Importance of detecting multidrug resistance proteins in acute leukemia prognosis and therapy.

Abstract:

:Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice of therapy. Literature showed that the detection of these proteins, mainly ABCB1, is important in the AL prognosis. However, there is controversy regarding the methodology used for their detection. In summary, the expression and activity profiles of ABCB1, ABCC1, and LRP, proteins capable of promoting the efflux of a variety of chemotherapeutic agents from the cell cytoplasm represent one of the greatest causes of failure in AL treatment.

journal_name

J Clin Lab Anal

authors

de Moraes AC,Maranho CK,Rauber GS,Santos-Silva MC

doi

10.1002/jcla.21563

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

62-71

issue

1

eissn

0887-8013

issn

1098-2825

journal_volume

27

pub_type

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