,Thom B,Kline N

    更新日期:2016-04-01 00:00:00

  • Safe handling of hazardous drugs: are you protected?

    abstract::Oncology nurses handle hazardous drugs when they administer medications to patients in inpatient and outpatient settings. Guidelines for the safe handling of hazardous drugs have been in place since the late 1980s; however, confusion still remains about the proper handling of the substances. Institutional policies var...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/09.CJON.433-439

    authors: Nixon S,Schulmeister L

    更新日期:2009-08-01 00:00:00

  • Optimizing nutrition for patients with cancer.

    abstract::Malnutrition is the most common secondary diagnosis in patients with cancer and is a major prognostic indicator for poor response to cancer therapy and shortened survival. The word CANCER can be used as an acronym to guide early nutritional intervention that combines an understanding of cancer cachexia with a plan to ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Wilson RL

    更新日期:2000-01-01 00:00:00

  • Colorectal Cancer Screening: An Educational Intervention for Nurse Practitioners to Increase Screening Awareness and Participation
.

    abstract::Colorectal cancer screening aims to detect colorectal cancer at an early stage, when treatment is more likely to be curative. Lack of participation in such screening is a major issue in primary care practices, where nurse practitioners (NPs) often provide care. This study aimed to determine whether an educational inte...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.543-546

    authors: Slyne TC,Gautam R,King V

    更新日期:2017-10-01 00:00:00

  • Malnutrition Screening: An Interprofessional Approach in Outpatient Oncology.

    abstract:BACKGROUND:Malnutrition is highly prevalent in the oncology population and is associated with poor treatment outcomes. OBJECTIVES:This study aimed to implement a malnutrition screening process using a validated tool in three outpatient cancer centers. METHODS:Nursing and nutrition department leaders collaborated to e...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.E28-E33

    authors: Schneider CK,Bressler T

    更新日期:2020-06-01 00:00:00

  • Decreasing patient misidentification before chemotherapy administration.

    abstract::More accurate patient identification is a Joint Commission National Patient Safety Goal. To decrease the possibility of patient misidentification during chemotherapy administration, nurses on the Bone Marrow Transplant Unit at the University of North Carolina-Chapel Hill instituted a bedside check and measured complia...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/09.CJON.716-717

    authors: Spruill A,Eron B,Coghill A,Talbert G

    更新日期:2009-12-01 00:00:00

  • Malignant melanoma and adjuvant alpha interferon-2b for patients at high risk of relapse.

    abstract::Malignant melanoma, the least common but most serious form of skin cancer, is increasing at a faster rate than any other form of cancer. Early diagnosis can lead to cures through surgery alone. Patients with deeper primary lesions (greater than 4 mm) or regional lymph node involvement have a high risk of relapse. High...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Gale DM,Kiley KE

    更新日期:1998-01-01 00:00:00

  • Integrating oral health throughout cancer care.

    abstract::Oral health is often not a priority during cancer treatment; however, patients with cancer are at increased risk for oral complications during and after treatment. This article focuses on the importance of oral health care before, during, and after cancer treatment using the head, eyes, ears, nose, oral cavity, and th...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.615-619

    authors: Hartnett E

    更新日期:2015-10-01 00:00:00

  • 5-Fluorouracil Infiltrations and Ambulatory Pumps: Education, Prevention, and Management Considerations.

    abstract::Although uncommon, 5-fluorouracil (5-FU) infiltrations do occur. Two case studies involving 5-FU infiltration from totally implanted venous access devices identified at the conclusion of a 46-hour continuous infusion via an ambulatory infusion pump are presented. These cases highlight the importance of patient and car...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.537-539

    authors: Bostelman C

    更新日期:2019-10-01 00:00:00

  • Chronic myelogenous leukemia.

