当前位置： SCI文献检索 > VIRUS GENES期刊下所有文献 > Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction.

Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction.

Abstract：

:Human T-cell leukemia virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia. HTLV-1 Tax1 transforming protein interacts with several PDZ domain-containing proteins, and the interaction is associated with the transforming activities of Tax1 as well as persistent HTLV-1 infection. In this study, we show that Tax1 interacts with the tumor suppressor Scribble containing PDZ domains. Unlike other Tax1-interacting PDZ domain proteins, the PDZ domain-binding motif (PBM) of Tax1 was not required for the interaction with transiently expressed Scribble in 293T cells, but it was essential for the interaction with endogenous Scribble. Endogenous Scribble in 293T cells was primarily localized at the plasma membrane and colocalized with Tax1 but not Tax1C lacking PBM, whereas transiently expressed Scribble was localized in the cytoplasm and colocalized with Tax1C as well as Tax1, thus suggesting that Tax1 is recruited to the site of endogenous Scribble, such as the plasma membrane, in a PBM-dependent manner, and thereafter it interacts with Scribble in a PBM-independent and PBM-dependent manner. Endogenous Scribble was diffusely localized at the plasma membrane of HTLV-1-uninfected T-cell lines, whereas it colocalized with Tax1 as small and large aggregate at the plasma membranes. These results suggest that Tax1 through two binding sites induce aberrant clustering of Scribble, thereby altering the functions in HTLV-1-infected cells, which may thus play a role in persistent HTLV-1 infection and the pathogenesis.

journal_name

Virus Genes

journal_title

Virus genes

authors

Okajima M,Takahashi M,Higuchi M,Ohsawa T,Yoshida S,Yoshida Y,Oie M,Tanaka Y,Gejyo F,Fujii M

doi

10.1007/s11262-008-0259-4

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

231-40

issue

2

eissn

0920-8569

issn

1572-994X

journal_volume

37

pub_type

杂志文章

相关文献

VIRUS GENES文献大全
  • Interaction between Translocation-associated membrane protein 1 and σC protein of novel duck reovirus controls virus infectivity.

    abstract：:Novel duck reovirus (NDRV), the prototype strain of the species Avian orthoreovirus (ARV), is associated with high mortality in Pekin ducklings. σC is an outer capsid protein encoded by the S1 genome segment of NDRV which mediates attachment to host cells. Our previous studies using immunoprecipitation and mass spectr...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-020-01750-8

    authors： Xiao R,Mi X,Sun J,Ding M,Li C,Zhu J,Liu G,Ma W,Zhou H,Chen Z

    更新日期：2020-06-01 00:00:00

  • Comparison of the sequence of the secretory glycoprotein A (gA) gene in Md5 and BC-1 strains of Marek's disease virus type 1.

    abstract：:DNA fragments containing the secretory glycoprotein A (gA) gene of Marek's disease virus type 1 (MDV1) were cloned from the DNA libraries of very virulent Md5 and virulent BC-1 strains and sequenced. Two open reading frames (ORF1 and ORF2) were identified for both strains. The ORF1 has the potential to code for a prot...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/BF00125125

    authors： Ihara T,Kato A,Ueda S,Ishihama A,Hirai K

    更新日期：1989-11-01 00:00:00

  • Detection and genetic characterization of porcine pegivirus from pigs in China.

    abstract：:Porcine pegiviruses (PPgV) have been first discovered in serum samples from domestic pigs in Germany in 2016 and then in the USA in 2018. To date, there is no documentation with respect to the presence of PPgVs in domestic pigs in China. Herein, we attempted to determine the presence and prevalence of PPgV in China an...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-018-1624-6

    authors： Lei D,Ye Y,Lin K,Zhang F,Huang D,Li K,Yuan W,Wu Q,Ding Z,Wang L,Song D,Tang Y

    更新日期：2019-04-01 00:00:00

  • European and American subgroup C isolates of avian metapneumovirus belong to different genetic lineages.

