Abstract:
:Studies of calcium metabolism in 38 patients with cancer indicated that: 1) intestinal absorption of calcium was reduced in patients with skeletal metastases and in those with hypercalcemia; 2) calcium-47 space (a measurement of bone turnover rate) was high in the patients with skeletal metastases; 3) hypercalcemic patients had higher urinary and endogenous fecal excretion of calcium than those who were normocalcemic; 4) levels of plasma immunoreactive parathyroid hormone were similar in normo- and hypercalcemic patients, but the levels for a given serum calcium in malignant disease were lower than those in primary hyperparathyroidism; and 5) some patients had elevated calcitonin levels. Hypercalcemia complicating malignant disease is therefore not due to hyperabsorption or diminished excretion of calcium, and a low calcium diet is unlikely to benefit these patients. Measurement of 47Ca space could be of use in monitoring therapy of patients with skeletal metastases, and measurement of plasma parathyroid hormone could be useful in the differential diagnosis of hypercalcemia.
journal_name
Cancerjournal_title
Cancerauthors
Coombes RS,Ward MK,Greenberg PB,Hillyard CJ,Tulloch BR,Morrison R,Joplin GFdoi
10.1002/1097-0142(197611)38:5<2111::aid-cncr282038subject
Has Abstractpub_date
1976-11-01 00:00:00pages
2111-20issue
5eissn
0008-543Xissn
1097-0142journal_volume
38pub_type
杂志文章相关文献
CANCER文献大全abstract::The immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen (CALLA)-positive and CALLA-negative T-acute lymphoblastic leukemia (ALL) and of CALLA-positive non-T, non-B ALL (common ALL) of childhood were compared. Twenty-seven percent of children with T-ALL had blasts that expressed CA...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870615)59:12<2020::aid-cncr282
更新日期:1987-06-15 00:00:00
abstract:BACKGROUND:Gastric carcinoids are uncommon, and are unlike carcinoids at other gastrointestinal sites, clinically and pathologically. METHODS:The authors studied specimens from 104 patients with gastric carcinoid, with study emphasis being placed on pathologic features, immunohistochemistry, clinical associations, and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940415)73:8<2053::aid-cncr2820
更新日期:1994-04-15 00:00:00
abstract:BACKGROUND:Conditional survival (CS) has emerged as a clinically relevant measure of prognosis for cancer survivors. The objective of this analysis was to provide melanoma-specific CS estimates to help clinicians promote more informed patient decision making. METHODS:Patients with melanoma and at least 5 years of foll...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24966
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Optimal treatments for vulvar and vaginal melanomas (VVMs) have not been identified. Herein, the authors compare molecular profiles between VVM and nongynecologic melanoma (NGM) subtypes with the objective of identifying novel, targetable biomarkers. METHODS:In total, 2304 samples of malignant melanoma that...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30473
更新日期:2017-04-15 00:00:00
abstract::The identification of important prognostic factors at diagnosis of childhood leukemia has been very useful in explaining the marked differences in disease outcome. After a complete remission is achieved, it is interesting to determine whether the ability to maintain a complete remission and the patient's survival cont...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:2<370::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract:BACKGROUND:Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. METHODS:Data were harmonized across 13 studies in the International Barrett's and Esophageal Adenocarcinoma Consortium, comprising 2309 esophageal adenocarcinom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32444
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the racial and ethnic disparities in outcomes and their association with process-of-care measures for elderly Medicare recipients with localized prostate cancer. METHODS:The Surveillance, Epidemiology, and End Results-Medicare databases for the period from 1995 to 2...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25812
更新日期:2011-06-01 00:00:00
abstract::The findings at autopsy of 79 patients with esophageal carcinoma over a period of 15 years were reviewed. Five patients were free of tumor, and another seven had disease localized to the esophagus and other mediastinal structures. Sixty-seven (85%) had metastatic disease. The average number of metastatic sites per pat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821015)50:8<1587::aid-cncr2820
更新日期:1982-10-15 00:00:00
abstract:BACKGROUND:This retrospective analysis examines the frequency, distribution, and the pattern of disease progression of bone metastasis in patients treated for cervical cancer and the use and results of palliative intent radiation therapy. METHODS:Charts, films, and other available records were reviewed for the 41 pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940501)73:9<2372::aid-cncr2820
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Current clinical guidelines recommend earlier, more intensive breast cancer screening with both magnetic resonance imaging (MRI) and mammography for women with breast cancer susceptibility gene (BRCA) mutations. Unspecified details of screening schedules are a challenge for implementing guidelines. METHODS:...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27864
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:Multiple intraesophageal primary cancer and upper aerodigestive tract (UADT) cancer associated with esophageal cancer are common diseases, especially in heavy drinkers. They are often explained by the concept of field cancerization, which suggests a similar etiology. However, little is known about the nature...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960515)77:10<1986::AID-C
更新日期:1996-05-15 00:00:00
abstract:BACKGROUND:The treatment of advanced, inoperable, or recurrent parotid tumors represents a clinical challenge. The results obtained with conventional radiotherapy are disappointing. To improve the early response and local control of parotid tumors, local microwave hyperthermia was used in combination with ionizing radi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19950215)75:4<908::aid-cncr28207
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:Colorectal cancer incidence rates vary widely internationally, by race and gender, and have changed over time. Investigation of the patterns by subsite within the colorectum may suggest clues of possible etiologic significance for further study. METHODS:Using population-based data on more than 120,000 cases...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<3819::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract:BACKGROUND:Hyperglycemia is often observed in medically ill patients. Previous studies have shown that patients with hyperglycemia during induction therapy for acute lymphoblastic leukemia develop more infections and have shorter disease-free survival. The authors hypothesized that hyperglycemia may be associated with ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22777
