Trastuzumab cardio-oncology: lessons learned.

Abstract:

:Treatment with the humanized monoclonal antibody trastuzumab can significantly improve outcomes for patients with early or metastatic HER2-positive breast cancer. In a small proportion of patients, trastuzumab is associated with an increased risk of cardiac dysfunction. Although the mechanisms have yet to be fully established, trastuzumab may block HER2 signaling in cardiomyocytes, which is believed to be important for protecting the cardiomyocytes from stress such as that induced by treatment with anthracyclines. The risk of trastuzumab-associated cardiac dysfunction can be reduced if patients are evaluated thoroughly for risk factors before treatment (e.g., hypertension, low ejection fraction at onset, hyperglycemia, prior congestive heart failure). In addition, cardiac function must be assessed before and during the treatment period. If cardiac dysfunction occurs during treatment, early intervention can expand the possibilities of reinstitution of trastuzumab treatment. The integration of nonanthracycline adjuvant regimens offers opportunities for cardiac-compromised patients.

journal_name

Clin J Oncol Nurs

authors

Frankel C

doi

10.1188/10.CJON.630-640

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

630-40

issue

5

eissn

1092-1095

issn

1538-067X

pii

R33N773W65542502

journal_volume

14

pub_type

杂志文章
  • The role of urinary assessment scores in the nursing management of patients receiving prostate brachytherapy.

    abstract::Nearly all patients experience some degree of urinary irritative or obstructive symptoms following brachytherapy for definitive treatment of early-stage prostate cancer. The American Urological Association (AUA) Symptom Index is a tool developed to measure urinary function and can be incorporated into postoperative nu...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Abel LJ,Blatt HJ,Stipetich RL,Fuscardo JA,Dafoe-Lambie JC,Dorsey AT,Butler WM,Merrick GS

    更新日期:2000-05-01 00:00:00

  • Exercise Intervention: Attrition, Compliance, Adherence, and Progression Following Hematopoietic Stem Cell Transplantation
.

    abstract:BACKGROUND:Exercise is widely touted as an effective intervention to optimize health and well-being after high-dose chemotherapy and hematopoietic stem cell transplantation. 
. OBJECTIVES:This article reports attrition, compliance, adherence, and progression from the strength training arm of the single-blind randomize...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/18.CJON.97-103

    authors: Peters T,Erdmann R,Hacker ED

    更新日期:2018-02-01 00:00:00

  • Hazardous Drugs: Legislative and Regulatory Efforts to Improve Safe Handling

    abstract::Several organizations have safety guidelines regarding handling of hazardous drugs. That said, only Washington and California have enforceable laws that regulate these practices. This article shares the experiences of three states-Washington, Michigan, and North Carolina-in advancing legislative and regulatory efforts...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.254-256

    authors: Walton AL,Eisenberg S,Friese CR

    更新日期:2017-04-01 00:00:00

  • Taste alterations among patients with cancer.

    abstract::Patients with cancer frequently develop taste alterations, which are manifested by food aversions and decreased caloric intake. Many etiologies are recognized, including the effect of tumors, cancer cell mitosis, vitamin deficiencies, and cytokine involvement. Preventing or improving taste alterations in patients with...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/02.CJON.73-77

    authors: Sherry VW

    更新日期:2002-03-01 00:00:00

  • Genetic Biomarkers: Implications of Increased Understanding and Identification in Lung Cancer Management.

    abstract:BACKGROUND:In the management of lung cancer, molecular profiling of the tumor is pivotal to defining a personalized treatment plan and is recommended for each patient. OBJECTIVES:The purpose of this article is to provide an update on genomic testing in lung cancer and the associated targeted treatment options. In addi...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.648-656

    authors: Martin JC

    更新日期:2020-12-01 00:00:00

  • Transitions of Care: A Hematopoietic Stem Cell Transplantation Nursing Education Project Across the Trajectory.

