Abstract：
BACKGROUND:The cerebral perfusion pressure that denotes the lower limit of cerebral blood flow autoregulation (LLA) is generally considered to be equivalent for reductions in arterial blood pressure (ABP) or increases in intracranial pressure (ICP). However, the effect of decreasing ABP at different levels of ICP has not been well studied. Our objective in the present study was to determine if the LLA during arterial hypotension was invariant with ICP. METHODS:Using continuous ventricular fluid infusion, anesthetized piglets were assigned to 1 of 3 groups: naïve ICP (n = 10), moderately elevated ICP (20 mm Hg; n = 11), or severely elevated ICP (40 mm Hg; n = 9). Gradual hypotension was induced by inflation of a balloon catheter in the inferior vena cava. The LLA was determined by monitoring cortical laser-Doppler flux. RESULTS:The naïve ICP group had an average CPP at the LLA (LLA(CPP)) of 29.8 mm Hg (95% CI: 26.5-33.0 mm Hg). However, the moderately elevated ICP group had a mean LLA(CPP) of 37.6 mm Hg (95% CI: 32.0-43.2 mm Hg), and the severely elevated ICP group had a mean LLA(CPP) of 51.4 mm Hg (95% CI: 41.2-61.7 mm Hg). The LLA significantly differed among groups, and the increase in LLA correlated with the increase in ICP. CONCLUSIONS:In this atraumatic, elevated ICP model in piglets, the LLA had a positive correlation with ICP, which suggests that compensating for an acute increase in ICP with an equal increase in ABP may not be sufficient to prevent cerebral ischemia.
journal_name
Anesth Analgjournal_title
Anesthesia and analgesiaauthors
Brady KM,Lee JK,Kibler KK,Easley RB,Koehler RC,Czosnyka M,Smielewski P,Shaffner DHdoi
10.1213/ane.0b013e3181964848subject
Has Abstractpub_date
2009-04-01 00:00:00pages
1278-83issue
4eissn
0003-2999issn
1526-7598pii
108/4/1278journal_volume
108pub_type
杂志文章abstract：:Fetal cocaine exposure has been associated with a variety of cardiovascular dysfunctions in humans. We treated pregnant rats with either saline or cocaine at 60 mg/kg by gastric lavage for the entire gestational period and for 14 days after parturition. We then performed high-frequency transthoracic echocardiography t...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/01.ane.0000074792.87311.db
更新日期：2003-09-01 00:00:00
abstract：UNLABELLED:Propofol and alfentanil are both rapid and short-acting drugs that can be used for sedation and analgesia during monitored anesthesia care (MAC). This study was designed to determine the optimal infusion rates of propofol and alfentanil when administered during local anesthesia. In this randomized, double-bl...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199709000-00015
更新日期：1997-09-01 00:00:00
abstract：:The protective effect of a nonionic surface-active polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studied in 21 dogs anesthetized with pentobarbital. Aortic, pulmonary artery and right ventricular pressures, cardiac output, end-tidal CO2 concentration, wasted ventilation,...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-197511000-00030
更新日期：1975-11-01 00:00:00
abstract：UNLABELLED:We conducted this retrospective study to document the efficacy and safety, and demonstrate the spectrum of indications for subcutaneously tunneled epidural catheters in the management of prolonged pain in pediatric patients. The charts of 25 patients with prolonged pain that was unresponsive to conventional ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-200106000-00016
更新日期：2001-06-01 00:00:00
abstract：:Combinations of benzodiazepines (midazolam and diazepam) with barbiturates (pentobarbital and phenobarbital) exhibit synergistic (supra-additive) hypnotic interactions in rats. Because both benzodiazepines and barbiturates interact with the gamma-aminobutyric acidA (GABAA) receptor complex, we have tested the hypothes...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-199309000-00030
更新日期：1993-09-01 00:00:00
abstract：:Elevated serum ammonia may play a role in central nervous system derangement after transurethral resection of the prostate. Glycine used as a surgical irrigant for prostate resection produces ammonia as a by-product after liver and renal metabolism. The presence of liver dysfunction often leads to an inability to remo...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：UNLABELLED:In this retrospective cohort study, we compared adverse cardiac outcomes after noncardiac surgery among patients with prior percutaneous transluminal coronary angioplasty (PTCA), patients with nonrevascularized coronary artery disease (CAD), and normal controls. Inpatient hospital discharge abstracts from al...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199909000-00003
更新日期：1999-09-01 00:00:00
abstract：:Large doses of morphine sulfate have been reported to cause myocardial lactate production and reduction in coronary blood flow in animals. Similar effects with clinical doses in man would significantly alter the management of cardiac patients. Eleven adult patients with significant coronary arterial disease and normal...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1982-02-01 00:00:00
