当前位置： SCI文献检索 > GLYCOCONJUGATE JOURNAL期刊下所有文献 > Sulfated sialic acid-polymers inhibit the cytotoxic action of bee and snake venom.

Sulfated sialic acid-polymers inhibit the cytotoxic action of bee and snake venom.

Abstract：

:Colominic acid is an alpha2,8-linked sialic acid polymer produced by Escherichia coli. We found that synthetic sulfated-colominic acids (SC) remarkably inhibited the cytotoxicity of bee and snake venom toward mouse fibroblast cells, but colominic acids showed no inhibition themselves, indicating the important role of sulfate groups in the inhibitory activity of SC. Other sulfated carbohydrates such as chondroitin sulfates, heparin and heparan sulfate showed no inhibition. SC also exhibited potent inhibition of melittin, a highly basic peptide, which is a major cytotoxic component of bee venom. SC did not inhibit phospholipase A2 activity in bee venom. This suggests that the inhibition of bee and snake venom by SC is due to inhibition of melittin and cardiotoxin, which is a cytolytic peptide in snake venom, respectively. SC with a higher sulfur content and a larger molecular mass showed more potent activity. The interaction between SC and melittin basically seems an ionic one, however, the conformation of SC is also likely important. For the binding of SC to melittin leading loss of its cytotoxic activity, the sulfate groups of SC must be properly arranged to interact with lysine and arginine residues of melittin molecules, which play an important role in the cytolytic activity. A higher molecular mass of SC substituted with more sulfate groups is required for more obvious inhibition of the cytotoxic activity.

journal_name

Glycoconj J

journal_title

Glycoconjugate journal

authors

Oda Y,Kinoshita M,Hamada K,Nakayama K,Ohta Y,Yamaguchi S,Tsukada Y,Kawai Y,Kakehi K

doi

10.1023/a:1007074410201

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

457-63

issue

8

eissn

0282-0080

issn

1573-4986

journal_volume

16

pub_type

杂志文章

相关文献

GLYCOCONJUGATE JOURNAL文献大全
  • Glycosylation of the N-terminal potential N-glycosylation sites in the human alpha1,3-fucosyltransferase V and -VI (hFucTV and -VI).

    abstract：:Human alpha1,3-fucosyltransferase V and -VI (hFucTV and -VI) each contain four potential N-glycosylation sites (hFucTV: Asn60, Asn105, Asn167 and Asn198 and hFucTVI: Asn46, Asn91, Asn153 and Asn184). Glycosylation of the two N-terminal potential N-glycosylation sites (hFucTV: Asn60, Asn105 and hFucTVI: Asn46 and Asn91...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1023/a:1010917229243

    authors： Christensen LL,Bross P,Ørntoft TF

    更新日期：2000-12-01 00:00:00

  • Interleukin-3-associated ganglioside GD1a is induced independently of normal interleukin-3 receptor in murine myelogenous leukaemia NFS60 cells transfected with the interleukin-3 gene.

    abstract：:The mechanism of interleukin-3 (IL-3) independent cell growth and of IL-3-associated ganglioside expression was analysed using the IL-3 dependent murine myelogenous leukaemia cell line NFS60-I7 and IL-3 gene-transfected sublines. The transfected cell lines showed autonomous cell growth, tumorigenicity, and IL-3 associ...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731500

    authors： Nakamura M,Kirito K,Tsunoda A,Hara K,Furukawa Y,Saito M

    更新日期：1996-04-01 00:00:00

  • In vitro production of proteoglycans in the articular-epiphyseal cartilage of growing pigs.

    abstract：:The failure of cartilage mineralization in osteochondrotic cartilage may be due to an impaired proteoglycan production. The in vitro production of proteoglycans was therefore studied in the joint cartilage of growing pigs, aged 9-18 weeks, after incubation of cartilage samples with 35S-sulfate. Cartilage was obtained ...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731147

    authors： Ekman S,Unger E,Kjellén L

    更新日期：1994-04-01 00:00:00

  • Influence of phospholipid chain length on verotoxin/globotriaosyl ceramide binding in model membranes: comparison of a supported bilayer film and liposomes.