    abstract:BACKGROUND:Hematopoietic stem cell transplantation (HCT) is a complicated treatment modality used to address hematologic malignancies and other disorders. The complex care of patients undergoing HCT places them at high risk for poor outcomes during times of transition. Education is a critical component of preparing pat...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.E74-E79

    authors: Thomson B,Gorospe G,Cooke L,Giesie P,Johnson S

    更新日期:2015-08-01 00:00:00

  • Can a Recent Nurse Graduate Thrive in the Oncology Setting?

    abstract::My personal experience with nursing school can be best described as floating in the middle of the ocean with a life vest while kicking and paddling to keep my head above the water. I spent countless hours studying for examinations, rewriting care plans, and practicing skills. In addition to my own efforts to survive, ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.455

    authors: Waldo A

    更新日期:2020-08-01 00:00:00

  • Application of Proteomics in Acute Graft-Versus-Host Disease Management: An Integrative Review and Nursing Implications.

    abstract:BACKGROUND:After allogeneic hematopoietic stem cell transplantation, one of the major barriers to clinical management of acute graft-versus-host disease (aGVHD) is a lack of reliable and validated noninvasive tests for diagnosis and prognosis. Proteomic studies have indicated a strong correlation between the level of c...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/15.CJON.758-763

    authors: Kalariya N,Brassil K

    更新日期:2015-12-01 00:00:00

  • Cancer-Related Pain Assessment: Monitoring the Effectiveness of Interventions.

    abstract:BACKGROUND:Cancer-related pain is a major health problem because of its magnitude, the subjective nature of the pain experience, and the complexity of the disease, making it difficult to assess and control. When assessment is not performed, poor pain control can result.
. OBJECTIVES:This article provides an overview o...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/17.CJON.S3.8-12

    authors: Gallagher E,Rogers BB,Brant JM

    更新日期:2017-06-01 00:00:00

  • Laboratory Process Improvement: A Quality Initiative in an Outpatient Oncology Clinic.

    abstract::The goal of achieving maximum productivity through process redesign and teamwork in oncology laboratory (lab) operations can be challenging in cancer care organizations. At an urban cancer center, missing lab orders occurred frequently and led to increases in lab errors, turnaround time, and patient wait times. Patien...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.571-574

    authors: Wojciechowski M,Rodts M

    更新日期:2020-10-01 00:00:00

  • Mediterranean Diet: Outcomes from an Education Session Among Patients With Cancer and Nursing Staff.

    abstract:BACKGROUND:Strong evidence supports the benefits of the Mediterranean diet, but little is reported among patients and nurses regarding knowledge about the diet and its health benefits. OBJECTIVES:A pre-/post-test practice initiative was implemented to identify level of knowledge about the Mediterranean diet in patient...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.177-185

    authors: Otten KR,Staffileno BA,Mozer M,Maidlow C

    更新日期:2020-04-01 00:00:00

  • Ovarian cancer surgery: a clinical pathway.

    abstract::Clinical pathways are useful tools in providing quality care while decreasing the cost of that care. Pathways help to facilitate managed care, identify patient and family educational needs, encourage multidisciplinary communication, and expedite patient discharge. This article discusses a clinical pathway for ovarian ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:

    authors: Tucci RA,Bartels KL

    更新日期:1998-04-01 00:00:00

  • The Role of Nursing in Preventing HPV-Related Cancers.

    abstract::Human papillomavirus (HPV) is commonly found on the cervix. However, new sites of the virus have emerged during the past 10 years, including the oropharynx in both sexes and the anus in men. According to Senkomago et al. (2019), 34,800 cancers reported annually in the United States from 2012 to 2016 were attributable ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.471

    authors: Baldwin CM

    更新日期:2020-10-01 00:00:00

  • Oncology nursing society putting evidence into practice resources: where are we now and what is next?

    abstract::Evidence-based practice can be hard to implement in the "real world" of clinical care. A set of reference cards with outcome-specific intervention options can make that practice possible. The Oncology Nursing Society Putting Evidence Into Practice (ONS PEP) resources cover 16 topics to improve care for patients with c...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/08.CJON.965-970

    authors: Doorenbos AZ,Berger AM,Brohard-Holbert C,Eaton L,Kozachik S,LoBiondo-Wood G,Mallory G,Rue T,Varricchio C

