Studies on the reductive amination of 3-deoxy-D-manno-octulosonic acid (Kdo).

abstract：:Grifola frondosa is an important fungal research resource. However, there was little report about hyperglycemic activity of Grifola frondosa polysaccharide on insulin resistance in vitro. In this study, the hypoglycemic activity of a polysaccharide obtained from Grifola frondosa (GFP) on HepG2 cell and hpyerglycemic m...

journal_title：Glycoconjugate journal

authors： Ma X,Zhou F,Chen Y,Zhang Y,Hou L,Cao X,Wang C

更新日期：2014-07-01 00:00:00

abstract：:The modulation of GnT-V activity by signaling molecules in PI-3-K/PKB pathway in human hepatocarcinoma cell line 7721 was studied. GnT-V activity was determined after the transfection of sense or antisense cDNA of PKB into the cells, as well as the addition of activators, specific inhibitors, and the antibodies to the...

journal_title：Glycoconjugate journal

authors： Guo HB,Shen ZH,Huang CX,Ma J,Huang Y,Chen HL

更新日期：2000-05-01 00:00:00

abstract：:The structures of the branched capsular polysaccharides of group B streptococcus type III (GBSIIIPS) and Streptococcus pneumoniae type 14 (Pn14PS) are identical apart from the (α2→3)-linked sialic acid in the side chains of GBSIIIPS. The present study tries to determine the minimal epitope in GBSIIIPS, using both a pa...

journal_title：Glycoconjugate journal

authors： Safari D,Dekker HA,Rijkers GT,van der Ende A,Kamerling JP,Snippe H

更新日期：2011-12-01 00:00:00

abstract：:We have examined structure-function relationships that have been proposed to account for the heparin-binding properties of basic fibroblast growth factor and its receptor, FGFR-1, using synthetic peptides, DNA synthesis assays and binding assays in a resonant mirror biosensor. The results suggest that the interaction ...

journal_title：Glycoconjugate journal

authors： Kinsella L,Chen HL,Smith JA,Rudland PS,Fernig DG

更新日期：1998-04-01 00:00:00

abstract：:Both infiltrating leukocytes and soluble immunoglobulin form aggregates in synovial fluid during the inflammatory process in rheumatoid arthritis (RA). Some of these changes are probably mediated by the adhesion molecule, E-selectin, which increases its expression with disease activity. As glycosylation changes in IgG...

journal_title：Glycoconjugate journal

authors： Goodarzi MT,Axford JS,Varanasi SS,Alavi A,Cunnane G,Fitzgerald O,Turner GA

更新日期：1998-12-01 00:00:00

abstract：:A novel cold-water-soluble polysaccharide (BEP), with a molecular weight of 6.0 × 106 Da, was isolated from Boletus edulis. BEP consists of galactose, glucose, xylose, mannose, glucuronic, and galacturonic acid in a ratio of 0.34:0.28:0.28:2.57:1.00:0.44. The IR results showed that BEP was an acid polysaccharide, cont...

journal_title：Glycoconjugate journal

authors： Meng T,Yu SS,Ji HY,Xu XM,Liu AJ

更新日期：2021-01-28 00:00:00

abstract：:Over the past two decades, sugar chain structures of human chorionic gonadotropin (hCG) produced in healthy people, three types of trophoblastic disease, and some types of cell lines have been analyzed. The abnormal biantennary structure of hCG is a good marker for the diagnosis of malignant choriocarcinoma. In spite ...

journal_title：Glycoconjugate journal

authors： Takamatsu S,Katsumata T,Inoue N,Watanabe T,Fujibayashi Y,Takeuchi M

更新日期：2004-01-01 00:00:00

abstract：:Cell surface lipopolysaccharide (LPS) is a well characterized virulence determinant for the human pathogen Haemophilus influenzae, so an investigation of LPS in the less pathogenic Haemophilus parainfluenzae could yield important insights. Using a panel of 18 commensal H. parainfluenzae isolates we demonstrate that th...

journal_title：Glycoconjugate journal

authors： Young RE,Hood DW

更新日期：2013-08-01 00:00:00

abstract：:Filamentous fungi are commonly used in the fermentation industry for large scale production of glycoproteins. Several of these proteins can be produced in concentrations up to 20-40 g per litre. The production of heterologous glycoproteins is at least one or two orders of magnitude lower but research is in progress to...

journal_title：Glycoconjugate journal

authors： Maras M,van Die I,Contreras R,van den Hondel CA

更新日期：1999-02-01 00:00:00

abstract：:The partitioning of the overall molecular charge distribution into atom centered monopole charges, while quantum mechanically ill-defined, is nevertheless a technique which finds applications in several broad classes of chemical problems. Charges derived from fits to electrostatic potentials have an intuitive appeal s...

