Abstract:
BACKGROUND:Pediatric patients with relapsed and refractory acute lymphoblastic leukemia are more often being treated with chimeric antigen receptor (CAR) T-cell therapy. As with any new therapy, the management of this patient population has a unique set of challenges. The side effects of this therapy can range from mild to severe, with cytokine release syndrome being the most common reason for hospitalization. . OBJECTIVES:This article presents common side effects, treatments, and challenges of caring for hospitalized patients who have received CAR T-cell therapy. . METHODS:A case study is used to illustrate a patient's inpatient hospitalization course after receiving CAR T-cell therapy, including the management of treatment-related toxicities. . FINDINGS:As treatments emerge, nurses will be challenged with learning the associated side effects and toxicities. CAR T-cell therapy can result in a unique trajectory of potential symptoms and the potential for complete resolution of disease.
journal_name
Clin J Oncol Nursjournal_title
Clinical journal of oncology nursingauthors
Smith L,Venella Kdoi
10.1188/17.CJON.S2.29-34subject
Has Abstractpub_date
2017-04-01 00:00:00pages
29-34issue
2 Suppleissn
1092-1095issn
1538-067Xjournal_volume
21pub_type
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journal_title:Clinical journal of oncology nursing
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abstract::Unexpected cardiac issues at an early age inspired me to return to school to pursue a career in nursing. While in school, a close relationship with a family member facing a terminal cancer diagnosis gave me insight into the importance of listening as a tool for keeping patients safe and delivering the most appropriate...
journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/07.CJON.349-359
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:
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journal_title:Clinical journal of oncology nursing
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更新日期:2006-08-01 00:00:00
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doi:10.1188/15.CJON.451-455
更新日期:2015-08-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:
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journal_title:Clinical journal of oncology nursing
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更新日期:2009-10-01 00:00:00
abstract::The blood-brain barrier (BBB) is a physiologic barrier that protects the brain from toxic substances, including most of the chemotherapeutic agents used today. The BBB may be partly responsible for the poor efficacy of chemotherapy for malignant primary or metastatic brain tumors. A technique of osmotic modification o...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/04.CJON.263-267
更新日期:2004-06-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
abstract::Ethical challenges are inherent in oncology clinical practice. Ranging from transitions in care to code status and treatment decisions, these ethical challenges can have an acute effect on nurses, with well-established connections to moral distress and other psycho-emotional sequelae. The availability of a nurse ethic...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/19.CJON.103-107
更新日期:2019-02-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/20.CJON.148-152
更新日期:2020-04-01 00:00:00
abstract::Screening for illness should be an evidence-based activity. Screening tests are useful only if they reduce mortality or morbidity. Therefore, healthcare professionals must know how to evaluate research about screening tests to be sure that, in fact, the tests actually accomplish their goals. Tests that generate many f...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/06.CJON.73-76
更新日期:2006-02-01 00:00:00
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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