Update on identifying and managing osteoporosis in women with breast cancer.

Abstract:

:Aromatase inhibitors (AIs) have become integral to the treatment of women with breast cancer and are the treatment of choice in postmenopausal women who have tumors that are estrogen receptor positive. The depletion of estrogen seen with AI therapy is significant and translates to beneficial tumor effect but has a negative impact on skeletal bone. Bone loss incurred from AI use creates an increased risk for osteoporosis and subsequent bone fractures. Menopausal women have additional bone loss when using AIs. In addition, younger women may develop risk for osteoporosis as a result of premature menopause from other therapies used in the treatment of breast cancer. The process by which a woman treated for breast cancer develops osteoporosis differs from the bone loss that occurs from menopause alone and should be considered as a separate process. The effects of AI therapy on women with breast cancer are profound, and patients may require specialized approaches to therapy. This article will discuss osteoporosis, including assessment and diagnosis, and review the available and experimental treatments, as well as nursing implications in the treatment of women with breast cancer on AI therapy.

journal_name

Clin J Oncol Nurs

authors

Yamamoto DS,Viale PH

doi

10.1188/09.CJON.E18-E29

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

E18-29

issue

5

eissn

1092-1095

issn

1538-067X

pii

1GQNRH438JX74G51

journal_volume

13

pub_type

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