Abstract：
PURPOSE:To determine if a positive response of macular cysts to treatment with dorzolamide eye drops in patients with juvenile X-linked retinoschisis (XLRS) can occur with mutations that result in different types of retinoschisin protein dysfunction. DESIGN:Retrospective case series. METHODS:Thirteen eyes of seven patients seen at the University of Illinois at Chicago with a known diagnosis of XLRS were included. Each patient had received or currently was receiving treatment with topical dorzolamide. One patient from each family was screened for a genetic mutation. Using the method of cell transfection and protein preparation, the mutation in each patient was analyzed further and was categorized into one of three groups: 1) total absence of retinoschisin protein secretion, 2) decreased expression of the secreted protein, or 3) secretion of a nonfunctional protein. The response to dorzolamide was observed using optical coherence tomography. RESULTS:Significant improvement in the foveal zone thickness was observed with the use of dorzolamide in three of four patients with absence of protein secretion, in two patients with a lack of protein expression, and in one patient with a nonfunctional protein secretion. CONCLUSIONS:This study showed that the response of macular cysts to dorzolamide in patients with XLRS may be observed independent of the mechanism responsible for retinoschisin protein dysfunction. Hence, treatment with dorzolamide may be effective in patients with different mechanisms of dysfunction in retinoschisin.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Walia S,Fishman GA,Molday RS,Dyka FM,Kumar NM,Ehlinger MA,Stone EMdoi
10.1016/j.ajo.2008.07.041subject
Has Abstractpub_date
2009-01-01 00:00:00pages
111-115.e1issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(08)00609-0journal_volume
147pub_type
杂志文章abstract：:Ciprofloxacin is a potent fluoroquinolone antibiotic with in vitro activity against many significant gram-positive and gram-negative ocular pathogens. A review of the experimental studies of this antibiotic shows bactericidal activity, a broad antimicrobial spectrum, and a low incidence of resistance. The growing body...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：
更新日期：1991-10-01 00:00:00
abstract：PURPOSE:To assess whether alcohol consumption is associated with the long-term incidence of cataract or cataract surgery. DESIGN:Population-based prospective cohort study. METHODS:A total of 3654 persons aged 49+ years were examined at baseline and 2564 were re-examined after 5 and/or 10 years. Lens photographs were ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.04.020
更新日期：2010-09-01 00:00:00
abstract：:The in vivo sites of the blood-aqueous barrier were determined in five animal species, using acriflavine neutral (224 mol. wt.), ultrafreezing and drying, fluorescence microscopy, and fluorometry. Not toxic, acriflavine had specific in vivo affinity for nuclear DNA and RNA, produced intense fluorescence, and did not p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90405-5
更新日期：1975-10-01 00:00:00
abstract：:We used a handheld disposable cautery for the diagnostic scraping of corneal ulcers. Sterility of the tip is obtained by activating the unit until the tip reaches a red-hot color and then allowing it to cool. The unit has a sturdy, well-defined tip, and is self-sterilizing, reusable, readily available, and simple to u...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75086-x
更新日期：1980-07-01 00:00:00
abstract：PURPOSE:To review the evolution of the understanding of diabetic retinopathy (DR) and methods of treating DR, the present clinically relevant practice for eye disease in patients with diabetes mellitus, and trends in clinical patient care over the next 3 to 5 years. DESIGN:Tabular review and presentation of clinical t...