    abstract::Chronic myelogenous leukemia (CML) represents about 14% of all leukemias and occurs with a frequency of about 1 in 100,000. It is rare in children. Symptoms include fatigue, weight loss, sweating, and abdominal discomfort from an enlarged spleen. The white blood cell count can range from 100-600 ul. CML has three phas...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/05.CJON.535-538

    authors: D'Antonio J

    更新日期:2005-10-01 00:00:00

  • Oncology nurses' grief: a literature review.

    abstract::The oncology practice setting can be a highly emotional workplace because nurses provide care to many of the same patients and their families over time. Comparing and contrasting nurses from different clinical settings would provide insight into the more common themes of nursing grief and might give guidance on how to...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/09.CJON.625-627

    authors: Brown C,Wood A

    更新日期:2009-12-01 00:00:00

  • Using failure-to-rescue simulation to assess the performance of advanced practice professionals.

    abstract::The use of advanced practice professionals (APPs) has been established in oncology care. APPs are frequently the most readily available ordering provider for care guidance when it becomes evident that a patient with cancer is failing. The purpose of the current preliminary descriptive project was to determine the best...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.301-306

    authors: Blackburn LM,Harkless S,Garvey P

    更新日期:2014-06-01 00:00:00

  • Care of patients with neutropenia.

    abstract::Neutropenia can be a significant problem in the oncology setting. Awareness of potential risks, management of neutropenia, and preventive measures guide nurses in providing comprehensive care that can make the difference between life and death. ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/06.CJON.164-166

    authors: Marrs JA

    更新日期:2006-04-01 00:00:00

  • Inflammatory breast cancer.

    abstract::IBC is a rare clinical occurrence. Signs and symptoms include erythema and edema of the skin. Diagnosis is made by skin biopsy. Treatment for this aggressive form of breast cancer is multimodal, including chemotherapy, surgery, radiation therapy, and hormonal therapy. Advances in treatment continue to improve prognosi...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Gordon L

    更新日期:2001-07-01 00:00:00

  • Cytokine Release Syndrome: Inpatient Care for Side Effects of CAR T-Cell Therapy
.

    abstract:BACKGROUND:Pediatric patients with relapsed and refractory acute lymphoblastic leukemia are more often being treated with chimeric antigen receptor (CAR) T-cell therapy. As with any new therapy, the management of this patient population has a unique set of challenges. The side effects of this therapy can range from mil...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.S2.29-34

    authors: Smith L,Venella K

    更新日期:2017-04-01 00:00:00

  • Implications of androgen-deprivation therapy in patients with prostate cancer: A case study.

    abstract::S.R., a 65-year-old male with a history of prostate cancer, went to a cancer center in 2003. He had developed symptoms of bladder outlet obstruction in 1999 and was seen by a urologist. His baseline prostate-specific antigen (PSA) was 44 ng/ml. On physical examination, his prostate was enlarged, and a biopsy in Januar...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/06.CJON.565-566

    authors: Doyle-Lindrud S

    更新日期:2006-10-01 00:00:00

  • Learning from disaster: 
patient safety and the role of oncology nurses.

    abstract::When the Oncology Nursing Society (ONS) was almost exactly half its present age, in November 1994, a Boston Globe health columnist named Betsy Lehman was admitted to the Dana-Farber Cancer Institute in Boston, Massachusetts, to receive an investigational regimen for breast cancer. Her treatment ended in disaster. In o...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.155-156

    authors: Glenn DG

    更新日期:2015-04-01 00:00:00

  • Acute myeloid leukemia: a classification and treatment update.

    abstract::Approximately 11,000 Americans will be diagnosed with acute myeloid leukemia (AML) in 2003, and about 75% ultimately will die from the disease. Despite significant advances in understanding biologic, molecular, and cytogenetic aspects of this malignancy, several other areas remain poorly understood. During the 1990s, ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/03.CJON.535-540

    authors: Iovino CS,Camacho LH

    更新日期:2003-09-01 00:00:00

  • Central Line Care: Reducing Central Line-Associated Bloodstream Infections on a Hematologic Malignancy and Stem Cell Transplant Unit.

