Abstract:
:Approximately 11,000 Americans will be diagnosed with acute myeloid leukemia (AML) in 2003, and about 75% ultimately will die from the disease. Despite significant advances in understanding biologic, molecular, and cytogenetic aspects of this malignancy, several other areas remain poorly understood. During the 1990s, significant advances in the characterization of this condition have shown that AML affects elderly patients more frequently. Treatment of patients in this age group poses a greater challenge partly because of increased tumor resistance and the presence of multiple medical comorbidities that may contraindicate therapy. New therapeutic approaches are promising and have renewed enthusiasm and optimism among patients and healthcare providers. Future treatment strategies for patients with AML most likely will include combinations of biologic agents with defined molecular targets (e.g., monoclonal antibodies, retinoids, hypomethylating agents, tyrosine kinase inhibitors).
journal_name
Clin J Oncol Nursjournal_title
Clinical journal of oncology nursingauthors
Iovino CS,Camacho LHdoi
10.1188/03.CJON.535-540subject
Has Abstractpub_date
2003-09-01 00:00:00pages
535-40issue
5eissn
1092-1095issn
1538-067Xjournal_volume
7pub_type
杂志文章,评审abstract:BACKGROUND:Duffy's Quality-Caring Model guides nursing practice at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, FL. No published studies using this model in oncology were found. OBJECTIVES:The purpose of this article is to determine patients' perceptions of nurse caring behaviors at the time of di...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/18.CJON.169-174
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Patients with hematologic malignancies and stem cell transplant recipients are at increased risk for infections because of their prolonged periods of profound neutropenia. Central line-associated bloodstream infections (CLABSIs) can result in lengthy hospitalizations, increased healthcare costs, and increase...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/20.CJON.148-152
更新日期:2020-04-01 00:00:00
abstract::Rapid rituximab infusion was approved as treatment for non-Hodgkin lymphoma by the U.S. Food and Drug Administration in 2012, but it has been administered clinically since approval of the drug rituximab in 1997. Because of the delay between the approval of the drug and the approval of the procedure, researchers sought...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/14.CJON.89-92
更新日期:2014-02-01 00:00:00
abstract::This article focuses on the symptoms of dyspnea and delirium, which can be extremely distressing to patients with cancer at the end of life. Oncology nurses are well suited to detect and treat these symptoms. . ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/16.CJON.244-246
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:With the advent of biosimilars into the U.S. healthcare market, knowledge deficits exist for nurses and patients regarding the regulatory approval process and key nursing considerations for each of these new medications. OBJECTIVES:This article provides essential clinical information for oncology nurses who...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/18.CJON.S1.21-26
更新日期:2018-10-01 00:00:00
abstract::First-line treatment for chronic myelogenous leukemia (CML) is imatinib, but some patients do not respond or develop resistance to the drug, leading to suboptimal responses. Dasatinib and nilotinib are approved second-line compounds for patients experiencing imatinib failure. In a prospective comparison of dasatinib w...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/09.CJON.537-542
更新日期:2009-10-01 00:00:00
abstract::The use of radiotherapy as a cancer treatment is common, so an appreciation of the biologic effects of radiation at a cellular level is essential to help nurses prepare their patients for the challenging journey ahead using appropriate lay language. The four Rs of radiotherapy (repair, redistribution, reoxygenation, a...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/13.CJON.412-417
更新日期:2013-08-01 00:00:00
abstract::Positron emission tomography (PET) scans use positrons, positively charged particles, to detect metabolic and chemical changes in the body. Although the clinical applications of this technology still are evolving, PET scans are being used to detect cancer and evaluate neurologic disorders, heart muscle function, and r...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/03.CJON.379-385
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Prevention strategies help to teach what individuals can do to potentially offset cancer risks. Screenings can detect cancer at earlier stages, allowing for earlier treatments and better outcomes. OBJECTIVES:This article seeks to identify best practices in cancer prevention and screening. METHODS:This arti...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/20.CJON.S2.45-48
更新日期:2020-10-01 00:00:00
abstract::Palliative care has become an essential component of oncology care, with a focus on maximizing quality of life and optimizing function, as well as promoting pain and symptom management. This article focuses on the care of a patient experiencing bowel obstruction and delirium, two common issues in patients with advance...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/12.CJON.391-398
更新日期:2012-08-01 00:00:00
abstract::Gastric cancer is a major cause of cancer-related mortality worldwide and is thought to be responsible for about 10% of cancer-related deaths across the globe. A small proportion of all gastric cancers arise because of a known hereditary syndrome, the most common of which is hereditary diffuse gastric cancer (HDGC). T...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/16.CJON.443-445
更新日期:2016-08-01 00:00:00
abstract::Advanced practice providers (APPs) are increasingly being used in a variety of healthcare settings to provide care, treatment, and services to patients with cancer. They are also being deployed to acute oncologic settings to enhance patient care delivery and address the ever-evolving needs of patients in academic medi...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.423-427
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Hematologic cancers can occur from the overactivity of Bruton's tyrosine kinase, a proto-oncogene in blood cell maturation. Ibrutinib, a new oral targeted therapy drug, is the first agent that binds to the Bruton's tyrosine kinases and inhibits overgrowth of B cells. In blocking this overgrowth, ibrutinib ha...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/15.CJON.E47-E51
更新日期:2015-06-01 00:00:00
abstract::Because of the Human Genome Project, nurses increasingly must understand how genetics impact health and treatment decisions. Although the sequencing of the human genome was crucial, the next step is advancing the understanding of genomics, interpreting genetic information, and using that information to improve health ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/11.CJON.330-332
