Concise synthesis of a heptasaccharide antigen found in the cell-wall lipopolysaccharide of Mycobacterium gordonae strain 990.

abstract：:Nucleotide sugar transporters play critical roles in glycosylation of proteins, lipids and proteoglycans, which are essential for organogenesis, development, mammalian cellular immunity and pathogenicity of human pathogenic agents. Functional deficiencies of these transporters result in global defects of glycoconjugat...

journal_title：Glycoconjugate journal

authors： Liu L,Hirschberg CB

更新日期：2013-01-01 00:00:00

abstract：:Altered glycosylation of plasma proteins has been directly implicated in the pathogenesis of rheumatoid arthritis (RA). The present study investigated the changes in the Concanavalin-A (Con-A)-bound plasma proteins in the RA patients in comparison to that of the healthy controls. Two proteins (MW approximately 32 kDa ...

journal_title：Glycoconjugate journal

authors： Raghav SK,Gupta B,Agrawal C,Saroha A,Das RH,Chaturvedi VP,Das HR

更新日期：2006-05-01 00:00:00

abstract：:Poly-N-acetyllactosamine (poly-LacNAc) structures have been identified as important ligands for galectin-mediated cell adhesion to extra-cellular matrix (ECM) proteins. We here present the biofunctionalization of surfaces with poly-LacNAc structures and subsequent binding of ECM glycoproteins. First, we synthesized be...

journal_title：Glycoconjugate journal

authors： Sauerzapfe B,Krenek K,Schmiedel J,Wakarchuk WW,Pelantová H,Kren V,Elling L

更新日期：2009-02-01 00:00:00

abstract：:Influenza virus neuraminidase inhibitors (NAIs), currently used as anti-influenza drugs, can lead to the appearance of drug-resistant variants. Resistance to NAIs appears due to mutations in the active site of the neuraminidase (NA) molecule that decrease the NA enzymatic activity and sometimes in the hemagglutinin (H...

journal_title：Glycoconjugate journal

authors： Mochalova L,Bright R,Xu X,Korchagina E,Chinarev A,Bovin N,Klimov A

更新日期：2010-04-01 00:00:00

abstract：:Abnormal glycosylation of proteins is known to be either resultant or causative of a variety of diseases. This makes glycoproteins appealing targets as potential biomarkers and focal points of molecular studies on the development and progression of human ailment. To date, a majority of efforts in disease glycoproteomi...

journal_title：Glycoconjugate journal

authors： Schumacher KN,Dodds ED

更新日期：2016-06-01 00:00:00

abstract：:A major impediment in the analysis of glycosaminoglycans is the difficulty to cleave quantitatively the glycosidic bonds because of the stabilisation of glycosidic bonds and of the relative instability of the liberated constituents. This manuscript describes a modified procedure of methanolysis in the presence of bari...

journal_title：Glycoconjugate journal

authors： Zanetta JP,Timmerman P,Leroy Y

更新日期：1999-10-01 00:00:00

abstract：:To elucidate the biological significance of the lactosylceramide (LacCer) branching in glycosphingolipid (GSL) biosynthesis, we established ganglioside GM3- and lactosylsulfatide SM3-reconstituted cells by introducing the GM3 synthase gene and the sulfotransferase gene, respectively. In SM3-expressing cells, the reduc...

journal_title：Glycoconjugate journal

authors： Inokuchi J,Kabayama K,Uemura S,Igarashi Y

更新日期：2004-01-01 00:00:00

abstract：:The intestinal pathogen Escherichia coli serotype O104:H4 (ECO104) can cause bloody diarrhea and haemolytic uremic syndrome. The ECO104 O antigen has the unique repeating unit structure [4Galα1-4Neu5,7,9Ac3α2-3Galβ1-3GalNAcβ1-], which includes the mammalian sialyl-T antigen as an internal structure. Previously, we ide...