journal_title：Glycoconjugate journal

authors： Carey C,Chirlian LE,Francl MM,Gange DM

更新日期：1997-06-01 00:00:00

abstract：:Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO(3)-3Gal-ceramide) and seminolipid (SO(3)-3Gal-alkylacylglycerol). Sulfatide is abundant in the myelin sheath and seminolipid is expressed on the spermatogenic cells. Cerebroside sulfotransferase (CST)-deficient mice generated by gene targetin...

journal_title：Glycoconjugate journal

authors： Honke K,Zhang Y,Cheng X,Kotani N,Taniguchi N

更新日期：2004-01-01 00:00:00

abstract：:Amphipathic sulpholipids have been shown to inhibit pancreatic serine proteases due to their detergent-like properties. To evaluate the structural requirement for this inhibitory activity, we examined the effects of various derivatives of sulphoglycolipids, some of which were prepared by deacylation with sphingolipid ...

journal_title：Glycoconjugate journal

authors： Suzuki H,Ito M,Kimura T,Iwamori Y,Iwamori M

更新日期：2000-11-01 00:00:00

abstract：:The sugar chain-binding specificity of tomato lectin (LEA) against glycoproteins was investigated qualitatively using lectin blot analysis. Glycoproteins containing tri- and tetra-antennary complex-type N-glycans were stained with LEA. Unexpectedly, glycoproteins containing high mannose-type N-glycans and a horseradis...

journal_title：Glycoconjugate journal

authors： Oguri S

更新日期：2005-11-01 00:00:00

abstract：:Glycosphingolipids were prepared from pig lung and pooled into two fractions with (i) < or = 3 sugar residues, and (ii) > or = 3 sugar residues. Oligosaccharides were prepared and used for gas chromatography, gas chromatography/mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry. The gl...

journal_title：Glycoconjugate journal

authors： Bäcker AE,Thorbert S,Rakotonirainy O,Hallberg EC,Olling A,Gustavsson M,Samuelsson BE,Soussi B

更新日期：1999-01-01 00:00:00

abstract：:A water-soluble polysaccharide CSPS-2B-2 with a molecular mass of 8.8 kDa, was obtained from the fruits of Capparis spinosa L. Chemical and NMR spectral analysis verified CSPS-2B-2 was a linear poly-(1-4)-α-D-galactopyranosyluronic acid in which 12.9±0.4% of carboxyl groups existed as methyl ester and 2.6±0.1% of D-Ga...

journal_title：Glycoconjugate journal

authors： Wang H,Wang H,Shi S,Duan J,Wang S

更新日期：2012-08-01 00:00:00

abstract：:Synthesis and antigenic reactivity of 6-O-sulfo sialylparagloboside (SPG) and sialyl Lewis X (sLeX) neo-glycolipids containing lactamized neuraminic acid are described. The suitably protected GlcNAc-beta (1-->3)-Gal-beta (1-->4)-GlcOSE derivative was glycosylated with NeuTFAc-alpha (2-->3)-Gal imidate to give NeuTFAc-...

journal_title：Glycoconjugate journal

authors： Yamaguchi M,Ishida H,Kanamori A,Kannagi R,Kiso M

更新日期：2005-03-01 00:00:00

abstract：:We report the postnatal developmental profiles of N-acetylneuraminic acid cytidylyltransferase (EC 2.7.7.43) (CMP-Neu5Ac synthetase) in different rat tissues. This enzyme, which catalyses the activation of NeuAc to CMP-Neu5Ac, was detected in brain, kidney, heart, spleen, liver, stomach, intestine, lung, thymus, prost...

journal_title：Glycoconjugate journal

authors： Revilla-Nuin B,Reglero A,Feo JC,Rodriguez-Aparicio LB,Ferrero MA

更新日期：1998-03-01 00:00:00

abstract：:UDP-GlcNAc:alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II (GnT II; EC 2.4.1.143) is a medial-Golgi resident enzyme that catalyses an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Screening a cDNA library from Xenopus laevis ovary with a human ...

journal_title：Glycoconjugate journal

authors： Mucha J,Svoboda B,Kappel S,Strasser R,Bencur P,Fröhwein U,Schachter H,Mach L,Glössl J

更新日期：2002-03-01 00:00:00

abstract：:The small keratan sulphate proteoglycan, fibromodulin, has been isolated from pooled human articular cartilage. The main chain repeat region and the chain caps from the attached N-linked keratan sulphate chains have been fragmented by keratanase II digestion, and the oligosaccharides generated have been reduced and is...

journal_title：Glycoconjugate journal

authors： Lauder RM,Huckerby TN,Nieduszynski IA

更新日期：1997-08-01 00:00:00

abstract：:Using printed glycan array (PGA) we compared the results of antibody profiling in undiluted, moderately (1:15) and highly (1:100) diluted human blood serum. Undiluted serum is suitable for studying blood as a tissue in its native state, whereas to study the serum of newborns or small animals one usually has to dilute ...