    abstract：:The importance of the surrounding lipid environment on the availability of glycolipid carbohydrate for ligand binding was demonstrated by studying the influence of phosphatidylcholine fatty acid chain length on binding of verotoxins (VT1 and VT2c) to their specific cell surface receptor, globotriaosylceramide (Gb3) in...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731490

    authors： Arab S,Lingwood CA

    更新日期：1996-04-01 00:00:00

  • Analysis of sugar chain-binding specificity of tomato lectin using lectin blot: recognition of high mannose-type N-glycans produced by plants and yeast.

    abstract：:The sugar chain-binding specificity of tomato lectin (LEA) against glycoproteins was investigated qualitatively using lectin blot analysis. Glycoproteins containing tri- and tetra-antennary complex-type N-glycans were stained with LEA. Unexpectedly, glycoproteins containing high mannose-type N-glycans and a horseradis...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-005-5329-4

    authors： Oguri S

    更新日期：2005-11-01 00:00:00

  • Screening for the presence of polyglycosylceramides in various tissues: partial characterization of blood group-active complex glycosphingolipids of rabbit and dog small intestines.

    abstract：:Twenty different human and animal tissues were investigated for the presence of polyglycosylceramides. The glycolipids were isolated by peracetylation of dry tissue residues left after conventional lipid extraction, followed by extraction with chloroform and subsequent Sephadex LH-20, Sephadex LH-60 and silica gel chr...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1023/a:1018545922728

    authors： Miller-Podraza H,Stenhagen G,Larsson T,Andersson C,Karlsson KA

    更新日期：1997-02-01 00:00:00

  • Rapid analysis of O-acetylated neuraminic acids by matrix assisted laser desorption/ionization time-of-flight mass spectrometry.

    abstract：:N-Acetylneuraminic acid (a sialic acid) occurs mainly as a terminal substituent of oligosaccharides of glycoconjugates. Derivatives of neuraminic acid occur widely, substituted in the amino and hydroxy side chains, as well in the C-9 carbon skeleton. These derivatives are responsible for specific functions of sialic a...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1023/a:1006965600322

    authors： Stehling P,Gohlke M,Fitzner R,Reutter W

    更新日期：1998-04-01 00:00:00

  • Species-specific expression of sialosyl-Le(x) on polymorphonuclear leukocytes (PMN), in relation to selectin-dependent PMN responses.

    abstract：:Sialosyl-Le(x) (SLex) and its positional isomer sialosyl-Le(a) are the epitopes recognized by the lectin domain of E- and P-selectins. Expression of SLex in polymorphonuclear leukocytes (PMN) plays an important role in recruitment of these cells at sites of inflammation through activation of selectins. We studied expr...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731223

    authors： Ito K,Handa K,Hakomori S

    更新日期：1994-06-01 00:00:00

  • Cloning and characterization of a sialidase from the filamentous fungus, Aspergillus fumigatus.

    abstract：:A gene encoding a putative sialidase was identified in the genome of the opportunistic fungal pathogen, Aspergillus fumigatus. Computational analysis showed that this protein has Asp box and FRIP domains, it was predicted to have an extracellular localization, and a mass of 42 kDa, all of which are characteristics of ...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-010-9299-9

    authors： Warwas ML,Yeung JH,Indurugalla D,Mooers AO,Bennet AJ,Moore MM

    更新日期：2010-07-01 00:00:00

  • Glycotargeting to improve cellular delivery efficiency of nucleic acids.