    abstract：:The gene encoding the attachment glycoprotein (G) was sequenced in three French isolates of-subgroup C avian metapneumovirus (APV-C) from ducks. With 1771 nt, this gene proved as long as recently published for North-American APV-C isolates from turkeys. The nt sequences of the duck viruses shared 99% identity but prov...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-005-5850-3

    authors： Toquin D,Guionie O,Jestin V,Zwingelstein F,Allee C,Eterradossi N

    更新日期：2006-02-01 00:00:00

  • Sequence of rice hoja blanca tenuivirus RNA-2.

    abstract：:The sequence of rice hoja blanca tenuivirus RNA-2 is analysed and compared to its counter-part in rice stripe tenuivirus. The RNA encodes two proteins, in an ambisense arrangement. The 94 kD pc2, located in the complementary sense RNA, has several features typical of viral membrane (glyco)proteins, and also has region...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/BF00284643

    authors： De Miranda JR,Muñoz M,Wu R,Hull R,Espinoza AM

    更新日期：1996-01-01 00:00:00

  • Recombinant core proteins of Japanese encephalitis virus as activators of the innate immune response.

    abstract：:Nitric oxide (NO) has been shown to suppress Japanese encephalitis virus (JEV) RNA synthesis, viral protein accumulation, and virus release from infected cells. In this article, the potential viral structural proteins as the activators of NO product were studied at the molecular level. First, the genomic region encodi...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-008-0299-9

    authors： Chen SO,Fang SH,Shih DY,Chang TJ,Liu JJ

    更新日期：2009-02-01 00:00:00

  • Sequence of Echinochloa hoja blanca tenuivirus RNA-4.

    abstract：:The sequence is presented of RNA-4 of Echinochloa hoja blanca tenuivirus (EHBV), one of two tenuiviruses associated with rice cultivation in Latin America (together with rice hoja blanca virus; RHBV). Analysis of the sequence shows that the coding regions of EHBV RNA-4 are closely related to those of RHBV RNA-4. Howev...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/BF00576979

    authors： de Miranda JR,Muñoz M,Wu R,Espinoza AM

    更新日期：1996-01-01 00:00:00

  • Sequencing and phylogenetic analysis of an avian reovirus genome.

    abstract：:Avian reovirus infection causes considerable economic loss to the commercial poultry industry. Live-attenuated vaccine strain S1133 (v-S1133, derived from parent strain S1133) is considered the safest and most effective vaccine and is currently used worldwide. To identify the genes responsible for its attenuation, DNA...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-013-1029-5

    authors： Teng L,Xie Z,Xie L,Liu J,Pang Y,Deng X,Xie Z,Fan Q,Luo S,Feng J,Khan MI

    更新日期：2014-04-01 00:00:00

  • Phylogenetic analysis of the bovine parainfluenza virus type 3 from cattle herds revealing the existence of a genotype A strain in China.

    abstract：:In 2009, a bovine parainfluenza virus (BPIV3), named as NM09, was isolated using MDBK cell culture from the nasal swabs of normal cattle in China. The NM09 isolate was characterized by RT-PCR and nucleotide sequence analysis. Its complete genome was 15,456 nucleotides in length. Similar to other sequenced PIV strains,...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-012-0810-1

    authors： Wen YJ,Shi XC,Wang FX,Wang W,Zhang SQ,Li G,Song N,Chen LZ,Cheng SP,Wu H

    更新日期：2012-12-01 00:00:00

  • Complete genome sequence of a sapovirus from a child in Zhejiang, China.

    abstract：:Although Sapovirus (Caliciviridae) has been accepted as one of the causes of acute gastroenteritis worldwide, little is known about the genetic characteristics of the whole genome of sapoviruses in China, especially those that infect humans. Here we report the complete genome sequence of a sapovirus strain, Human/Zhej...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-016-1343-9

    authors： Zhou X,Sun Y,Shang X,Gao J,Zhao X,Shuai H,Zhang R,Zhang Y

    更新日期：2016-10-01 00:00:00

  • Characterization of H5N1 highly pathogenic avian influenza viruses isolated from poultry in Pakistan 2006-2008.

