Cytokine Release Syndrome: Inpatient Care for Side Effects of CAR T-Cell Therapy
.

Abstract:

BACKGROUND:Pediatric patients with relapsed and refractory acute lymphoblastic leukemia are more often being treated with chimeric antigen receptor (CAR) T-cell therapy. As with any new therapy, the management of this patient population has a unique set of challenges. The side effects of this therapy can range from mild to severe, with cytokine release syndrome being the most common reason for hospitalization.
. OBJECTIVES:This article presents common side effects, treatments, and challenges of caring for hospitalized patients who have received CAR T-cell therapy.
. METHODS:A case study is used to illustrate a patient's inpatient hospitalization course after receiving CAR T-cell therapy, including the management of treatment-related toxicities.
. FINDINGS:As treatments emerge, nurses will be challenged with learning the associated side effects and toxicities. CAR T-cell therapy can result in a unique trajectory of potential symptoms and the potential for complete resolution of disease.

journal_name

Clin J Oncol Nurs

authors

Smith L,Venella K

doi

10.1188/17.CJON.S2.29-34

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

29-34

issue

2 Suppl

eissn

1092-1095

issn

1538-067X

journal_volume

21

pub_type

杂志文章
  • Celiac plexus block in pancreatic neuroendocrine tumors.

    abstract::Pancreatic neuroendocrine tumors (pNETs), an uncommon finding, are distinct from pancreatic carcinomas. When pNETs are unresectable and progressive, visceral pain often presents and is challenging to treat. Opioids commonly used for pain control are difficult to implement in this setting because of adverse side effect...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/11.CJON.218-220

    authors: Morturano RA,Dunphy EP

    更新日期:2011-04-01 00:00:00

  • Tell Me About You: Experiences Teach a Nurse the Importance of Listeningg.

    abstract::Unexpected cardiac issues at an early age inspired me to return to school to pursue a career in nursing. While in school, a close relationship with a family member facing a terminal cancer diagnosis gave me insight into the importance of listening as a tool for keeping patients safe and delivering the most appropriate...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.13-14

    authors: Beck J

    更新日期:2017-02-01 00:00:00

  • In Cancer Care, What is Loss and What is Victory?

    abstract::The challenges faced in my first year as a new oncology nurse included learning the beauty of small victories and understanding loss. Family and friends often mention how sad and hard this profession is. It is hard to explain how much I love this job to those who view it as somewhat depressing. The victories are the s...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.112

    authors: Parker A

    更新日期:2019-02-01 00:00:00

  • Prevention of venous thromboembolism in adult patients with cancer in the acute care setting.

    abstract::Adult patients with cancer in the acute care setting face numerous potential complications related to malignancy. Risk for development of venous thromboembolism (VTE) is among the most critical of adverse outcomes for this patient population, ultimately leading to increased morbidity and mortality rates. Nurses must b...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.18-03AP

    authors: Grier MA

    更新日期:2014-06-01 00:00:00

  • Cancer-related anemia: clinical review and management update.

    abstract::Anemia is a decrease in circulating red blood cells that contributes to a complex group of symptoms. Anemia may be present in more than half of all patients with cancer but often is assessed, documented, prevented, and treated inadequately. Individuals with cancer are living longer, and the number of cancer treatment ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/07.CJON.349-359

    authors: Hurter B,Bush NJ

    更新日期:2007-06-01 00:00:00

  • A review of paclitaxel (Taxol) administration, stability, and compatibility issues.

    abstract::The purpose of this article is to review information relative to the administration, stability, and compatibility of paclitaxel (Taxol, Mead Johnson Oncology Products, Princeton, NJ). The unique formulation used to solubilize paclitaxel has led to an increased awareness of plasticizer-leaching issues, paclitaxel stabi...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Boyle DA,Goldspiel BR

    更新日期:1998-10-01 00:00:00

  • Administration of the cytoprotectant amifostine.

    abstract::This article provides guidelines for the use of amifostine (Ethyol, Alza Pharmaceuticals, Palo Alto, CA, and U.S. Bioscience, Inc., West Conshohocken, PA), a pancytoprotective agent approved for reducing renal toxicity associated with cisplatin administration in patients with advanced ovarian or non-small cell lung ca...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:

    authors: Lindemann K

    更新日期:1998-07-01 00:00:00

  • Assessing workplace compliance with handling of antineoplastic agents.

    abstract::Oncology nurses and ancillary support personnel who work in oncology settings are at risk for exposure to antineoplastic drugs in their workplaces. A review of the literature reveals issues of environmental contamination and personal exposure. Although the United States has no formal regulations regarding hazardous dr...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/06.CJON.473-477

    authors: Gambrell J,Moore S

    更新日期:2006-08-01 00:00:00

  • Optimal Topical Agent for Radiation Dermatitis During Breast Radiotherapy: A Pilot Study.

    abstract:BACKGROUND:Women receiving radiation to the breast will likely be recommended to use a topical cream to minimize and delay the development of radiation dermatitis. Although many topical products are commercially available and have been tested for safety and efficacy, few studies have compared various products to one an...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.451-455

    authors: Fenton-Kerimian M,Cartwright F,Peat E,Florentino R,Maisonet O,Budin W,Rolnitzky L,Formenti S

