Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice.

Abstract:

:The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model. Gastric tissue histology, myeloperoxidase (MPO) activity, cyclooxygenases (COX) 1 and 2 expression, prostaglandin E2 (PGE2) synthesis, and modulation of pro/anti inflammatory cytokines expression were studied for this purpose. Histological study shows that TEps (20 mg/kg) effectively healed the gastric ulceration. Based on biochemical results, the healing capacities of TEps could be attributed to reduction of MPO activity and protection of mucosal mucin content. Enhanced synthesis of PGE2 by modulation of COX-1 and COX-2 expression and a prominent shift of cytokines expression from pro (TNF-α, IL-1ß) to anti inflammatory (IL-10) side are also held responsible for ulcer healing. The preliminary study highlights the anti-ulcerogenic property of polysaccharide-rich fraction of Termitomyces eurhizus and opens an alternative cure for NSAID induced gastroduodenal diseases.

journal_name

Glycoconj J

journal_title

Glycoconjugate journal

authors

Chatterjee A,Khatua S,Chatterjee S,Mukherjee S,Mukherjee A,Paloi S,Acharya K,Bandyopadhyay SK

doi

10.1007/s10719-013-9479-5

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

759-68

issue

8

eissn

0282-0080

issn

1573-4986

journal_volume

30

pub_type

杂志文章
  • Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation.

    abstract::Glycans serve as important regulators of antibody activities and half-lives. IgE is the most heavily glycosylated antibody, but in comparison to other antibodies little is known about its glycan structure function relationships. We therefore describe the site specific IgE glycosylation from a patient with a novel hype...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-015-9638-y

    authors: Wu G,Hitchen PG,Panico M,North SJ,Barbouche MR,Binet D,Morris HR,Dell A,Haslam SM

    更新日期:2016-06-01 00:00:00

  • Quantitation of Glycopeptides by ESI/MS - size of the peptide part strongly affects the relative proportions and allows discovery of new glycan compositions of Ceruloplasmin.

    abstract::Significant changes of glycan structures are observed in humans if diseases like cancer, arthritis or inflammation are present. Thus, interest in biomarkers based on glycan structures has rapidly emerged in recent years and monitoring disease specific changes of glycosylation and their quantification is of great inter...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-018-9852-5

    authors: Baerenfaenger M,Moritz M,Meyer B

    更新日期:2019-02-01 00:00:00

  • Protein-bound carbohydrates on cell-surface as targets of recognition: an odyssey in understanding them.

    abstract::Multidisciplinary approaches by a number of investigators have established that cell-surface carbohydrates are integral components of recognition systems regulating survival, migration, adhesion, growth and differentiation of various cells. Our own experience and contributions to this exciting field are described. We ...

    journal_title:Glycoconjugate journal

    pub_type: 传,历史文章,杂志文章

    doi:10.1023/a:1011078627247

    authors: Muramatsu T

    更新日期:2000-07-01 00:00:00

  • The transcripts of the apomucin genes MUC2, MUC4, and MUC5AC are large and appear as distinct bands.

    abstract::RNA from four colorectal carcinoma cell lines was prepared and analysed in Northern blots using probes for the MUC2, MUC4, and MUC5AC mucin apoprotein genes. The sizes of the transcripts were very large, in the order of at least 12-16 kb. The presence of distinct bands is in contrast to earlier reports, where these tr...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/BF00702347

    authors: Baeckström D,Hansson GC

    更新日期:1996-10-01 00:00:00

  • Site-specific characterization of N-linked glycosylation in human urinary glycoproteins and endogenous glycopeptides.

    abstract::Glycosylation is a very important post-translational modification involved in various cellular processes, such as cell adhesion, signal transduction and immune response. Urine is a rich source of glycoproteins and attractive biological fluid for biomarker discovery, owing to its availability, ease of collection, and c...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-016-9677-z

    authors: Kawahara R,Saad J,Angeli CB,Palmisano G

    更新日期:2016-12-01 00:00:00

  • Nano-biosensor development for bacterial detection during human kidney infection: use of glycoconjugate-specific antibody-bound gold NanoWire arrays (GNWA).

    abstract::Infectious disease, commonly caused by bacterial pathogens, is now the world's leading cause of premature death and third overall cause behind cardiovascular disease and cancer. Urinary Tract Infection (UTI), caused by E. coli bacteria, is a very common bacterial infection, a majority in women (85%) and may result in ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-004-5539-1

    authors: Basu M,Seggerson S,Henshaw J,Jiang J,del A Cordona R,Lefave C,Boyle PJ,Miller A,Pugia M,Basu S

    更新日期:2004-01-01 00:00:00

  • Characterization of beta-D-xyloside-initiated glycosaminoglycan synthesized by human skin fibroblasts in the presence of tunicamycin.

