Abstract:
:Chronic myelogenous leukemia (CML) represents about 14% of all leukemias and occurs with a frequency of about 1 in 100,000. It is rare in children. Symptoms include fatigue, weight loss, sweating, and abdominal discomfort from an enlarged spleen. The white blood cell count can range from 100-600 ul. CML has three phases: the chronic phase, accelerated phase, and blast phase. Most patients are diagnosed during the chronic phase. Ionizing radiation has been implicated in some cases of CML, but in most individuals no cause is known. The Philadelphia chromosome, an acquired genetic mutation represented by a translocation of chromosome 22 and chromosome 9, drives the leukemic changes in CML. Imatinib mesylate, a tyrosine kinase inhibitor, was approved in 2002 for the treatment of all phases of CML. Because of its effectiveness, imatinib has become the treatment of choice for most patients with CML. Stem cell transplantation also is an option for eligible patients. It is the only curative treatment for CML. Two drugs under study for patients who cannot tolerate or who become resistant to imatinib are BMS-354825 and AMN107. Oncology nurses who are knowledgeable about new therapies for CML can be effective resources for their patients.
journal_name
Clin J Oncol Nursjournal_title
Clinical journal of oncology nursingauthors
D'Antonio Jdoi
10.1188/05.CJON.535-538subject
Has Abstractpub_date
2005-10-01 00:00:00pages
535-8issue
5eissn
1092-1095issn
1538-067Xjournal_volume
9pub_type
杂志文章,评审abstract:BACKGROUND:Hematopoietic stem cell transplantation (HCT) is a complicated treatment modality used to address hematologic malignancies and other disorders. The complex care of patients undergoing HCT places them at high risk for poor outcomes during times of transition. Education is a critical component of preparing pat...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/15.CJON.E74-E79
更新日期:2015-08-01 00:00:00
abstract::Older patients with cancer who may be more susceptible than younger patients to the myelosuppressive effects of chemotherapy undergo dose delays and reductions that can compromise treatment outcomes. Incidence of neutropenic complications and suboptimal chemotherapy delivery can be reduced with prophylactic colony-sti...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1188/10.CJON.81-86
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The use of theory can provide structure for understanding the dynamics of adherence to oral agents for cancer (OACs) and facilitate the development of strategies for patient assessment and care planning related to oral adherence. OBJECTIVES:The focus of this article is to identify common theories pertinent ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/15.S1.CJON.31-35
更新日期:2015-06-01 00:00:00
abstract::The oncology practice setting can be a highly emotional workplace because nurses provide care to many of the same patients and their families over time. Comparing and contrasting nurses from different clinical settings would provide insight into the more common themes of nursing grief and might give guidance on how to...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/09.CJON.625-627
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:New administrative requirements to provide assessment and treatment for distress in patients with cancer, as well as concern for positive patient outcomes, highlight oncology practitioners' need for a high-quality distress management program. OBJECTIVES:Researchers designed, developed, implemented, and eval...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/16.CJON.E9-E15
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Transitions from acute clinical care to the outpatient setting can be daunting. Clear explanations of discharge instructions from nurses and assessment of the patient's understanding can have a positive impact. OBJECTIVES:The purpose of this study was to assess the effect of an education intervention on nur...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/19.CJON.288-294
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Financial toxicity causes significant psychological and practical distress for patients and can affect their ability and willingness to undertake optimal treatment. Although different models of financial support are typically available to patients undergoing cancer treatments, not all models can offer equal ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/19.CJON.S2.14-18
更新日期:2019-10-01 00:00:00
abstract::Patients with cancer have an increased risk of thromboembolism. This complication is connected to a variety of different factors and is influenced by the conditions described in Virchow's triad: stasis, vascular endothelial damage, and hypercoagulability. Once thromboembolism is diagnosed, treatment in patients with c...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/04.CJON.465-469
更新日期:2004-10-01 00:00:00
abstract::I recently earned my baccalaureate nursing degree and passed the nursing boards. Soon, I hope to practice as a clinical oncology nurse. As a new RN, I frequently reflect on the people and situations that have influenced my growth so far as a nurse. I have been fortunate to work with many clinical mentors who have been...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/18.CJON.120
更新日期:2018-02-01 00:00:00
abstract::Patients with cancer are often dependent on blood transfusions during treatment. Frequent vital sign monitoring during transfusions may interrupt sleep and the patient's ability to ambulate or participate in unit activities. Relying heavily on vital sign findings may also overshadow unmeasurable symptoms of transfusio...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/15.CJON.516-520
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Although guidelines for the safe handling of hazardous drugs (HDs) have existed for several decades, they have not been enforceable by state or federal agencies. USP <800>, the latest chapter issued by the U.S. Pharmacopeial Convention, expands on existing guidelines and provides detailed information on comp...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/17.CJON.179-187
更新日期:2017-04-01 00:00:00
abstract::Palliative care as a foundation for patient-centered care is not adequately covered in nursing curricula. This gap in education means that pediatric oncology nurses may lack necessary palliative care competencies to provide comprehensive care to patients. A literature review was performed to determine if nurses believ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/19.CJON.565-568
更新日期:2019-12-01 00:00:00
abstract::Most nurses agree that incorporating evidence into practice is necessary to provide quality care, but barriers such as time, resources, and knowledge often interfere with the actual implementation of practice change. Published practice guidelines are one source to direct practice; this article focuses on the use of th...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/07.CJON.817-821