    abstract：:Nine avian influenza viruses (AIV), H5N1 subtype, were isolated from dead poultry in the Karachi region of Pakistan from 2006 to 2008. The intravenous pathogenicity indices and HA protein cleavage sites of all nine viruses were consistent with highly pathogenic AIV. Based on phylogenetic analysis of the HA genes, thes...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-011-0689-2

    authors： Wasilenko JL,Pantin-Jackwood M,Khan TA,Ahmed A,Rehmani SF,Lone NA,Swayne DE,Spackman E

    更新日期：2012-04-01 00:00:00

  • The minimal sequence essential for replication and movement of Cotton leaf curl Multan betasatellite DNA by a helper virus in plant cells.

    abstract：:Betasatellites are single-stranded circular DNAs associated with a number of monopartite begomoviruses. Betasatellites rely on the helper begomoviruses for replication and movement in plant tissues and plant-to-plant transmission by vectors. Their genomes are approximately half the size of the helper viruses and consi...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-016-1354-6

    authors： Eini O,Behjatnia SA

    更新日期：2016-10-01 00:00:00

  • Genomic characterization of Molluscum contagiosum virus type 1: identification of the repetitive DNA sequences in the viral genome.

    abstract：:The genomes (188 kbp) of the prototype Molluscum contagiosum virus type 1 (MCV-1) and a variant strain (MCV-1v) were characterized by construction of the physical maps of the viral DNA for the restriction enzymes BamHI, ClaI, EcoRI, and HindIII using a defined gene library harboring the DNA sequences of the MCV-1 geno...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/BF00125128

    authors： Bugert J,Rösen-Wolff A,Darai G

    更新日期：1989-11-01 00:00:00

  • Complete sequence of the RNA genome of pneumonia virus of mice (PVM).

    abstract：:Pneumonia virus of mice (PVM) is an enveloped RNA-containing virus of Family Paramyxoviridae. Sequences had been determined previously for a number of PVM genes, although these represented cloned cDNAs rather than consensus sequences. Sequences were not available for the 3' -leader and 5' -trailer regions that constit...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-004-5631-4

    authors： Krempl CD,Lamirande EW,Collins PL

    更新日期：2005-03-01 00:00:00

  • First complete genome sequences of genogroup V, genotype 3 porcine sapoviruses: common 5'-terminal genomic feature of sapoviruses.

    abstract：:Sapoviruses (SaVs) are enteric viruses and have been detected in various mammals. They are divided into multiple genogroups and genotypes based on the entire major capsid protein (VP1) encoding region sequences. In this study, we determined the first complete genome sequences of two genogroup V, genotype 3 (GV.3) SaV ...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-017-1481-8

    authors： Oka T,Doan YH,Shimoike T,Haga K,Takizawa T

    更新日期：2017-12-01 00:00:00

  • Unique evolution characteristics of the envelope protein of EIAV(LN₄₀), a virulent strain of equine infectious anemia virus.

    abstract：:The Chinese equine infectious anemia virus (EIAV) virulent strain EIAV(LN40) is derived from a naturally occurring virus by continuously passing in horses for 16 generations. Its genome sequence is 23% different from that of the American strains or the Japanese strains, and the variation of envelope gp90 surface unit ...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-010-0563-7

    authors： Wang X,Wang S,Lin Y,Jiang C,Ma J,Zhao L,Lv X,Wang F,Shen R,Zhou J

    更新日期：2011-04-01 00:00:00

  • Biophysical and biochemical properties of baculovirus-expressed CaMV P1 protein.

    abstract：:Cauliflower mosaic virus (CaMV) gene I encodes a protein (P1) that has been implicated in the control of virus movement in infected plants. To assist in the characterization of the mechanism of action of P1, gene I has been expressed efficiently in Spodoptera frugiperda (Sf) cells using recombinant baculovirus. Contro...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/BF01703753

    authors： Maule AJ,Usmany M,Wilson IG,Boudazin G,Vlak JM

    更新日期：1992-01-01 00:00:00

  • Binding of cellular proteins to the leader RNA of equine arteritis virus.

