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Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues.

Abstract：

:We report the synthesis and properties of oligonucleotides incorporating N(6)-[N-(pyren-1-ylmethyl)carbamoyl]-deoxyadenosine (dA(pymcm)). We designed the ODN which incorporated two consecutive dA(pymcm) residues. It was revealed that on hybridization with the target DNA and RNA oligomers, the fluorescence spectra of ODNs having two consecutive dA(pymcm) molecules near the 5'-terminal position can change from the pyrene monomer emission to the excimer, depending on the chain length of the target DNA and RNA. These results indicated that dA(pymcm)-modified ODNs can be used as interesting hybridization sensors that are sensitive to the size of the target strand.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Seio K,Mizuta M,Tasaki K,Tamaki K,Ohkubo A,Sekine M

doi

10.1016/j.bmc.2008.05.042

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

8287-93

issue

17

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)00469-0

journal_volume

16

pub_type

杂志文章

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