更新日期:2007-07-01 00:00:00
abstract::A 17-year-old girl was operated for a solitary well-circumscribed pulmonary parenchymal tumor and reoperated ten times for multiple recurrent similar pulmonary tumors during 24 years. Histologic examination revealed the so-called intravascular bronchioloalveolar tumor (IVBAT) in all instances. The patient died from pn...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19871115)60:10<2471::aid-cncr282
更新日期:1987-11-15 00:00:00
abstract:BACKGROUND:The authors reviewed changes in the initial clinical presentation, management techniques, and patterns of disease recurrence over time (1981-1996) in patients with breast carcinoma treated with breast-conserving therapy (BCT) at a single institution. The goals of the current study were to determine the frequ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20410
更新日期:2004-08-15 00:00:00
abstract::The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells with blastematous qualities separ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19881015)62:8<1516::aid-cncr2820
更新日期:1988-10-15 00:00:00
abstract:BACKGROUND:Black females have lower breast carcinoma survival rates compared with white females. One possible reason is that black females have more advanced-stage breast disease. Another factor may be racial differences in the utilization of cancer treatments. METHODS:The authors determined racial differences in 6-ye...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11411
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:The demonstration of the monoclonality of immunoglobulin heavy chain (IgH) gene rearrangement is an indispensable method for the diagnosis of B-cell lymphoma as well as histocytochemical analysis. For the detection of IgH gene rearrangement, the extraction of DNA from a homogenous cell population is necessar...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11331
更新日期:2003-08-25 00:00:00
abstract:BACKGROUND:This study analyzed whether proliferative activity and expression of P-glycoprotein 170 (P-170) or glutathione S-transferase-pi (GST-pi) in human non-small cell lung carcinomas (NSCLC) represent independent factors in resistance to doxorubicin or whether an association exists between these factors. METHODS:...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920815)70:4<764::aid-cncr28207
更新日期:1992-08-15 00:00:00
abstract::Data from the Cancer Registry in the Netherlands Antilles made clear that the incidence rate of cancer of the upper digestive tract in this country was among the highest in the world. To study the long-term trends in the incidence rate a retrospective population-based case-finding survey was performed. The author pres...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840401)53:7<1618::aid-cncr2820
更新日期:1984-04-01 00:00:00
abstract::Sixty percent of all cancer occurs in persons aged > or =65 years. This article provides an overview of aspects of the burden of cancer in the elderly, highlighting certain demographic and epidemiologic data. It served as a frame of reference for participants in the Oncology Geriatric Education Retreat, San Juan, Puer...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract::This is a statistical analysis of the use of mammography in the symptomatic patient. Eighty-eight percent of women older than 50 years who had a palpable cancer of the breast had a positive mammogram; only 57% of women younger than 51 years of age had a positive mammogram. When the cancer presented as nipple discharge...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890401)63:7<1412::aid-cncr2820
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Immunohistological markers specific for a single type of epithelium are rare. Recently, urothelium tissue-specific genes were cloned. The genes encoded a family of transmembrane proteins, uroplakins, that are expressed only in urothelial mucosa. Using uroplakin antibodies on paraffin-embedded tissue, a previ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.9032
更新日期:2001-06-25 00:00:00
abstract:BACKGROUND:The authors previously demonstrated that never-smokers with stage IIIB/IV nonsmall cell lung cancer (NSCLC) lived 50% longer than former/current smokers. This observation persisted after adjusting for age, performance status, and sex. In this study, the authors hypothesized that smoking-dependent differences...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27637
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Little is known about genetic aberrations associated with development and progression of biliary tract carcinomas. METHODS:To study chromosomal aberrations associated with development and progression of biliary tract carcinomas, the authors used comparative genomic hybridization to examine 50 such carcinoma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010201)91:3<570::aid-cncr1036>
更新日期:2001-02-01 00:00:00
abstract::Epidemiologic variables related to breast cancer risk were assessed in a case-control study of 332 women with breast carcinoma and 1353 comparison women. Risk factors for breast cancer as a whole included nulliparity, late age at first childbirth, early age at menarche, late age at menopause, personal history of benig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820501)49:9<1937::aid-cncr2820
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Cisplatin has been reported to enhance the cell-killing effect of radiation. The current study was conducted to evaluate the efficacy and toxicity of radiotherapy combined with cisplatin in patients with locally advanced pancreatic carcinoma. METHODS:Forty-one patients with pancreatic carcinoma that was unr...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010401)91:7<1384::aid-cncr1142
更新日期:2001-04-01 00:00:00
abstract::Indirect data supporting a preexisting immunologic impairment in patients with Hodgkin's disease (HD) have been presented in recent years. These immunologic defects are supposed to be related to genetic and/or environmental factors. In this study, 65 first-degree relatives and 12 spouses of 21 consecutive patients wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901101)66:9<1938::aid-cncr2820
更新日期:1990-11-01 00:00:00
abstract::A bronchogenic tumor was removed from a 12-year-old girl. Histology showed a clear cell lesion with electron microscope features compatible with serous acinic cell origin. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197608)38:2<830::aid-cncr2820380
更新日期:1976-08-01 00:00:00