journal_title：American journal of ophthalmology
pub_type： 社论,评审
doi：10.1016/s0002-9394(03)00219-8
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:To investigate the prevalence of peripheral pigmented retinal lesions and associated clinical findings in patients with Stargardt disease. DESIGN:Retrospective case series. METHODS:Records at a single academic institution were reviewed for patients with genetically confirmed Stargardt disease with peripheral ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.12.011
更新日期：2018-04-01 00:00:00
abstract：PURPOSE/METHODS:We examined a patient with progressive outer retinal necrosis, which is presumably caused by the varicella-zoster virus in patients with the acquired immunodeficiency syndrome. RESULTS/CONCLUSIONS:The patient was successfully treated with a combination of intravitreal ganciclovir and oral sorivudine. T...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71242-5
更新日期：1995-04-01 00:00:00
abstract：PURPOSE:To report a patient with unilateral vision loss and neovascular glaucoma after attempted superior ophthalmic vein embolization in the treatment of a carotid-cavernous sinus fistula. METHODS:A 69-year-old man with a history of a left dural carotid-cavernous sinus fistula underwent attempted treatment with super...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71711-8
更新日期：1997-12-01 00:00:00
abstract：:We studied five cases of leukemia with invasion of the optic disk and optic nerve. Two patients had acute lymphoblastic leukemia and three had acute myelogenous leukemia. All patients received intrathecal injections of chemotherapeutic drugs including methotrexate, cytarabine, and prednisolone. Three patients underwen...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90013-x
更新日期：1988-03-15 00:00:00
abstract：PURPOSE:To report a case of Serratia Marcescens corneal ulcer as a complication of orthokeratology treatment. METHODS:Case report. RESULTS:A 9-year-old male who underwent orthokeratology treatment for 6 months suffered from a corneal ulcer. The refractive state of lesion eye was -5.5D/-1.25D x 180 degrees, and visual...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)00931-x
更新日期：2001-08-01 00:00:00
abstract：:We compared endothelial preservation of paired corneas by scanning electron microscopy after storage in McCarey-Kaufman medium for two or three days to 2.5% chondroitin sulfate (K-Sol) for seven or ten days. One cornea from each of ten pairs of eyes was placed in McCarey-Kaufman medium and the opposite cornea was plac...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74106-6
更新日期：1987-11-15 00:00:00
abstract：PURPOSE:To report the features of idiopathic intracranial hypertension in prepubertal children, with emphasis on presentation, treatment, and outcome. METHODS:We retrospectively reviewed the charts of all patients 11 years and younger diagnosed with idiopathic intracranial hypertension at two university-affiliated med...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00386-9
更新日期：1999-02-01 00:00:00
abstract：:A 59-year-old woman with no evidence of glaucoma developed secondary open-angle glaucoma after an intracapsular cataract extraction complicated by vitreous and iris incarceration. Histopathologic and scanning and electron microscopic studies of the enucleated eye 22 years later revealed extensive proliferation of iris...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90520-8
更新日期：1979-09-01 00:00:00
abstract：:Of 30 consecutive patients with ocular adnexal basal cell carcinoma, 18 (60%) had at least one additional unsuspected foci of basal cell carcinoma. The patients most likely to have additional basal cell skin cancer were women, those with previous basal cell carcinoma, and those whose eyelid lesions were recurrent, loc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90002-2
更新日期：1982-11-01 00:00:00
abstract：:Conjunctivodacryocystorhinostomy with a Jones tube is an accepted procedure for the treatment of epiphora resulting from obstructed canaliculi. Because of our clinical impression that a high rate of functional success after surgery is associated with a lower rate of patient satisfaction, we analyzed the results and pa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70070-4
更新日期：1994-05-15 00:00:00
abstract：PURPOSE:To determine the 24-month results of patients who had pro re nata (PRN) aflibercept treatment owing to recurrent or resistant neovascular macular degeneration. DESIGN:Retrospective, interventional, consecutive case series. METHODS:Eighty-one eyes of 78 patients with resistant or multiple recurrences of intrar...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.03.038
更新日期：2016-07-01 00:00:00
abstract：:Ocular abnormalities were present in five of 11 patients with Freeman-Sheldon syndrome. The predominant ocular findings were strabismus and blepharoptosis. Stiffness of the extraocular muscles, demonstrated in three patients by forced duction testing, made surgery difficult. Two patients underwent frontalis muscle sli...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90009-7
更新日期：1986-09-15 00:00:00
