Abstract:
BACKGROUND:Hematologic cancers can occur from the overactivity of Bruton's tyrosine kinase, a proto-oncogene in blood cell maturation. Ibrutinib, a new oral targeted therapy drug, is the first agent that binds to the Bruton's tyrosine kinases and inhibits overgrowth of B cells. In blocking this overgrowth, ibrutinib has been shown to achieve lengthy remissions for patients with mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). Remissions are highly valued in these cancers; cure is rare in MCL, and CLL is incurable. OBJECTIVES:This article reviews ibrutinib, its risks and benefits, and the role that oncology nurses play in educating patients and promoting drug adherence. METHODS:A comprehensive review of the literature was conducted using key words such as ibrutinib, mantle cell lymphoma, chronic lymphocytic leukemia, tyrosine kinase inhibitor, and oral chemotherapy. FINDINGS:Ibrutinib has been shown to be well tolerated, with manageable, low-grade toxicities compared to traditional cytotoxic agents. For all patients with a hematologic cancer, but particularly for the large proportion of older adults affected by hematologic malignancies, ibrutinib provides a new treatment option with a low toxicity profile.
journal_name
Clin J Oncol Nursjournal_title
Clinical journal of oncology nursingauthors
Smithson CR,Schneider SMdoi
10.1188/15.CJON.E47-E51subject
Has Abstractpub_date
2015-06-01 00:00:00pages
E47-51issue
3eissn
1092-1095issn
1538-067Xjournal_volume
19pub_type
杂志文章,评审abstract::An intervention with the Scored Patient-Generated Subjective Global Assessment was implemented at a community cancer center to identify patients with sarcoma at risk for malnutrition. This population usually is not considered to be at nutritional risk because of young age and the site of diagnosis; however, 60% of pat...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/10.CJON.375-377
更新日期:2010-06-01 00:00:00
abstract::IBC is a rare clinical occurrence. Signs and symptoms include erythema and edema of the skin. Diagnosis is made by skin biopsy. Treatment for this aggressive form of breast cancer is multimodal, including chemotherapy, surgery, radiation therapy, and hormonal therapy. Advances in treatment continue to improve prognosi...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:
更新日期:2001-07-01 00:00:00
abstract::The challenges faced in my first year as a new oncology nurse included learning the beauty of small victories and understanding loss. Family and friends often mention how sad and hard this profession is. It is hard to explain how much I love this job to those who view it as somewhat depressing. The victories are the s...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/19.CJON.112
更新日期:2019-02-01 00:00:00
abstract::The number of hematopoietic stem cell transplantations (HSCTs) performed annually is increasing. Although general survival rates have risen since 1990, mortality and morbidity from preventable complications can be improved. As a result, this article will review developments in preventing and managing infections in neu...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/11.CJON.133-139
更新日期:2011-04-01 00:00:00
abstract::Infection is among the leading causes of morbidity and mortality in patients undergoing bone marrow transplantation. Although all infections create difficulties, the most troublesome to those patients are fungal infections. Therapies used to prevent rejection and graft-versus-host disease, as well as an increase in po...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/08.CJON.108-112
更新日期:2008-02-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) have an incidence of 7-15 occurrences per million people. Tyrosine kinase inhibitors (TKIs) have significantly improved clinical outcomes as part of multidisciplinary disease management. The authors will review developments in the management of GISTs, including diagnosis, risk s...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/11.CJON.533-545
更新日期:2011-10-01 00:00:00
abstract::Increased understanding of the molecular composition of breast cancer tumors has led to the development of targeted anticancer agents. Novel therapies directed against human epidermal growth factor receptor 2 (HER2) in breast cancer have been developed. One such agent, trastuzumab emtansine (T-DM1), is an antibody dru...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/13.CJON.E58-E62
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Women receiving radiation to the breast will likely be recommended to use a topical cream to minimize and delay the development of radiation dermatitis. Although many topical products are commercially available and have been tested for safety and efficacy, few studies have compared various products to one an...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/15.CJON.451-455
更新日期:2015-08-01 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is the most commonly diagnosed form of leukemia in the Western world, accounting for approximately 20%-30% of all cases of leukemia. Despite recent medical and scientific advances, the literature on the subjective experience and nursing care of patients diagnosed with CLL remains sca...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/08.CJON.417-423
更新日期:2008-06-01 00:00:00
abstract::Malignant melanoma, the least common but most serious form of skin cancer, is increasing at a faster rate than any other form of cancer. Early diagnosis can lead to cures through surgery alone. Patients with deeper primary lesions (greater than 4 mm) or regional lymph node involvement have a high risk of relapse. High...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::Smoking cessation remains a high priority in oncology nursing practice. That priority gained additional visibility in 2014 when the Oncology Nursing Society (ONS) endorsed the tobacco position statement of the International Society of Nurses in Cancer Care, emphasizing the potential for nurses to reduce adult and yout...
