Altered expression and glycosylation of plasma proteins in rheumatoid arthritis.

abstract：:Carbohydrate-carbohydrate interaction is a reliable and versatile mechanism for cell adhesion and recognition. Glycosphingolipid (GSL) clusters at the cell membrane are mainly involved in this interaction. To investigate carbohydrate-carbohydrate interaction an integrated strategy (Glyconanotechnology) was developed. ...

journal_title：Glycoconjugate journal

authors： de la Fuente JM,Penadés S

更新日期：2004-01-01 00:00:00

abstract：:UDP-GlcNAc:alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II (GnT II; EC 2.4.1.143) is a medial-Golgi resident enzyme that catalyses an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Screening a cDNA library from Xenopus laevis ovary with a human ...

journal_title：Glycoconjugate journal

authors： Mucha J,Svoboda B,Kappel S,Strasser R,Bencur P,Fröhwein U,Schachter H,Mach L,Glössl J

更新日期：2002-03-01 00:00:00

abstract：:Mammalian milk/colostrum usually contains oligosaccharides along with the predominant disaccharide lactose. It has been found that the number and identity of these milk oligosaccharides varies among mammalian species. Oligosaccharides predominate over lactose in the milk/colostrum of Arctoidea species (Carnivora), whe...

journal_title：Glycoconjugate journal

authors： Mineguchi Y,Miyoshi M,Taufik E,Kawamura A,Asakawa T,Suzuki I,Souma K,Okubo M,Saito T,Fukuda K,Asakuma S,Urashima T

更新日期：2018-12-01 00:00:00

abstract：:The partitioning of the overall molecular charge distribution into atom centered monopole charges, while quantum mechanically ill-defined, is nevertheless a technique which finds applications in several broad classes of chemical problems. Charges derived from fits to electrostatic potentials have an intuitive appeal s...

journal_title：Glycoconjugate journal

authors： Carey C,Chirlian LE,Francl MM,Gange DM

更新日期：1997-06-01 00:00:00

abstract：:Chondroitin sulfate (CS) and dermatan sulfate (DS) interact with various extracellular molecules such as growth factors, cytokines/chemokines, neurotrophic factors, morphogens, and viral proteins, thereby playing roles in a variety of biological processes including cell adhesion, proliferation, tissue morphogenesis, n...

journal_title：Glycoconjugate journal

authors： Mizumoto S,Fongmoon D,Sugahara K

更新日期：2013-08-01 00:00:00

abstract：:Proteoglycans and glycosaminoglycans modulate numerous cellular processes relevant to tumour progression, including cell proliferation, cell-matrix interactions, cell motility and invasive growth. Among the glycosaminoglycans with a well-documented role in tumour progression are heparan sulphate, chondroitin/dermatan ...

journal_title：Glycoconjugate journal

authors： Viola M,Brüggemann K,Karousou E,Caon I,Caravà E,Vigetti D,Greve B,Stock C,De Luca G,Passi A,Götte M

更新日期：2017-06-01 00:00:00

abstract：:The SewA385T mutation of the FUT2 gene was found to correlate with both the erthrocyte Le(a + b+) and/or salivary ABH partial-secretor phenotypes of Polynesians. Constructs with FUT1 and FUT2 wild type genes, and the FUT2 SewA385T, seG428A and seC571T mutated alleles, were cloned into pcDNAI, and expressed in COS-7 ce...

journal_title：Glycoconjugate journal

authors： Henry S,Mollicone R,Fernandez P,Samuelsson B,Oriol R,Larson G

更新日期：1996-12-01 00:00:00

abstract：:Oral exposure to lectins or the presence or absence of bacteria in the rat small intestine were shown by histological methods using anti-lectin antibodies or digoxigenin-labelled lectins to have major effects on the state of glycosylation of lumenal membranes and cytoplasmic glycoconjugates of epithelial cells. Taken ...

journal_title：Glycoconjugate journal

authors： Pusztai A,Ewen SW,Grant G,Peumans WJ,Van Damme EJ,Coates ME,Bardocz S

更新日期：1995-02-01 00:00:00

abstract：:A gene encoding a putative sialidase was identified in the genome of the opportunistic fungal pathogen, Aspergillus fumigatus. Computational analysis showed that this protein has Asp box and FRIP domains, it was predicted to have an extracellular localization, and a mass of 42 kDa, all of which are characteristics of ...

journal_title：Glycoconjugate journal

authors： Warwas ML,Yeung JH,Indurugalla D,Mooers AO,Bennet AJ,Moore MM

更新日期：2010-07-01 00:00:00

abstract：:The human glioma D-54MG cell line grown in vitro primarily expresses ganglio series gangliosides, particularly GM2. Subcutaneous injection of these cells into nude mice produced xenografts with an increased content of the human glioma-associated lacto series gangliosides, primarily 3'-isoLM1, an alteration that was do...

journal_title：Glycoconjugate journal

authors： Fredman P,Wikstrand CJ,Månsson JE,Reifenberger G,Bigner SH,Rasheed A,Svennerholm L,Bigner DD

