Abstract:
:Gastrointestinal stromal tumors (GISTs) have an incidence of 7-15 occurrences per million people. Tyrosine kinase inhibitors (TKIs) have significantly improved clinical outcomes as part of multidisciplinary disease management. The authors will review developments in the management of GISTs, including diagnosis, risk stratification, prognosis, and treatment with imatinib. Imatinib is recommended for postsurgical adjuvant therapy and, where appropriate, neoadjuvant therapy. Clinical practice guidelines recommend first-line imatinib for metastatic and unresectable GISTs based on trials showing efficacy at the standard dose (400 mg per day) and at higher doses of 600-800 mg per day. Oncology nurses play a key role in patient management through (a) patient education about GISTs and their treatment including the use of imatinib, (b) timely scheduling of radiologic follow-up to assess treatment response, (c) monitoring treatment adherence, (d) helping to sustain imatinib dose intensity by monitoring toxicities and drug interactions and by counseling patients to prevent treatment interruptions, and (e) collaborating with the multidisciplinary medical team to pursue imatinib dose escalation or other treatment options if patients have primary or acquired mutation-based resistance to imatinib.
journal_name
Clin J Oncol Nursjournal_title
Clinical journal of oncology nursingauthors
Barnes T,Reinke Ddoi
10.1188/11.CJON.533-545subject
Has Abstractpub_date
2011-10-01 00:00:00pages
533-45issue
5eissn
1092-1095issn
1538-067Xpii
T562077811254R56journal_volume
15pub_type
杂志文章,评审abstract::Highly specialized care is required for critically ill patients with cancer, but continuity of care equally is important to their survival when they are admitted to the critical care setting. The use of oncology nurses as liaisons to critical care nurses may help ensure the continuity of care and reduce rates of morbi...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/07.CJON.925-927
更新日期:2007-12-01 00:00:00
abstract::Oncology nurses handle hazardous drugs when they administer medications to patients in inpatient and outpatient settings. Guidelines for the safe handling of hazardous drugs have been in place since the late 1980s; however, confusion still remains about the proper handling of the substances. Institutional policies var...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/09.CJON.433-439
更新日期:2009-08-01 00:00:00
abstract::Because of the COVID-19 pandemic, we are at an unprecedented time in history. We practice at Monter Cancer Center in Lake Success, New York, which is part of Northwell Health, the largest health system in New York state, located in the initial epicenter of COVID-19 in the United States. ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/20.CJON.711
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Chimeric antigen receptor (CAR) T-cell therapy program development has regulatory demands and unique operational processes that vary across settings. The infrastructure in which CAR T-cell therapy is implemented has implications for nursing education and competencies. OBJECTIVES:This article presents an ove...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/19.CJON.S1.20-26
更新日期:2019-04-01 00:00:00
abstract::Oral health is often not a priority during cancer treatment; however, patients with cancer are at increased risk for oral complications during and after treatment. This article focuses on the importance of oral health care before, during, and after cancer treatment using the head, eyes, ears, nose, oral cavity, and th...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/15.CJON.615-619
更新日期:2015-10-01 00:00:00
abstract::A key concern for young patients with cancer and survivors is the desire to parent a child. With infertility being a well-established long-term effect of many oncologic regimens, patients who want to have children often become distressed when faced with the possibility of losing their fertility. Several organizations ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/12.CJON.205-210
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Pediatric patients with relapsed and refractory acute lymphoblastic leukemia are more often being treated with chimeric antigen receptor (CAR) T-cell therapy. As with any new therapy, the management of this patient population has a unique set of challenges. The side effects of this therapy can range from mil...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.S2.29-34
更新日期:2017-04-01 00:00:00
abstract::Patients with cancer receiving therapy may face a variety of complicated and stressful symptoms. Oncology nurses can advocate for patients by performing their roles as educators and comanagers of cancer-related side effects. In addition, symptom-focused education provided by oncology nurses can enable patients to admi...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/11.CJON.253-258
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects women who are African American, younger, or carriers of the BRCA1 gene. No targeted treatments exist for the disease, which has distinct features and presents unique challenges to patients who have bee...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/15.CJON.62-67
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Women who have been identified with a BRCA mutation benefit from a multidisciplinary, individualized medical evaluation to reduce their risk of developing cancers. Identifying women who would gain from testing for BRCA mutations is essential. Nurse practitioners (NPs) as primary care providers are important ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/16.CJON.327-331
更新日期:2016-06-01 00:00:00
abstract::Nearly all patients experience some degree of urinary irritative or obstructive symptoms following brachytherapy for definitive treatment of early-stage prostate cancer. The American Urological Association (AUA) Symptom Index is a tool developed to measure urinary function and can be incorporated into postoperative nu...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::Positron emission tomography (PET) scans use positrons, positively charged particles, to detect metabolic and chemical changes in the body. Although the clinical applications of this technology still are evolving, PET scans are being used to detect cancer and evaluate neurologic disorders, heart muscle function, and r...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/03.CJON.379-385
更新日期:2003-07-01 00:00:00
abstract::Today, I am writing for the first time as the new editor of the Clinical Journal of Oncology Nursing (CJON). It is my honor to assume this role from my colleague and mentor, Deborah K. Mayer, PhD, RN, AOCN, FAAN. For eight years, Deb served as the editor of one of the most widely read journals in oncology nursing, CJO...