journal_title：Glycoconjugate journal

authors： Czuchry D,Szarek WA,Brockhausen I

更新日期：2018-02-01 00:00:00

abstract：:Rice (Oryza sativa) expresses different putative carbohydrate-binding proteins belonging to the class of lectins containing an Euonymus lectin (EUL)-related domain, one of them being OrysaEULS2. The OrysaEULS2 sequence consists of a 56 amino acid N-terminal domain followed by the EUL sequence. In this paper the origin...

journal_title：Glycoconjugate journal

authors： Al Atalah B,Rougé P,Smith DF,Proost P,Lasanajak Y,Van Damme EJ

更新日期：2012-10-01 00:00:00

abstract：:Oxygen-requiring enzymes, such as Δ4-desaturase (dihydroceramide desaturase), sphingolipid Δ4-desaturase/C-4-hydroxylase, and fatty acid 2-hydroxylase are involved in ceramide synthesis. We prepared free ceramides, sphingomyelins and glycosphingolipids (GSLs) from cancer cells cultivated under conditions of normoxia a...

journal_title：Glycoconjugate journal

authors： Tanaka K,Tamiya-Koizumi K,Yamada M,Murate T,Kannagi R,Kyogashima M

更新日期：2015-11-01 00:00:00

abstract：:Chondroitin sulfate (CS) and dermatan sulfate (DS) interact with various extracellular molecules such as growth factors, cytokines/chemokines, neurotrophic factors, morphogens, and viral proteins, thereby playing roles in a variety of biological processes including cell adhesion, proliferation, tissue morphogenesis, n...

journal_title：Glycoconjugate journal

authors： Mizumoto S,Fongmoon D,Sugahara K

更新日期：2013-08-01 00:00:00

abstract：:The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model. Gastric tissue histology, myeloperoxidase (MPO) activity, cyclooxygenases (COX) 1 and 2 expression, ...

journal_title：Glycoconjugate journal

authors： Chatterjee A,Khatua S,Chatterjee S,Mukherjee S,Mukherjee A,Paloi S,Acharya K,Bandyopadhyay SK

更新日期：2013-11-01 00:00:00

abstract：:Macrophages from various origins are known to express membrane lectins that mediate the endocytosis of mannose-bearing glycoconjugates. Most macrophage tumor cell-lines lack such receptors. In this paper we show by flow cytometry analysis that a newly generated macrophage hybridoma (2C11-12), which displays several ma...

journal_title：Glycoconjugate journal

authors： Pimpaneau V,Midoux P,Durand G,De Baetselier P,Monsigny M,Roche AC

更新日期：1989-01-01 00:00:00

abstract：:Chondroitin sulfate (CS) and dermatan sulfate (DS) were extracted and purified from skins or bones of salmon (Salmo salar), snakehead (Channa argus), monkfish (Lophius litulon) and skipjack tuna (Katsuwonus pelamis). Size, structural sequences and sulfate groups of oligosaccharides in the purified CS and DS could be c...

journal_title：Glycoconjugate journal

authors： Lin N,Mo X,Yang Y,Zhang H

更新日期：2017-04-01 00:00:00

abstract：:In this study the comparative TLC immunostaining investigation of neutral GSLs and gangliosides from human skeletal and heart muscle is described. A panel of specific polyclonal and monoclonal antibodies as well as the GM1-specific choleragenoid were used for the overlay assays, combined with preceding neuraminidase t...

journal_title：Glycoconjugate journal

authors： Müthing J,Cacić M

更新日期：1997-01-01 00:00:00

abstract：:Using printed glycan array (PGA) we compared the results of antibody profiling in undiluted, moderately (1:15) and highly (1:100) diluted human blood serum. Undiluted serum is suitable for studying blood as a tissue in its native state, whereas to study the serum of newborns or small animals one usually has to dilute ...

