Abstract:
:A number of 5-aminosubstituted 20(S)-camptothecin analogues were prepared via semi-synthesis starting from 20(S)-camptothecin and 9-methoxy 20(S)-camptothecin. In vitro anti-cancer activity of these analogues was determined using 60 human tumor cell line assay. Although water solubility of most of these compounds was improved compared to 20(S)-camptothecin, their anti-cancer activity was considerably diminished. However, only smaller substituents such as methylamine or hydroxylamine as present in 8s and 8t, respectively, showed good activity with improved water solubility.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Subrahmanyam D,Sarma VM,Venkateswarlu A,Sastry TV,Kulakarni AP,Rao DS,Reddy KVdoi
10.1016/s0968-0896(99)00130-3subject
Has Abstractpub_date
1999-09-01 00:00:00pages
2013-20issue
9eissn
0968-0896issn
1464-3391pii
S0968089699001303journal_volume
7pub_type
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