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A simple synthesis of four stereoisomers of roseoside and their inhibitory activity on leukotriene release from mice bone marrow-derived cultured mast cells.

Abstract：

:Four stereoisomers of roseoside (vomifoliol glucosides) were synthesized using glucose as a chiral resolving reagent. The four synthetic stereoisomers exhibited inhibitory activity on leukotriene release from mouse bone marrow-derived cultured mast cells (BMCMC). The (6S)-isomers of roseoside were about twice as active as (6R)-isomers.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Yajima A,Oono Y,Nakagawa R,Nukada T,Yabuta G

doi

10.1016/j.bmc.2008.11.002

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

189-94

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)01061-4

journal_volume

17

pub_type

杂志文章

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