    abstract：:Nucleic acids bearing glycans of various structures have been under vigorous investigation in the past decade. The carbohydrate moieties of such complexes can serve as recognition sites for carbohydrate-binding proteins-lectins-and initiate receptor-mediated endocytosis. Therefore, carbohydrates can enhance cell targe...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章,评审

    doi：10.1007/s10719-006-9023-y

    authors： Yan H,Tram K

    更新日期：2007-04-01 00:00:00

  • A full assignment of proton resonances for an alpha(1-3)-linked fucose residue in keratan sulphate from bovine articular cartilage.

    abstract：:Full proton NMR assignments have been achieved for the alpha(1-3)-linked fucose residues contained in alkaline borohydride reduced keratan sulphate chains derived from bovine articular cartilage. This involved 500 MHz spectroscopy at 60 degrees C and included COSY and RELAYED-COSY determinations. ...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731641

    authors： Huckerby TN,Nieduszynski IA,Brown GM,Cockin GH

    更新日期：1991-02-01 00:00:00

  • Structural analysis of novel rhamnose-branched oligosaccharides from the glycophosphosphingolipids of Leptomonas samueli.

    abstract：:Mild alkaline hydrolysis of the glycophosphosphingolipids of the protozoan Leptomonas samueli liberated several phosphoinositol-containing oligosaccharides (PI-oligosaccharides), which were purified by high performance anion exchange chromatography. The oligosaccharides in the resulting four fractions were characteriz...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00732429

    authors： Previato JO,Wait R,Jones C,Mendonça-Previato L

    更新日期：1994-02-01 00:00:00

  • Expression of neutral glycosphingolipids and gangliosides in human skeletal and heart muscle determined by indirect immunofluorescence staining.

    abstract：:The expression of neutral glycosphingolipids and gangliosides has been studied in human skeletal and heart muscle using indirect immunofluorescence microscopy. Transversal and longitudinal cryosections were immunostained with specific monoclonal and polyclonal antibodies against the neural glycosphingolipids lactosylc...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731284

    authors： Cacić M,Müthing J,Kracun I,Neumann U,Weber-Schürholz S

    更新日期：1994-10-01 00:00:00

  • Human galectin-8 isoforms and cancer.

    abstract：:Galectins are animal lectins that can specifically bind beta-galactosides. Thirteen galectins have already been described. This review focuses on a specific member of this family: galectin-8. This galectin was discovered in prostate cancer cells eight years ago and has been studied extensively in the last few years. T...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章,评审

    doi：10.1023/B:GLYC.0000014086.38343.98

    authors： Bidon-Wagner N,Le Pennec JP

    更新日期：2002-01-01 00:00:00

  • Inhibitory activity of sulphoglycolipid derivatives towards pancreatic trypsin.

    abstract：:Amphipathic sulpholipids have been shown to inhibit pancreatic serine proteases due to their detergent-like properties. To evaluate the structural requirement for this inhibitory activity, we examined the effects of various derivatives of sulphoglycolipids, some of which were prepared by deacylation with sphingolipid ...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1023/a:1010988709764

    authors： Suzuki H,Ito M,Kimura T,Iwamori Y,Iwamori M

    更新日期：2000-11-01 00:00:00

  • Glycosylation potential of human prostate cancer cell lines.

    abstract：:Altered glycosylation is a universal feature of cancer cells and altered glycans can help cancer cells escape immune surveillance, facilitate tumor invasion, and increase malignancy. The goal of this study was to identify specific glycoenzymes, which could distinguish prostate cancer cells from normal prostatic cells....

