Nursing perspectives on trastuzumab emtansine for the treatment of metastatic breast cancer.

Abstract:

:Increased understanding of the molecular composition of breast cancer tumors has led to the development of targeted anticancer agents. Novel therapies directed against human epidermal growth factor receptor 2 (HER2) in breast cancer have been developed. One such agent, trastuzumab emtansine (T-DM1), is an antibody drug conjugate that has been shown to be effective in the treatment of women with HER2-positive breast cancer. Phase I and II studies have determined a maximum tolerated dose, and several phase Ib/II, II, and III studies have shown improved tolerability and efficacy compared with the combination of trastuzumab and chemotherapy. The most concerning grade 3 or higher adverse events associated with T-DM1 include thrombocytopenia and transaminitis. To ensure that these adverse events do not delay or interrupt treatment, oncology nurses need to familiarize themselves with these risks and their management. This article reviews the clinical development of T-DM1 and its usage, with a focus on the nurse's role in preventing and managing adverse events associated with T-DM1 therapy.

journal_name

Clin J Oncol Nurs

authors

Bourdeanu L,Luu T

doi

10.1188/13.CJON.E58-E62

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

E58-62

issue

5

eissn

1092-1095

issn

1538-067X

pii

F7394G177R2075G1

journal_volume

17

pub_type

杂志文章
  • Cate's Story: Hereditary Diffuse Gastric Cancer.

    abstract::Gastric cancer is a major cause of cancer-related mortality worldwide and is thought to be responsible for about 10% of cancer-related deaths across the globe. A small proportion of all gastric cancers arise because of a known hereditary syndrome, the most common of which is hereditary diffuse gastric cancer (HDGC). T...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/16.CJON.443-445

    authors: Rogers M

    更新日期:2016-08-01 00:00:00

  • Cardio-Oncology: A Continually Evolving Subspecialty in Oncology Nursing.

    abstract::Cardio-oncology is a unique subspecialty within oncology nursing that focuses on the assessment, identification, and management of cardiotoxicity induced or exacerbated by cancer treatment. Nurses are pivotal to the delivery of evidence-based assessment of and care for individuals who have preexisting cardiac conditio...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/21.CJON.93-96

    authors:

    更新日期:2021-02-01 00:00:00

  • Challenges associated with hereditary cancer susceptibility testing.

    abstract::Selection of letters to be published is the decision of the editor. For acceptance, letters must be signed. A letter can appear anonymously if requested by the author. All letters are subject to editing. A letter that questions, criticizes, or responds to a previously published Clinical Journal of Oncology Nursing art...

    journal_title:Clinical journal of oncology nursing

    pub_type: 信件

    doi:10.1188/14.CJON.14-15

    authors: Mayer DK

    更新日期:2014-02-01 00:00:00

  • Dyspnea and Delirium at the End of Life.

    abstract::This article focuses on the symptoms of dyspnea and delirium, which can be extremely distressing to patients with cancer at the end of life. Oncology nurses are well suited to detect and treat these symptoms.

. ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/16.CJON.244-246

    authors: Bobb B

    更新日期:2016-06-01 00:00:00

  • The role of urinary assessment scores in the nursing management of patients receiving prostate brachytherapy.

    abstract::Nearly all patients experience some degree of urinary irritative or obstructive symptoms following brachytherapy for definitive treatment of early-stage prostate cancer. The American Urological Association (AUA) Symptom Index is a tool developed to measure urinary function and can be incorporated into postoperative nu...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Abel LJ,Blatt HJ,Stipetich RL,Fuscardo JA,Dafoe-Lambie JC,Dorsey AT,Butler WM,Merrick GS

    更新日期:2000-05-01 00:00:00

  • Communication in oncology care: the effectiveness of skills training workshops for healthcare providers.

