Sialyl Lewis(x) expression on IgG in rheumatoid arthritis and other arthritic conditions: a preliminary study.

abstract：:A monoclonal antibody (mAb 8281) specific for the terminal beta-galactose (beta Gal) of glycosphingolipids (GSL) and glycoproteins was produced from mice immunized with lipid extract from fresh acute lymphocytic leukemia (ALL) cells. Immuno-thin layer chromatography (ITLC) and competition assays with purified neutral ...

journal_title：Glycoconjugate journal

authors： Kalisiak A,Oosterwijk E,Minniti JG,Old LJ,Scheinberg DA

更新日期：1991-02-01 00:00:00

abstract：:Multidisciplinary approaches by a number of investigators have established that cell-surface carbohydrates are integral components of recognition systems regulating survival, migration, adhesion, growth and differentiation of various cells. Our own experience and contributions to this exciting field are described. We ...

journal_title：Glycoconjugate journal

authors： Muramatsu T

更新日期：2000-07-01 00:00:00

abstract：:Rice (Oryza sativa) expresses different putative carbohydrate-binding proteins belonging to the class of lectins containing an Euonymus lectin (EUL)-related domain, one of them being OrysaEULS2. The OrysaEULS2 sequence consists of a 56 amino acid N-terminal domain followed by the EUL sequence. In this paper the origin...

journal_title：Glycoconjugate journal

authors： Al Atalah B,Rougé P,Smith DF,Proost P,Lasanajak Y,Van Damme EJ

更新日期：2012-10-01 00:00:00

abstract：:As part of our ongoing program aimed at understanding the structural significance of GlcNAcβAsn linkage conserved in all eukaryotic N-glycoproteins, the present study reports on the synthesis and X-ray crystal structures of N-(3-deoxy-3-acetamido-β-D-glycopyranosyl)acetamide (Glc3NAcβNHAc) and the corresponding propio...

journal_title：Glycoconjugate journal

authors： Mathiselvam M,Varghese B,Loganathan D

更新日期：2011-12-01 00:00:00

abstract：:The importance of the surrounding lipid environment on the availability of glycolipid carbohydrate for ligand binding was demonstrated by studying the influence of phosphatidylcholine fatty acid chain length on binding of verotoxins (VT1 and VT2c) to their specific cell surface receptor, globotriaosylceramide (Gb3) in...

journal_title：Glycoconjugate journal

authors： Arab S,Lingwood CA

更新日期：1996-04-01 00:00:00

abstract：:The metabolism of glycosphingolipids is strictly regulated during the mitotic cell cycle. Before the G1-to-S transition, the ceramide and glucosylceramide concentration is elevated. Ceramide induces apoptosis synergistically with the pro-apoptotic protein prostate apoptosis response 4 (PAR-4) that may be asymmetricall...

journal_title：Glycoconjugate journal

authors： Bieberich E

更新日期：2004-01-01 00:00:00

abstract：:The Maillard reaction was discovered in 1912 by Louis C. Maillard when he observed the browning phenomena with aroma formation in a heated solution containing a sugar and an amino acid. The Maillard reaction starts from the reactions between carbonyl groups of various sugars and amino groups of amino acids/ proteins, ...

journal_title：Glycoconjugate journal

authors： Murata M

更新日期：2020-09-10 00:00:00

abstract：:The partial oligosaccharide sequences of glycoconjugates and the nature of their glycosidic linkages were investigated in normal human prostate, benign prostatic hyperplasia (BPH) and prostatic carcinoma by means of lectin histochemistry, using light microscopy and Western blot analysis. The labeling pattern of BPH di...

journal_title：Glycoconjugate journal

authors： Arenas MI,Romo E,de Gaspar I,de Bethencourt FR,Sánchez-Chapado M,Fraile B,Paniagua R

更新日期：1999-07-01 00:00:00

abstract：:Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens o...

journal_title：Glycoconjugate journal

authors： Nakamura Y,Miyata Y,Matsuo T,Shida Y,Hakariya T,Ohba K,Taima T,Ito A,Suda T,Hakomori SI,Saito S,Sakai H

更新日期：2019-10-01 00:00:00

abstract：:Maackia amurensis haemagglutinin (MAH) is a leguminous lectin which preferentially binds to a cluster of sialylated O-linked carbohydrate chains (Konami Y, Yamamoto K. Osawa T, Irimura T (1994) FEBS Lett 342:334-38). In the present study a 950 bp cDNA clone encoding MAH was isolated from a cDNA library constructed fro...

journal_title：Glycoconjugate journal

authors： Yamamoto K,Ishida C,Saito M,Konami Y,Osawa T,Irimura T

更新日期：1994-12-01 00:00:00

abstract：:Type 1 ABO blood group antigens (peripheral core structure: Gal beta 1-3GlcNAc beta 1-R) are expressed mainly in endodermally-derived tissues, but are not synthesized in mesodermally-derived tissues. In the former tissues, H type 1 antigen is generated largely by alpha-2-L-fucosyltransferase encoded by secretor (Se) g...

