Calcium metabolism in cancer. Studies using calcium isotopes and immunoassays for parathyroid hormone and calcitonin.

Abstract:

:Studies of calcium metabolism in 38 patients with cancer indicated that: 1) intestinal absorption of calcium was reduced in patients with skeletal metastases and in those with hypercalcemia; 2) calcium-47 space (a measurement of bone turnover rate) was high in the patients with skeletal metastases; 3) hypercalcemic patients had higher urinary and endogenous fecal excretion of calcium than those who were normocalcemic; 4) levels of plasma immunoreactive parathyroid hormone were similar in normo- and hypercalcemic patients, but the levels for a given serum calcium in malignant disease were lower than those in primary hyperparathyroidism; and 5) some patients had elevated calcitonin levels. Hypercalcemia complicating malignant disease is therefore not due to hyperabsorption or diminished excretion of calcium, and a low calcium diet is unlikely to benefit these patients. Measurement of 47Ca space could be of use in monitoring therapy of patients with skeletal metastases, and measurement of plasma parathyroid hormone could be useful in the differential diagnosis of hypercalcemia.

journal_name

Cancer

journal_title

Cancer

authors

Coombes RS,Ward MK,Greenberg PB,Hillyard CJ,Tulloch BR,Morrison R,Joplin GF

doi

10.1002/1097-0142(197611)38:5<2111::aid-cncr282038

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

2111-20

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

38

pub_type

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