    abstract::Communication skills are the cornerstone of the patient-provider relationship in cancer care. Lack of these skills can diminish patient disclosure, increase patient anxiety, and decrease satisfaction with care. The purpose of this article is to evaluate the literature regarding the efficacy and outcomes of communicati...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/05.CJON.305-312

    authors: Kennedy Sheldon L

    更新日期:2005-06-01 00:00:00

  • Highly reliable health care in the context of oncology nursing: part I.

    abstract::Oncology care is delivered under challenging circumstances. The principles of reliability science are used extensively in numerous high-risk and high-tech industries to improve quality and safety. This two-part series will discuss the concept of reliability science in the context of oncology nursing practice as a way ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.151-153

    authors: Sheridan-Leos N

    更新日期:2014-04-01 00:00:00

  • Trastuzumab cardio-oncology: lessons learned.

    abstract::Treatment with the humanized monoclonal antibody trastuzumab can significantly improve outcomes for patients with early or metastatic HER2-positive breast cancer. In a small proportion of patients, trastuzumab is associated with an increased risk of cardiac dysfunction. Although the mechanisms have yet to be fully est...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/10.CJON.630-640

    authors: Frankel C

    更新日期:2010-10-01 00:00:00

  • Safe handling of hazardous drugs: are you protected?

    abstract::Oncology nurses handle hazardous drugs when they administer medications to patients in inpatient and outpatient settings. Guidelines for the safe handling of hazardous drugs have been in place since the late 1980s; however, confusion still remains about the proper handling of the substances. Institutional policies var...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/09.CJON.433-439

    authors: Nixon S,Schulmeister L

    更新日期:2009-08-01 00:00:00

  • Theoretical foundations of adherence behaviors: synthesis and application in adherence to oral oncology agents.

    abstract:BACKGROUND:The use of theory can provide structure for understanding the dynamics of adherence to oral agents for cancer (OACs) and facilitate the development of strategies for patient assessment and care planning related to oral adherence. OBJECTIVES:The focus of this article is to identify common theories pertinent ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/15.S1.CJON.31-35

    authors: Irwin M

    更新日期:2015-06-01 00:00:00

  • Central Line Care: Reducing Central Line-Associated Bloodstream Infections on a Hematologic Malignancy and Stem Cell Transplant Unit.

    abstract:BACKGROUND:Patients with hematologic malignancies and stem cell transplant recipients are at increased risk for infections because of their prolonged periods of profound neutropenia. Central line-associated bloodstream infections (CLABSIs) can result in lengthy hospitalizations, increased healthcare costs, and increase...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.148-152

    authors: Beaudry J,ScottoDiMaso K

    更新日期:2020-04-01 00:00:00

  • Roles played by advanced practitioners in oncology: 
present status and future outlook.

    abstract::The 40th anniversary of the Oncology Nursing Society is the perfect time to reflect on the role that advanced practitioners in oncology (APOs) play in the care of patients with cancer. APOs have become an important part of cancer care. This group of professionals practicing in various settings includes physician assis...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.226-227

    authors: Ewing JC

    更新日期:2015-04-01 00:00:00

  • COVID-19 Vaccines: Preparing for Vaccination in the Context of Clinical Oncology Care.

    abstract:BACKGROUND:In the environment of an infectious pandemic, vaccines are a primary public health strategy to prevent the spread of disease. With the COVID-19 pandemic, there is heightened interest in safe and effective vaccines and their use in the context of clinical oncology practice. OBJECTIVES:This article provides f...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/21.CJON.76-84

    authors: Carr E

    更新日期:2021-02-01 00:00:00

  • Multidisciplinary Cancer Care Model: A Positive Association Between Oncology Nurse Navigation and Improved Outcomes for Patients With Cancer.

    abstract:BACKGROUND:Patients with cancer often experience prominent deficiencies in cancer care in the immediate period following initial cancer diagnosis. OBJECTIVES:This article aims to determine whether the inclusion of a gastrointestinal (GI) oncology nurse navigator (ONN) on the multidisciplinary cancer care team is assoc...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/18.CJON.E141-E145

    authors: Muñoz R,Farshidpour L,Chaudhary UB,Fathi AH

    更新日期:2018-10-01 00:00:00

  • Pancreatic cancer: a review and update.