abstract：:We evaluated the effects of adding clonidine for continuous peripheral nerve infusions. Sixty patients undergoing total knee arthroplasty under combined single-injection sciatic block and continuous femoral infusion were randomly allocated to three groups: block induction with 0.75% ropivacaine followed by 0.2% ropiva...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1213/01.ANE.0000143952.75985.8F
更新日期：2005-03-01 00:00:00
abstract：UNLABELLED:With the development of new computer-assisted target-controlled infusion (TCI) systems and the availability of short-acting anesthetics, total IV anesthesia (TIVA) has become increasingly popular. The aim of this study was to compare costs of TCI-based anesthesia with two standard anesthesia regimens. Sixty ...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验,收录出版
doi：10.1097/00000539-199901000-00015
更新日期：1999-01-01 00:00:00
abstract：:Nicardipine is used in the treatment of premature labor. There are no previous reports in the anesthesia literature of serious side effects associated with this drug. We report a case of pulmonary edema induced by nicardipine therapy for tocolysis in a pregnant 27-yr-old patient admitted to our hospital for preterm la...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/01.ANE.0000135182.79774.A0
更新日期：2004-09-01 00:00:00
abstract：:A randomized double-blind study was conducted in 50 orthopedic patients to determine the effect of epinephrine and phenylephrine on the anesthetic properties of intrathecally administered tetracaine. Two doses of each vasoconstrictor agent were studied: 0.2 mg of epinephrine, 0.3 mg of epinephrine, 1 mg of phenylephri...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1984-02-01 00:00:00
abstract：:The purpose of this study was to compare meperidine to meperidine with bupivacaine when used for patient-controlled epidural analgesia (PCEA) after thoracotomy. For 3 days after thoracotomy patients received thoracic PCEA with meperidine 0.1% plain or with added bupivacaine 0.1% or 0.01%. No background infusion was us...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199607000-00014
更新日期：1996-07-01 00:00:00
abstract：UNLABELLED:Inhaled nitric oxide (iNO) is superior to i.v. vasodilators for treatment of pulmonary hypertension (PH) after cardiac surgery, but iNO is a potentially toxic gas, and patient subsets who benefit from iNO are not yet clearly defined. We administered iNO 40 ppm, prostaglandin E1 (PGE1) 0.1 microg x kg(-1) min...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-11-01 00:00:00
abstract：BACKGROUND:Musculoskeletal deformities in mucopolysaccharidoses (MPSs) patients pose unique challenges when patients present for surgery, especially nonspinal surgery. MPS patients have developed postsurgical neurological deficits after nonspinal surgery. While the incidence of neurological deficits after nonspinal sur...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000004215
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Cannabinoid agonists induce norepinephrine release in central, spinal, and peripheral sites. Previous studies suggest an interaction between the cannabinoid and adrenergic systems on antinociception. In this study, we sought to verify whether the CB1 and CB2 cannabinoid receptor agonists anandamide and N-pal...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0b013e3182707859
更新日期：2013-02-01 00:00:00
abstract：UNLABELLED:Tropisetron is a 5-hydroxytryptamine subtype 3 receptor antagonist that is primarily used in the prevention of chemotherapy-induced nausea and vomiting. We evaluated the prophylactic effect of tropisetron on postoperative nausea and vomiting associated with epidural morphine. Dexamethasone and saline served ...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-200203000-00050
更新日期：2002-03-01 00:00:00
abstract：:Nitrous oxide increases peripheral vascular tone in animals and humans and constricts epicardial coronary arteries in dogs. Current studies sought both to determine whether nitrous oxide caused epicardial coronary artery constriction in a second animal species, pigs, and to investigate mechanisms. Left anterior descen...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-199308000-00005
更新日期：1993-08-01 00:00:00
abstract：:To compare the dose-response of remifentanil for tracheal intubation in infants and children, 32 healthy full-term infants and 32 children were anesthetized with 10 mug/kg glycopyrrolate and 4.0 mg/kg propofol and administered 1 of 4 doses of remifentanil (1.25, 1.50, 1.75, or 2.00 microg/kg) to facilitate tracheal in...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1213/01.ANE.0000150940.57369.B5
更新日期：2005-06-01 00:00:00
abstract：:The existence of a dose-response relation between nitrous oxide concentration and regional dysfunction in compromised myocardium, and whether or not halothane-induced myocardial depression alleviated this regional dysfunction was examined. Nitrous oxide was administered to eight dogs with experimentally induced left a...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:Current guidelines from the American College of Obstetricians and Gynecologists recommend antibiotic prophylaxis for cesarean delivery immediately before incision. The purpose of this study was to measure and describe correlates of adherence to these guidelines in a sample of United States anesthesiologists....
