Abstract:
:The levels of several soluble cytokine receptors in body fluids of healthy individuals change with age. Clinical application of the measurement of the serum soluble interleukin-1 receptor type I (sIL-1RI) level depends critically on the samples used as the controls. At present, there is no information regarding the levels of serum sIL-1RI in healthy subjects. The purpose of this study is to reveal the age-related changes that occur in the serum sIL-1RIlevels of healthy individuals. We determined the serum sIL-1RI levels of healthy Japanese children using ELISA. The serum sIL-1RI level of children (0-14 years) was significantly higher than that of adults (more than 15 years) (P = 0.0138, n = 90). Thus, it is recommended that when the serum sIL-1RI level of patients is evaluated, it should be compared against age-matched controls.
journal_name
J Clin Lab Analjournal_title
Journal of clinical laboratory analysisauthors
Okamoto Y,Tanaka M,Miyahara N,Tanabe M,Gotoh Y,Nagai T,Fujita N,Fukui T,Masuzawa Tdoi
10.1002/jcla.20315subject
Has Abstractpub_date
2009-01-01 00:00:00pages
175-8issue
3eissn
0887-8013issn
1098-2825journal_volume
23pub_type
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journal_title:Journal of clinical laboratory analysis
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