journal_title：Glycoconjugate journal

authors： Tanegashima A,Nishi K,Fukunaga T,Rand S,Brinkmann B

更新日期：1996-08-01 00:00:00

abstract：:The complex microenvironment that surrounds hematopoietic stem cells (HSCs) in the bone marrow niche involves different coordinated signaling pathways. The stem cells establish permanent interactions with distinct cell types such as mesenchymal stromal cells, osteoblasts, osteoclasts or endothelial cells and with secr...

journal_title：Glycoconjugate journal

authors： Papy-Garcia D,Albanese P

更新日期：2017-06-01 00:00:00

abstract：:Influenza virus neuraminidase inhibitors (NAIs), currently used as anti-influenza drugs, can lead to the appearance of drug-resistant variants. Resistance to NAIs appears due to mutations in the active site of the neuraminidase (NA) molecule that decrease the NA enzymatic activity and sometimes in the hemagglutinin (H...

journal_title：Glycoconjugate journal

authors： Mochalova L,Bright R,Xu X,Korchagina E,Chinarev A,Bovin N,Klimov A

更新日期：2010-04-01 00:00:00

abstract：:Five monoclonal antibodies AS17, 22, 25, 38 and 48, a single monoclonal antibody ACH55, and three monoclonal antibodies NAH33, 43, 46, that recognize acharan sulfate (IdoA2S-GlcNAc)n, acharan (IdoA-GlcNAc)n and N-acetyl-heparosan (GlcA-GlcNAc)n, respectively, were generated by immunization of mice with keyhole limpet ...

journal_title：Glycoconjugate journal

authors： Suzuki K,Yamamoto K,Kariya Y,Maeda H,Ishimaru T,Miyaura S,Fujii M,Yusa A,Joo EJ,Kimata K,Kannagi R,Kim YS,Kyogashima M

更新日期：2008-11-01 00:00:00

abstract：:The human glioma D-54MG cell line grown in vitro primarily expresses ganglio series gangliosides, particularly GM2. Subcutaneous injection of these cells into nude mice produced xenografts with an increased content of the human glioma-associated lacto series gangliosides, primarily 3'-isoLM1, an alteration that was do...

journal_title：Glycoconjugate journal

authors： Fredman P,Wikstrand CJ,Månsson JE,Reifenberger G,Bigner SH,Rasheed A,Svennerholm L,Bigner DD

更新日期：1996-06-01 00:00:00

abstract：:A major impediment in the analysis of glycosaminoglycans is the difficulty to cleave quantitatively the glycosidic bonds because of the stabilisation of glycosidic bonds and of the relative instability of the liberated constituents. This manuscript describes a modified procedure of methanolysis in the presence of bari...

journal_title：Glycoconjugate journal

authors： Zanetta JP,Timmerman P,Leroy Y

更新日期：1999-10-01 00:00:00

abstract：:The classical function of human chorionic gonadotropin (hCG) is its role in supporting pregnancy. hCG is a dimer consisting of two highly glycosylated subunits, alpha (CGA) and beta (CGB). The beta-hCG protein is encoded by CGB3, CGB5, CGB7 and CGB8 genes. CGB3, 5 and 8 code for an identical protein, CGB3/5/8, whereas...

journal_title：Glycoconjugate journal

authors： Biskup K,Blanchard V,Castillo-Binder P,Alexander H,Engeland K,Schug S

更新日期：2020-10-01 00:00:00

abstract：:This review discusses the challenges facing research in 'functional glycomics' and the novel technologies that are being developed to advance the field. The structural complexity of glycans and glycoconjugates makes studies of both their structures and recognition difficult. However, these intricate structures can be ...

journal_title：Glycoconjugate journal

authors： Song X,Heimburg-Molinaro J,Smith DF,Cummings RD

更新日期：2015-10-01 00:00:00

abstract：:By employing a bovine UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyl transferase (O-GalNAc transferase) cDNA as a probe, we isolated four overlapping cDNAs from a porcine lung cDNA library. Both the nucleotide sequence of the porcine cDNA and the predicted primary structure of the protein (559 amino aci...

journal_title：Glycoconjugate journal

authors： Yoshida A,Hara T,Ikenaga H,Takeuchi M

更新日期：1995-12-01 00:00:00

abstract：:Glycosphingolipids were prepared from pig lung and pooled into two fractions with (i) < or = 3 sugar residues, and (ii) > or = 3 sugar residues. Oligosaccharides were prepared and used for gas chromatography, gas chromatography/mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry. The gl...

journal_title：Glycoconjugate journal

authors： Bäcker AE,Thorbert S,Rakotonirainy O,Hallberg EC,Olling A,Gustavsson M,Samuelsson BE,Soussi B

更新日期：1999-01-01 00:00:00

abstract：:Blood group oligosaccharides are one of the most clinically important antigen families and they may also act as secondary ligands for bacterial toxins from Escherichia coli and Vibrio cholerae. Herein we report the synthesis of spacered (sp = CH2CH2CH2NH2) glycosides of A antigen {α-D-GalNAc-(l→3)-[α-L-Fuc-(l→2)]-β-D-...