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,随机对照试验
doi：10.1213/ANE.0b013e318276cf72
更新日期：2013-03-01 00:00:00
abstract：:The purpose of the present study was to assess patients' anxiety level and information requirement in the preoperative phase. During routine preoperative screening, 320 patients were asked to assess their anxiety and information requirement on a six-item questionnaire, the Amsterdam Preoperative Anxiety and Informatio...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199603000-00002
更新日期：1996-03-01 00:00:00
abstract：:We have recently reported a chronic allodynialike symptom in rats after ischemic spinal cord injury. This pain-related behavior is resistant to a number of pharmacologic treatments, including morphine, clonidine, carbamazepine, baclofen, and muscimol. In the present report, we present evidence indicating that systemic...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-199205000-00005
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:We hypothesized that, compared to remifentanil, dexmedetomidine used for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) performed under monitored anesthesia care (MAC) in nonintubated patients would result in fewer episodes of major respiratory adverse events (number of episodes...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,随机对照试验
doi：10.1213/ANE.0000000000003633
更新日期：2019-01-01 00:00:00
abstract：:Bolus doses of propofol in patients for cardioversion often produce hypotension and apnea. Etomidate provides cardiovascular stability in these patients, but myoclonus may interfere with electrocardiographic interpretation. This study was designed to demonstrate whether propofol, when given as a low-dose infusion, can...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1213/00000539-199310000-00006
更新日期：1993-10-01 00:00:00
abstract：:Artificial intelligence-driven anesthesiology and perioperative care may just be around the corner. However, its promises of improved safety and patient outcomes can only become a reality if we take the time to examine its technical, ethical, and moral implications. The aim of perioperative medicine is to diagnose, tr...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,评审
doi：10.1213/ANE.0000000000004728
更新日期：2020-05-01 00:00:00
abstract：:Ketamine has many neuromuscular effects in vitro. Its neuromuscular effects in vivo have been controversial and inconsistent. To systematically examine its neuromuscular effects over a wide dose range and its interaction with all popular nondepolarizing neuromuscular relaxants, the effects of ketamine 2, 5, and 10 mg/...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Halothane, enflurane, isoflurane, and fentanyl were examined for their potential to exacerbate liver dysfunction in rats with preexisting cirrhosis. Male Wistar rats given sodium phenobarbital for 2 weeks are assigned randomly to two groups. One group (cirrhotic) was exposed by inhalation to carbon tetrachloride (CCl4...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：UNLABELLED:In the present study, we examined whether preincisional treatment with dextromethorphan (DM) provides preemptive analgesia. Ninety patients scheduled for laparoscopic cholecystectomy were included. Patients receiving chlorpheniramine maleate (CPM) 20 mg via an IM injection 30 min before skin incision were de...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199906000-00025
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:We determined whether whole blood impedance aggregometry using the Multiplate detects the effects of antiplatelet drugs as reliably as does classical light transmission aggregometry (LTA) or the platelet function analyzer PFA-100(R). METHODS:Multiplate (M) assays, measuring changes in electrical resistance ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ane.0b013e31818524c1
更新日期：2008-12-01 00:00:00