更新日期：1996-06-01 00:00:00

abstract：:This review summarizes fifty years of carbohydrate chemistry, from studies of reaction mechanisms and development of synthetic methods to the design of specific compounds for investigations of cancer glycoproteins. Through these years of intensive research, many carbohydrate derivatives were shown to be biologically r...

journal_title：Glycoconjugate journal

authors： Paulsen H,Brockhausen I

更新日期：2001-11-01 00:00:00

abstract：:Two azidohexasaccharide building blocks, of which the glycosyl acceptor was the 5-(methoxycarbonyl)pentyl glycoside, were coupled using the trichloroacetimidate technology. The 12 azido functions present in the dodecasaccharide thus formed were then converted to amino groups using hydrogen sulfide as a reducing reagen...

journal_title：Glycoconjugate journal

authors： Ogawa Y,Kovac P

更新日期：1997-06-01 00:00:00

abstract：:Alterations in cell membrane glycosylation play important role in oral carcinogenesis. The present study evaluated salivary sialylation changes i.e. total sialic acid (TSA), sialidase activity, linkage specific (α2-3 and α2-6) sialoproteins and sialyl transferase (ST) activity in controls, patients with oral precancer...

journal_title：Glycoconjugate journal

authors： Vajaria BN,Patel KR,Begum R,Patel JB,Shah FD,Joshi GM,Patel PS

更新日期：2014-12-01 00:00:00

abstract：:Transmembrane signaling requires modular interactions between signaling proteins, phosphorylation or dephosphorylation of the interacting protein partners and temporary elaboration of supramolecular structures, to convey the molecular information from the cell surface to the nucleus. Such signaling complexes at the pl...

journal_title：Glycoconjugate journal

authors： Hoessli DC,Ilangumaran S,Soltermann A,Robinson PJ,Borisch B,Nasir-Ud-Din

更新日期：2000-03-01 00:00:00

abstract：:Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO(3)-3Gal-ceramide) and seminolipid (SO(3)-3Gal-alkylacylglycerol). Sulfatide is abundant in the myelin sheath and seminolipid is expressed on the spermatogenic cells. Cerebroside sulfotransferase (CST)-deficient mice generated by gene targetin...

journal_title：Glycoconjugate journal

authors： Honke K,Zhang Y,Cheng X,Kotani N,Taniguchi N

更新日期：2004-01-01 00:00:00

abstract：:The classical function of human chorionic gonadotropin (hCG) is its role in supporting pregnancy. hCG is a dimer consisting of two highly glycosylated subunits, alpha (CGA) and beta (CGB). The beta-hCG protein is encoded by CGB3, CGB5, CGB7 and CGB8 genes. CGB3, 5 and 8 code for an identical protein, CGB3/5/8, whereas...

journal_title：Glycoconjugate journal

authors： Biskup K,Blanchard V,Castillo-Binder P,Alexander H,Engeland K,Schug S

更新日期：2020-10-01 00:00:00

abstract：:We have previously shown that murine resident peritoneal macrophages (PEMs) are activated in response to uptake of oligomannose-coated liposomes (OMLs), leading to production of interleukin (IL)-12. To understand the mechanism of activation of PEMs by OMLs, in the present study we investigated the role of a mannose-bi...

journal_title：Glycoconjugate journal

authors： Kato C,Kojima N

更新日期：2010-07-01 00:00:00

abstract：:Five monoclonal antibodies AS17, 22, 25, 38 and 48, a single monoclonal antibody ACH55, and three monoclonal antibodies NAH33, 43, 46, that recognize acharan sulfate (IdoA2S-GlcNAc)n, acharan (IdoA-GlcNAc)n and N-acetyl-heparosan (GlcA-GlcNAc)n, respectively, were generated by immunization of mice with keyhole limpet ...

journal_title：Glycoconjugate journal

authors： Suzuki K,Yamamoto K,Kariya Y,Maeda H,Ishimaru T,Miyaura S,Fujii M,Yusa A,Joo EJ,Kimata K,Kannagi R,Kim YS,Kyogashima M

更新日期：2008-11-01 00:00:00

abstract：:Congenital disorders of glycosylation (CDG) are genetic diseases characterized by deficient synthesis (CDG type I) and/or abnormal processing (CDG type II) of glycan moieties linked to protein and lipids. The impact of the molecular defects on protein glycosylation and in turn on the clinical phenotypes of patients wi...

journal_title：Glycoconjugate journal

authors： Sturiale L,Bianca S,Garozzo D,Terracciano A,Agolini E,Messina A,Palmigiano A,Esposito F,Barone C,Novelli A,Fiumara A,Jaeken J,Barone R

更新日期：2019-12-01 00:00:00

abstract：:A group of fluorescent statistical glycopolymers, prepared via reversible addition-fragmentation chain-transfer (RAFT)-based polymerizations, were successfully employed in lectin-mediated bacterial binding studies. The resultant glycopolymers contained three different monomers: N-(2-hydroxyethyl) acrylamide (HEAA), N-...