    更新日期:2008-12-01 00:00:00

  • Screening for disease: making evidence-based choices.

    abstract::Screening for illness should be an evidence-based activity. Screening tests are useful only if they reduce mortality or morbidity. Therefore, healthcare professionals must know how to evaluate research about screening tests to be sure that, in fact, the tests actually accomplish their goals. Tests that generate many f...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/06.CJON.73-76

    authors: Fields MM,Chevlen E

    更新日期:2006-02-01 00:00:00

  • Use of Exemplars: Identification of Best Practices in Cancer Prevention and Screening.

    abstract:BACKGROUND:Prevention strategies help to teach what individuals can do to potentially offset cancer risks. Screenings can detect cancer at earlier stages, allowing for earlier treatments and better outcomes. OBJECTIVES:This article seeks to identify best practices in cancer prevention and screening. METHODS:This arti...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.S2.45-48

    authors: O'Leary C

    更新日期:2020-10-01 00:00:00

  • Enteral Versus Parenteral Nutrition: Use in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation.

    abstract:BACKGROUND:Pretransplantation chemotherapy and side effects of transplantation can cause reduced oral intake, contributing to malnutrition. OBJECTIVES:The aim was to evaluate the current evidence comparing enteral nutrition (EN) to parenteral nutrition in the adult hematopoietic stem cell transplantation (HSCT) popula...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/19.CJON.173-179

    authors: Reese MK,Hewlings S

    更新日期:2019-04-01 00:00:00

  • Program preferences to reduce stress in caregivers of patients with brain tumors.

    abstract::Providing care for patients with cancer places caregivers at risk for experiencing elevated levels of stress. Caregivers of patients with brain tumors may be at increased risk because of the multifaceted needs of this patient population. As such, the authors sought to determine caregiver preferences toward various typ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/07.CJON.723-727

    authors: Swartz JJ,Keir ST

    更新日期:2007-10-01 00:00:00

  • Safe handling of hazardous drugs: are you protected?

    abstract::Oncology nurses handle hazardous drugs when they administer medications to patients in inpatient and outpatient settings. Guidelines for the safe handling of hazardous drugs have been in place since the late 1980s; however, confusion still remains about the proper handling of the substances. Institutional policies var...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/09.CJON.433-439

    authors: Nixon S,Schulmeister L

    更新日期:2009-08-01 00:00:00

  • Fertility preservation for patients with cancer.

    abstract::A key concern for young patients with cancer and survivors is the desire to parent a child. With infertility being a well-established long-term effect of many oncologic regimens, patients who want to have children often become distressed when faced with the possibility of losing their fertility. Several organizations ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/12.CJON.205-210

    authors: Kelvin JF,Kroon L,Ogle SK

    更新日期:2012-04-01 00:00:00

  • Effect of massage therapy for postsurgical mastectomy recipients.

    abstract::This quality improvement pilot study evaluated the effect of massage therapy on pain, anxiety, and overall well-being in women who received mastectomies at a busy hospital practice. Participants reported a significant reduction in pain, stress, and muscle tension, as well as an increase in relaxation. Oncology nurses ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/12.CJON.121-124

    authors: Drackley NL,Degnim AC,Jakub JW,Cutshall SM,Thomley BS,Brodt JK,Vanderlei LK,Case JK,Bungum LD,Cha SS,Bauer BA,Boughey JC

    更新日期:2012-04-01 00:00:00

  • Reevaluating the neutropenic diet: time to change.

    abstract::The neutropenic diet historically has been a mainstay in oncology practice, with many providers continuing to adhere tightly to the diet for patients with neutropenia. However, clinically sound evidence remains limited and weak and does not support the diet as a foundation for policy and practice. Therefore, two quest...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.239-241

    authors: Foster M

    更新日期:2014-04-01 00:00:00

  • The Power of 2.5 Million Words.