    abstract::Pancreatic cancer will account for about 6% of all cancer-related deaths in 2008. Patients often present with advanced disease, so treatment remains a challenge. This article will review the risk factors, pathology features, clinical symptoms, diagnosis and staging guidelines, treatment, and nursing implications of pa...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/08.CJON.735-741

    authors: Dunphy EP

    更新日期:2008-10-01 00:00:00

  • Oncology nurse navigator role delineation study: an oncology nursing society report.

    abstract::The purpose of the Oncology Nursing Society (ONS) Oncology Nurse Navigator Role Delineation Study was to examine the job-function activities of the oncology nurse navigator, thus providing an understanding of this unique role. The Role Delineation Advisory Committee consisting mainly of oncology nurse navigators was f...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/12.CJON.581-585

    authors: Brown CG,Cantril C,McMullen L,Barkley DL,Dietz M,Murphy CM,Fabrey LJ

    更新日期:2012-12-01 00:00:00

  • Equianalgesic dosing: principles of practice for the care team.

    abstract::Opioids are the basis for managing cancer-related pain. Pain assessment and management are critical competencies for the clinical care team to improve quality of life for patients with cancer. Knowledge and application of evidence-based practice approaches to cancer pain relief, including the principles of equianalges...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.80-83

    authors: Gaguski ME,Karcheski T

    更新日期:2013-02-01 00:00:00

  • Computer-Based Cognitive Training for Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors.

    abstract:BACKGROUND:Advancements in chemotherapy have greatly increased breast cancer survival, leading to an increased focus on the management of long-term effects of treatment. Chemotherapy-related cognitive impairment, one such long-term effect, is experienced by as many as 90% of breast cancer survivors (BCS) and negatively...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/16.CJON.504-509

    authors: Bail J,Meneses K

    更新日期:2016-10-01 00:00:00

  • Evaluation of a patient navigation program.

    abstract::This study examined the value and effectiveness of a patient navigation program in terms of timeliness of access to cancer care, resolution of barriers, and satisfaction in 55 patients over a six-month period. Although not statistically significant, the time interval between diagnostic biopsy to first consultation wit...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/11.CJON.41-48

    authors: Koh C,Nelson JM,Cook PF

    更新日期:2011-02-01 00:00:00

  • Development of a policy and procedure for accidental chemotherapy overdose.

    abstract::A policy regarding rapid response to chemotherapy overdoses was developed by the authors in an attempt to minimize morbidity and mortality. The parameters of a chemotherapy overdose were defined to promote early recognition of an overdose incident. Resources needed to guide potential therapeutic interventions and requ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.18-04AP

    authors: Nelson WK,Moore J,Grasso JA,Barbarotta L,Fischer DS

    更新日期:2014-08-01 00:00:00

  • Prevention of venous thromboembolism in adult patients with cancer in the acute care setting.

    abstract::Adult patients with cancer in the acute care setting face numerous potential complications related to malignancy. Risk for development of venous thromboembolism (VTE) is among the most critical of adverse outcomes for this patient population, ultimately leading to increased morbidity and mortality rates. Nurses must b...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.18-03AP

    authors: Grier MA

    更新日期:2014-06-01 00:00:00

  • Laboratory Process Improvement: A Quality Initiative in an Outpatient Oncology Clinic.

    abstract::The goal of achieving maximum productivity through process redesign and teamwork in oncology laboratory (lab) operations can be challenging in cancer care organizations. At an urban cancer center, missing lab orders occurred frequently and led to increases in lab errors, turnaround time, and patient wait times. Patien...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.571-574

    authors: Wojciechowski M,Rodts M

    更新日期:2020-10-01 00:00:00

  • Tell Me About You: Experiences Teach a Nurse the Importance of Listeningg.