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-012-9428-8

    authors： Gao Y,Chachadi VB,Cheng PW,Brockhausen I

    更新日期：2012-10-01 00:00:00

  • Enzymatic characterization of CMP-NeuAc:Gal beta 1-4GlcNAc-R alpha(2-3)-sialyltransferase from human placenta.

    abstract：:In this report we present the enzymatic characterization of CMP-NeuAc:Gal beta 1-4GlcNAc-R alpha(2-3)-sialyltransferase from human placenta using placenta membranes as an enzyme preparation. This sialyltransferase is highly sensitive to detergents and prefers type 2 chain (Gal beta 1-4GlcNAc) over type 1 chain (Gal be...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731193

    authors： Nemansky M,van den Eijnden DH

    更新日期：1993-02-01 00:00:00

  • SIGNR1 ligation on murine peritoneal macrophages induces IL-12 production through NFkappaB activation.

    abstract：:We have previously shown that murine resident peritoneal macrophages (PEMs) are activated in response to uptake of oligomannose-coated liposomes (OMLs), leading to production of interleukin (IL)-12. To understand the mechanism of activation of PEMs by OMLs, in the present study we investigated the role of a mannose-bi...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-010-9298-x

    authors： Kato C,Kojima N

    更新日期：2010-07-01 00:00:00

  • Lectin analysis of human immunoglobulin G N-glycan sialylation.

    abstract：:The lectins Sambucus nigra agglutinin (SNA) and Ricinus communis agglutinin (RCA), specific for alpha2,6 linked sialylation, and terminal galactose respectively were used to study the occurrence, linkage and distribution of human immunoglobulin G (IgG) sialylation. SNA was shown to bind N-glycan alpha2,6-linked sialic...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1023/a:1007183915921

    authors： Dalziel M,McFarlane I,Axford JS

    更新日期：1999-12-01 00:00:00

  • Studies on the conformational behaviour of GlcNAc-Man3-GlcNAc2 oligosaccharides using molecular dynamics simulations.

    abstract：:Three-dimensional structures of the natural substrate unit for the enzyme N-acetylglucosamine-transferase II, GIcNAc-Man3-GlcNAc2, were investigated by molecular modelling methods. Molecular dynamics (MD) and molecular mechanics calculations on two hexasaccharides, namely GlcNAc-Man3-GlcNAc2-Asn and GlcNAc-Man3-GlcNAc...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1023/a:1006976408074

    authors： Kozar T,Tvaroska I,Carver JP

    更新日期：1998-02-01 00:00:00

  • Enzymatic synthesis of fucose-containing galacto-oligosaccharides using β-galactosidase and identification of novel disaccharide structures.

    abstract：:Fucosylated oligosaccharides have an important role in maintaining a healthy immune system and homeostatic gut microflora. This study employed a commercial β-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose. The production was optimized using experiment desig...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-017-9794-3

    authors： Usvalampi A,Maaheimo H,Tossavainen O,Frey AD

    更新日期：2018-02-01 00:00:00

  • Surface glycoprotein of human natural killer cells recognized by wheat germ agglutinin.

    abstract：:We analyzed surface glycoproteins of human natural killer (NK) cells by utilizing lectins. Among the lectins tested, wheat germ agglutinin (WGA) was found to bind preferentially to CD16(Leu11)-positive lymphocytes as determined by two-colour flow cytometry. Analysis of glycoproteins in the lysate prepared from NK cell...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731165

    authors： Harada K,Yamane H,Imai Y,Tsuji T,Toyoshima S,Osawa T

    更新日期：1992-08-01 00:00:00

  • Identification of receptors responsible for binding of the mannose specific lectin to the gut epithelial membrane of the target insects.

    abstract：:The sap-sucking homopteran insects, commonly known as aphids and leafhoppers are responsible for a huge amount of lost productivity of mustard, chickpea, cabbage, rice and many other important crops. Due to their unique feeding habits and ability to build up a huge population in a very short time, they are very diffic...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1023/B:GLYC.0000043288.72051.7c

    authors： Majumder P,Banerjee S,Das S

    更新日期：2004-01-01 00:00:00

  • Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer.

    abstract：:The carbohydrate determinants, sialyl Lewis A and sialyl Lewis X, which are frequently expressed on human cancer cells, serve as ligands for a cell adhesion molecule of the selectin family, E-selectin, which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of can...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章,评审

    doi：10.1023/a:1018532409041

    authors： Kannagi R

    更新日期：1997-08-01 00:00:00

  • Structural features of the lysosomal hydrolase mannose 6-phosphate uncovering enzyme.