    更新日期:2015-08-01 00:00:00

  • Atypical fatigue.

    abstract:CASE STUDY:Mrs. S is a 63-year-old retired teacher who returns to the office for breast cancer follow-up. She was diagnosed with intraductal carcinoma, and her treatment included a modified radial mastectomy followed by four cycles of doxorubicin and cyclophosphamide. Her tumor was estrogen receptor-positive, progester...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/07.628-630

    authors: Sharp K

    更新日期:2007-10-01 00:00:00

  • Patient Dignity: Exploring Oncology Nurses' Perceptions During End-of-Life Care.

    abstract:BACKGROUND:Research on nurses' perceptions of dignity is limited, with much work instead focusing on patients' experiences. Maintaining the dignity of patients is considered to be an important element of nursing care; however, it is often diminished by the acts and omissions of healthcare providers. OBJECTIVES:The pur...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.E46-E51

    authors: Crump B

    更新日期:2019-06-01 00:00:00

  • A critical pathway for patients undergoing one-day breast cancer surgery.

    abstract::As the trend of surgical procedures shifting from inpatient to outpatient settings continues, outpatient-focused standardized care processes will become more of a necessity. A multidisciplinary critical pathway (CP) for breast cancer surgery can assist care providers in meeting patients' educational and psychosocial n...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:

    authors: Sladek ML,Swenson KK,Ritz LJ,Schroeder LM

    更新日期:1999-07-01 00:00:00

  • Suboptimal responses to imatinib in chronic myelogenous leukemia: what are they and how do they affect treatment?

    abstract::First-line treatment for chronic myelogenous leukemia (CML) is imatinib, but some patients do not respond or develop resistance to the drug, leading to suboptimal responses. Dasatinib and nilotinib are approved second-line compounds for patients experiencing imatinib failure. In a prospective comparison of dasatinib w...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/09.CJON.537-542

    authors: Allen-Bard S

    更新日期:2009-10-01 00:00:00

  • Osmotic blood-brain barrier modification for the treatment of malignant brain tumors.

    abstract::The blood-brain barrier (BBB) is a physiologic barrier that protects the brain from toxic substances, including most of the chemotherapeutic agents used today. The BBB may be partly responsible for the poor efficacy of chemotherapy for malignant primary or metastatic brain tumors. A technique of osmotic modification o...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/04.CJON.263-267

    authors: Haluska M,Anthony ML

    更新日期:2004-06-01 00:00:00

  • Practical management of imatinib in gastrointestinal stromal tumors.

    abstract::Gastrointestinal stromal tumors (GISTs) have an incidence of 7-15 occurrences per million people. Tyrosine kinase inhibitors (TKIs) have significantly improved clinical outcomes as part of multidisciplinary disease management. The authors will review developments in the management of GISTs, including diagnosis, risk s...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/11.CJON.533-545

    authors: Barnes T,Reinke D

    更新日期:2011-10-01 00:00:00

  • The Role of Oncology Nurses as Ethicists: Training, Opportunities, and Implications for Practice.

    abstract::Ethical challenges are inherent in oncology clinical practice. Ranging from transitions in care to code status and treatment decisions, these ethical challenges can have an acute effect on nurses, with well-established connections to moral distress and other psycho-emotional sequelae. The availability of a nurse ethic...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.103-107

    authors: Neumann J,Counts V,Jernigan C

    更新日期:2019-02-01 00:00:00

  • Central Line Care: Reducing Central Line-Associated Bloodstream Infections on a Hematologic Malignancy and Stem Cell Transplant Unit.

    abstract:BACKGROUND:Patients with hematologic malignancies and stem cell transplant recipients are at increased risk for infections because of their prolonged periods of profound neutropenia. Central line-associated bloodstream infections (CLABSIs) can result in lengthy hospitalizations, increased healthcare costs, and increase...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.148-152

    authors: Beaudry J,ScottoDiMaso K

    更新日期:2020-04-01 00:00:00

  • Screening for disease: making evidence-based choices.

    abstract::Screening for illness should be an evidence-based activity. Screening tests are useful only if they reduce mortality or morbidity. Therefore, healthcare professionals must know how to evaluate research about screening tests to be sure that, in fact, the tests actually accomplish their goals. Tests that generate many f...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/06.CJON.73-76

    authors: Fields MM,Chevlen E

    更新日期:2006-02-01 00:00:00

  • Computer-Based Cognitive Training for Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors.

    abstract:BACKGROUND:Advancements in chemotherapy have greatly increased breast cancer survival, leading to an increased focus on the management of long-term effects of treatment. Chemotherapy-related cognitive impairment, one such long-term effect, is experienced by as many as 90% of breast cancer survivors (BCS) and negatively...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/16.CJON.504-509

    authors: Bail J,Meneses K

    更新日期:2016-10-01 00:00:00

  • Roles played by advanced practitioners in oncology: 
present status and future outlook.