    abstract:BACKGROUND:Patients with hematologic malignancies and stem cell transplant recipients are at increased risk for infections because of their prolonged periods of profound neutropenia. Central line-associated bloodstream infections (CLABSIs) can result in lengthy hospitalizations, increased healthcare costs, and increase...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.148-152

    authors: Beaudry J,ScottoDiMaso K

    更新日期:2020-04-01 00:00:00

  • Enteral Versus Parenteral Nutrition: Use in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation.

    abstract:BACKGROUND:Pretransplantation chemotherapy and side effects of transplantation can cause reduced oral intake, contributing to malnutrition. OBJECTIVES:The aim was to evaluate the current evidence comparing enteral nutrition (EN) to parenteral nutrition in the adult hematopoietic stem cell transplantation (HSCT) popula...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.173-179

    authors: Reese MK,Hewlings S

    更新日期:2019-04-01 00:00:00

  • Cardio-Oncology: A Continually Evolving Subspecialty in Oncology Nursing.

    abstract::Cardio-oncology is a unique subspecialty within oncology nursing that focuses on the assessment, identification, and management of cardiotoxicity induced or exacerbated by cancer treatment. Nurses are pivotal to the delivery of evidence-based assessment of and care for individuals who have preexisting cardiac conditio...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/21.CJON.93-96

    authors:

    更新日期:2021-02-01 00:00:00

  • Neurologic Complications: Effects of Ipilimumab and Nivolumab Therapy in Patients With Metastatic Melanoma.

    abstract::Checkpoint inhibitors are a form of immunotherapy that have revolutionized treatment for malignant melanoma, resulting in longer survival and better disease control. Multiple autoimmune disorders can occur with the use of checkpoint inhibitors, including severe, potentially fatal neurologic complications. Although neu...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.355-358

    authors: Latchman J,Guastella A,Tofthagen C

    更新日期:2019-08-01 00:00:00

  • The science of patient safety: implications for oncology nursing practice.

    abstract::Patient safety is one of the most frequent terms used in health care today. Patients and their families are, first and foremost, focused on receiving effective and safe care, and oncology nurses strive to incorporate clinical evidence into day-to-day practice. This article provides a road map on how to incorporate eme...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.601-603

    authors: Sheridan CA

    更新日期:2013-12-01 00:00:00

  • Biofield therapies and cancer-related symptoms: a review.

    abstract::Patients with cancer can experience several treatment-related symptoms, and conventional care focuses primarily on cure and survival without a holistic approach to disease. Subsequently, an increasing number of patients are accustomed to complementary modalities to improve well-being. Biofield therapies (BTs) are comp...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/14.CJON.568-576

    authors: Gonella S,Garrino L,Dimonte V

    更新日期:2014-10-01 00:00:00

  • Evidence-based research for intraperitoneal chemotherapy in epithelial ovarian cancer.

    abstract::Intraperitoneal (IP) therapy is the administration of chemotherapy or biologic agents directly into the peritoneal cavity. A recent Gynecologic Oncology Group trial showed a survival advantage for women with advanced ovarian cancer and small residual disease after initial surgical staging and debulking who received IP...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,病人教育讲义,评审

    doi:10.1188/07.CJON.211-216

    authors: Almadrones L

    更新日期:2007-04-01 00:00:00

  • Aromatherapy: The Effect of Lavender on Anxiety and Sleep Quality in Patients Treated With Chemotherapy

    abstract:BACKGROUND:A cancer diagnosis is a serious stressor that is associated with anxiety, depression, sleep disorders, and inability to fulfill daily routines. Many pharmacologic and nonpharmacologic options are available to help patients with cancer manage anxiety. OBJECTIVES:This randomized, controlled trial examined the...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,随机对照试验

    doi:10.1188/18.CJON.203-210

    authors: Ozkaraman A,Dügüm Ö,Özen Yılmaz H,Usta Yesilbalkan Ö

    更新日期:2018-04-01 00:00:00