    abstract::Human skin fibroblasts were incubated with a fluorogenic xyloside, 4-methylumbelliferyl-beta-D-xyloside (Xyl-MU), in the presence or absence of tunicamycin. The xyloside-initiated glycosaminoglycans (GAG-MUs) were isolated from the culture medium, and their structures characterized. When the cells were incubated with ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1023/a:1006935003534

    authors: Takagaki K,Tazawa T,Munakata H,Nakamura T,Endo M

    更新日期:1998-05-01 00:00:00

  • Immunochemical characterization of synthetic hexa-, octa- and decasaccharide conjugate vaccines for Vibrio cholerae O:1 serotype Ogawa with emphasis on antigenic density and chain length.

    abstract::Cholera remains to be a global health problem without suitable vaccines for endemic control or outbreak relief. Here we describe a new parenteral vaccine based on neoglyco-conjugate of synthetic fragments of O-specific polysaccharide (O-SP) of Vibrio cholerae O1, serotype Ogawa. Hexa-, octa- and decasaccharides of the...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-013-9491-9

    authors: Ftacek P,Nelson V,Szu SC

    更新日期:2013-12-01 00:00:00

  • A monoclonal antibody for terminal beta-galactose. Use in analysis of glycosphingolipids.

    abstract::A monoclonal antibody (mAb 8281) specific for the terminal beta-galactose (beta Gal) of glycosphingolipids (GSL) and glycoproteins was produced from mice immunized with lipid extract from fresh acute lymphocytic leukemia (ALL) cells. Immuno-thin layer chromatography (ITLC) and competition assays with purified neutral ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/BF00731643

    authors: Kalisiak A,Oosterwijk E,Minniti JG,Old LJ,Scheinberg DA

    更新日期:1991-02-01 00:00:00

  • Effect of carbohydrate structure on biological activity of artificially N-glycosylated eel calcitonin.

    abstract::To reveal the function of the carbohydrate portion of glycopeptides and glycoproteins, we chemo-enzymatically synthesized artificially N-glycosylated derivatives of eel calcitonin and studied their three-dimensional structure and biological activity. The CD and NMR spectra in trifluoroethanol-H(2)O solution showed tha...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1023/a:1016082017366

    authors: Tagashira M,Tanaka A,Hisatani K,Isogai Y,Hori M,Takamatsu S,Fujibayashi Y,Yamamoto K,Haneda K,Inazu T,Toma K

    更新日期:2001-06-01 00:00:00

  • Glycation changes the charge distribution of type I collagen fibrils.

    abstract::In aging and diabetes, glycation of collagen molecules leads to the formation of cross-links that could alter the surface charge on collagen fibrils, and hence affect the properties and correct functioning of a number of tissues. The electron-optical stain phosphotungstic acid (PTA) binds to positively charged amino a...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1023/a:1006928403140

    authors: Hadley JC,Meek KM,Malik NS

    更新日期:1998-08-01 00:00:00

  • Sulfated sialic acid-polymers inhibit the cytotoxic action of bee and snake venom.

    abstract::Colominic acid is an alpha2,8-linked sialic acid polymer produced by Escherichia coli. We found that synthetic sulfated-colominic acids (SC) remarkably inhibited the cytotoxicity of bee and snake venom toward mouse fibroblast cells, but colominic acids showed no inhibition themselves, indicating the important role of ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1023/a:1007074410201

    authors: Oda Y,Kinoshita M,Hamada K,Nakayama K,Ohta Y,Yamaguchi S,Tsukada Y,Kawai Y,Kakehi K

    更新日期:1999-08-01 00:00:00

  • Analysis of Heparan sulfate/heparin from Colla corii asini by liquid chromatography-electrospray ion trap mass spectrometry.

    abstract::Colla corii asini (CCA) made from donkey-hide has been widely used as a health-care food and an ingredient of traditional Chinese medicine. Heparan sulfate (HS)/heparin is a structurally complex class of glycosaminoglycans (GAGs) that have been implicated in a wide range of biological activities. However, their presen...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-019-09868-0

    authors: Du J,Liu S,Liang Q,Lin J,Jiang L,Chen F,Wei Z

    更新日期:2019-06-01 00:00:00

  • MUC1 gene polymorphism and gastric cancer--an epidemiological study.

    abstract::Gastric carcinoma is a major cause of cancer death worldwide and, like most human cancers, probably develops after environmental insults acting on normal individuals and/or individuals with increased genetic susceptibility. Mucins are attractive molecules to study the relationship between genetics and environment beca...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1023/a:1018573201347

    authors: Carvalho F,Seruca R,David L,Amorim A,Seixas M,Bennett E,Clausen H,Sobrinho-Simões M

    更新日期:1997-01-01 00:00:00

  • Glycosylation potential of human prostate cancer cell lines.

    abstract::Altered glycosylation is a universal feature of cancer cells and altered glycans can help cancer cells escape immune surveillance, facilitate tumor invasion, and increase malignancy. The goal of this study was to identify specific glycoenzymes, which could distinguish prostate cancer cells from normal prostatic cells....