journal_title：Glycoconjugate journal

authors： Shilova N,Navakouski M,Khasbiullina N,Blixt O,Bovin N

更新日期：2012-04-01 00:00:00

abstract：:Synthetic thioglycoside-analogs of gangliosides such as Neu5Ac alpha(2-S-6)Glc beta(1-1)Ceramide (1) and the GM3 analog Neu5Ac alpha(2-S-6)Gal beta(1-4)Glc beta(1-1)Ceramide (2), competitively inhibited GM3 hydrolysis by the sialidase of different subtypes of human and animal influenza viruses with an apparent Ki valu...

journal_title：Glycoconjugate journal

authors： Suzuki Y,Sato K,Kiso M,Hasegawa A

更新日期：1990-01-01 00:00:00

abstract：:Five monoclonal antibodies AS17, 22, 25, 38 and 48, a single monoclonal antibody ACH55, and three monoclonal antibodies NAH33, 43, 46, that recognize acharan sulfate (IdoA2S-GlcNAc)n, acharan (IdoA-GlcNAc)n and N-acetyl-heparosan (GlcA-GlcNAc)n, respectively, were generated by immunization of mice with keyhole limpet ...

journal_title：Glycoconjugate journal

authors： Suzuki K,Yamamoto K,Kariya Y,Maeda H,Ishimaru T,Miyaura S,Fujii M,Yusa A,Joo EJ,Kimata K,Kannagi R,Kim YS,Kyogashima M

更新日期：2008-11-01 00:00:00

abstract：:Heteropolysaccarides were isolated from the Korean medicinal plant, Phellodendri cortex (Hwangbek), by hot water and alkali extractions. The extracted polysaccharides were fractionated into eight fractions and they are mainly composed of D-N-acetylglucosamine, D-galactose, D-mannose, and D-glucose. Among the polysacch...

journal_title：Glycoconjugate journal

authors： Park JI,Shim JK,Do JW,Kim SY,Seo EK,Kwon HJ,Lee TK,Kim JK,Choi DY,Kim CH

更新日期：1999-03-01 00:00:00

abstract：:The human glioma D-54MG cell line grown in vitro primarily expresses ganglio series gangliosides, particularly GM2. Subcutaneous injection of these cells into nude mice produced xenografts with an increased content of the human glioma-associated lacto series gangliosides, primarily 3'-isoLM1, an alteration that was do...

journal_title：Glycoconjugate journal

authors： Fredman P,Wikstrand CJ,Månsson JE,Reifenberger G,Bigner SH,Rasheed A,Svennerholm L,Bigner DD

更新日期：1996-06-01 00:00:00

abstract：:Diabetic mellitus is attended by the development of endothelial dysfunction which is suggested to be accompanied with a chronic low-degree of inflammation. During a chronic hepatic inflammatory response, specific changes in glycosylation of the acute phase protein alpha1-acid glycoprotein (AGP) can be detected. In thi...

journal_title：Glycoconjugate journal

authors： Poland DC,Schalkwijk CG,Stehouwer CD,Koeleman CA,van het Hof B,van Dijk W

更新日期：2001-03-01 00:00:00

abstract：:Duffy antigen/receptor for chemokines (DARC) is a glycosylated seven-transmembrane protein acting as a blood group antigen, a chemokine binding protein and a receptor for Plasmodium vivax malaria parasite. It is present on erythrocytes and endothelial cells of postcapillary venules. The N-terminal extracellular domain...

journal_title：Glycoconjugate journal

authors： Grodecka M,Bertrand O,Karolak E,Lisowski M,Waśniowska K

更新日期：2012-04-01 00:00:00

abstract：:Human β-1,4-galactosyltransferase (β-1,4-GalT) V was shown to be involved in the biosynthesis of N-glycans, O-glycans and lactosylceramide (Lac-Cer) by in vitro studies. To determine its substrate specificity, enzymatic activity and its products were analyzed using mouse embryonic fibroblast (MEF) cells from β-1,4-Gal...

