Abstract:
:A modified simulation procedure based on a statistical approach was investigated. The procedure predicts the time course of fed-batch culture for glutamic acid production by a temperature-sensitive strain of Brevibacterium flavum. The statistical approach requires only a data base of state points obtained in experiments, and not perfect identification of fermentation models. The simulation procedure is based on regression analysis to estimate specific rate parameters of system equations using the data points selected with reference to the Euclid distance. It was modified in that the data selection procedure included the use of the Maharanobis distance as well as a modified distance defined in this study. Simulation results using the modified procedure allow reasonable prediction of the time course of fed-batch culture for glutamic acid compared to that involving the Euclid distance alone.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Kishimoto M,Alfafara CG,Nakajima M,Yoshida T,Taguchi Hdoi
10.1002/bit.260330208subject
Has Abstractpub_date
1989-01-10 00:00:00pages
191-6issue
2eissn
0006-3592issn
1097-0290journal_volume
33pub_type
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