Abstract：
:Rapid prototyping (RP) is a useful method for designing and fabricating a wide variety of devices used for neuroscience research. The present study confirms the utility of using fused deposition modeling, a specific form of RP, to produce three devices commonly used for basic science experimentation. The accuracy and precision of the RP method varies according to the type and quality of the printer as well as the thermoplastic substrate. The printer was capable of creating device channels with a minimum diameter of 0.4 or 0.6mm depending on the orientation of fabrication. RP enabled the computer-aided design and fabrication of three custom devices including a cortical recording/stroke induction platform capable of monitoring electrophysiological function during ischemic challenge. In addition to the recording platform, two perfusion chambers and a cranial window device were replicated with sub-millimeter precision. The ability to repeatedly modify the design of each device with minimal effort and low turn-around time is helpful for oft-unpredictable experimental conditions. Results obtained from validation studies using both the cortical recording platform and perfusion chamber did not vary from previous results using traditional hand-fabricated or commercially available devices. Combined with computer-aided design, rapid prototyping is an excellent alternative for developing and fabricating custom devices for neuroscience research.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Tek P,Chiganos TC,Mohammed JS,Eddington DT,Fall CP,Ifft P,Rousche PJdoi
10.1016/j.jneumeth.2008.03.011subject
Has Abstractpub_date
2008-07-30 00:00:00pages
263-9issue
2eissn
0165-0270issn
1872-678Xpii
S0165-0270(08)00163-5journal_volume
172pub_type
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