Abstract:
:Protein C inhibitor (PCI) is a versatile serine protease inhibitor with both pro- and anticoagulant and other properties. Interactions of certain ligands with PCI, including heparin, affect its specificity for proteases. In this study, heparin was found to enhance PCI inhibition of factor Xa up to 42-fold in the presence of a physiological Ca(2+) concentration, whereas no heparin-induced activation was observed in the absence of Ca(2+). These results thus show that factor Xa adds to the group of proteases whose inhibition by PCI is enhanced by heparin and that such inhibition contributes to the anticoagulant properties of PCI by a Ca(2+)-dependent mechanism.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Sun W,Eriksson AS,Schedin-Weiss Sdoi
10.1021/bi802138msubject
Has Abstractpub_date
2009-02-10 00:00:00pages
1094-8issue
5eissn
0006-2960issn
1520-4995pii
10.1021/bi802138mjournal_volume
48pub_type
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