    abstract::The 40th anniversary of the Oncology Nursing Society is the perfect time to reflect on the role that advanced practitioners in oncology (APOs) play in the care of patients with cancer. APOs have become an important part of cancer care. This group of professionals practicing in various settings includes physician assis...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.226-227

    authors: Ewing JC

    更新日期:2015-04-01 00:00:00

  • An intervention to manage patient-reported symptoms during cancer treatment.

    abstract::Patients with cancer receiving therapy may face a variety of complicated and stressful symptoms. Oncology nurses can advocate for patients by performing their roles as educators and comanagers of cancer-related side effects. In addition, symptom-focused education provided by oncology nurses can enable patients to admi...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/11.CJON.253-258

    authors: Williams PD,Williams K,Lafaver-Roling S,Johnson R,Williams AR

    更新日期:2011-06-01 00:00:00

  • Evidence-based research for intraperitoneal chemotherapy in epithelial ovarian cancer.

    abstract::Intraperitoneal (IP) therapy is the administration of chemotherapy or biologic agents directly into the peritoneal cavity. A recent Gynecologic Oncology Group trial showed a survival advantage for women with advanced ovarian cancer and small residual disease after initial surgical staging and debulking who received IP...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,病人教育讲义,评审

    doi:10.1188/07.CJON.211-216

    authors: Almadrones L

    更新日期:2007-04-01 00:00:00

  • Native cancer navigation: the state of the science.

    abstract::The purpose of this literature review is to determine the current state of the science for the effectiveness of patient navigation on improving outcomes of cancer care across the continuum among Native Americans. The research will help healthcare professionals ascertain potential evidence-based practice guidelines and...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/12.CJON.73-82

    authors: Eschiti V,Burhansstipanov L,Watanabe-Galloway S

    更新日期:2012-02-01 00:00:00

  • The science of patient safety: implications for oncology nursing practice.

    abstract::Patient safety is one of the most frequent terms used in health care today. Patients and their families are, first and foremost, focused on receiving effective and safe care, and oncology nurses strive to incorporate clinical evidence into day-to-day practice. This article provides a road map on how to incorporate eme...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.601-603

    authors: Sheridan CA

    更新日期:2013-12-01 00:00:00

  • Clinical Nurse Consultant Support: Management of Patients With Melanoma Receiving Immunotherapy 
and Targeted Therapy
.

    abstract:BACKGROUND:Targeted therapy and immunotherapy agents for advanced melanoma are associated with novel toxicities. Melanoma clinical nurse consultants (CNCs) provide multifaceted clinical care.
. OBJECTIVES:The objective was to evaluate the type of support, excluding clinic and inpatient care, provided by CNCs for patie...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/17.CJON.E93-E98

    authors: Lomax AJ,Nielsen T,Visintin L,O'Carrigan B,Honeyball F,Shum B,Saw RPM,McNeil C

    更新日期:2017-08-01 00:00:00

  • Reevaluating the neutropenic diet: time to change.

    abstract::The neutropenic diet historically has been a mainstay in oncology practice, with many providers continuing to adhere tightly to the diet for patients with neutropenia. However, clinically sound evidence remains limited and weak and does not support the diet as a foundation for policy and practice. Therefore, two quest...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.239-241

    authors: Foster M

    更新日期:2014-04-01 00:00:00

  • Current methods for the assessment and management of taxane-related neuropathy.

    abstract::Taxane-induced peripheral neuropathy (TIPN) affects a number of patients with breast cancer. To properly manage these patients, nurses must be able to identify and assess TIPN, as well as educate patients on TIPN as a side effect of taxane therapy. This article provides practical suggestions regarding how nurses can i...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.S1.22-34

    authors: Smith EM

    更新日期:2013-02-01 00:00:00

  • The role of urinary assessment scores in the nursing management of patients receiving prostate brachytherapy.

    abstract::Nearly all patients experience some degree of urinary irritative or obstructive symptoms following brachytherapy for definitive treatment of early-stage prostate cancer. The American Urological Association (AUA) Symptom Index is a tool developed to measure urinary function and can be incorporated into postoperative nu...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Abel LJ,Blatt HJ,Stipetich RL,Fuscardo JA,Dafoe-Lambie JC,Dorsey AT,Butler WM,Merrick GS

    更新日期:2000-05-01 00:00:00

  • Exercise guidelines for adults with cancer: a vital role in survivorship.

    abstract::Cancer survivors face many challenges as a result of their cancer diagnosis and treatment, most importantly the maintenance of physical well-being. Nurses and other health professionals strive to address the needs of cancer survivors, including providing appropriate health-promotion information for a physically active...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/11.CJON.683-686

    authors: Jankowski CM,Matthews EE

    更新日期:2011-12-01 00:00:00

  • Cancer Moonshot: What It Means for Patients.

    abstract::You may have heard of the National Cancer Moonshot Initiative led by former Vice President Joe Biden. It has brought together many people through a task force, blue ribbon panel, and many public forums to discuss how best "to dramatically accelerate efforts to prevent, diagnose, and treat cancer - to achieve a decade'...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.141-142

    authors: Mayer DK,Fuld Nasso S

    更新日期:2017-04-01 00:00:00