    abstract：:The uncovering enzyme (UCE) removes N-acetylglucosamine from lysosomal enzymes to uncover the mannose 6-phosphate (Man-6-P) determinant necessary for targeting these enzymes to lysosomes. Failure to create the Man-6-P determinant is one cause of lysosomal storage diseases. Despite its medical importance, little struct...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-005-0846-8

    authors： Wei Y,Yen TY,Cai J,Trent JO,Pierce WM,Young WW Jr

    更新日期：2005-02-01 00:00:00

  • Early stage fetal neocortex exhibits a complex ganglioside profile as revealed by high resolution tandem mass spectrometry.

    abstract：:In this study we report on the first mass spectrometric (MS) investigation of gangliosides and preliminary assessment of the expression and structure in normal fetal neocortex in early developmental stages: 14th (Neo14) and 16th (Neo16) gestational weeks. Ganglioside analysis was carried out using a hybrid quadrupole ...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-014-9517-y

    authors： Ghiulai RM,Sarbu M,Vukelić Ž,Ilie C,Zamfir AD

    更新日期：2014-04-01 00:00:00

  • Signaling through sphingolipid microdomains of the plasma membrane: the concept of signaling platform.

    abstract：:Transmembrane signaling requires modular interactions between signaling proteins, phosphorylation or dephosphorylation of the interacting protein partners and temporary elaboration of supramolecular structures, to convey the molecular information from the cell surface to the nucleus. Such signaling complexes at the pl...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章,评审

    doi：10.1023/a:1026585006064

    authors： Hoessli DC,Ilangumaran S,Soltermann A,Robinson PJ,Borisch B,Nasir-Ud-Din

    更新日期：2000-03-01 00:00:00

  • Ab initio fragment molecular orbital studies of influenza virus hemagglutinin-sialosaccharide complexes toward chemical clarification about the virus host range determination.

    abstract：:If we predict the host range of new or mutant influenza virus in advance, we are able to measure against pandemic human influenza immediately after the new virus emerges somewhere. Influenza viral hemagglutinin(HA)-sialoside receptor interaction is a target event for in silico chemical prediction studies about the vir...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-008-9141-9

    authors： Sawada T,Hashimoto T,Tokiwa H,Suzuki T,Nakano H,Ishida H,Kiso M,Suzuki Y

    更新日期：2008-12-01 00:00:00

  • A monoclonal antibody for terminal beta-galactose. Use in analysis of glycosphingolipids.

    abstract：:A monoclonal antibody (mAb 8281) specific for the terminal beta-galactose (beta Gal) of glycosphingolipids (GSL) and glycoproteins was produced from mice immunized with lipid extract from fresh acute lymphocytic leukemia (ALL) cells. Immuno-thin layer chromatography (ITLC) and competition assays with purified neutral ...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/BF00731643

    authors： Kalisiak A,Oosterwijk E,Minniti JG,Old LJ,Scheinberg DA

    更新日期：1991-02-01 00:00:00

  • Analysis of Heparan sulfate/heparin from Colla corii asini by liquid chromatography-electrospray ion trap mass spectrometry.

    abstract：:Colla corii asini (CCA) made from donkey-hide has been widely used as a health-care food and an ingredient of traditional Chinese medicine. Heparan sulfate (HS)/heparin is a structurally complex class of glycosaminoglycans (GAGs) that have been implicated in a wide range of biological activities. However, their presen...

    journal_title：Glycoconjugate journal

    pub_type： 杂志文章

    doi：10.1007/s10719-019-09868-0

    authors： Du J,Liu S,Liang Q,Lin J,Jiang L,Chen F,Wei Z

    更新日期：2019-06-01 00:00:00