journal_title：Glycoconjugate journal

authors： Kumagai T,Sato T,Natsuka S,Kobayashi Y,Zhou D,Shinkai T,Hayakawa S,Furukawa K

更新日期：2010-10-01 00:00:00

abstract：:Using a focused glycan-gene microarray, we compared the glycosyltransferase (GT) and sulfotransferase gene expression profiles of human monocytes, dendritic cells (DCs) and macrophages (Mphis), isolated or differentiated from the same donors. Microarray analysis indicated that monocytes express transcripts for a full ...

journal_title：Glycoconjugate journal

authors： Trottein F,Schaffer L,Ivanov S,Paget C,Vendeville C,Cazet A,Groux-Degroote S,Lee S,Krzewinski-Recchi MA,Faveeuw C,Head SR,Gosset P,Delannoy P

更新日期：2009-12-01 00:00:00

abstract：:The surface of the spermatozoa is coated with glycoproteins the redistribution of which during in vitro capacitation plays a key role in the subsequent fertilization process. Lipid rafts are membrane microdomains involved in signal transduction through receptors and include or recruit specific types of proteins and gl...

journal_title：Glycoconjugate journal

authors： López-Salguero JB,Fierro R,Michalski JC,Jiménez-Morales I,Lefebvre T,Mondragón-Payne O,Baldini SF,Vercoutter-Edouart AS,González-Márquez H

更新日期：2020-08-01 00:00:00

abstract：:A sialoglycopeptide was isolated from buffalo colostrum in pure form by chromatography on Sephadex G-25 and QAE-Sephadex A-25. This was found to be homogeneous by cellulose acetate membrane electrophoresis and reverse phase HPLC. It consisted of fucose, galactose, mannose, N-acetyl glucosamine and N-acetyl neuraminic ...

journal_title：Glycoconjugate journal

authors： Aparna HS,Salimath PV

更新日期：1996-02-01 00:00:00

abstract：:In this work, we characterized chemically the N-acetyl-D-galactosamine specific lectin from Amaranthus leucocarpus syn hypocondriacus lectin (ALL). It is a dimeric glycoprotein composed by three isoforms with pl at 4.8, 4.9, and 5.2. Circular dichroism analysis indicated that the secondary structure of ALL contains 45...

journal_title：Glycoconjugate journal

authors： Hernández P,Debray H,Jaekel H,Garfias Y,Jiménez Md Mdel C,Martínez-Cairo S,Zenteno E

更新日期：2001-04-01 00:00:00

abstract：:Proteoglycans contain a unique carbohydrate component, glycosaminoglycan, which consists of repeating, typically sulfated disaccharides, and is capable of interacting with diverse molecules. Specific, clustered arrangements of sulfate on the glycosaminoglycan backbone form binding sites for many biologically important...

journal_title：Glycoconjugate journal

authors： Yanagishita M,Podyma-Inoue KA,Yokoyama M

更新日期：2009-11-01 00:00:00

abstract：:Matrix proteoglycans (PGs) have shown promise as biomarker in malignancies. We employed agarose gel eletrophoresis, quantitative real- time reverse transcription-polymerase chain reaction and immunohistochemistry to evaluate the content of sulfated glicosaminoglycans (chondroitin sulfate and heparan sulfate) and expre...

journal_title：Glycoconjugate journal

authors： Rangel MP,de Sá VK,Prieto T,Martins JRM,Olivieri ER,Carraro D,Takagaki T,Capelozzi VL

更新日期：2018-04-01 00:00:00

abstract：:Frog integumentary mucin B.1 (FIM-B.1) represents a polymorphic extracellular mosaic protein which contains tandemly arranged serine/threonine-rich modules as well as cysteine-rich domains. The latter are probably important for oligomerization of FIM-B.1 and have also been found in many proteins of the complement casc...

journal_title：Glycoconjugate journal

authors： Joba W,Hoffmann W

更新日期：1996-10-01 00:00:00