    abstract：:The genome of equine arteritis virus (EAV) produces a 3' coterminal-nested set of six subgenomic (sg) viral RNAs during virus replication cycle, and each set possesses a common leader sequence of 206 nucleotides (nt) in length derived from the 5' end of the viral genome. Given the presence of the leader region within ...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-004-4589-6

    authors： Archambault D,St-Louis MC,Martin S

    更新日期：2005-01-01 00:00:00

  • Cloning and characterization of a totivirus double-stranded RNA from the plant pathogenic fungus, Helicobasidium mompa Tanaka.

    abstract：:Virus-like particles (VLPs, named HmTV1-17), about 40 nm in diameter were found in the violet root rot fungus Helicobasidium mompa Tanaka strain No. 17, which had been isolated from an apple tree. Purified preparations of HmTV1-17 contained two species of double-stranded RNA (dsRNA), designated 17L and 17S. cDNAs were...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1023/a:1024453111809

    authors： Nomura K,Osaki H,Iwanami T,Matsumoto N,Ohtsu Y

    更新日期：2003-05-01 00:00:00

  • Influenza A viruses: why focusing on M2e-based universal vaccines.

    abstract：:The threat of highly virulent avian influenza, such as H5N1 and swine-origin H1N1 influenza viruses, bring out an urgent need to develop a universal influenza vaccine, which may provide cross-protection against different strain of influenza A viruses. The extra-domain of influenza M2 protein (M2e), which is almost com...

    journal_title：Virus genes

    pub_type： 杂志文章,评审

    doi：10.1007/s11262-010-0547-7

    authors： Ebrahimi SM,Tebianian M

    更新日期：2011-02-01 00:00:00

  • Novel parvovirus sublineage in the family of Parvoviridae.

    abstract：:Parvoviridae, which are classified into two subfamilies Parvovirinae and Densovirinae, can infect both vertebrate and insects and are related to a wide range of diseases in insects, animals, and humans. In this report, several new parvoviruses were identified in swine sera collected in southeastern China. The sequence...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-010-0506-3

    authors： Wang F,Wei Y,Zhu C,Huang X,Xu Y,Yu L,Yu X

    更新日期：2010-10-01 00:00:00

  • Genomic characterization of a novel partitivirus infecting. Aspergillus ochraceus.

    abstract：:Three double-stranded RNA (dsRNA) segments from Aspergillus ochraceus isolate FA 0611, designated as AoR1, AoR2, and AoR3, were cloned and sequenced. AoR1 was identical with AoV dsRNA 1 previously reported from A. ochraceus ATCC 28706, which putatively encoded an RNA-dependent RNA polymerase of an unidentified mycovir...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-008-0265-6

    authors： Liu W,Duns G,Chen J

    更新日期：2008-12-01 00:00:00

  • Loss of linkage disequilibrium and accelerated protein divergence in duplicated cytomegalovirus chemokine genes.

    abstract：:Human CMV (hCMV) encodes several captured chemokine ligand and chemokine receptor genes that may play a role in immune evasion. The adjacent viral alpha-chemokine genes UL146 and UL147 appear to have duplicated subsequent to a recent gene capture event. Sequence data from multiple hCMV isolates suggest accelerated pro...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-005-2201-3

    authors： Arav-Boger R,Zong JC,Foster CB

    更新日期：2005-08-01 00:00:00

  • Genetic characterization of Thai swine influenza viruses after the introduction of pandemic H1N1 2009.

    abstract：:Pandemic H1N1 2009 (pH1N1), influenza virus containing triple reassortant internal genes (TRIG) from avian, human, and swine influenza viruses emerged in 2009 as a highly infectious virus that was able to be transmitted from humans to pigs. During June 2010-May 2012, influenza virus surveillance was conducted in Thai ...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-013-0927-x

    authors： Charoenvisal N,Keawcharoen J,Sreta D,Chaiyawong S,Nonthabenjawan N,Tantawet S,Jittimanee S,Arunorat J,Amonsin A,Thanawongnuwech R