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-012-9428-8

    authors: Gao Y,Chachadi VB,Cheng PW,Brockhausen I

    更新日期:2012-10-01 00:00:00

  • Expression of neutral glycosphingolipids and gangliosides in human skeletal and heart muscle determined by indirect immunofluorescence staining.

    abstract::The expression of neutral glycosphingolipids and gangliosides has been studied in human skeletal and heart muscle using indirect immunofluorescence microscopy. Transversal and longitudinal cryosections were immunostained with specific monoclonal and polyclonal antibodies against the neural glycosphingolipids lactosylc...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/BF00731284

    authors: Cacić M,Müthing J,Kracun I,Neumann U,Weber-Schürholz S

    更新日期:1994-10-01 00:00:00

  • Identification of lipid raft glycoproteins obtained from boar spermatozoa.

    abstract::The surface of the spermatozoa is coated with glycoproteins the redistribution of which during in vitro capacitation plays a key role in the subsequent fertilization process. Lipid rafts are membrane microdomains involved in signal transduction through receptors and include or recruit specific types of proteins and gl...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-020-09924-0

    authors: López-Salguero JB,Fierro R,Michalski JC,Jiménez-Morales I,Lefebvre T,Mondragón-Payne O,Baldini SF,Vercoutter-Edouart AS,González-Márquez H

    更新日期:2020-08-01 00:00:00

  • Structures and gene clusters of the O-specific polysaccharides of the lipopolysaccharides of Escherichia coli O69 and O146 containing glycolactilic acids: ether conjugates of D-GlcNAc and D-Glc with (R)- and (S)-lactic acid.

    abstract::Based on the O-specific polysaccharides of the lipopolysaccharides (O-polysaccharides, O-antigens), strains of a clonal species Escherichia coli are classified into 184 O serogroups. In this work, structures of the O-polysaccharides of E. coli O69 and O146 were elucidated and gene clusters for their biosynthesis were ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-016-9730-y

    authors: Knirel YA,Guo X,Senchenkova SN,Perepelov AV,Liu B,Shashkov AS

    更新日期:2017-02-01 00:00:00

  • Purification and sequence characterization of chondroitin sulfate and dermatan sulfate from fishes.

    abstract::Chondroitin sulfate (CS) and dermatan sulfate (DS) were extracted and purified from skins or bones of salmon (Salmo salar), snakehead (Channa argus), monkfish (Lophius litulon) and skipjack tuna (Katsuwonus pelamis). Size, structural sequences and sulfate groups of oligosaccharides in the purified CS and DS could be c...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-016-9759-y

    authors: Lin N,Mo X,Yang Y,Zhang H

    更新日期:2017-04-01 00:00:00

  • Developmentally regulated O-acetylated sialoglycans in the central nervous system revealed by a new monoclonal antibody 493D4 recognizing a wide range of O-acetylated glycoconjugates.

    abstract::We have previously detected an alkali-labile and developmentally regulated antigen in rat embryonic cerebral cortex, which may be 9-O-acetylsialylated GT3 ganglioside (Hirabayashi Y, Hirota M, Suzuki Y, Matsumoto M, Obata K, Ando S (1989) Neurosci Lett 106:193-98). In this study we established a mouse monoclonal antib...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1023/a:1018542105832

    authors: Zhang G,Ji L,Kurono S,Fujita SC,Furuya S,Hirabayashi Y

    更新日期:1997-11-01 00:00:00

  • Beyond CHELP: improved potential derived charges for sugars.

    abstract::The partitioning of the overall molecular charge distribution into atom centered monopole charges, while quantum mechanically ill-defined, is nevertheless a technique which finds applications in several broad classes of chemical problems. Charges derived from fits to electrostatic potentials have an intuitive appeal s...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1023/a:1018511804498

    authors: Carey C,Chirlian LE,Francl MM,Gange DM

    更新日期:1997-06-01 00:00:00

  • Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides.

    abstract::We have examined structure-function relationships that have been proposed to account for the heparin-binding properties of basic fibroblast growth factor and its receptor, FGFR-1, using synthetic peptides, DNA synthesis assays and binding assays in a resonant mirror biosensor. The results suggest that the interaction ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1023/a:1006986104865

    authors: Kinsella L,Chen HL,Smith JA,Rudland PS,Fernig DG

    更新日期:1998-04-01 00:00:00

  • Cloning and characterization of a sialidase from the filamentous fungus, Aspergillus fumigatus.