    abstract::Today, I am writing for the first time as the new editor of the Clinical Journal of Oncology Nursing (CJON). It is my honor to assume this role from my colleague and mentor, Deborah K. Mayer, PhD, RN, AOCN, FAAN. For eight years, Deb served as the editor of one of the most widely read journals in oncology nursing, CJO...

    journal_title:Clinical journal of oncology nursing

    pub_type: 社论

    doi:10.1188/15.CJON.387

    authors: Kennedy Sheldon L

    更新日期:2015-08-01 00:00:00

  • Helping nurses cope with grief and compassion fatigue: an educational intervention.

    abstract::Oncology nurses may experience intense physical and emotional exhaustion, identified in the literature as symptoms of cumulative grief and compassion fatigue, with significant consequences for both nurses and organizations. The first step in preventing these consequences is recognition. Organizations should provide nu...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.454-458

    authors: Houck D

    更新日期:2014-08-01 00:00:00

  • Quality of life and mood state in Iranian women post mastectomy.

    abstract::This study was conducted to examine mood state and quality of life (QOL) in patients who had undergone a mastectomy. The study used a descriptive design and was conducted in outpatient oncology clinics in northeastern Iran. Using the Profile of Mood States and the Ferrans and Powers Quality of Life Index, the mood sta...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/12.CJON.E118-E122

    authors: Tirgari B,Iranmanesh S,Fazel A,Kalantari B

    更新日期:2012-06-01 00:00:00

  • Implications of androgen-deprivation therapy in patients with prostate cancer: A case study.

    abstract::S.R., a 65-year-old male with a history of prostate cancer, went to a cancer center in 2003. He had developed symptoms of bladder outlet obstruction in 1999 and was seen by a urologist. His baseline prostate-specific antigen (PSA) was 44 ng/ml. On physical examination, his prostate was enlarged, and a biopsy in Januar...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/06.CJON.565-566

    authors: Doyle-Lindrud S

    更新日期:2006-10-01 00:00:00

  • Intralesional Therapy: Consensus Statements for Best Practices in Administration From the Melanoma Nursing Initiative
.

    abstract:BACKGROUND:Talimogene laherparepvec (T-VEC) is the first intralesional therapy for melanoma approved by the U.S. Food and Drug Administration. This oncolytic viral immunotherapy has improved outcomes for patients with locoregional recurrent melanoma and is showing promise in combination with systemic therapies. 
. OBJ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.S4.76-86

    authors: Seery V

    更新日期:2017-08-01 00:00:00

  • Radiation safety guidelines for radioimmunotherapy with yttrium 90 ibritumomab tiuxetan.

    abstract::Radioimmunotherapy is a new cancer therapy that combines the cytotoxicity of radiation with the tumor-specific targeting of monoclonal antibodies. Yttrium 90 (Y-90) ibritumomab tiuxetan (Zevalin, IDEC Pharmaceuticals Corporation, San Diego, CA) is indicated for the treatment of patients with relapsed or refractory low...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/04.CJON.31-34

    authors: Hendrix C

    更新日期:2004-02-01 00:00:00

  • Equianalgesic dosing: principles of practice for the care team.

    abstract::Opioids are the basis for managing cancer-related pain. Pain assessment and management are critical competencies for the clinical care team to improve quality of life for patients with cancer. Knowledge and application of evidence-based practice approaches to cancer pain relief, including the principles of equianalges...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.80-83

    authors: Gaguski ME,Karcheski T

    更新日期:2013-02-01 00:00:00

  • Recognizing hyperviscosity syndrome in patients with Waldenstrom macroglobulinemia.

    abstract::Hyperviscosity syndrome can develop in patients with plasma cell dyscrasias, particularly Waldenstrom macroglobulinemia (WM). Occurring in 10%-30% of patients with hyperviscosity syndrome, WM is an uncommon B-cell proliferative disorder characterized by bone marrow infiltration and production of monoclonal immunoglobu...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/07.CJON.87-95

    authors: Mullen EC,Wang M

    更新日期:2007-02-01 00:00:00