A review of paclitaxel (Taxol) administration, stability, and compatibility issues.

Abstract:

:The purpose of this article is to review information relative to the administration, stability, and compatibility of paclitaxel (Taxol, Mead Johnson Oncology Products, Princeton, NJ). The unique formulation used to solubilize paclitaxel has led to an increased awareness of plasticizer-leaching issues, paclitaxel stability in solution, and paclitaxel compatibility with other medications. Particularly with longer paclitaxel infusion schedules (greater than 48 hours), both drug stability in solution and pump apparatus congruence require careful consideration to minimize plasticizer-leaching problems and to ensure optimum drug delivery. Despite knowledge of the physical compatibility of paclitaxel with numerous drugs, a paucity of research has documented the specifics of paclitaxel's chemical compatibility with other medications.

journal_name

Clin J Oncol Nurs

authors

Boyle DA,Goldspiel BR

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

141-5

issue

4

eissn

1092-1095

issn

1538-067X

journal_volume

2

pub_type

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