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Malnutrition is highly prevalent in the oncology population and is associated with poor treatment outcomes. OBJECTIVES:This study aimed to implement a malnutrition screening process using a validated tool in three outpatient cancer centers. METHODS:Nursing and nutrition department leaders collaborated to e...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/20.CJON.E28-E33
更新日期:2020-06-01 00:00:00
abstract::Aromatase inhibitors (AIs) have become integral to the treatment of women with breast cancer and are the treatment of choice in postmenopausal women who have tumors that are estrogen receptor positive. The depletion of estrogen seen with AI therapy is significant and translates to beneficial tumor effect but has a neg...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/09.CJON.E18-E29
更新日期:2009-10-01 00:00:00
abstract::Providing care for patients with cancer places caregivers at risk for experiencing elevated levels of stress. Caregivers of patients with brain tumors may be at increased risk because of the multifaceted needs of this patient population. As such, the authors sought to determine caregiver preferences toward various typ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/07.CJON.723-727
更新日期:2007-10-01 00:00:00
abstract::Nurses play a crucial role in identifying bone metastases and managing clinical sequelae, such as pain. Understanding the metastatic process is necessary for delivering effective nursing care. Part I of this article described the pathophysiology and assessment. Part II will provide an overview of the nursing managemen...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Although guidelines for the safe handling of hazardous drugs (HDs) have existed for several decades, they have not been enforceable by state or federal agencies. USP <800>, the latest chapter issued by the U.S. Pharmacopeial Convention, expands on existing guidelines and provides detailed information on comp...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.179-187
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Pediatric patients with relapsed and refractory acute lymphoblastic leukemia are more often being treated with chimeric antigen receptor (CAR) T-cell therapy. As with any new therapy, the management of this patient population has a unique set of challenges. The side effects of this therapy can range from mil...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.S2.29-34
更新日期:2017-04-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) have an incidence of 7-15 occurrences per million people. Tyrosine kinase inhibitors (TKIs) have significantly improved clinical outcomes as part of multidisciplinary disease management. The authors will review developments in the management of GISTs, including diagnosis, risk s...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/11.CJON.533-545
更新日期:2011-10-01 00:00:00
abstract::Several organizations have safety guidelines regarding handling of hazardous drugs. That said, only Washington and California have enforceable laws that regulate these practices. This article shares the experiences of three states-Washington, Michigan, and North Carolina-in advancing legislative and regulatory efforts...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.254-256
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Many patients with incurable cancer do not accurately understand their prognosis, which can lead to aggressive and, often, futile treatment. Improved prognostic awareness can help patients to appropriately de-escalate aggressive treatment sooner in an illness trajectory. OBJECTIVES:The purpose of this artic...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/16.CJON.385-390
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Patients with cancer often experience prominent deficiencies in cancer care in the immediate period following initial cancer diagnosis. OBJECTIVES:This article aims to determine whether the inclusion of a gastrointestinal (GI) oncology nurse navigator (ONN) on the multidisciplinary cancer care team is assoc...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/18.CJON.E141-E145
更新日期:2018-10-01 00:00:00
abstract::Patients with cancer receiving therapy may face a variety of complicated and stressful symptoms. Oncology nurses can advocate for patients by performing their roles as educators and comanagers of cancer-related side effects. In addition, symptom-focused education provided by oncology nurses can enable patients to admi...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/11.CJON.253-258
更新日期:2011-06-01 00:00:00
abstract::Cardio-oncology is a unique subspecialty within oncology nursing that focuses on the assessment, identification, and management of cardiotoxicity induced or exacerbated by cancer treatment. Nurses are pivotal to the delivery of evidence-based assessment of and care for individuals who have preexisting cardiac conditio...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/21.CJON.93-96
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:The concept of transitional care and the methods and processes to efficiently and effectively transition patients between a variety of care settings remains a continuous healthcare goal. Despite the numerous transitional care models that have been developed and implemented in a myriad of healthcare settings,...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/18.CJON.S2.37-41
更新日期:2018-12-01 00:00:00
abstract::Screening for illness should be an evidence-based activity. Screening tests are useful only if they reduce mortality or morbidity. Therefore, healthcare professionals must know how to evaluate research about screening tests to be sure that, in fact, the tests actually accomplish their goals. Tests that generate many f...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/06.CJON.73-76
更新日期:2006-02-01 00:00:00
abstract::Therapeutic cancer vaccines that use attenuated vaccinia viruses as delivery vectors are undergoing clinical trials at dozens of sites internationally. Even in an attenuated form, these live viruses can cause severe illness if they are accidentally transmitted to immunocompromised people, pregnant women, or people wit...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/16.CJON.602-604
更新日期:2016-12-01 00:00:00
abstract::Gastric cancer is difficult to diagnose at an early stage. Signs and symptoms of the disease often only occur when advanced or metastatic disease is present. A very small number of gastric cancers are hereditary. The mutation to the E-cadherin gene has high penetrance and confers a lifetime risk of gastric cancer of 8...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/02.CJON.161-162
更新日期:2002-05-01 00:00:00