    abstract::Unexpected cardiac issues at an early age inspired me to return to school to pursue a career in nursing. While in school, a close relationship with a family member facing a terminal cancer diagnosis gave me insight into the importance of listening as a tool for keeping patients safe and delivering the most appropriate...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.13-14

    authors: Beck J

    更新日期:2017-02-01 00:00:00

  • The science of patient safety: implications for oncology nursing practice.

    abstract::Patient safety is one of the most frequent terms used in health care today. Patients and their families are, first and foremost, focused on receiving effective and safe care, and oncology nurses strive to incorporate clinical evidence into day-to-day practice. This article provides a road map on how to incorporate eme...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.601-603

    authors: Sheridan CA

    更新日期:2013-12-01 00:00:00

  • Clinical Nurse Consultant Support: Management of Patients With Melanoma Receiving Immunotherapy 
and Targeted Therapy
.

    abstract:BACKGROUND:Targeted therapy and immunotherapy agents for advanced melanoma are associated with novel toxicities. Melanoma clinical nurse consultants (CNCs) provide multifaceted clinical care.
. OBJECTIVES:The objective was to evaluate the type of support, excluding clinic and inpatient care, provided by CNCs for patie...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/17.CJON.E93-E98

    authors: Lomax AJ,Nielsen T,Visintin L,O'Carrigan B,Honeyball F,Shum B,Saw RPM,McNeil C

    更新日期:2017-08-01 00:00:00

  • Neurologic Complications: Effects of Ipilimumab and Nivolumab Therapy in Patients With Metastatic Melanoma.

    abstract::Checkpoint inhibitors are a form of immunotherapy that have revolutionized treatment for malignant melanoma, resulting in longer survival and better disease control. Multiple autoimmune disorders can occur with the use of checkpoint inhibitors, including severe, potentially fatal neurologic complications. Although neu...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.355-358

    authors: Latchman J,Guastella A,Tofthagen C

    更新日期:2019-08-01 00:00:00

  • Evaluating the frequency of vital sign monitoring during blood transfusion: an evidence-based practice initiative.

    abstract::Patients with cancer are often dependent on blood transfusions during treatment. Frequent vital sign monitoring during transfusions may interrupt sleep and the patient's ability to ambulate or participate in unit activities. Relying heavily on vital sign findings may also overshadow unmeasurable symptoms of transfusio...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.516-520

    authors: DeYoung Sullivan K,Vu T,Richardson G,Castillo E,Martinez F

    更新日期:2015-10-01 00:00:00

  • Reliably Addressing "What Matters" Through a Quality Improvement Process.

    abstract::Oncology nurses have a critical role in mitigating the intense vulnerability, loss of control, and fear of the unknown that characterizes the experiences of patients with cancer and their family members. Reliably inquiring about the issues that are at the forefront for patients and their loved ones can encourage a dee...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/16.CJON.20-22

    authors: Rutherford PA

    更新日期:2016-02-01 00:00:00

  • A review of paclitaxel (Taxol) administration, stability, and compatibility issues.

    abstract::The purpose of this article is to review information relative to the administration, stability, and compatibility of paclitaxel (Taxol, Mead Johnson Oncology Products, Princeton, NJ). The unique formulation used to solubilize paclitaxel has led to an increased awareness of plasticizer-leaching issues, paclitaxel stabi...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Boyle DA,Goldspiel BR

    更新日期:1998-10-01 00:00:00

  • Acute myeloid leukemia: a classification and treatment update.

    abstract::Approximately 11,000 Americans will be diagnosed with acute myeloid leukemia (AML) in 2003, and about 75% ultimately will die from the disease. Despite significant advances in understanding biologic, molecular, and cytogenetic aspects of this malignancy, several other areas remain poorly understood. During the 1990s, ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/03.CJON.535-540

    authors: Iovino CS,Camacho LH

    更新日期:2003-09-01 00:00:00