    更新日期：2013-08-01 00:00:00

  • Parrot bornavirus-2 and -4 RNA detected in wild bird samples in Japan are phylogenetically adjacent to those found in pet birds in Japan.

    abstract：:Bornaviruses (family Bornaviridae) are non-segmented negative-strand RNA viruses. Avian bornaviruses (ABVs), which are causative agents of proventricular dilatation disease, are a genetically diverse group with at least 15 genotypes, including parrot bornaviruses (PaBVs) and aquatic bird bornavirus 1(ABBV-1). Borna di...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-015-1240-7

    authors： Sassa Y,Bui VN,Saitoh K,Watanabe Y,Koyama S,Endoh D,Horie M,Tomonaga K,Furuya T,Nagai M,Omatsu T,Imai K,Ogawa H,Mizutani T

    更新日期：2015-10-01 00:00:00

  • Merkel cell polyomavirus in Merkel cell carcinogenesis: small T antigen-mediates c-Jun phosphorylation.

    abstract：:Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer associated with the Merkel cell polyomavirus (MCPyV). The MCPyV genome, which is clonally integrated in the majority of MCCs, encodes the regulatory small T (sT) antigen. Previously, reports have established MCPyV sT antigen as a potent onco...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-016-1304-3

    authors： Wu JH,Simonette RA,Nguyen HP,Rady PL,Tyring SK

    更新日期：2016-06-01 00:00:00

  • The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation.

    abstract：:Several tumor viruses, such as human T-cell leukemia virus (HTLV), human papilloma virus (HPV), human adenovirus, have high-oncogenic and low-oncogenic subtypes, and such subtype-specific oncogenesis is associated with the PDZ-domain binding motif (PBM) in their transforming proteins. HTLV-1, the causative agent of ad...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-009-0447-x

    authors： Aoyagi T,Takahashi M,Higuchi M,Oie M,Tanaka Y,Kiyono T,Aoyagi Y,Fujii M

    更新日期：2010-04-01 00:00:00

  • Rapid detection of highly pathogenic porcine reproductive and respiratory syndrome virus by a fluorescent probe-based isothermal recombinase polymerase amplification assay.

    abstract：:A novel fluorescent probe-based real-time reverse transcription recombinase polymerase amplification (real-time RT-RPA) assay was developed for rapid detection of highly pathogenic type 2 porcine reproductive and respiratory syndrome virus (HP-PRRSV). The sensitivity analysis showed that the detection limit of RPA was...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-016-1378-y

    authors： Yang Y,Qin X,Sun Y,Chen T,Zhang Z

    更新日期：2016-12-01 00:00:00

  • Human heart cell proteins interacting with a C-terminally truncated 2A protein of coxsackie B3 virus: identification by the yeast two-hybrid system.

    abstract：:Protein 2A is a non-structural protein of coxsackievirus B3 (CVB3), an important human pathogen that can cause a variety of human diseases. Protein 2A not only participates in viral life cycle, but also regulates host cell functions; however, the underlying mechanisms remain poorly understood. In order to better under...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/s11262-015-1270-1

    authors： Zhao T,Huang X,Xia Y

    更新日期：2016-04-01 00:00:00

  • Genetic mechanisms of antigenic variation in infectious bursal disease virus: analysis of a naturally occurring variant virus.

    abstract：:The major immunogenic protein VP2 from a pathogenic field isolate (variant A virus) of infectious bursal disease virus (IBDV) was cloned and sequenced to examine antigenic variations. The VP2 open reading frame consists of 1509 nucleotides and codes for a 503 amino acid protein. Overall, the VP2 amino acid sequence of...

    journal_title：Virus genes

    pub_type： 杂志文章

    doi：10.1007/BF01702563

    authors： Lana DP,Beisel CE,Silva RF

    更新日期：1992-08-01 00:00:00