journal_title:Clinical journal of oncology nursing
pub_type: 社论
doi:10.1188/15.CJON.387
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Since the completion of the Human Genome Project in 2003, the implications of genetics and genomics for health and illness have become clearer. All nurses, at all levels and across all specialties, must have a basic understanding of genetics and genomics to provide appropriate care. . OBJECTIVES:This artic...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/17.CJON.747-753
更新日期:2017-12-01 00:00:00
abstract::Anemia is a decrease in circulating red blood cells that contributes to a complex group of symptoms. Anemia may be present in more than half of all patients with cancer but often is assessed, documented, prevented, and treated inadequately. Individuals with cancer are living longer, and the number of cancer treatment ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/07.CJON.349-359
更新日期:2007-06-01 00:00:00
abstract::Increased understanding of the molecular composition of breast cancer tumors has led to the development of targeted anticancer agents. Novel therapies directed against human epidermal growth factor receptor 2 (HER2) in breast cancer have been developed. One such agent, trastuzumab emtansine (T-DM1), is an antibody dru...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/13.CJON.E58-E62
更新日期:2013-10-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fifth most common cause of all malignancies and causes approximately one million deaths each year. Surgical liver resection is the only cure for HCC; however, few patients are eligible to undergo this procedure. Hepatic artery chemoembolization (HACE) is a technique that delivers ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/05.CJON.69-75
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Caregiver burden associated with caring for women with ovarian cancer has received limited focus. However, these patients often have complex needs, requiring a high level of care at home and imposing substantial burdens on caregivers. OBJECTIVES:This pilot study assessed the level of caregiver burden experi...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/16.CJON.169-173
更新日期:2016-04-01 00:00:00
abstract::Radioimmunotherapy is a new cancer therapy that combines the cytotoxicity of radiation with the tumor-specific targeting of monoclonal antibodies. Yttrium 90 (Y-90) ibritumomab tiuxetan (Zevalin, IDEC Pharmaceuticals Corporation, San Diego, CA) is indicated for the treatment of patients with relapsed or refractory low...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/04.CJON.31-34
更新日期:2004-02-01 00:00:00
abstract::The oncology practice setting can be a highly emotional workplace because nurses provide care to many of the same patients and their families over time. Comparing and contrasting nurses from different clinical settings would provide insight into the more common themes of nursing grief and might give guidance on how to...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/09.CJON.625-627
更新日期:2009-12-01 00:00:00
abstract::As the trend of surgical procedures shifting from inpatient to outpatient settings continues, outpatient-focused standardized care processes will become more of a necessity. A multidisciplinary critical pathway (CP) for breast cancer surgery can assist care providers in meeting patients' educational and psychosocial n...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::Knowing the differences and potential benefits of hospice and palliative care can help healthcare professionals advocate for their patients and make proactive decisions about patient care. Providing admission into the appropriate program can facilitate symptom management and impart the best quality of life possible fo...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/10.CJON.273-275
更新日期:2010-06-01 00:00:00
abstract::The purpose of this literature review is to determine the current state of the science for the effectiveness of patient navigation on improving outcomes of cancer care across the continuum among Native Americans. The research will help healthcare professionals ascertain potential evidence-based practice guidelines and...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/12.CJON.73-82
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Nurses and other healthcare workers are at risk for adverse health consequences from occupational exposure to hazardous drugs. OBJECTIVES:An evidence-based program for nurses was implemented to improve safe handling practices and reduce exposure to hazardous drugs. METHODS:A quasiexperimental design was us...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.73-78
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Talimogene laherparepvec (T-VEC) is the first intralesional therapy for melanoma approved by the U.S. Food and Drug Administration. This oncolytic viral immunotherapy has improved outcomes for patients with locoregional recurrent melanoma and is showing promise in combination with systemic therapies. . OBJ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.S4.76-86
更新日期:2017-08-01 00:00:00
abstract::Patients with cancer can experience several treatment-related symptoms, and conventional care focuses primarily on cure and survival without a holistic approach to disease. Subsequently, an increasing number of patients are accustomed to complementary modalities to improve well-being. Biofield therapies (BTs) are comp...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/14.CJON.568-576
更新日期:2014-10-01 00:00:00
abstract::Although uncommon, 5-fluorouracil (5-FU) infiltrations do occur. Two case studies involving 5-FU infiltration from totally implanted venous access devices identified at the conclusion of a 46-hour continuous infusion via an ambulatory infusion pump are presented. These cases highlight the importance of patient and car...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/19.CJON.537-539
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Exercise, light physical activity, and decreased sedentary time all have been associated with health benefits following cancer diagnoses. Commercially available wearable activity trackers may help patients monitor and self-manage their behaviors to achieve these benefits. OBJECTIVES:This article highlights ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/16.CJON.606-610
更新日期:2016-12-01 00:00:00
abstract::The focus of this new column will be to showcase innovative work that has advanced quality in areas of practice and care delivery that are of interest to the practicing oncology nurse. Examples include, but are not limited to, practice environment innovation, patient outcomes and experiences of care, team effectivenes...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/13.CJON.236-238
更新日期:2013-06-01 00:00:00
abstract::Palliative care has become an essential component of oncology care, with a focus on maximizing quality of life and optimizing function, as well as promoting pain and symptom management. This article focuses on the care of a patient experiencing bowel obstruction and delirium, two common issues in patients with advance...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/12.CJON.391-398
更新日期:2012-08-01 00:00:00