abstract：:A 65-year-old white man had an unusual disseminated lymphoid tumor that first appeared in the subconjunctival tissues of the right eye. The tumor later appeared in the skin, lymph nodes, and left upper eyelid and orbit. A monoclonal serum IgA spike was present although the urine did not contain Bence Jones proteins. T...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90082-3
更新日期：1975-02-01 00:00:00
abstract：PURPOSE:To evaluate whether retinal vessel abnormalities are associated with early or late age-related macular degeneration (AMD) in adult Chinese. DESIGN:Population-based prevalence study. METHODS:The Beijing Eye Study included 4439 (83.4%) subjects of 5324 living in a rural area or urban region of Greater Beijing, ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.05.028
更新日期：2006-10-01 00:00:00
abstract：PURPOSE:To examine whether indocyanine green (ICG) dye induces apoptosis in human retinal pigment epithelial (RPE) cells. DESIGN:Laboratory investigation. METHODS:Pure cultures of human RPE cells were isolated. Retinal pigment epithelial cells were incubated with different concentrations of ICG dye (1 mg/ml, 5 mg/ml,...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.11.016
更新日期：2004-05-01 00:00:00
abstract：:Of a series of 57 formerly amblyopic patients who attained equal visual acuities (20/20 or better in each eye), only 29 were able to alternate after treatment. The oldest patient was 5 years old. The pattern visual-evoked response of the previously amblyopic eye in nonalternators showed a reduced amplitude as compared...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75868-4
更新日期：1985-01-15 00:00:00
abstract：PURPOSE:To evaluate persistency of pharmacotherapy in primary open-angle glaucoma suspects (glaucoma suspects) treated with latanoprost and timolol. DESIGN:Retrospective, cohort study using the Protocare Sciences managed care database; approximately 3 million members in commercial health maintenance organizations and ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.10.034
更新日期：2004-01-01 00:00:00
abstract：:We reviewed the charts of 29 patients with large subretinal hemorrhages involving the center of the fovea to evaluate factors that might be prognostic of visual outcome. The average final visual acuity was 20/480 with a mean follow-up of three years. Patients with thick hemorrhages (causing an obvious elevation of the...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75575-8
更新日期：1990-01-15 00:00:00
abstract：PURPOSE:To evaluate long-term retention rates and complications of silicone punctal plugs among dry eye patients. DESIGN:Prospective, observational cohort study. METHODS:Ninety-five silicone punctal plugs (FCI plugs; FCI Ophthalmics, Issy-les-Moulineaux Cedex, France) were placed in 93 eyes of 47 dry eye patients. Wi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.05.019
更新日期：2007-09-01 00:00:00
abstract：:Cell loss and regeneration were investigated and compared in the retinal microvasculature of age- and sex-matched normal and streptozotocin diabetic rats. Selective pericyte loss in the diabetic rat was characterized by changes in the pericyte to endothelial cell ratio in retinal capillaries isolated for microscopy by...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74982-7
更新日期：1985-07-15 00:00:00
abstract：PURPOSE:To analyze the long-term growth patterns of type 1 neovascularization (NV) in eyes with age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor (VEGF) therapy. DESIGN:Retrospective cohort study. METHODS:Patients were enrolled from 2 eye centers and underwent optical coherence ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2017.12.005
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:To investigate the effect of nocturnal blood pressure (BP) dips on the occurrence of optic disc hemorrhage (ODH) in normal-tension glaucoma (NTG) patients and determine whether ODH is associated with greater likelihood of visual field progression (VFP). DESIGN:Prospective case-control study. METHODS:This stud...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.01.002
更新日期：2017-04-01 00:00:00
abstract：:Digital fundus angiography has advantages over conventional photography. However, digital angiography as it is normally performed, provides no stereoscopic information. Because stereoscopic data can be crucial in the evaluation of conditions such as age-related macular degeneration, we developed methods to record ster...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71409-6
更新日期：1993-10-15 00:00:00
abstract：PURPOSE:To compare tear film thickness between normal subjects and aqueous tear deficiency dry eye patients by tear interferometry. DESIGN:Prospective case-control study. METHODS:Central precorneal tear film thickness was measured noninvasively using an interference thin-film thickness measurement device (Quore MSPA1...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.07.019
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:To report a transient cataract after bleb needling and subconjunctival injection of 5-fluorouracil. DESIGN:Observational case report. METHODS:A 51-year-old man had an encapsulated bleb after filtering surgery. The bleb was needled, and 5 mg of 5-fluorouracil was injected adjacent to the bleb. RESULTS:Within ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01828-7
更新日期：2003-01-01 00:00:00