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Hematologic cancers can occur from the overactivity of Bruton's tyrosine kinase, a proto-oncogene in blood cell maturation. Ibrutinib, a new oral targeted therapy drug, is the first agent that binds to the Bruton's tyrosine kinases and inhibits overgrowth of B cells. In blocking this overgrowth, ibrutinib ha...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/15.CJON.E47-E51
更新日期:2015-06-01 00:00:00
abstract::IBC is a rare clinical occurrence. Signs and symptoms include erythema and edema of the skin. Diagnosis is made by skin biopsy. Treatment for this aggressive form of breast cancer is multimodal, including chemotherapy, surgery, radiation therapy, and hormonal therapy. Advances in treatment continue to improve prognosi...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:
更新日期:2001-07-01 00:00:00
abstract::Half of all patients with cancer experience some level of pain, so pain management is an important topic for oncology nurses. Pharmacologic measures traditionally are the primary intervention for bone, visceral, neuropathic, and procedural pain; however, many patients are turning to an integrative approach of Western ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/11.CJON.374-379
更新日期:2011-08-01 00:00:00
abstract::Oncology nurses have a critical role in mitigating the intense vulnerability, loss of control, and fear of the unknown that characterizes the experiences of patients with cancer and their family members. Reliably inquiring about the issues that are at the forefront for patients and their loved ones can encourage a dee...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/16.CJON.20-22
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Many patients with incurable cancer do not accurately understand their prognosis, which can lead to aggressive and, often, futile treatment. Improved prognostic awareness can help patients to appropriately de-escalate aggressive treatment sooner in an illness trajectory. OBJECTIVES:The purpose of this artic...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/16.CJON.385-390
更新日期:2016-08-01 00:00:00
abstract::Taxane-induced peripheral neuropathy (TIPN) affects a number of patients with breast cancer. To properly manage these patients, nurses must be able to identify and assess TIPN, as well as educate patients on TIPN as a side effect of taxane therapy. This article provides practical suggestions regarding how nurses can i...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/13.CJON.S1.22-34
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Sipuleucel-T, an autologous cellular immunotherapy, is approved for the treatment of certain patients with metastatic castration-resistant prostate cancer (mCRPC). Sipuleucel-T is the first personalized treatment for prostate cancer to be manufactured using the immune system of each individual patient. Patie...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/15.CJON.297-303
更新日期:2015-06-01 00:00:00
abstract::Central venous access plays an important role in modern medical patient assessment and treatment. The use of central venous access devices has become routine in the oncology setting. Clinical oncology nurses need to know how the devices function, how to provide proper care, and how to manage potential side effects. Th...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/07.CJON.485-488
更新日期:2007-08-01 00:00:00
abstract::As the trend of surgical procedures shifting from inpatient to outpatient settings continues, outpatient-focused standardized care processes will become more of a necessity. A multidisciplinary critical pathway (CP) for breast cancer surgery can assist care providers in meeting patients' educational and psychosocial n...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:A cancer diagnosis is a serious stressor that is associated with anxiety, depression, sleep disorders, and inability to fulfill daily routines. Many pharmacologic and nonpharmacologic options are available to help patients with cancer manage anxiety. OBJECTIVES:This randomized, controlled trial examined the...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,随机对照试验
doi:10.1188/18.CJON.203-210
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The concept of transitional care and the methods and processes to efficiently and effectively transition patients between a variety of care settings remains a continuous healthcare goal. Despite the numerous transitional care models that have been developed and implemented in a myriad of healthcare settings,...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/18.CJON.S2.37-41
更新日期:2018-12-01 00:00:00
abstract::To assess the effectiveness of multidimensional rehabilitation programs (MDRPs) in terms of maintaining or improving the physical and psychosocial well-being of adult cancer survivors. ...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/14.CJON.722-723
更新日期:2014-12-01 00:00:00
abstract::An intervention with the Scored Patient-Generated Subjective Global Assessment was implemented at a community cancer center to identify patients with sarcoma at risk for malnutrition. This population usually is not considered to be at nutritional risk because of young age and the site of diagnosis; however, 60% of pat...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/10.CJON.375-377
更新日期:2010-06-01 00:00:00
abstract::Pancreatic neuroendocrine tumors (pNETs), an uncommon finding, are distinct from pancreatic carcinomas. When pNETs are unresectable and progressive, visceral pain often presents and is challenging to treat. Opioids commonly used for pain control are difficult to implement in this setting because of adverse side effect...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/11.CJON.218-220
更新日期:2011-04-01 00:00:00
abstract::Palliative care has become an essential component of oncology care, with a focus on maximizing quality of life and optimizing function, as well as promoting pain and symptom management. This article focuses on the care of a patient experiencing bowel obstruction and delirium, two common issues in patients with advance...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章,评审
doi:10.1188/12.CJON.391-398
更新日期:2012-08-01 00:00:00
abstract::Ribavirin is used in the treatment of respiratory syncytial virus (RSV) in high-risk patients, including patients who have undergone hematopoietic stem cell transplantation, to reduce mortality from RSV pneumonia. It is classified as a hazardous drug with potential for carcinogenicity and teratogenicity. Very few rece...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:10.1188/14.CJON.E93-E96
更新日期:2014-10-01 00:00:00
abstract::T.J.'s case was interesting from the standpoint of both diagnosis and management. The recommended treatment for this drug reaction was prednisone: however, the use of a steroid in a patient who is neutropenic and has a fever is risky because the because the steroid can mask the symptoms of infection (e.g., fever). Ad...
journal_title:Clinical journal of oncology nursing
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00