journal_title：Glycoconjugate journal

authors： Wang W,Chance DL,Mossine VV,Mawhinney TP

更新日期：2014-02-01 00:00:00

abstract：:Mannose 6-phosphate receptor proteins (MPR 300 and 46) are type 1 transmembrane glycoproteins that mediate transport of lysosomal enzymes to lysosomes. In a recent study we have purified both receptors from goat liver and raised antibodies. An ELISA method was developed that allowed quantification of both receptors in...

journal_title：Glycoconjugate journal

authors： Suresh K,Vegiraju SR,Nadimpalli SK

更新日期：2004-01-01 00:00:00

abstract：:The N-glycan moiety of ascorbic acid oxidase from zucchini (Cucurbita pepo) has been described to be a core-pentasaccharide with a xylose [D'Andrea et al. (1988) Glycoconjugate J 5:151-7]. Ascorbic acid oxidase is sometimes used to characterize antibodies directed against carbohydrate determinants on plant glycoprotei...

journal_title：Glycoconjugate journal

authors： Altmann F

更新日期：1998-01-01 00:00:00

abstract：:Colla corii asini (CCA) made from donkey-hide has been widely used as a health-care food and an ingredient of traditional Chinese medicine. Heparan sulfate (HS)/heparin is a structurally complex class of glycosaminoglycans (GAGs) that have been implicated in a wide range of biological activities. However, their presen...

journal_title：Glycoconjugate journal

authors： Du J,Liu S,Liang Q,Lin J,Jiang L,Chen F,Wei Z

更新日期：2019-06-01 00:00:00

abstract：:The sugar chain-binding specificity of tomato lectin (LEA) against glycoproteins was investigated qualitatively using lectin blot analysis. Glycoproteins containing tri- and tetra-antennary complex-type N-glycans were stained with LEA. Unexpectedly, glycoproteins containing high mannose-type N-glycans and a horseradis...

journal_title：Glycoconjugate journal

authors： Oguri S

更新日期：2005-11-01 00:00:00

abstract：:As part of our ongoing program aimed at understanding the structural significance of GlcNAcβAsn linkage conserved in all eukaryotic N-glycoproteins, the present study reports on the synthesis and X-ray crystal structures of N-(3-deoxy-3-acetamido-β-D-glycopyranosyl)acetamide (Glc3NAcβNHAc) and the corresponding propio...

journal_title：Glycoconjugate journal

authors： Mathiselvam M,Varghese B,Loganathan D

更新日期：2011-12-01 00:00:00

abstract：:A new method for determination of alpha1,6fucosyltransferase activity has been described. Recently, the disialyl-biantennary undecasaccharide was prepared in high yield from egg yolk [(1996), Carbohydr Lett 2: 137-42]. By treatment of this oligosaccharide with neuraminidase and beta-galactosidase, we readily obtained ...

journal_title：Glycoconjugate journal

authors： Yazawa S,Kochibe N,Nishimura T,Shima C,Takai I,Adachi M,Asao T,Hada T,Enoki Y,Juneja LR

更新日期：1998-09-01 00:00:00

abstract：:Reductive amination of 3-deoxy-D-manno-octulosonic acid (Kdo) with allylamine (AIIN) or 2-(4-aminophenyl)ethylamine (APEA) yields epimer pairs of 2-N-allylamino and 2-N-[2-(4-aminophenyl)ethylamino]-2,3-dideoxy-D-glycero-D-galacto- and -2,3-dideoxy-D-glycero-D-talo-octonic acid. The yields were 50-60% due to reduction...

journal_title：Glycoconjugate journal

authors： Grimmecke HD,Brade H

更新日期：1998-06-01 00:00:00

abstract：:C-Mannosylation, a protein-modification found in various eukaryotes, involves the attachment of a single mannose molecule to selected tryptophan residues of proteins. Since C-mannosyl tryptophan (CMW) was detected in human urine, it is generally thought that CMW is not catabolized inside our body and instead is excret...

journal_title：Glycoconjugate journal

authors： Hossain TJ,Manabe S,Ito Y,Iida T,Kosono S,Ueda K,Hosomi A,Inoue D,Suzuki T

更新日期：2018-04-01 00:00:00

abstract：:Frog integumentary mucin B.1 (FIM-B.1) represents a polymorphic extracellular mosaic protein which contains tandemly arranged serine/threonine-rich modules as well as cysteine-rich domains. The latter are probably important for oligomerization of FIM-B.1 and have also been found in many proteins of the complement casc...

journal_title：Glycoconjugate journal

authors： Joba W,Hoffmann W

更新日期：1996-10-01 00:00:00

abstract：:Galectin-1 has demonstrated a diverse range of activities in relation to cell survival and proliferation. In different circumstances, it acts as a mitogen, as an inhibitor of cell proliferation, and as a promoter of cellular apoptosis. Many of these activities, particularly the mitogenic and apoptotic responses, follo...

journal_title：Glycoconjugate journal

authors： Scott K,Weinberg C

更新日期：2002-01-01 00:00:00