    abstract::A gene encoding a putative sialidase was identified in the genome of the opportunistic fungal pathogen, Aspergillus fumigatus. Computational analysis showed that this protein has Asp box and FRIP domains, it was predicted to have an extracellular localization, and a mass of 42 kDa, all of which are characteristics of ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-010-9299-9

    authors: Warwas ML,Yeung JH,Indurugalla D,Mooers AO,Bennet AJ,Moore MM

    更新日期:2010-07-01 00:00:00

  • MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin-/dermatan sulfate and hyaluronan biosynthesis.

    abstract::Proteoglycans and glycosaminoglycans modulate numerous cellular processes relevant to tumour progression, including cell proliferation, cell-matrix interactions, cell motility and invasive growth. Among the glycosaminoglycans with a well-documented role in tumour progression are heparan sulphate, chondroitin/dermatan ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-016-9735-6

    authors: Viola M,Brüggemann K,Karousou E,Caon I,Caravà E,Vigetti D,Greve B,Stock C,De Luca G,Passi A,Götte M

    更新日期:2017-06-01 00:00:00

  • Extraction and separation of proteoglycans.

    abstract::Proteoglycans contain a unique carbohydrate component, glycosaminoglycan, which consists of repeating, typically sulfated disaccharides, and is capable of interacting with diverse molecules. Specific, clustered arrangements of sulfate on the glycosaminoglycan backbone form binding sites for many biologically important...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-008-9138-4

    authors: Yanagishita M,Podyma-Inoue KA,Yokoyama M

    更新日期:2009-11-01 00:00:00

  • Printed glycan array: antibodies as probed in undiluted serum and effects of dilution.

    abstract::Using printed glycan array (PGA) we compared the results of antibody profiling in undiluted, moderately (1:15) and highly (1:100) diluted human blood serum. Undiluted serum is suitable for studying blood as a tissue in its native state, whereas to study the serum of newborns or small animals one usually has to dilute ...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-011-9368-8

    authors: Shilova N,Navakouski M,Khasbiullina N,Blixt O,Bovin N

    更新日期:2012-04-01 00:00:00

  • Clinicopathological significance of ganglioside DSGb5 expression in renal cell carcinoma.

    abstract::Disialosyl globopentaosylceramide (DSGb5) is a ganglioside originally isolated from tissue extracts of renal cell carcinoma (RCC) with metastasis. Previous in vitro experiments have suggested that DSGb5 promotes metastasis by enhancing the migration of RCC cells and downregulating NK cell cytotoxicity against RCC cell...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-017-9763-x

    authors: Itoh J,Ito A,Shimada S,Kawasaki Y,Kakoi N,Saito H,Mitsuzuka K,Watanabe M,Satoh M,Saito S,Arai Y

    更新日期:2017-04-01 00:00:00

  • Mass spectrometric analysis of genetic and post-translational heterogeneity in the lectins Jacalin and Maclura pomifera agglutinin.

    abstract::Jacalin and M. pomifera agglutinin are T-antigen specific lectins with alpha 4 beta 4 structures that show far greater micro-heterogeneity than plant lectins from other families, due to multiple genetic isoforms and post-translational processing. Electrospray mass spectrometry and combined liquid chromatography-electr...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/BF00731357

    authors: Young NM,Watson DC,Thibault P

    更新日期:1995-04-01 00:00:00

  • A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway.

    abstract::Grifola frondosa is an important fungal research resource. However, there was little report about hyperglycemic activity of Grifola frondosa polysaccharide on insulin resistance in vitro. In this study, the hypoglycemic activity of a polysaccharide obtained from Grifola frondosa (GFP) on HepG2 cell and hpyerglycemic m...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-014-9526-x

    authors: Ma X,Zhou F,Chen Y,Zhang Y,Hou L,Cao X,Wang C

    更新日期:2014-07-01 00:00:00

  • A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells.

    abstract::Humans, in contrast to other mammals, do not synthesize N-glycolyl-neuraminic acid (Neu5Gc) due to a deletion in the gene (cmah) encoding the enzyme responsible for this conversion, the cytidine monophospho-N-acetyl-neuraminic acid hydroxylase (CMP-Neu5Ac hydroxylase). The detection of considerable amounts of Neu5Gc-s...

    journal_title:Glycoconjugate journal

    pub_type: 杂志文章

    doi:10.1007/s10719-013-9473-y

    authors: Casadesús AV,Fernández-Marrero Y,Clavell M,Gómez JA,Hernández T,Moreno E,López-Requena A

    更新日期:2013-10-01 00:00:00