Abstract:
:Treatment with the humanized monoclonal antibody trastuzumab can significantly improve outcomes for patients with early or metastatic HER2-positive breast cancer. In a small proportion of patients, trastuzumab is associated with an increased risk of cardiac dysfunction. Although the mechanisms have yet to be fully established, trastuzumab may block HER2 signaling in cardiomyocytes, which is believed to be important for protecting the cardiomyocytes from stress such as that induced by treatment with anthracyclines. The risk of trastuzumab-associated cardiac dysfunction can be reduced if patients are evaluated thoroughly for risk factors before treatment (e.g., hypertension, low ejection fraction at onset, hyperglycemia, prior congestive heart failure). In addition, cardiac function must be assessed before and during the treatment period. If cardiac dysfunction occurs during treatment, early intervention can expand the possibilities of reinstitution of trastuzumab treatment. The integration of nonanthracycline adjuvant regimens offers opportunities for cardiac-compromised patients.
journal_name
Clin J Oncol Nursjournal_title
Clinical journal of oncology nursingauthors
Frankel Cdoi
10.1188/10.CJON.630-640subject
Has Abstractpub_date
2010-10-01 00:00:00pages
630-40issue
5eissn
1092-1095issn
1538-067Xpii
R33N773W65542502journal_volume
14pub_type
杂志文章abstract::Nearly all patients experience some degree of urinary irritative or obstructive symptoms following brachytherapy for definitive treatment of early-stage prostate cancer. The American Urological Association (AUA) Symptom Index is a tool developed to measure urinary function and can be incorporated into postoperative nu...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Exercise is widely touted as an effective intervention to optimize health and well-being after high-dose chemotherapy and hematopoietic stem cell transplantation. . OBJECTIVES:This article reports attrition, compliance, adherence, and progression from the strength training arm of the single-blind randomize...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/18.CJON.97-103
更新日期:2018-02-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.254-256
更新日期:2017-04-01 00:00:00
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journal_title:Clinical journal of oncology nursing
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更新日期:2002-03-01 00:00:00
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/15.CJON.E74-E79
更新日期:2015-08-01 00:00:00
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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更新日期:2020-10-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/20.CJON.471
更新日期:2020-10-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/08.CJON.965-970
更新日期:2008-12-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/06.CJON.73-76
更新日期:2006-02-01 00:00:00
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doi:10.1188/20.CJON.S2.45-48
更新日期:2020-10-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/19.CJON.173-179
更新日期:2019-04-01 00:00:00
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/07.CJON.723-727
更新日期:2007-10-01 00:00:00
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journal_title:Clinical journal of oncology nursing
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doi:10.1188/09.CJON.433-439
更新日期:2009-08-01 00:00:00
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journal_title:Clinical journal of oncology nursing
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更新日期:2012-04-01 00:00:00
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journal_title:Clinical journal of oncology nursing
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doi:10.1188/12.CJON.121-124
更新日期:2012-04-01 00:00:00
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pub_type: 社论
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更新日期:2015-08-01 00:00:00
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
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journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
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