journal_title：Glycoconjugate journal

authors： Shilova N,Navakouski M,Khasbiullina N,Blixt O,Bovin N

更新日期：2012-04-01 00:00:00

abstract：:Comparing the properties of 'young' and senescent ('aged') O+ erythrocytes isolated by applying ultracentrifugation in a self-forming Percoll gradient, we demonstrate that the sialic acids of membrane glycoconjugates control the life span of erythrocytes and that the desialylation of glycans is responsible for the cle...

journal_title：Glycoconjugate journal

authors： Bratosin D,Mazurier J,Debray H,Lecocq M,Boilly B,Alonso C,Moisei M,Motas C,Montreuil J

更新日期：1995-06-01 00:00:00

abstract：:Mannose 6-phosphate receptor proteins (MPR 300 and 46) are type 1 transmembrane glycoproteins that mediate transport of lysosomal enzymes to lysosomes. In a recent study we have purified both receptors from goat liver and raised antibodies. An ELISA method was developed that allowed quantification of both receptors in...

journal_title：Glycoconjugate journal

authors： Suresh K,Vegiraju SR,Nadimpalli SK

更新日期：2004-01-01 00:00:00

abstract：:Gastric carcinoma is a major cause of cancer death worldwide and, like most human cancers, probably develops after environmental insults acting on normal individuals and/or individuals with increased genetic susceptibility. Mucins are attractive molecules to study the relationship between genetics and environment beca...

journal_title：Glycoconjugate journal

authors： Carvalho F,Seruca R,David L,Amorim A,Seixas M,Bennett E,Clausen H,Sobrinho-Simões M

更新日期：1997-01-01 00:00:00

abstract：:Rotaviruses are the leading cause of childhood diarrhea. The entry of rotaviruses into the host cell is a complex process that includes several interactions of the outer layer proteins of the virus with different cell surface molecules. The fact that neuraminidase treatment of the cells, or preincubation of the virus ...

journal_title：Glycoconjugate journal

authors： Isa P,Arias CF,López S

更新日期：2006-02-01 00:00:00

abstract：:The IgG Fc glycans strongly influence the Fcγ receptor interactions and Fc-mediated effector mechanisms. Changes in the structure of IgG glycans are associated with various diseases, such as infections and autoimmunity. However, the possible role of Fc glycans in tumor immunity is not yet fully understood. The aim of ...

journal_title：Glycoconjugate journal

authors： Kodar K,Stadlmann J,Klaamas K,Sergeyev B,Kurtenkov O

更新日期：2012-01-01 00:00:00

abstract：:Type 1 ABO blood group antigens (peripheral core structure: Gal beta 1-3GlcNAc beta 1-R) are expressed mainly in endodermally-derived tissues, but are not synthesized in mesodermally-derived tissues. In the former tissues, H type 1 antigen is generated largely by alpha-2-L-fucosyltransferase encoded by secretor (Se) g...

journal_title：Glycoconjugate journal

authors： Tanegashima A,Nishi K,Fukunaga T,Rand S,Brinkmann B

更新日期：1996-08-01 00:00:00

abstract：:The novel glycosphingolipid, SEGLx (Galbeta1-4(Fucalpha1-3)Glcbeta1-3GalbetaCer), which was identified by us (Kawakami Y, et al. (1993) J Biochem 114: 677-83), shows a characteristic spectrum on 1H-NMR analysis, in which the anomeric proton resonances of a reducing end galactose and a glucose are split. To elucidate t...

journal_title：Glycoconjugate journal

authors： Kawakami J,Kawakami Y,Nakamura K,Kojima H,Ito S,Tamai Y

更新日期：1998-02-01 00:00:00

abstract：:Cholera remains to be a global health problem without suitable vaccines for endemic control or outbreak relief. Here we describe a new parenteral vaccine based on neoglyco-conjugate of synthetic fragments of O-specific polysaccharide (O-SP) of Vibrio cholerae O1, serotype Ogawa. Hexa-, octa- and decasaccharides of the...

journal_title：Glycoconjugate journal

authors： Ftacek P,Nelson V,Szu SC

更新日期：2013-12-01 00:00:00

abstract：:Syndecan-4 is a transmembrane heparan sulfate proteoglycan belonging to the syndecan family. Syndecan-4-deficient [(Synd4(-/-)] mice were produced to clarify the in vivo role of syndecan-4. Synd4(-/-) mice were more susceptible to kappa-carrageenan-induced nephropathy, and the placental labyrinth from the deficient em...

journal_title：Glycoconjugate journal

authors： Ishiguro K,Kojima T,Muramatsu T

更新日期：2002-05-01 00:00:00

abstract：:Human alpha1,3-fucosyltransferase V and -VI (hFucTV and -VI) each contain four potential N-glycosylation sites (hFucTV: Asn60, Asn105, Asn167 and Asn198 and hFucTVI: Asn46, Asn91, Asn153 and Asn184). Glycosylation of the two N-terminal potential N-glycosylation sites (hFucTV: Asn60, Asn105 and hFucTVI: Asn46 and Asn91...

journal_title：Glycoconjugate journal

authors： Christensen LL,Bross P,Ørntoft TF

更新日期：2000-12-01 00:00:00