journal_title:Clinical journal of oncology nursing
pub_type: 社论
doi:10.1188/18.CJON.243-244
更新日期:2018-06-01 00:00:00
abstract::T.J.'s case was interesting from the standpoint of both diagnosis and management. The recommended treatment for this drug reaction was prednisone: however, the use of a steroid in a patient who is neutropenic and has a fever is risky because the because the steroid can mask the symptoms of infection (e.g., fever). Ad...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Since the completion of the Human Genome Project in 2003, the implications of genetics and genomics for health and illness have become clearer. All nurses, at all levels and across all specialties, must have a basic understanding of genetics and genomics to provide appropriate care. . OBJECTIVES:This artic...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/17.CJON.747-753
更新日期:2017-12-01 00:00:00
abstract::Communication skills are the cornerstone of the patient-provider relationship in cancer care. Lack of these skills can diminish patient disclosure, increase patient anxiety, and decrease satisfaction with care. The purpose of this article is to evaluate the literature regarding the efficacy and outcomes of communicati...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/05.CJON.305-312
更新日期:2005-06-01 00:00:00
abstract::Ethical challenges are inherent in oncology clinical practice. Ranging from transitions in care to code status and treatment decisions, these ethical challenges can have an acute effect on nurses, with well-established connections to moral distress and other psycho-emotional sequelae. The availability of a nurse ethic...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/19.CJON.103-107
更新日期:2019-02-01 00:00:00
abstract::The blood-brain barrier (BBB) is a physiologic barrier that protects the brain from toxic substances, including most of the chemotherapeutic agents used today. The BBB may be partly responsible for the poor efficacy of chemotherapy for malignant primary or metastatic brain tumors. A technique of osmotic modification o...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/04.CJON.263-267
更新日期:2004-06-01 00:00:00
abstract::Providing care for patients with cancer places caregivers at risk for experiencing elevated levels of stress. Caregivers of patients with brain tumors may be at increased risk because of the multifaceted needs of this patient population. As such, the authors sought to determine caregiver preferences toward various typ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/07.CJON.723-727
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:In the environment of an infectious pandemic, vaccines are a primary public health strategy to prevent the spread of disease. With the COVID-19 pandemic, there is heightened interest in safe and effective vaccines and their use in the context of clinical oncology practice. OBJECTIVES:This article provides f...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/21.CJON.76-84
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Cancer-related pain is a major health problem because of its magnitude, the subjective nature of the pain experience, and the complexity of the disease, making it difficult to assess and control. When assessment is not performed, poor pain control can result. . OBJECTIVES:This article provides an overview o...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/17.CJON.S3.8-12
更新日期:2017-06-01 00:00:00
abstract::This study was conducted to examine mood state and quality of life (QOL) in patients who had undergone a mastectomy. The study used a descriptive design and was conducted in outpatient oncology clinics in northeastern Iran. Using the Profile of Mood States and the Ferrans and Powers Quality of Life Index, the mood sta...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/12.CJON.E118-E122
更新日期:2012-06-01 00:00:00
abstract::Knowing the differences and potential benefits of hospice and palliative care can help healthcare professionals advocate for their patients and make proactive decisions about patient care. Providing admission into the appropriate program can facilitate symptom management and impart the best quality of life possible fo...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/10.CJON.273-275
更新日期:2010-06-01 00:00:00
abstract::Checkpoint inhibitors are a form of immunotherapy that have revolutionized treatment for malignant melanoma, resulting in longer survival and better disease control. Multiple autoimmune disorders can occur with the use of checkpoint inhibitors, including severe, potentially fatal neurologic complications. Although neu...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/19.CJON.355-358
更新日期:2019-08-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) ranks as the eighth most common cancer in the world. Although uncommon in North America, the incidence of HCC in the United States has increased by 70% since the 1980s (Yu, Yuan, Govindarajan, & Ross, 2000). The most frequent causes of malignant hepatic disease in the United States are m...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/03.CJON.647-652
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Hematopoietic stem cell transplantation (HCT) is a complicated treatment modality used to address hematologic malignancies and other disorders. The complex care of patients undergoing HCT places them at high risk for poor outcomes during times of transition. Education is a critical component of preparing pat...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/15.CJON.E74-E79
更新日期:2015-08-01 00:00:00
abstract::You may have heard of the National Cancer Moonshot Initiative led by former Vice President Joe Biden. It has brought together many people through a task force, blue ribbon panel, and many public forums to discuss how best "to dramatically accelerate efforts to prevent, diagnose, and treat cancer - to achieve a decade'...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.141-142
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Exercise is widely touted as an effective intervention to optimize health and well-being after high-dose chemotherapy and hematopoietic stem cell transplantation. . OBJECTIVES:This article reports attrition, compliance, adherence, and progression from the strength training arm of the single-blind randomize...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/18.CJON.97-103
更新日期:2018-02-01 00:00:00
abstract::Cancer-related lymphedema is a progressive and chronic syndrome of abnormal swelling and multiple symptoms resulting from cancer treatment. Even with modern medical advances, lymphedema remains a major health problem affecting thousands of cancer survivors. To provide healthcare professionals with evidence-based clini...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/14.CJON.S3.68-79
更新日期:2014-01-01 00:00:00
abstract::Palliative care has become an essential component of oncology care, with a focus on maximizing quality of life and optimizing function, as well as promoting pain and symptom management. This article focuses on the care of a patient experiencing bowel obstruction and delirium, two common issues in patients with advance...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/12.CJON.391-398
更新日期:2012-08-01 00:00:00
abstract::Pancreatic neuroendocrine tumors (pNETs), an uncommon finding, are distinct from pancreatic carcinomas. When pNETs are unresectable and progressive, visceral pain often presents and is challenging to treat. Opioids commonly used for pain control are difficult to implement in this setting because of adverse side effect...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/11.CJON.218-220
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Chimeric antigen receptor (CAR) T-cell therapy program development has regulatory demands and unique operational processes that vary across settings. The infrastructure in which CAR T-cell therapy is implemented has implications for nursing education and competencies. OBJECTIVES:This article presents an ove...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/19.CJON.S1.20-26
更新日期:2019-04-01 00:00:00