journal_title：Glycoconjugate journal

authors： Karki G,Mishra VN,Mandal PK

更新日期：2016-02-01 00:00:00

abstract：:In this study, the antibody 3G9-A was assayed for activity against human erythrocyte glycosphingolipids. The antibody was found to recognize glycosphingolipid components from blood group A erythrocytes but not glycosphingolipids from blood group B or O erythrocytes. Subsequent investigation revealed that the glycosphi...

journal_title：Glycoconjugate journal

authors： Briggs JB,Mandrell R,Macher BA

更新日期：1996-06-01 00:00:00

abstract：:Disialosyl globopentaosylceramide (DSGb5) is a ganglioside originally isolated from tissue extracts of renal cell carcinoma (RCC) with metastasis. Previous in vitro experiments have suggested that DSGb5 promotes metastasis by enhancing the migration of RCC cells and downregulating NK cell cytotoxicity against RCC cell...

journal_title：Glycoconjugate journal

authors： Itoh J,Ito A,Shimada S,Kawasaki Y,Kakoi N,Saito H,Mitsuzuka K,Watanabe M,Satoh M,Saito S,Arai Y

更新日期：2017-04-01 00:00:00

abstract：:A non-enzymatic reaction between sugars or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules, which could impair their structural integrity and function. This process begins with the conversion of reversible Schiff base adducts, and then to more stable, cov...

journal_title：Glycoconjugate journal

authors： Yamagishi S,Taguchi K,Fukami K

更新日期：2016-08-01 00:00:00

abstract：:In this study, a novel water soluble polysaccharide (named GFP-4) was extracted from Grifola frondosa at 4 oC, and its preliminary structure and inhibitory effects on human gastric carcinoma MKN-45 cells through the Fas/FasL death receptor apoptosis pathway were investigated. High-performance gel permeation chromatogr...

journal_title：Glycoconjugate journal

authors： Liu C,Ji HY,Wu P,Yu J,Liu AJ

更新日期：2020-08-01 00:00:00

abstract：:Various oligosaccharides containing galactose(s) and one glucosamine (or N-acetylglucosamine) residues with beta1-4, alpha1-6 and beta1-6 glycosidic bond were synthesized; Galbeta1-4GlcNH(2), Galalpha1-6GlcNH(2), Galalpha1-6GlcNAc, Galbeta1-6GlcNH(2), Galbeta1-4Galbeta1-4GlcNH(2) and Galbeta1-4Galbeta1-4GlcNAc. Galalp...

journal_title：Glycoconjugate journal

authors： Hosomi O,Misawa Y,Takeya A,Matahira Y,Sugahara K,Kubohara Y,Yamakura F,Kudo S

更新日期：2009-02-01 00:00:00

abstract：:Colominic acid is an alpha2,8-linked sialic acid polymer produced by Escherichia coli. We found that synthetic sulfated-colominic acids (SC) remarkably inhibited the cytotoxicity of bee and snake venom toward mouse fibroblast cells, but colominic acids showed no inhibition themselves, indicating the important role of ...

journal_title：Glycoconjugate journal

authors： Oda Y,Kinoshita M,Hamada K,Nakayama K,Ohta Y,Yamaguchi S,Tsukada Y,Kawai Y,Kakehi K

更新日期：1999-08-01 00:00:00

abstract：:Eggs from Amphibia are surrounded by several layers of jelly that are needed for proper fertilization. Jelly coat is composed of highly glycosylated mucin-type glycoproteins containing up to 60% of carbohydrates, which display a remarkable species-specificity. This material obtained from Triturus alpestris was submitt...

journal_title：Glycoconjugate journal

authors： Florea D,Maes E,Guérardel Y,Page A,Zanetta JP,Cogalniceanu D,Strecker G

更新日期：2006-07-01 00:00:00

abstract：:Infectious disease, commonly caused by bacterial pathogens, is now the world's leading cause of premature death and third overall cause behind cardiovascular disease and cancer. Urinary Tract Infection (UTI), caused by E. coli bacteria, is a very common bacterial infection, a majority in women (85%) and may result in ...

journal_title：Glycoconjugate journal

authors： Basu M,Seggerson S,Henshaw J,Jiang J,del A Cordona R,Lefave C,Boyle PJ,Miller A,Pugia M,Basu S

更新日期：2004-01-01 00:00:00

abstract：:Two azidohexasaccharide building blocks, of which the glycosyl acceptor was the 5-(methoxycarbonyl)pentyl glycoside, were coupled using the trichloroacetimidate technology. The 12 azido functions present in the dodecasaccharide thus formed were then converted to amino groups using hydrogen sulfide as a reducing reagen...

journal_title：Glycoconjugate journal

authors： Ogawa Y,Kovac P

更新日期：1997-06-01 00:00:00